The rodent uterotrophic assay: Critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay

Regulatory Toxicology and Pharmacology

Volumn 25, Issue 2, 1997, Pages 176-188

  Odum, J ^a   Lefevre, P A ^a   Tittensor, S ^a   Paton, D ^a   Routledge, E J ^b   Beresford, N A ^b   Sumpter, J P ^b   Ashby, J ^a  

^a ASTRAZENECA   (United Kingdom)

^b BRUNEL UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIESTROGEN; ESTRADIOL; ESTRADIOL DERIVATIVE; ESTROGEN RECEPTOR; METHOXYCHLOR; NONYLPHENOL; PHENOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG TOXICITY; ESTROGEN ACTIVITY; FEMALE; INTERMETHOD COMPARISON; METABOLISM; METHODOLOGY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE; SUBCUTANEOUS DRUG ADMINISTRATION; UTERUS WEIGHT; YEAST;

EID: 0031128361     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.1997.1100     Document Type: Article

References (31)

1. Ashby J. Endocrine modulation of human reproduction by environmental chemicals. Environ. Toxicol. Pharmacol. 1997.
2. Ashby J., Houthoff E., Kennedy S. J., Stevens J., Bars R., Jekat F. W., Campbell P., Van Miller J., Carpanini F. M., Randall G. L. P. The challenge posed by endocrine disrupting chemicals. Environ. Health Perspect. 105:1997a;164-169.
3. Ashby J., Lefevre P. A., Odum J., Harris C. A., Routledge E. J., Sumpter J. P. Synergism between synthetic oestrogens? Nature. 385:1997b;494.
4. Ashby J., Odum J., Tinwell H., Lefevre P. A. Assessing the risks of adverse endocrine-mediated effects: Where to from here? Reg. Toxicol. Pharmacol. 1997c.
5. Bicknell R. J., Herbison A. E., Sumpter J. P. Oestrogenic activity of an environmentally persistent alkylphenol in the reproductive tract, but not the brain of rodents. J. Steroid Biochem. Mol. Biol. 54:1995;7-9.
6. Branham S., Leamons M. L., Sheehan D. M. Estrogen and antiestrogen-induced ornothine decarboxylase activity and uterine growth in the rat. J. Steroid Biochem. 29:1988;153-159.
7. Bulger W. H., Muccitelli R. M., Kupfer D. Studies on thein vivoin vitro. Biochem. Pharmacol. 28:1978;2417-2423.
8. Colborn T., Clement C. Chemically-Induced Alterations in Sexual and Functional Development. 1992;Princeton Scientific Publishing.
9. Evans G. L., Bryant H. U., Magee D. E., Turner R. T. Raloxifene inhibits bone turnover and prevents further cancellous bone loss in adult ovariectomized rats with established osteopenia. Endocrinology. 137:1996;4139-4144.
10. Fanchenko N. D., Sturchak S. V., Shchedrina R. N., Pivnitskii K. K., Novikov E. A., Ishkov V. L. The specificity of the human uterine receptor. Acta Endocrinol. (Copenhagen). 90:1979;167-175.
11. François P., Levisalles J. Bromination dans les séries du diméthyl-(α)estrane et du méthyl-5(β)-estrane. Remarques sur l'ouverture des époxydes néopentyliques. Bull. Soc. Chim. France. 1968;318-329.
12. Gunstone F. D., Harwood J. L., Padley F. B. The Lipid Handbook. 1994;Chapman and Hall.
13. Huggins C., Jensen E. V. The depression of estrone-induced uterine growth by phenolic estrogens with oxygenated functions at positions 6 or 16: The impeded estrogens. J. Exp. Med. 102:1955;335-346.
14. Katzenellenbogen J. A. Commentary: The structural pervasiveness of estrogenic activity. Environ. Health Perspect. 103:1995;99-101.
15. Lee P. C., Lee W. In vivo. Bull. Environ. Contam. Toxicol. 57:1996;341-348.
16. Markarevich B. M., Webb B., Densmore C. L., Gregory R. R. The effects of coumestrol on estrogen receptor function and uterine growth in ovariectomized rats. Environ. Health Perspect. 103:1995;574-581.
17. McLachlan J. A. Functional toxicology: A new approach to detect functionally active xenobiotics. Environ. Health Perspect. 101:1993;386-387.
18. McLachlan J. A., Korach K. S. Estrogens in the environment III: Global health implications. Environ. Health Perspect. 103:1995;3-178.
19. Neumann F. Pharmacology and potential use of cyproterone acetate. Horm. Metab. Res. 9:1977;1-8.
20. O'Connor J. C., Cook J. C., Craven S. C., Van Pelt C. S., Obourn J. D. Anin vivo. Fundam. Appl. Toxicol. 3:1996;182-195.
21. Reel J. R., Lamb J. C., Neal B. H. Survey and assessment of mammalian estrogen biological assays for hazard characterization. Fundam. Appl. Toxicol. 34:1996;288-305.
22. Routledge E. J., Sumpter J. P. Estrogenic activity of surfactants and their degradation products assessed using a recombinant yeast screen. Environ. Toxicol. Chem. 15:1996;241-248.
23. Routledge E. J., Sumpter J. P. Structural features of alkylphenolic chemicals associated with estrogenic activity. J. Biol. Chem. 272:1997;3280-3288.
24. Sanborn J. R. An hypothesis for estrogenicity of alkylphenols and the possible role of metabolism. Pest. Outlook. Oct. 1996;36-37.
25. Shelby M. D., Newbold R. R., Tully D. B., Chae K., Davis V. L. Assessing environmental chemicals for estrogenicity using a combination ofin vitroin vivo. Environ. Health Perspect. 104:1996;1296-1300.
26. Soto A. M., Sonnenschein C., Chung K. L., Fernandez M. F., Olea N., Serrano F. O. The E-screen assay as a tool to identify estrogens: An update on estrogenic environmental pollutants. Environ. Health Perspect. 103:1995;113-122.
27. Wakeling A. E., Dukes M., Bowler J. A potent pure antiestrogen with clinical potential. Cancer Res. 51:1991;3867-3873.
28. Wakeling A. E., Valcaccia B. Antiestrogenic and antitumour activities of a series of non-steroidal antiestrogens. J. Endocr. 99:1983;445-464.
29. Waller C. L., Oprea T. I., Chae K., Park H.-K., Korach K. S., Laws S. C., Weise T. E., Kelce W. R., Gray L. E. Ligand-based identification of environmental estrogens. Chem. Res. Toxicol. 9:1996;1240-1248.
30. Warhurst A. M. An Environmental Assessment of Alkylphenol Ethoxylates and Alkylphenols. 1994;Friends of the Earth, Edinburgh. p. 1-15.
31. White R., Jobling S., Hoare S. A., Sumpter J. P., Parker M. G. Environmentally persistent alkylphenol compounds are estrogenic. Endocrinology. 135:1994;175-182.