Does transmembrane communication through gap junctions enable stem cells to overcome stromal inhibition?

Leukemia

Volumn 11, Issue 8, 1997, Pages 1281-1289

  Rosendaal, M ^a   Mayen, A ^b   De Koning, A ^b   Dunina Barkovskaya, T ^a   Krenacs T ^a   Ploemacher, R ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

Amphotericin B; Blood formation; Cx43; Gap junctions; Haemopoietic regulation; Stem cells; Stroma

Indexed keywords

AMPHOTERICIN B; CHEMOKINE; CYTOKINE; LUCIFER YELLOW; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; BONE MARROW CULTURE; CELL COMMUNICATION; CELL GROWTH; CELL JUNCTION; CELL MEMBRANE; COLONY FORMATION; CONTROLLED STUDY; CULTURE MEDIUM; FETUS; FETUS LIVER; GENETIC TRANSCRIPTION; GROWTH INHIBITION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; MICROINJECTION; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; STROMA;

EID: 0030954812     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400744     Document Type: Article

References (15)

1. Johnson GR, Moore MA. Role of stem cell migration in initiation of mouse foetal liver haemopoiesis. Nature 1975; 258: 726-728.
2. Dexter TM, Allen TD, Lajtha LG. Conditions controlling the proliferation of haemopoietic stem cells in vitro. J Cell Physiol 1977; 91: 335-344.
3. Bentley SA. Close range cell:cell interaction required for stem cell maintenance in continuous bone marrow culture. Exp Hematol 1981; 9: 308-312.
4. Brandt J, Srour EF, van Besien K, Briddell RA, Hoffman R. Cytokine-dependent long-term culture of highly enriched precursors of hematopoietic progenitor cells from human bone marrow. J Clin Invest 1990; 86: 932-941.
5. Verfaillie CM. Direct contact between human primitive hematopoietic progenitors and bone marrow stroma is not required for long-term in vitro hematopoiesis. Blood 1992; 79: 2821-2826.
6. Verfaillie CM. Soluble factor(s) produced by human bone marrow stroma increase cytokine-induced proliferation and maturation of primitive hematopoietic progenitors while preventing their terminal differentiation. Blood 1993; 82: 2045-2053.
7. Eaves CJ, Cashman JD, Kay RJ, Dougherty GJ, Otsuka T, Gaboury LA, Hogge DE, Lansdorp PM, Eaves AC, Humphries RK. Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer. Blood 1991; 78: 110-117.
8. Graham GJ, Wright EG, Hewick R, Wolpe SD, Wilkie NM, Donaldson D, Lorimore S, Pragnell IB. Identification and characterization of an inhibitor of haemopoietic stem cell proliferation. Nature 1990; 344: 442-144.
9. Broxmeyer HE, Sherry B, Lu L, Cooper S, Oh KO, Tekamp Olson P, Kwon BS, Cerami A. Enhancing and suppressing effects of recombinant murine macrophage inflammatory proteins on colony formation in vitro by bone marrow myeloid progenitor cells. Blood 1990; 76: 1110-1116.
10. Eaves CJ, Cashman JD, Wolpe SD, Eaves AC. Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatory protein 1 alpha, an inhibitor of primitive normal hematopoietic cells. Proc Natl Acad Sci USA 1993; 90: 12015-12019.
11. Hurley RW, McCarthy JB, Verfaillie CM. Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferation. J Clin Invest 1995; 96: 511-519.
12. Rosendaal M, Gregan A, Green CR. Direct cell-cell communication in the blood-forming system. Tiss Cell 1991; 23: 457-470.
13. Rosendaal M, Green CR, Rahman A, Morgan D. Up-regulation of the connexin43+ gap junction network in haemopoietic tissue before the growth of stem cells. J Cell Sci 1994; 107: 29-37.
14. Rosendaal M. Gap junctions in blood forming tissues. Microsc Res Tech 1995; 31: 396-407.
15. Kumar NM, Gilula NB. The gap junction communication channel. Cell 1996; 84: 381-388.