The Hedgehog Pathway: Revisited [3]

Dermatologic Surgery

Volumn 30, Issue 4 I, 2004, Pages 583-584

  Yu, Thomas C ^a   Miller, Stanley J ^a  

^a Kenilworth Surgery Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPAMINE; MEMBRANE PROTEIN; ONCOPROTEIN; PLANT EXTRACT; SONIC HEDGEHOG PROTEIN; STEROID; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ALOPECIA; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; DERMATOFIBROMA; DEVELOPMENTAL DISORDER; EMBRYO DEVELOPMENT; FIBROSARCOMA; GENE EXPRESSION; GENE MUTATION; GENE SILENCING; GENETIC SUSCEPTIBILITY; HAIR FOLLICLE; HUMAN; LETTER; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SEBACEOUS NEVUS; SIGNAL TRANSDUCTION; SKIN FUNCTION; TRICHOEPITHELIOMA; WOUND HEALING;

HAIR FOLLICLE; HEDGEHOG PROTEINS; HUMANS; NEOPLASMS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

EID: 1942466591     PISSN: 10760512     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1524-4725.2004.30185.x     Document Type: Letter

References (20)

1. Kalderon D. Transducing the hedgehog signal. Cell 2000;103:371-4.
2. Chen CH, von Kessler DP, Park W, et al. Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell 1999;98:305-16.
3. McMahon AP. More surprises in the hedgehog signaling pathway. Cell 2000;100:185-8.
4. Joike C, Mizutani T, Ito T, et al. Introduction of wide-type patched gene suppresses the oncogenic potential of human squamous cell carcinoma cell lines including A431. Oncogene 2002; 21:2670-8.
5. Johnson RL, Rothman AL, Xie J, et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 1996;272:1668-71.
6. Aszterbaum M, Beech J, Epstein EH. Ultraviolet radiation mutagenesis of hedgehog pathway genes in basal cell carcinoma. J Invest Dermatol Symp Proc 1999;4:41-5.
7. Gailani MR, Bale AE. Developmental genes and cancer: role of patched in basal cell carcinoma of the skin. J Natl Cancer Inst 1997;89:1103-9.
8. Xie J, Murone M, Luoh SM, et al. Activating smoothened mutations in sporadic basal cell carcinoma. Nature 1998;391:90-2.
9. Lam CW, Xie J, To KF, et al. A frequent activated smoothened mutation in sporadic basal cell carcinomas. Oncogene 1999;18:833-6.
10. Xin H, Matt D, Qin JZ, Burg G, Boni R. The sebaceous nevus: a nevus with deletions of the PTCH gene. Cancer Res 1999;59:1834-6.
11. Vorechovsky I, Uden AB, Sandstedt B, Toftgard R, Stahle-Backdahl M. Trichoepitheliomas contain somatic mutations in the overexpressed PTCH gene: support for a gatekeeper mechanism in skin tumorigenesis. Cancer Res 1997;57:4677-81.
12. Hahn H, Wojnowski L, Miller G, Zimmer A. The patched signaling pathway in tumorigenesis and development: lessons from animal models. J Mol Med 1999;77:459-68.
13. Leong PM, Kauffman CL, Moressi JM, et al. Basal cell carcinoma-like epidermal changes overlying dermatofibromas often reveal loss of heterozygosity in the PTCH gene. J Invest Dermatol 1999;113:279-80.
14. Incardona JP, Gaffield W, Kapur RP, Roelink H. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development 1998;125:3553-62.
15. Taipale J, Chen JK, Cooper MK, et al. Effects of oncogenic mutations in smoothened and patched can be reversed by cyclopamine. Nature 2000;406:1005-9.
16. Chen JK, Taipale J, Young KE, Maiti T, Beachy PA. Small molecule modulation of smoothened activity. Proc Natl Acad Sci USA 2002; 99:14071-6.
17. Chiang C, Swan RZ, Grachtchouk M, et al. Essential role for Sonic hedgehog during hair follicle morphogenesis. Dev Biol 1999;205:1-9.
18. Nanba D, Nakanishi Y, Hieda Y. Role of Sonic hedgehog signaling in epithelial and mesenchymal development of hair follicle in an organ culture of embryonic mouse skin. Dev Growth Differ 2003; 45:231-9.
19. Frank-Kamenetsky M, Zhang XM, Botteg S, et al. Small-molecule modulator of hedgehog signaling: identification and characterization of smoothened agonists and antagonists. J Biol 2002;1:10.
20. Berman DM, Karhadkar SS, Hallahan AR, et al. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 2002; 297:1559-61.