Endocrine Disruptors and Hypothalamic Sexual Differentiation

Annual Review of Biomedical Sciences

Volumn 5, Issue , 2003, Pages 87-94

  Pereira, Oduvaldo C M ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Brain sexual differentiation; Endocrine disruptors; Estrogen; Fertility; Reproductive function; Sexual behavior

Indexed keywords

ANTIANDROGEN; ENDOCRINE DISRUPTOR; ENVIRONMENTAL CHEMICAL; ESTROGEN; ESTROGEN RECEPTOR; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

EMBRYO DEVELOPMENT; ESTROGEN ACTIVITY; FERTILITY; GONAD; HYPOTHALAMUS; IMMOBILIZATION STRESS; NONHUMAN; PERINATAL PERIOD; REPRODUCTION; SEX DIFFERENTIATION; SEXUAL BEHAVIOR; SHORT SURVEY; VIRILIZATION;

EID: 1942424747     PISSN: 18068774     EISSN: None     Source Type: Journal    
DOI: 10.5016/1806-8774.2003v5p87     Document Type: Short Survey

References (39)

1. Anderson RH, Fleming DE, Rhees RW, Kinghorn E. Relationships between sexual activity, plasma testosterone, and volume of the sexually dimorphic nucleus of the preoptic area in prenatally stressed and non-stressed rats. Brain Res 1986;370:1-10.
2. Andrade AJM, Araújo S, Santana GM, Ohi M, Dalsenter PR. Screening for in vivo (anti) estrogenic and (anti)androgenic activities of technical and formulated deltamethrin. Reg Toxicol Pharmacol 2002;35:379-82.
3. Arena AC, Pereira OCM. Neonatal inhalatory anesthetic exposure: reproductive changes in male rats. Comp Biochem Physiol 2002;133:633-40.
4. Ashby J, Lefevre PA, Odum J, Tinwell H, Kennedy SJ, Beresford N, Sumpter JP. Failure to confirm estrogenic activity for benzoic acid and clofibrate: implications for lists of endocrine-disrupting agents. Reg Toxicol Pharmacol 1997;26:96-101.
5. Bardin CW, Catterall JF. Testosterone: A major determinant of extragenital sexual dimorphism. Science 1981;211:1285-94.
6. Carlos CP, Lemonica IP, Kempinas WG, Pereira OCM. Does the male reproductive performance depend on the early lactation milk in rats? Physiol Behav 1996;59:147-52.
7. Chapin RE, Stevens JT, Hughles CL, Kelce WR, Hess RA, Daston GP. Endocrine modulation of reproduction. Fundamental and Applied Toxicology 1996;29:1-17.
8. Cooper RL, Kavlock RJ. Endocrine disruptors and reproductive development: a weight-of-evidence overview. J Endocrinol 1997;152:159-66.
9. Corbier P, Edwards DA, Roffi J. The neonatal testosterone surge: a comparative study. Arch Int Physiol Biochem Biophys 1992;100:127-31.
10. Dohler KD. The pre- and postnatal influence of hormones and neurotransmitters on sexual differentiation of the mammalian hypothalamus. Int Rev Cytol 1991;131:1-57.
11. Gerardin DCC, Pereira OCM. Reproductive changes in male rats treated with an aromatase inhibitor. Pharmacol Biochem Behav 2002;71, 309-13.
12. Hiort O, Holterhus PM. The molecular basis of male sexual differentiation. Eur J Endocrinol 2000;142:101-10.
13. Kacsóh B, Nagy Gy, Veress Z, Tóth BE, Kanyicska B, Csernus V, Köves K. Data suggesting that milk of early lactation period might be involved in sexual differentiation of rat brain. Endocrinol Exp 1986;20:155-66.
14. Kang KS, Kim HS, Ryu DY, Che JH, Lee YS. Immature uterotrophic assay is more sensitive than ovariectomized uterotrophic assay for the detection of estrogenicity of p-nonylphenol in Sprague-Dawley rats. Toxicology Letters 2000;118:109-15.
15. Kavlock RJ, Daston GP, DeRosa C, Fenner-Crisp P, Gray LE, Kaattari S, Lucier G, Luster M, Mac MJ, Maczka C, Miller R, Moore J, Rolland R, Scott G, Sheehan DM, Sinks, T, Tilson HA. Research needs for the risk assessment of health and environmental effects on endocrine disruptors: A report of the US EPA-sponsored workshop. Environ Health Perspect 1996;104:715-40.
16. Lephart ED. A review of brain aromatase cytochrome P450. Brain Res 1996;22:1-26.
17. MacLusky NJ, Bowlby DA, Brown TJ, Peterson RE, Hochberg RB. Sex and the developing brain: suppression of neuronal estrogen sensitivity by developmental androgen exposure. Neurochem Res 1997;22:1395-414.
18. MacLusky NJ, Naftolin F. Sexual differentiation of the central nervous system. Science 1981;211:1294-303.
19. Matuszczyk JV, Silverin B, Larsson K. Influence of environmental events immediately after birth on postnatal testosterone secretion and adult sexual behavior in the male rat. Horm Behav 1990;24:450-8.
20. McCarthy MM, Davis AL, Mong JA. Excitatory neurotransmission and sexual differentiation of the brain. Brain Res Bull 1997;4:487-95.
21. McCormick CM, Furey B, Child, M, Sawyer MJ, Donohue SM. Neonatal sex hormones have 'organizational' effects on the hypothalamic-pituitary-adrenal axis of male rats. Dev Brain Res 1998;105:295-307.
22. Negri-Cesi P, Colciago A, Motta M, Martini L, Celotti F. Aromatase expression and activity in male and female cultured rat hypothalamic neurons: effect of androgens. Mol Cell Endocrinol 2001;178:1-10.
23. Odum J, Lefevre PA, Tittensor S, Paton D, Routledge EJ, Beresford NA, Sumpter JP, Ashby J. The rodent uterotrophic assay: critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay. Reg Toxicol Pharmac 1997;25:176-88.
24. Pereira OCM, Arena AC, Yasuhara F, Kempinas WG. Effects of prenatal hydrocortisone acetate exposure on fertility and sexual behavior in male rats. Reg Toxicol Pharmacol 2003a;38:36-42.
25. Pereira OCM, Carvalho NFS, Carlos CP. Perinatal estrogen exposure: later repercussion on the fertility of rats. Comp Biochem Physiol 1997;118:241-5.
26. Pereira OCM, Coneglian-Marise MSP, Gerardin DCC. Effects of neonatal clomiphene citrate on fertility and sexual behavior in male rats. Comp Biochem Physiol 2003b;134:545-50.
27. Pereira OCM, Yasuhara F, Arena AC. Cholinergic responses of seminal vesicles isolated from rats exposed perinatally to hydrocortisone. Pharmacol Res 2003c;48:91-5.
28. Rhees RW, Kirk BA, Sephton S, Lephart ED. Effects of prenatal testosterone on sexual behavior, reproductive morphology and LH secretion in the female rat. Dev Neurosci 1997;19:430-7.
29. Roselli CE, Klosterman SA. Sexual differentiation of aromatase activity in the rat brain: effects of perinatal steroid exposure. Endocrinology 1998;139:3193-212.
30. Silva MRP, Oliveira CA, Felicio LF, Nasello AG, Bernardi MM. Perinatal treatment with picrotoxin induces sexual, behavioral, and neuroendocrine changes in male rats. Pharmacol Biochem Behav 1998;60:203-8.
31. Spearow JL, Doemeny P, Sera R, Leffler R, Barkley M. Genetic variation in susceptibility to endocrine disruption by estrogen in mice. Science 1999;285:1259-60.
32. Sultan C, Balaguer P, Terouanne B, Georget V, Paris F, Jeandel C, Lumbroso S, Nicolas J-C. Enviromental xenoestrogens, antiandrogens and disorders of male sexual differentiation. Mol Cell Endocrinol 2001;178:99-105.
33. Teodorov E, Salzgeber SA, Felicio LF, Varolli FMF, Bernardi MM. Effects of perinatal picrotoxin and sexual experience on heterosexual and homosexual behavior in male rats. Neurotoxicol Teratol 2002;24:235-45.
34. Toppari J, Skakkebaek NE. Sexual differentiation and environmental endocrine disrupters. In: Baillière-Tindall (ed.). Baillière's Clinical Endocrinology and Metabolism, 1998;143-56.
35. Velazquez-Moctezuma J, Salazar ED, Rueda MLC. The effect of prenatal stress on adult sexual behavior in rats depends on the nature of the stressor. Physiol Behav 1993;53:443-8.
36. Ward IL. Prenatal stress feminizes and demasculinizes the behaviors of males. Science 1972;175:82-4.
37. Ward IL, Weisz L. Differential effects of maternal stress on circulating levels of corticosterone, progesterone, and testosterone in male and female rats fetuses and their mothers. Endocrinology 1984;114:1635-44.
38. Wilson JD, George FW, Griffin JE. The hormonal control of sexual development. Science 1981;211:1278-84.
39. Yamada T, Sunami O, Kunimatsu T, Kamita Y, Okuno Y, Seki T, Nakatsuka I, Matsuo M. Dissection and weighing of accessory sex glands after formalin fixation, and a 53-day assay using young mature rats are reliable and feasible in the Hershberger assay. Toxicology 2001;162:103-19.