The effects of electrically assisted methods on transdermal delivery of nalbuphine benzoate and sebacoyl dinalbuphine ester from solutions and hydrogels

International Journal of Pharmaceutics

Volumn 297, Issue 1-2, 2005, Pages 162-171

  Huang, Jeng Fen ^a   Sung, K C ^a   Hu, Oliver Yoa Pu ^b   Wang, Jhi Joung ^c   Lin, Yi Hsin ^a   Fang, Jia You ^d  

^a CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c CHI MEI MEDICAL CENTER   (Taiwan)

^d CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Electroporation; Hydrogels; Iontophoresis; Nalbuphine; Prodrugs; Transdermal delivery

Indexed keywords

CARBOXYMETHYLCELLULOSE; HYDROXYPROPYLCELLULOSE; NALBUPHINE; NALBUPHINE BENZOATE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHEMICAL COMPOSITION; CONCENTRATION (PARAMETERS); DIFFUSION; DRUG DELIVERY SYSTEM; DRUG PENETRATION; ELECTRIC ACTIVITY; ELECTRIC FIELD; ELECTROPORATION; FEASIBILITY STUDY; FEMALE; HYDROGEL; IONTOPHORESIS; LIPOPHILICITY; MOLECULAR SIZE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN PERMEABILITY; TRANSDERMAL DRUG ADMINISTRATION; VISCOSITY;

ADMINISTRATION, CUTANEOUS; ANALGESICS, OPIOID; ANIMALS; CARBOXYMETHYLCELLULOSE; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DIFFUSION; ELECTRIC STIMULATION; ELECTROPORATION; EXCIPIENTS; FEMALE; HYDROGELS; IONTOPHORESIS; MICE; MICE, INBRED BALB C; MICE, NUDE; NALBUPHINE; PHARMACEUTICAL SOLUTIONS; PRODRUGS; VISCOSITY;

EID: 19344374256     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.03.015     Document Type: Article

References (23)

1. A.K. Banga, S. Bose, and T.K. Ghosh Iontophoresis and electroporation: comparisons and contrasts Int. J. Pharm. 179 1999 1 19
2. N.I. Cherny Opoid analgesics: comparative features and prescribing guidelines Drugs 51 1996 713 737
3. C. Cullander What are the pathways of iontophoretic current flow through mammalian skin? Adv. Drug Deliv. Rev. 9 1992 119 135
4. J.Y. Fang, Y.B. Huang, H.H. Lin, and Y.H. Tsai Transdermal iontophoresis of sodium nonivamide acetate IV. Effect of polymer formulation. Int. J. Pharm. 173 1998 127 140
5. J.Y. Fang, T.L. Hwang, Y.B. Huang, and Y.H. Tsai Transdermal iontophoresis of sodium nonivamide acetate V. Combined effect of physical enhancement methods Int. J. Pharm. 235 2002 95 105
6. J.Y. Fang, K.C. Sung, O.Y.P. Hu, and H.Y. Chen Transdermal delivery of nalbuphine and nalbuphine pivalate from hydrogels by passive diffusion and iontophoresis Arzneim-Forsch./Drug Res. 51 2001 408 413
7. B.C. Finnin, and T.M. Morgan Transdermal penetration enhancers: application, limitation, and potential J. Pharm. Sci. 88 1999 955 958
8. S. Grond, L. Radbruch, and K.A. Lehmann Clinical pharmacokinetics of transdermal opioids Clin. Pharmacokinet. 38 2000 59 89
9. J. Hirvonen, and R.H. Guy Iontophoretic delivery across the skin: electroosmosis and its modulation by drug substances Pharm. Res. 14 1997 1258 1263
10. H.O. Ho, F.C. Huang, T.D. Sokoloski, and M.T. Sheu The influence of cosolvents on the in-vitro percutaneous penetration of diclofenac sodium from a gel system J. Pharm. Pharmacol. 46 1994 636 642
11. A. Jadoul, N. Lecouturier, J. Mesens, W. Caers, and V. Préat Transdermal alniditan delivery by skin electroporation J. Control. Release 54 1998 265 272
12. A. Jadoul, and V. Préat Electrically enhanced transdermal delivery of domperidone Int. J. Pharm. 154 1997 229 234
13. M.W. Lo, W.L. Schary, and C.C. Whitney Jr. The disposition and bioavailability of intravenous and oral nalbuphine in healthy volunteers J. Clin. Pharmacol. 27 1987 866 873
14. L.H. Pao, C.H. Hsiong, O.Y.P. Hu, and S.T. Ho High-performance liquid chromatographic method for the simultaneous determination of nalbuphine and its prodrugs, sebacoyl dinalbuphine ester, in dog plasma and application to pharmacokinetic studies in dogs J. Chromatogr. B 746 2000 241 247
15. M.R. Prausnitz, E.R. Edelman, J.A. Gimm, R. Langer, and J.C. Weaver Transdermal delivery of heparin by skin electroporation Biotechnology 13 1995 1205 1209
16. J.E. Riviere, and M.C. Heit Electrically-assisted transdermal drug delivery Pharm. Res. 14 1997 687 697
17. S.D. Roy, S.Y.E. Hou, S.L. Witham, and G.L. Flynn Transdermal delivery of narcotic analgesics: comparative metabolism and permeability of human cadaver skin and hairless mouse skin J. Pharm. Sci. 83 1994 1723 1728
18. A. Stinchcomb, A. Paliwal, R. Dua, H. Imoto, R.W. Woodard, and G.L. Flynn Permeation of buprenorphine and its ester prodrugs through skin Pharm. Res. 13 1996 1519 1523
19. K.C. Sung, J.Y. Fang, and O.Y.P. Hu Delivery of nalbuphine and its prodrugs across skin by passive diffusion and iontophoresis J. Control. Release 67 2000 1 8
20. K.C. Sung, J.Y. Fang, J.J. Wang, and O.Y.P. Hu Transdermal delivery of nalbuphine and its prodrugs by electroporation Eur. J. Pharm. Sci. 18 2003 63 70
21. K.C. Sung, R.Y. Han, O.Y.P. Hu, and L.R. Hsu Controlled release of nalbuphine prodrugs from biodegradable polymer matrices: influence of prodrug hydrophilicity and polymer composition Int. J. Pharm. 172 1998 17 25
22. P. Tyle Iontophoretic devices for drug delivery Pharm. Res. 3 1986 318 326
23. Wang, J.J., 1992. Pharmacodynamic and pharmacokinetic studies with long acting novel nalbuphine prodrugs. Ph.D. Thesis, National Defense Medical Center, Taiwan.