Dissection and weighing of accessory sex glands after formalin fixation, and a 5-day assay using young mature rats are reliable and feasible in the Hershberger assay

Toxicology

Volumn 162, Issue 2, 2001, Pages 103-119

  Yamada, Tomoya ^a   Sunami, Osamu ^a   Kunimatsu, Takeshi ^a   Kamita, Yusuke ^a   Okuno, Yasuyoshi ^a   Seki, Takaki ^a   Nakatsuka, Iwao ^a   Matsuo, Masatoshi ^a  

^a SUMITOMO CHEMICAL CO LTD   (Japan)

Author keywords

(Anti)androgen; Endocrine disruptor; Hershberger assay; Immature mature rat; p, p DDE; Screening

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; ANTIANDROGEN; CORN OIL; FLUTAMIDE; FORMALDEHYDE; TESTOSTERONE PROPIONATE;

ACCESSORY SEX GLAND; AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSAY; CASTRATION; CONTROLLED STUDY; DESICCATION; DISSECTION; DOSE RESPONSE; ESTROGEN ACTIVITY; FEASIBILITY STUDY; INTERMETHOD COMPARISON; MALE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; PROSTATE; RAT; RELIABILITY; REPRODUCTIVE TOXICITY; SEMINAL VESICLE; TECHNIQUE; TISSUE FIXATION; TOXICITY TESTING; VALIDATION PROCESS;

ANDROGENS; ANIMALS; DICHLORODIPHENYL DICHLOROETHYLENE; DISSECTION; FORMALDEHYDE; HORMONE ANTAGONISTS; MALE; ORCHIECTOMY; ORGAN SIZE; PROSTATE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SEMINAL VESICLES; SENSITIVITY AND SPECIFICITY; SEXUAL MATURATION; TESTOSTERONE; TIME FACTORS; TISSUE FIXATION; TOXICITY TESTS;

EID: 0035843875     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(01)00361-4     Document Type: Article

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