Connexins in leukocytes: Shuttling messages?

Cardiovascular Research

Volumn 62, Issue 2, 2004, Pages 357-367

  Wong, Cindy W ^a   Christen, Thomas ^a   Kwak, Brenda R ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Atherosclerosis; Cell communication; Connexins; Gap junctions; Leukocytes

Indexed keywords

CONNEXIN 37; CONNEXIN 43; CONNEXIN 45; GAP JUNCTION PROTEIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 10; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ANTIGEN PRESENTING CELL; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; B LYMPHOCYTE; CELL ACTIVATION; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL INTERACTION; CELL MATURATION; CYTOKINE PRODUCTION; ELECTRIC CURRENT; EMBRYO DEVELOPMENT; GAP JUNCTION; HEMATOPOIESIS; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; LANGERHANS CELL; LEUKOCYTE; LYMPHOCYTE; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; MONOCYTE; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVIEW; STEM CELL; T LYMPHOCYTE;

ANIMALS; ARTERIOSCLEROSIS; CELL COMMUNICATION; CHEMOTAXIS, LEUKOCYTE; CONNEXINS; GAP JUNCTIONS; HUMANS; LEUKOCYTES;

EID: 1942502888     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2003.12.015     Document Type: Review

References (82)

1. Butcher E.C., Picker L.J. Lymphocyte homing and homeostasis. Science. 272:1996;60-66.
2. Springer T.A. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 76:1994;301-314.
3. Aurrand-Lions M., Johnson-Leger C., Imhof B.A. Role of interendothelial adhesion molecules in the control of vascular functions. Vasc. Pharmacol. 39:2002;239-246.
4. Luscinskas F.W., Ma S., Nusrat A., Parkos C.A., Shaw S.K. The role of endothelial cell lateral junctions during leukocyte trafficking. Immunol. Rev. 186:2002;57-67.
5. Evans W.H., Martin P.E. Gap junctions: structure and function (Review). Mol. Membr. Biol. 19:2002;121-136.
6. Willecke K., Eiberger J., Degen J.et al. Structural and functional diversity of connexin genes in the mouse and human genome. Biol. Chem. 383:2002;725-737.
7. Harris A.L. Emerging issues of connexin channels: biophysics fills the gap. Q. Rev. Biophys. 34:2001;325-472.
8. White T.W. Nonredundant gap junction functions. News Physiol. Sci. 18:2003;95-99.
9. Goodenough D.A., Paul D.L. Beyond the gap: functions of unpaired connexon channels. Nat. Rev., Mol. Cell Biol. 4:2003;285-294.
10. Saez J.C., Berthoud V.M., Branes M.C., Martinez A.D., Beyer E.C. Plasma membrane channels formed by connexins: their regulation and functions. Physiol. Rev. 83:2003;1359-1400.
11. Saez J.C., Contreras J.E., Bukauskas F.F., Retamal M.A., Bennett M.V. Gap junction hemichannels in astrocytes of the CNS. Acta Physiol. Scand. 179:2003;9-22.
12. John S., Cesario D., Weiss J.N. Gap junctional hemichannels in the heart. Acta Physiol. Scand. 179:2003;23-31.
13. Vergara L., Bao X., Bello-Reuss E., Reuss L. Do connexin 43 gap-junctional hemichannels activate and cause cell damage during ATP depletion of renal-tubule cells? Acta Physiol. Scand. 179:2003;33-38.
14. Hu J., Cotgreave I.A. Differential regulation of gap junctions by proinflammatory mediators in vitro. J. Clin. Invest. 99:1997;2312-2316.
15. Huang S., Dudez T., Scerri I.et al. Defective activation of c-Src in cystic fibrosis airway epithelial cells results in loss of tumor necrosis factor-alpha-induced gap junction regulation. J. Biol. Chem. 278:2003;8326-8332.
16. De Maio A., Vega V.L., Contreras J.E. Gap junctions, homeostasis, and injury. J. Cell Physiol. 191:2002;269-282.
17. Qiu C., Coutinho P., Frank S.et al. Targeting connexin43 expression accelerates the rate of wound repair. Curr. Biol. 13:2003;1697-1703.
18. Frossard J.L., Rubbia-Brandt L., Wallig M.A.et al. Severe acute pancreatitis and reduced acinar cell apoptosis in the exocrine pancreas of mice deficient for the Cx32 gene. Gastroenterology. 124:2003;481-493.
19. Watanabe Y. Fine structure of bone marrow stroma. Nippon Ketsueki Gakkai Zasshi. 48:1985;1688-1700.
20. Campbell F.R. Gap junctions between cells of bone marrow: an ultrastructural study using tannic acid. Anat. Rec. 196:1980;101-107.
21. Campbell F.R. Ultrastructural studies of intercellular contacts (junctions) in bone marrow. A review. Scand. Electron. Microsc. 1986;621-629.
22. Rosendaal M., Gregan A., Green C.R. Direct cell-cell communication in the blood-forming system. Tissue Cell. 23:1991;457-470.
23. Dorshkind K., Green L., Godwin A., Fletcher W.H. Connexin-43-type gap junctions mediate communication between bone marrow stromal cells. Blood. 82:1993;38-45.
24. Rosendaal M., Green C.R., Rahman A., Morgan D. Up-regulation of the connexin43+ gap junction network in haemopoietic tissue before the growth of stem cells. J. Cell Sci. 107(Pt. 1):1994;29-37.
25. Alves L.A., Campos de Carvalho A.C., Lima Cirne E.O.et al. Functional gap junctions in thymic epithelial cells are formed by connexin 43. Eur. J. Immunol. 25:1995;431-437.
26. Cancelas J.A., Koevoet W.L., de Koning A.E.et al. Connexin-43 gap junctions are involved in multiconnexin-expressing stromal support of hemopoietic progenitors and stem cells. Blood. 96:2000;498-505.
27. Krenacs T., Rosendaal M. Connexin43 gap junctions in normal, regenerating, and cultured mouse bone marrow and in human leukemias: their possible involvement in blood formation. Am. J. Pathol. 152:1998;993-1004.
28. Umezawa A., Hata J. Expression of gap-junctional protein (connexin 43 or alpha 1 gap junction) is down-regulated at the transcriptional level during adipocyte differentiation of H-1/A marrow stromal cells. Cell Struct. Funct. 17:1992;177-184.
29. Montecino-Rodriguez E., Leathers H., Dorshkind K. Expression of connexin 43 (Cx43) is critical for normal hematopoiesis. Blood. 96:2000;917-924.
30. Rosendaal M., Mayen A., de Koning A.et al. Does transmembrane communication through gap junctions enable stem cells to overcome stromal inhibition? Leukemia. 11:1997;1281-1289.
31. Jara P.I., Boric M.P., Saez J.C. Leukocytes express connexin 43 after activation with lipopolysaccharide and appear to form gap junctions with endothelial cells after ischemia-reperfusion. Proc. Natl. Acad. Sci. U. S. A. 92:1995;7011-7015.
32. Afonso A., Lousada S., Silva J., Ellis A.E., Silva M.T. Neutrophil and macrophage responses to inflammation in the peritoneal cavity of rainbow trout Oncorhynchus mykiss. A light and electron microscopic cytochemical study. Dis. Aquat. Org. 34:1998;27-37.
33. Branes M.C., Contreras J.E., Saez J.C. Activation of human polymorphonuclear cells induces formation of functional gap junctions and expression of connexins. Med. Sci. Monit. 8:2002;BR313-BR323.
34. Zahler S., Hoffmann A., Gloe T., Pohl U. Gap-junctional coupling between neutrophils and endothelial cells: a novel modulator of transendothelial migration. J. Leukoc. Biol. 73:2003;118-126.
35. Levy J.A., Weiss R.M., Dirksen E.R., Rosen M.R. Possible communication between murine macrophages oriented in linear chains in tissue culture. Exp. Cell Res. 103:1976;375-385.
36. Porvaznik M., MacVittie T.J. Detection of gap junctions between the progeny of a canine macrophage colony-forming cell in vitro. J. Cell Biol. 82:1979;555-564.
37. Martin C.A., el-Sabban M.E., Zhao L., Burakoff R., Homaidan F.R. Adhesion and cytosolic dye transfer between macrophages and intestinal epithelial cells. Cell Adhes. Commun. 5:1998;83-95.
38. Eugenin E.A., Eckardt D., Theis M.et al. Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-gamma and tumor necrosis factor-alpha. Proc. Natl. Acad. Sci. U. S. A. 98:2001;4190-4195.
39. Eugenin E.A., Branes M.C., Berman J.W., Saez J.C. TNF-alpha plus IFN-gamma induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses. J. Immunol. 170:2003;1320-1328.
40. Polacek D., Lal R., Volin M.V., Davies P.F. Gap junctional communication between vascular cells. Induction of connexin43 messenger RNA in macrophage foam cells of atherosclerotic lesions. Am. J. Pathol. 142:1993;593-606.
41. Alves L.A., Coutinho-Silva R., Persechini P.M.et al. Are there functional gap junctions or junctional hemichannels in macrophages? Blood. 88:1996;328-334.
42. Beyer E.C., Steinberg T.H. Evidence that the gap junction protein connexin-43 is the ATP-induced pore of mouse macrophages. J. Biol. Chem. 266:1991;7971-7974.
43. Kwak B.R., Mulhaupt F., Veillard N., Gros D.B., Mach F. Altered pattern of vascular connexin expression in atherosclerotic plaques. Arterioscler. Thromb. Vasc. Biol. 22:2002;225-230.
44. Hulser D.F., Peters J.H. Intercellular communication in phytohemagglutinin-induced lymphocyte agglutinates. Eur. J. Immunol. 1:1971;494-495.
45. Hulser D.F., Peters J.H. Contact cooperation in stimulated lymphocytes: II. Electrophysiological investigations on intercellular communication. Exp. Cell Res. 74:1972;319-326.
46. Oliveira-Castro G.M., Barcinski M.A., Cukierman S. Intercellular communication in stimulated human lymphocytes. J. Immunol. 111:1973;1616-1619.
47. Oliveira-Castro G.M., Barcinski M.A. Calcium-induced uncoupling in communicating human lymphocytes. Biochim. Biophys. Acta. 352:1974;338-343.
48. Gaziri I.F., Oliveira-Castro G.M., Machado R.D., Barcinski M.A. Structure and permeability of junctions in phytohemagglutinin stimulated human lymphocytes. Experientia. 31:1975;172-174.
49. Kapsenberg M.L., Leene W. Formation of B type gap junctions between PHA-stimulated rabbit lymphocytes. Exp. Cell Res. 120:1979;211-222.
50. Campbell F.R. Intercellular contacts of lymphocytes during migration across high-endothelial venules of lymph nodes. An electron microscopic study. Anat. Rec. 207:1983;643-652.
51. Concha M., Figueroa C.D., Caorsi I. Ultrastructural characteristics of the contact zones between Langerhans cells and lymphocytes. J. Pathol. 156:1988;29-36.
52. Concha M., Vidal A., Garces G., Figueroa C.D., Caorsi I. Physical interaction between Langerhans cells and T-lymphocytes during antigen presentation in vitro. J. Invest. Dermatol. 100:1993;429-434.
53. Guinan E.C., Smith B.R., Davies P.F., Pober J.S. Cytoplasmic transfer between endothelium and lymphocytes: quantitation by flow cytometry. Am. J. Pathol. 132:1988;406-409.
54. Oviedo-Orta E., Hoy T., Evans W.H. Intercellular communication in the immune system: differential expression of connexin40 and 43, and perturbation of gap junction channel functions in peripheral blood and tonsil human lymphocyte subpopulations. Immunology. 99:2000;578-590.
55. Sáez J.C., Araya R., Brañes M.C.et al. Gap junctions in inflammatory responses: connexins, regulation and possible functional roles. Peracchia C. Current Topics in Membranes. Gap Junctions - Molecular Basis of Cell Communication in Health and Diseases. vol. 49:2000;555-579 Academic Press, San Diego.
56. Krenacs T., van Dartel M., Lindhout E., Rosendaal M. Direct cell/cell communication in the lymphoid germinal center: connexin43 gap junctions functionally couple follicular dendritic cells to each other and to B lymphocytes. Eur. J. Immunol. 27:1997;1489-1497.
57. Oviedo-Orta E., Gasque P., Evans W.H. Immunoglobulin and cytokine expression in mixed lymphocyte cultures is reduced by disruption of gap junction intercellular communication. FASEB J. 15:2001;768-774.
58. Sáez J.C., Sepúlveda M.A., Araya R., Sáez C.G., Palisson F. Concanavalin A-activated lymphocytes form gap junctions that increase their rate of DNA replication. Werner R. Gap Junctions. 1998;372-381 IOS Press, Amsterdam.
59. Bromley S.K., Burack W.R., Johnson K.G.et al. The immunological synapse. Annu. Rev. Immunol. 19:2001;375-396.
60. Brand C.U., Hunziker T., Schaffner T.et al. Activated immunocompetent cells in human skin lymph derived from irritant contact dermatitis: an immunomorphological study. Br. J. Dermatol. 132:1995;39-45.
61. Oviedo-Orta E., Evans W.H. Gap junctions and connexins: potential contributors to the immunological synapse. J. Leukoc. Biol. 72:2002;636-642.
62. van Kempen M.J., Jongsma H.J. Distribution of connexin37, connexin40 and connexin43 in the aorta and coronary artery of several mammals. Histochem. Cell Biol. 112:1999;479-486.
63. van Rijen H.V., van Kempen M.J., Postma S., Jongsma H.J. Tumour necrosis factor alpha alters the expression of connexin43, connexin40, and connexin37 in human umbilical vein endothelial cells. Cytokine. 10:1998;258-264.
64. Oviedo-Orta E., Errington R.J., Evans W.H. Gap junction intercellular communication during lymphocyte transendothelial migration. Cell Biol. Int. 26:2002;253-263.
65. Glass C.K., Witztum J.L. Atherosclerosis. the road ahead. Cell. 104:2001;503-516.
66. Libby P. Inflammation in atherosclerosis. Nature. 420:2002;868-874.
67. Polacek D., Bech F., McKinsey J.F., Davies P.F. Connexin43 gene expression in the rabbit arterial wall: effects of hypercholesterolemia, balloon injury and their combination. J. Vasc. Res. 34:1997;19-30.
68. Blackburn J.P., Peters N.S., Yeh H.I.et al. Upregulation of connexin43 gap junctions during early stages of human coronary atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 15:1995;1219-1228.
69. Boerma M., Forsberg L., Van Zeijl L.et al. A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque development. J. Intern. Med. 246:1999;211-218.
70. Yeh H.I., Chou Y., Liu H.F., Chang S.C., Tsai C.H. Connexin37 gene polymorphism and coronary artery disease in Taiwan. Int. J. Cardiol. 81:2001;251-255.
71. Yamada Y., Izawa H., Ichihara S.et al. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. Eng. Med. J. 347:2002;1916-1923.
72. Kwak B.R., Veillard N., Pelli G.et al. Reduced connexin43 expression inhibits atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice. Circulation. 107:2003;1033-1039.
73. Wong C.W., Burger F., Pelli G., Mach F., Kwak B.R. Dual benefit of reduced Cx43 on atherosclerosis in LDL receptor-deficient mice. Cell Commun. Adhes. 10:2003;395-400.
74. Ross R. Atherosclerosis - an inflammatory disease. N. Engl. J. Med. 340:1999;115-126.
75. Doukas J., Pober J.S. Lymphocyte-mediated activation of cultured endothelial cells (EC). CD4+ T cells inhibit EC class II MHC expression despite secreting IFN-gamma and increasing EC class I MHC and intercellular adhesion molecule-1 expression. J. Immunol. 145:1990;1088-1098.
76. Hansson G.K., Holm J., Jonasson L. Detection of activated T lymphocytes in the human atherosclerotic plaque. Am. J. Pathol. 135:1989;169-175.
77. Chanson M., Scerri I., Suter S. Defective regulation of gap junctional coupling in cystic fibrosis pancreatic duct cells. J. Clin. Invest. 103:1999;1677-1684.
78. Gingalewski C., De Maio A. Differential decrease in connexin 32 expression in ischemic and nonischemic regions of rat liver during ischemia/reperfusion. J. Cell Physiol. 171:1997;20-27.
79. Fernandez-Cobo M., Gingalewski C., Drujan D., De Maio A. Downregulation of connexin 43 gene expression in rat heart during inflammation. The role of tumour necrosis factor. Cytokine. 11:1999;216-224.
80. El-Sabban M.E., Merhi R.A., Haidar H.A.et al. Human T-cell lymphotropic virus type 1-transformed cells induce angiogenesis and establish functional gap junctions with endothelial cells. Blood. 99:2002;3383-3389.
81. Saez J.C., Martinez A.D., Branes M.C., Gonzalez H.E. Regulation of gap junctions by protein phosphorylation. Braz. J. Med. Biol. Res. 31:1998;593-600.
82. Saez J.C., Branes M.C., Corvalan L.A.et al. Gap junctions in cells of the immune system: structure, regulation and possible functional roles. Braz. J. Med. Biol. Res. 33:2000;447-455.