Basal cell carcinoma-like epidermal changes overlying dermatofibromas often reveal loss of heterozygosity in the PTCH gene [2]

Journal of Investigative Dermatology

Volumn 113, Issue 2, 1999, Pages 279-280

  Leong, Paul M ^a   Lisa Kauffman, C ^b   Margaret Moresi, J ^d   Wu, Li ^c   Jeronimo, Carmen ^c   Sidransky, David M ^c   Miller, Stanley J ^c,e  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c DEPARTMENT OF PATHOLOGY   (United States)

^d Department of Dermatology ^*  (United States)

^e JHOC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

BASAL CELL CARCINOMA; CELL PROLIFERATION; DERMATOFIBROMA; EPIDERMIS; HETEROZYGOSITY LOSS; HUMAN; LETTER; PRIORITY JOURNAL; SKIN CARCINOGENESIS; SKIN TUMOR; TUMOR SUPPRESSOR GENE;

EID: 0033513393     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.1999.00688.x     Document Type: Letter

References (5)

1. M.R. Gailani A.E. Bale Developmental genes and cancer: role of patched in basal cell carcinoma of the skin JNCI 89 1997 1103 1109
2. A.G. Knudson Mutation and cancer: statistical study of retinoblastoma Proc Natl Acad Sci USA 68 1971 820 823
3. H. Nawroz P. van der Riet R. Hruban W. Koch J. Ruppert D. Sidransky Allelotype of head and neck squamous cell carcinoma Cancer Res 54 1994 1152 1155
4. D. Sidransky Is human patched the gatekeeper of common skin cancers? (editorial) Nat Genet 14 1996 7 8
5. I. Vorechovsky A.B. Unden B. Sandstedt R. Toftgard M. Stahle-Backdahl Trichoepitheliomas contain somatic mutations in the overexpressed PTCH gene: support for a gatekeeper mechanism in skin tumorigenesis Cancer Res 57 1997 4677 4681