Transdermal delivery of nalbuphine and nalbuphine pivalate from hydrogels by passive diffusion and iontophoresis

Arzneimittel-Forschung/Drug Research

Volumn 51, Issue 5, 2001, Pages 408-413

  Fang, Jia You ^a,b   Sung, Kuo Chun ^c   Hu, Oliver Yoa Pu ^d   Chen, Hsiang Yin ^a,b  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^d NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

CAS 23277 43 2; Iontophoresis; Nalbuphine; Nalbuphine pivalate; Transdermal drug delivery, diffusion

Indexed keywords

HYDROXYPROPYLCELLULOSE; NALBUPHINE; NALBUPHINE PIVALATE; POLYMER; POVIDONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG DIFFUSION; DRUG FORMULATION; FEMALE; HYDROGEL; IONTOPHORESIS; MOUSE; NONHUMAN;

EID: 0035018138     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300055     Document Type: Article

References (17)

1. [1] Cherny, N. I., Opoid analgesics: comparative features and prescribing guidelines, Drugs 51, 713 (1996)
2. [2] Lo, M. W., Schary, W. L., Whitney Jr., C. C., The disposition and bioavailability of intravenous and oral nalbuphine in healthy volunteers, J. Clin. Pharmacol. 27, 866 (1987)
3. [3] Wang, J. J., Pharmacodynamic and pharmacokinetic studies with long acting novel nalbuphine prodrugs, Ph. D. Thesis, National Defense Medical Center, Taiwan (1992)
4. [4] Sung, K. C., Han, R. Y., Hu, O. Y. et al., Controlled release of nalbuphine prodrugs from biodegradable polymer matrices: influence of prodrug hydrophilicity and polymer composition, Int, J. Pharm. 172, 17 (1998)
5. [5] Han, R. Y., Fang, J. Y., Sung, K. C. et al., Mucoadhesive buccal disks for novel nalbuphine prodrug controlled delivery: effect of formulation variables on drug release and mucoadhesive performance, Int. J. Pharm. 177, 201 (1999)
6. [6] Abraham, M, H., Chadha, H. S., Mitchell, R. C., Hydrogen bonding. 33. Factors that influence the distribution of solutes between blood and brain. J. Pharm. Sci. 83, 1257 (1994)
7. [7] Prausnitz, M. R., Lee, C. S., Liu, C. H. et al., Transdermal transport efficiency during skin electroporation and iontophoresis. J. Controlled Release 38, 205 (1996)
8. [8] Banga, A. K., Bose, S., Ghosh, T. K., Iontophoresis and electroporation: Comparisons and contrasts. Int. J. Pharm. 179, 1 (1999)
9. [9] Sung, K. C., Fang, J. Y, Hu, O. Y. P, Delivery of nalbuphine and its prodrugs across skin by passive diffusion and iontophoresis, J. Controlled Release 67, 1 (2000)
10. [10] Fang, J. Y., Sung, K. C, Chien, S. C., Influence of coupling medium on in vitro sonophoresis of clobetasol 17-propionate, Pharmazie 54, 709 (1999)
11. [11] Riviere, J. E., Heit, M. C., Electrically assisted transdermal drug delivery, Pharm. Res. 14, 687 (1997)
12. [12] Kim, A., Green, P. G., Rao, G. et al., Convective solvent flow across the skin during iontophoresis, Pharm, Res. 10, 1315 (1993)
13. [13] Wakerly, Z., Fell, J,, Attwood, D. et al., Studies on amidated pectins as potential carriers in colonic drug delivery, J. Pharm. Pharmacol. 49, 622 (1997)
14. [14] Doelker, E., in: Hydrogels in medicine and pharmacy, vol. II, N. A, Peppas (ed.), pp. 115-160, CRC Press, Boca Raton (1987)
15. [15] Sung, K. C., Topp, E. M., Effect of drug hydropholicity and membrane hydration on diffusion in hyaluronic acid ester membranes, J. Controlled Release 37, 95 (1995)
16. [16] Joshi, H, N., Topp, E. M., Hydration in hyaluronic acid and its esters using differential scanning calorimetry, Int, J. Pharm. 80, 213 (1992)
17. [17] Kontturi, K., Murtomaki, L, Mechanistic model for transdermal transport including iontophoresis, J. Controlled Release 41, 177 (1996)