Contribution of oxygen radicals to altered NO-dependent pulmonary vasodilation in acute and chronic hypoxia

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 286, Issue 5 30-5, 2004, Pages

  Jernigan, Nikki L ^a   Resta, Thomas C ^a   Walker, Benjimen R ^a  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

Dichlorofluorescein; Endothelin 1; Nitric oxide; Pulmonary hypertension; S nitroso N acetyl penicillamine; Superoxide dismutase; Tiron

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; DICHLOROFLUORESCEIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; GUANYLATE CYCLASE; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; OXYGEN RADICAL; SCAVENGER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; FLUORESCENCE; HEART RIGHT VENTRICLE HYPERTROPHY; HYPOXIA; ISOLATED LUNG; LUNG ARTERY; LUNG BLOOD VESSEL; LUNG VASCULAR RESISTANCE; NONHUMAN; OXIDATIVE STRESS; POLYCYTHEMIA; PRESSOR RESPONSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; RAT; VASODILATATION;

ANIMALS; ANOXIA; FEMALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PULMONARY ARTERY; PULMONARY CIRCULATION; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; VASODILATION;

EID: 1942485296     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00215.2003     Document Type: Article

References (40)

1. Beckman JS, Beckman TW, Chen J, Marshall PA, and Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87: 1620-1624, 1990.
2. Brennan LA, Steinhorn RH, Wedgwood S, Mata-Greenwood E, Roark EA, Russell JA, and Black SM. Increased superoxide generation is associated with pulmonary hypertension in fetal lambs: a role for NADPH oxidase. Circ Res 92: 683-691, 2003.
3. Clancy RM, Leszczynska-Piziak J, and Abramson SB. Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase. J Clin Invest 90: 1116-1121, 1992.
4. Cote CG, Yu FS, Zulueta JJ, Vosatka RJ, and Hassoun PM. Regulation of intracellular xanthine oxidase by endothelial-derived nitric oxide. Am J Physiol Lung Cell Mol Physiol 271: L869-L874, 1996.
5. Eddahibi S, Raffestin B, Tayarani Y, Carville C, and Adnot S. Hypoxia-reoxygenation impairs NO-mediated vasodilation in rat lungs. Am J Physiol Lung Cell Mol Physiol 271: L441-L449, 1996.
6. Fagan KA, Fouty BW, Tyler RC, Morris KG Jr, Hepler LK, Sato K, LeCras TD, Abman SH, Weinberger HD, Huang PL, McMurtry IF, and Rodman DM. The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia. J Clin Invest 103: 291-299, 1999.
7. Fagan KA, Morrissey B, Fouty BW, Sato K, Harral JW, Morris KG Jr, Hoedt-Miller M, Vidmar S, McMurtry IF, and Rodman DM. Upregulation of nitric oxide synthase in mice with severe hypoxia-induced pulmonary hypertension. Respir Res 2: 306-313, 2001.
8. Gryglewski RJ, Palmer RM, and Moncada S. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature 320: 454-456, 1986.
9. Guzik TJ, West NE, Pillai R, Taggart DP, and Channon KM. Nitric oxide modulates superoxide release and peroxynitrite formation in human blood vessels. Hypertension 39: 1088-1094, 2002.
10. Isaacson T, Hampl V, Weir E, Nelson D, and Archer S. Increased endothelium-derived NO in hypertensive pulmonary circulation of chronically hypoxic rats. J Appl Physiol 76: 933-940, 1994.
11. Jernigan NL and Resta TC. Chronic hypoxia attenuates cGMP-dependent pulmonary vasodilation. Am J Physiol Lung Cell Mol Physiol 282: L1366-L1375, 2002.
12. Jernigan NL, Walker BR, and Resta TC. Pulmonary PKG-1 is upregulated following chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 285: L634-L642, 2003.
13. Killilea DW, Hester R, Balczon R, Babal P, and Gillespie MN. Free radical production in hypoxic pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 279: L408-L412, 2000.
14. Le Cras T, Xue C, Rengasamy A, and Johns R. Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung. Am J Physiol Lung Cell Mol Physiol 270: L164-L170, 1996.
15. Le Cras TD and McMurtry IF. Nitric oxide production in the hypoxic lung. Am J Physiol Lung Cell Mol Physiol 280: L575-L582, 2001.
16. Liu JQ, Sham JS, Shimoda LA, Kuppusamy P, and Sylvester JT. Hypoxic constriction and reactive oxygen species in porcine distal pulmonary arteries. Am J Physiol Lung Cell Mol Physiol 285: L322-L333, 2003.
17. Marshall C, Mamary AJ, Verhoeven AJ, and Marshall BE. Pulmonary artery NADPH-oxidase is activated in hypoxic pulmonary vasoconstriction. Am J Respir Cell Mol Biol 15: 633-644, 1996.
18. Matsubara T and Ziff M. Superoxide anion release by human endothelial cells: synergism between a phorbol ester and a calcium ionophore. J Cell Physiol 127: 207-210, 1986.
19. 2-elicited responses. Am J Physiol Lung Cell Mol Physiol 269: L637-L644, 1995.
20. Muramatsu M, Tyler R, Rodman D, and McMurtry I. Thapsigargin stimulates increased NO activity in hypoxic hypertensive rat lungs and pulmonary arteries. J Appl Physiol 80: 1336-1344, 1996.
21. Muzaffar S, Jeremy JY, Angelini GD, Stuart-Smith K, and Shukla N. Role of the endothelium and nitric oxide synthases in modulating superoxide formation induced by endotoxin and cytokines in porcine pulmonary arteries. Thorax 58: 598-604, 2003.
22. Myhre O, Andersen JM, Aarnes H, and Fonnum F. Evaluation of the probes 2′,7′-dichlorofluorescein diacetate, luminol, and lucigenin as indicators of reactive species formation. Biochem Pharmacol 65: 1575-1582, 2003.
23. Nakanishi K, Tajima F, Nakamura A, Yagura S, Ookawara T, Yamashita H, Suzuki K, Taniguchi N, and Ohno H. Effects of hypobaric hypoxia on antioxidant enzymes in rats. J Physiol 489: 869-876 1995.
24. 2 and cGMP. Am J Physiol Lung Cell Mol Physiol 264: L141-L145, 1993.
25. Ou J, Ou Z, Ackerman AW, Oldham KT, and Pritchard KA Jr. Inhibition of heat shock protein 90 (hsp90) in proliferating endothelial cells uncouples endothelial nitric oxide synthase activity. Free Radic Biol Med 34: 269-276, 2003.
26. Pagano PJ, Tornheim K, and Cohen RA. Superoxide anion production by rabbit thoracic aorta: effect of endothelium-derived nitric oxide. Am J Physiol Heart Circ Physiol 265: H707-H712, 1993.
27. Puntarulo S and Cederbaum AI. Production of reactive oxygen species by microsomes enriched in specific human cytochrome P450 enzymes. Free Radic Biol Med 24: 1324-1330, 1998.
28. Reeve HL, Michelakis E, Nelson DP, Weir EK, and Archer SL. Alterations in a redox oxygen sensing mechanism in chronic hypoxia. J Appl Physiol 90: 2249-2256, 2001.
29. Resta TC, Chicoine LG, Omdahl JL, and Walker BR. Maintained upregulation of pulmonary eNOS gene and protein expression during recovery from chronic hypoxia. Am J Physiol Heart Circ Physiol 276: H699-H708, 1999.
30. Resta TC, Kanagy NL, and Walker BR. Estradiol-induced attenuation of pulmonary hypertension is not associated with altered eNOS expression. Am J Physiol Lung Cell Mol Physiol 280: L88-L97, 2001.
31. Resta TC, Sanders TC, Eichinger MR, Crowley MR, and Walker BR. Segmental vasodilatory effectiveness of inhaled NO in lungs from chronically hypoxic rats. Respir Physiol 114: 161-173, 1998.
32. Resta TC and Walker BR. Chronic hypoxia selectively augments endothelium-dependent pulmonary arterial vasodilation. Am J Physiol Heart Circ Physiol 270: H888-H896, 1996.
33. Roos C, Frank D, Xue C, Johns R, and Rich G. Chronic inhaled nitric oxide: effects on pulmonary vascular endothelial function and pathology in rats. J Appl Physiol 80: 252-260, 1996.
34. Rubanyi GM and Vanhoutte PM. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. Am J Physiol Heart Circ Physiol 250: H822-H827, 1986.
35. Schinetti ML, Sbarbati R, and Scarlattini M. Superoxide production by human umbilical vein endothelial cells in an anoxia-reoxygenation model. Cardiovasc Res 23: 76-80, 1989.
36. Seki S, Flavahan NA, Smedira NG, and Murray PA. Superoxide anion scavengers restore NO-mediated pulmonary vasodilation after lung transplantation. Am J Physiol Heart Circ Physiol 276: H42-H46, 1999.
37. Shaul P, North A, Brannon T, Ujiie K, Wells L, Nisen P, Lowenstein C, Snyder S, and Star R. Prolonged in vivo hypoxia enhances nitric oxide synthase type I and type III gene expression in adult rat lung. Am J Respir Cell Mol Biol 13: 167-174, 1995.
38. Terada LS, Guidot AM, Leff JA, Willingham IR, Hanley ME, Piermatei D, and Repine JE. Hypoxia injures endothelial cells by increasing endogenous xanthine oxidase activity. Proc Natl Acad Sci USA 89: 3362-3366, 1992.
39. Tyler RC, Muramatsu M, Abman SH, Stelzner TJ, Rodman DM, Bloch KD, and McMurtry IF. Variable expression of endothelial NO synthase in three forms of rat pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 276: L297-L303, 1999.
40. Wanstall JC, Kaye JA, and Gambino A. The in vitro pulmonary vascular effects of FK409 (nitric oxide donor): a study in normotensive and pulmonary hypertensive rats. Br J Pharmacol 121: 280-286, 1997.