Effects of neonatal clomiphene citrate on fertility and sexual behavior in male rats

Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Volumn 134, Issue 3, 2003, Pages 545-550

  Pereira, O C M ^a   Coneglian Marise, M S P ^a   Gerardin, D C C ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Antioestrogen; Brain sexual differentiation; Clomiphene; Estrogen; Male rat; Reproduction; Sexual behavior

Indexed keywords

CLOMIFENE CITRATE; ESTROGEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CASTRATION; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FERTILITY; MALE; MOUSE; NEWBORN PERIOD; NONHUMAN; PREGNANCY; SEXUAL BEHAVIOR; SEXUAL MATURATION; TESTIS WEIGHT;

EID: 0037364648     PISSN: 10956433     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1095-6433(02)00355-0     Document Type: Article

References (26)

1. Almeida S.A., Kempinas W.G., Lamano-Carvalho T.L. Sexual behavior and fertility of male rats submitted to prolonged immobilization-induced stress. Braz. J. Med. Biol. Res. 33:2000;1105-1109.
2. Arteche E., Strippoli G., Loirand G., et al. An analysis of the mechanisms involved in the okadaic acid induced contraction of the estrogen-primed rat uterus. J. Pharmacol. Exp. Ther. 282:1997;201-207.
3. Bailey J.M., Willerman L., Parks C. A test of the maternal stress theory of human male homosexuality. Arch. Sex. Behav. 20:1991;277-293.
4. Bakker J., Ophemert J.V., Slob A.K. Sexual differentiation of odor and partner preference in the rat. Physiol. Behav. 60:1996;489-494.
5. Cooper R.L., Kavlock R.J. Endocrine disruptors and reproductive development: a weight-of-evidence overview. J. Endocrinol. 152:1997;159-166.
6. Corbier P., Edwards D.A., Roffi J. The neonatal testosterone surge: a comparative study. Arch. Int. Physiol. Biochem. Biophys. 100:1992;127-131.
7. Ellis L., Ames M.A., Peckham W., Burke D. Sexual orientation of human offspring may be altered by severe maternal stress during pregnancy. J. Sex Res. 25:1988;152-157.
8. Farabollini F., Porrini S., Dessì-Fulgheri F. Perinatal exposure to the estrogenic pollutant bisphenol a affects behavior in male and female rats. Pharmacol. Biochem. Behav. 64:1999;687-694.
9. Freeman L.M., Rissman E.F. Neural aromatization and the control of sexual behavior. Trends Endocrinol. Metab. 7:1996;334-338.
10. Gerardin D.C.C., Pereira O.C.M. Reproductive changes in male rats treated perinatally with an aromatase inhibitor. Pharmacol. Biochem. Behav. 71:2002;309-313.
11. Giannakopoulou M., Bozas E., Philippidis H., Stylianopoulou F. Protooncogene c-fos involvement in the molecular mechanism of rat brain sexual differentiation. Neuroendocrinology. 73:2001;387-396.
12. Gray L.E. Jr., Ostby J.S., Kelce W.R. Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rat. Toxicol. Appl. Pharmacol. 129:1994;46-52.
13. Henry C., Arsaut J., Arnauld E., Demotes-Mainard J. Transient neonatal elevation in hypothalamic estrogen receptor mRNA in prenatally-stressed male rats. Neurosci. Lett. 216:1996;141-145.
14. Hiort O., Holterhus P.M. The molecular basis of male sexual differentiation. Eur. J. Endocrinol. 142:2000;101-110.
15. Lephart E.D. A review of brain aromatase cytochrome P450. Brain Res. Rev. 22:1996;1-26.
16. MacLusky N.J., Bowlby D.A., Brown T.J., Peterson R.E., Hochberg R.B. Sex and the developing brain: suppression of neuronal estrogen sensitivity by developmental androgen exposure. Neurochem. Res. 22:1997;1395-1414.
17. MacLusky N.J., Naftolin F. Sexual differentiation of the central nervous system. Science. 211:1981;1294-1303.
18. Matuszczyk J.V., Silverin B., Larsson K. Influence of environmental events immediately after birth on postnatal testosterone secretion and adult sexual behavior in the male rat. Horm. Behav. 24:1990;450-458.
19. McCarthy M.M., Davis A.L., Mong J.A. Excitatory neurotransmission and sexual differentiation of the brain. Brain Res. Bull. 4:1997;487-495.
20. McCormick C.M., Furey B.F., Child M., Sawyer M.J., Donohue S.M. Neonatal sex hormones have 'organizational' effects on the hypothalamic-pituitary-adrenal axis of male rats. Dev. Brain Res. 105:1998;295-307.
21. Pereira O.C.M., Carvalho N.F.S., Carlos C.P. Perinatal estrogen exposure: later repercussion on the fertility of rats. Comp. Biochem. Physiol. 118:1997;241-245.
22. Roselli C.E., Klosterman S.A. Sexual differentiation of aromatase activity in the rat brain: effects of perinatal steroid exposure. Endocrinology. 139:1998;3193-3201.
23. Sayag N., Snapir N., Arnon E., El-Halawani M.E., Grimm V.E., Robinzon B. Sexual differentiation of copulatory behaviour in the male chick requires gonadal steroids. Br. Poultry Sci. 32:1991;607-614.
24. Shughrue P.J., Lane M.V., Merchenthaler I. Regulation of progesterone receptor messenger ribonucleic acid in the rat medial preoptic nucleus by estrogenic and antiestrogenic compounds: an in situ hybridization study. Endocrinology. 138:1997;5476-5484.
25. Swaab D.F., Gooren L.J.G., Hofman M.A. Gender and sexual orientation in relation to hypothalamic structures. Horm. Res. 38:1992;51-61.
26. Tena-Sempere M., Navarro J., Pinilla L., González L.C., Huhtaniemi I., Aguilar E. Neonatal exposure to estrogen differentially alters estrogen receptor α and β mRNA expression in rat testis during postnatal development. J. Endocrinol. 165:2000;345-357.