Electrically-assisted transdermal drug delivery

Pharmaceutical Research

Volumn 14, Issue 6, 1997, Pages 687-697

  Riviere, Jim E ^a   Heit, Mark C ^b  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b PFIZER INC   (United States)

Author keywords

Electrically assisted delivery; Electroosmosis; Electroporation; Iontophoresis; Transdermal

Indexed keywords

ARGIPRESSIN; GONADORELIN; LIDOCAINE; N,N DIETHYL N' (1 ETHYL 6 METHYL 8ALPHA ERGOLINYL)SULFAMIDE; PENETRATION ENHANCING AGENT; PIROXICAM; TOLAZOLINE;

ELECTROOSMOSIS; ELECTROPORATION; HUMAN; ION CURRENT; IONTOPHORESIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SKIN ABSORPTION; SKIN PENETRATION; SKIN PERMEABILITY; TRANSDERMAL DRUG ADMINISTRATION;

ADMINISTRATION, CUTANEOUS; ANIMALS; DRUG DELIVERY SYSTEMS; ELECTROPORATION; HUMANS; IONTOPHORESIS; OSMOSIS; PHARMACEUTICAL PREPARATIONS; SKIN; SKIN ABSORPTION;

EID: 0030998244     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012129801406     Document Type: Review

References (77)

1. S. Leduc. Introduction of medicinal substances into the depth of tissues by electric current. Ann. d'Electrobiol. 3:545-560 (1900).
2. N. A. Monteiro-Riviere. Comparative anatomy, physiology and biochemistry of mammalian skin. In: Dermal and Ocular Toxicology Fundamentals and Methods Hobson DW (Ed)., CRC Press, Boca Raton, Chapter 1, pp. 3-71, (1991).
3. N. A. Monteiro-Riviere. Anatomical factors affecting barrier function. In Dermatotoxicology, 5th Edition Marzulli FN, Maibach HI (Eds)., Taylor and Francis Publishers, Washington, DC, Chapter 1, pp. 3-18, (1996).
4. P. M. Elias. Epidermal lipids, barrier function and desquamation. J Invest Dermatol 80:44-49, (1983).
5. L. Landmann. The epidermal permeability barrier. Anat Embryol 178:1-13, (1988).
6. H. J. Yardley. Epidermal Lipids In: The Biochemistry and Physiology of Skin. L. A. Goldsmith (Ed), Oxford University Press, NY 363-381, (1983).
7. J.-C. Tsai, R. H. Guy, C. R. Thornfeldt, K. R. Faingold, and P. M. Elias. Metabolic approaches to enhance transdermal drug delivery. I. Effect of lipid synthesis inhibition. J. Pharm. Sci. 85:643-648, (1996).
8. C. Cullander. What are the pathways of iontophoretic current flow through mammalian skin? Adv Drug Del Rev 9:119-135, (1992).
9. H. A. Abramson and M. H. Gorin. The electrophoretic demonstration of the patent pores of the living human skin: its relation to the charge of the skin. J Phys Chem 44:1094-1102, (1940).
10. R. R. Burnette and B. Ongpipattanakul. Characterization of the pore transport properties and tissue alteration of excised human skin during iontophoresis. J Pharm Sci 77:132-137, (1988).
11. C. Cullander and R. H. Guy. Sites of iontophoretic current flow into the skin; identification and characterization with the vibrating probe electrode. J Invest Derm 97:55-64, (1991).
12. R. D. Lee, H. S. White, and E. R. Scott. Visualization of iontophoretic transport paths in cultured and animal skin models. J. Pharm. Sci. 85:1186-1190, (1996).
13. E. R. Scott, A. I. Laplaza, H. S. White, and J. B. Phipps. Transport of ionic species in skin: contribution of pores to the overall skin conductance. Pharm Res 10:1699-1709, (1993).
14. H. E. Bodde, F. H. N. De Haan, L. Kornet, W. H. M. Craanevan Hinsberg, and M. A. Salomons. Transdermal iontophoresis of mercuric chloride in vitro: electron microscopic visualization of pathways. Proceed Intern Symp Control Rel Bioact Mater 18:301-302, (1991).
15. N. A. Monteiro-Riviere, A. O. Inman, and J. E. Riviere: Identification of the pathway of transdermal iontophoretic drug delivery: Light and ultrastructural studies using mercuric chloride in pigs. Pharm. Res. 11:251-256, (1994).
16. L. A. R. M. Pechtold, W. Abraham, and R. O. Potts. The influence of an electric field on ion and water accessibility to stratum corneum lipid lamellae. Pharm. Res. 13:1168-1173, (1996).
17. R. R. Burnette. Iontophoresis. In Transdermal Drug Delivery: Developmental Issues and Research Initiatives J. Hadgraft and R. H. Guy (Eds.), Marcel Dekker, Inc., New York. 35:247-291, (1989).
18. G. B. Kasting. Theoretical models for iontophoretic delivery. Adv Drug Del Rev 9:177-199, (1992).
19. A. K. Banga and Y. W. Chien. Iontophoretic delivery of drugs: fundamentals, developments and biomedical applications. J Cont Rel 8:1-24, (1988).
20. J. C. Keister, and G. B. Kasting. Ionic mass transport through a homogenous membrane in the presence of a uniform electric field. J Membr Sci 29:155-167, (1986).
21. T. Masada, W. I. Higuchi, V. Srinivasan, U. Rohr, J. Fox, C. Behl, and S. Pons. Examination of iontophoretic transport of ionic drugs across skin: baseline studies with the four-electrode system. Int J Pharm 49:57-62, (1989).
22. L. P. Gangarosa, H. H. Park, C. A. Wiggins, and J. M. Hill. Increased penetration of nonelectrolytes into mouse skin during iontophoretic water transport (iontohydrokinesis). J Pharmacol Exp Ther 212:377-381, (1980).
23. R. R. Burnette, and D. Marrero. Comparison between the iontophoretic and passive transport of thyrotropin releasing hormone across excised nude mouse skin. J Pharm Sci 75:738-743, (1986).
24. H. A. Abramson, and M. H. Gorin. Relationship of skin permeability to electrophoresis of biologically active materials into the living human skin. J Phys Chem 43:335-346, (1939).
25. H. Rein. Experimental Studien uber elektroendosmose an uberlebender menschlicher haut. Z Biol (Munich) 81:81-125, (1924).
26. R. R. Burnette and B. Ongpipattanakul. Characterization of the permselective properties of excised human skin during iontophoresis. J Pharm Sci 76:765-773, (1987).
27. J. B. Phipps, and J. R. Gyory. Transdermal ion migration. Adv Drug Del Rev 9:137-176, (1992).
28. A. M. Rodriquez-Bayou, and R. H. Guy. Iontophoresis of nafarelin across human skin in vitro. Pharm Res. 13:798-800, (1996).
29. P. G. Green, R. S. Hinz, C. Cullander, G. Yamane, and R. H. Guy. Iontophoretic delivery of amino acids and amino acid derivatives across the skin in vitro. Pharm Res 8:1113-1120, (1991).
30. M. J. Pikal. Transport mechanisms in iontophoresis. I. A theoretical model for the effect of electroosmotic flow on flux enhancement in transdermal iontophoresis. Pharm Res 7:118-126, (1990).
31. M. J. Pikal, and S. Shah. Transport mechanisms in iontophoresis. II. Electroosmotic flow and transference number measurements for hairless mouse skin. Pharm Res 7:213-221, (1990).
32. M. J. Pikal. The role of electroosmotic flow in transdermal iontophoresis. Adv Drug Del Rev 9:201-237, (1992).
33. K. D. Peck, V. Srinivasan, S. K. Li, W. I. Higuchi and A-H Ghanem. Quantitative description of the effect of molecular size upon electroosmotic flux enhancement during iontophoresis for a synthetic membrane and human epidermal membrane. J. Pharm. Sci. 85:781-788, (1996).
34. + permeability of excised nude mouse skin. J Pharm Sci 77:492-497, (1986).
35. M. J. Pikal and S. Shah. Transport mechanisms in iontophoresis. III. An experimental study of the contributions of electroosmotic flow and permeability change in transport of low and high molecular weight solutes. Pharm Res 7:222-229, (1990).
36. S. M. Sims, W. I. Higuchi, and V. Srinivasan. Skin alterations and convective solvent flow effects during iontophoresis: I neutral solute transport across human skin. Int J Pharm 69:109-121, (1991).
37. V. Srinivasan, W. I. Higuchi, S. M. Sims, A. H. Ghanem, and C. R. Behl. Transdermal iontophoretic drug delivery: Mechanistic analysis and application to polypeptide delivery. J Pharm Sci 78:370-375, (1989).
38. N. A. Monteiro-Riviere. Altered epidermal morphology secondary to lidocaine iontophoresis: In vivo and in vitro studies in porcine skin. Fundam Appl Toxicology 15:174-185, (1990).
39. Y. N. Kalia, L. B. Nonato, and R. H. Guy. The effect of iontophoresis on skin barrier integrity: Non-invasive evaluation by impedance spectroscopy and transepidermal water loss. Pharm Res 13:957-960, (1996).
40. D. Bommannan, J. Tamada, L. Leung, and R. O. Potts. Effect of electroporation on transdermal iontophoretic delivery of luteinizing hormone releasing hormone (LHRH) in vitro. Pharm. Res. 11:1809-1814, (1994).
41. M. R. Prausnitz, V. G. Bose, R. Langer, and J. C. Weaver. Electroporation of mammalian skin. A mechanism to enhance transdermal drug delivery. Proc. Natl Acad. Sci. USA 90:10504-10508, (1993).
42. M. R. Prausnitz, E. R. Edelman, J. A. Gimm, R. Langer and J. C. Weaver. Transdermal delivery of heparin by skin electroporation. Bio/Technology 13:1205-1209, (1995).
43. J. E. Riviere, N. A. Monteiro-Riviere, R. A. Rogers, D. Bommannan, J. A. Tamada, and R. O. Potts: Pulsatile transdermal delivery of LHRH using electroporation. Drug delivery and skin toxicology. J. Contr. Release 36:229-233, (1995).
44. G. Hofman, W. Rustrum W, Suder K. Electroincorporation of microcarriers as a method for the transdermal delivery of large molecules. Bioelectrochem. Bioenergetics 38:209-222, (1995).
45. M. C. Heit, P. L. Williams, F. L. Jayes, S. K. Chang, and J. E. Riviere. Transdermal iontophoretic peptide delivery; in vitro and in vivo studies with luteinizing hormone releasing hormone. J Pharm Sci 82:240-243, (1993).
46. J. E. Riviere, K. F. Bowman, N. A. Monteiro-Riviere, L. P. Dix, and M. P. Carver. The isolated perfused porcine skin flap (IPPSF) 1. A novel in vitro model for percutaneous absorbtion and cutaneous toxicologic studies. Fundam Appl Toxicol 7:444-453, (1986).
47. J. E. Riviere and N. A. Monteiro-Riviere. The isolated perfused porcine skin flap as an in vitro model for percutaneous absorption and cutaneous toxicology. CRC Critical Review in Toxicology, 21:329-344, (1991).
48. J. E. Riviere, P. L. Williams, R. Hillman, and L. Mishky: Quantitative prediction of transdermal iontophoretic delivery of arbutamine in humans using the in vitro isolated perfused porcine skin flap (IPPSF). J. Pharm. Sci. 8:504-507, (1992).
49. M. H. Su, V. Srinivasan, A. H. Ghanem, and W. I. Higuchi. Quantitative in vivo iontophoretic studies. J Pharm Sci 83:12-17, (1994).
50. P. L. Williams and J. E. Riviere: A "full-space" method for predicting in vivo transdermal plasma drug profiles reflecting both cutaneous and systemic variability. J. Pharm. Sci. 83:1062-1064, (1994).
51. M. C. Heit, A. McFarland, R. Bock, and J. E. Riviere. Isoelectric focusing and capillary zone electrophoretic studies using luteinizing hormone releasing hormone and its analog. J Pharm Sci 83:654-656, (1994).
52. B. B. VanOrman, C. R. Daniels, G. G. Liversidge, and G. L. McIntire. Capillary electrophoresis: a physic-chemical model of iontophoretic drug delivery. Pharm Res 7:S-184, (1990).
53. N. H. Yoshida and M. S. Roberts. Solute molecular size and transdermal iontophoresis across excised human skin. J Contr Rel 25:177-195, (1993).
54. S. Del Terzo, C. R. Behl, and R. A. Nash. Iontophoretic transport of a homologous series of ionized and unionized model compounds: influences of hydrophobicity and mechanistic interpretation. Pharm Res 6:85-90, (1989).
55. L. L. Wearley, K. Tojo, and Y. W. Chien. A numerical approach to study the effect of binding on the iontophoretic transport of a series of amino acids. J Pharm Sci 79:992-998, (1990).
56. J. Hirvonen, Y. N. Kalia, and R. H. Guy. Transdermal delivery of peptides by iontophoresis. Nature Biotechnology 14:1710-1713, (1966).
57. L. L. Miller and G. A. Smith. Iontophoretic transport of acetate and carboxylate ions through hairless mouse skin. A cation exchange membrane model. Int J Pharm 49:15-22, (1989).
58. P. Lelawongs, J. C. Liu, O. Siddiqui, and Y. W. Chien. Transdermal iontophoretic delivery of arginine-vasopressin I: physicochemical considerations. Int J Pharm 56:13-22, (1989).
59. N. H. Bellantone, S. Rim, M. L. Francoeur, and B. Rasadi B. Enhanced percutaneous absorption via iontophoresis I. Evaluation of an in vitro system and transport of model compounds. Int J Pharm 30:63-72, (1986).
60. G. A. Lattin, R. V. Padmanabhan, and J. B. Phipps. Electronic control of iontophoretic drug delivery. Annals NY Acad Sci 8:450-464, (1991).
61. P. Lelawongs, J. C. Liu, and Y. W. Chien. Transdermal iontophoretic delivery of arginine-vasopressin (II): Evaluation of electrical and operational factors. Int J Pharm 61:179-188, (1990).
62. J. B. Phipps, R. V. Padmanabhan, and G. A. Lattin. Iontophoretic delivery of model inorganic and drug ions. J Pharm Sci 78:365-369, (1989).
63. J. C. Liu, Y. Sun, O. Siddiqui, Y. W. Chien, W. M. Shi and J. Li. Blood glucose control in diabetic rats by transdermal iontophoretic delivery of insulin. Int J Pharm 44:197-204, (1988).
64. M. J. Pikal and S. Shah. Study of the mechanisms of flux enhancement through hairless mouse skin by pulsed DC iontophoresis. Pharm Res 8:365-369, (1991).
65. O. Siddiqui, Y. Sun, J. C. Liu and Y. W. Chien. Facilitated Transport of Insulin. J Pharm Sci 76:341-345, (1987).
66. D. F. Hager, M. J. Laubach, J. W. Sharkey, and J. R. Siverly JR. In vitro iontophoretic delivery of CQA 206-291: influence of ethanol. J Cont Rel 23:175-182, (1993).
67. A. K. Banga and Y. W. Chien. Hydrogel-based iontotherapeutic delivery devices for transdermal delivery of peptide/protein drugs. Pharm Res 10:697-702, (1993).
68. L. L. Wearley, J. C. Liu, and Y. W. Chien, Iontophoresis-facilitated transdermal delivery of verapamil II. Factors affecting the reversibility of skin permeability. J Cont Rel 9:231-242, (1989).
69. M. C. Heit, N. A. Monteiro-Riviere, F. L. Jayes, and J. E. Riviere. Transdermal iontophoretic delivery of luteinizing hormone releasing hormone (LHRH): effect of repeated administration. Pharm Res 11:1000-1003, (1994).
70. V. Srinivasan, M. H. Su, W. I. Higuchi, and C. R. Behl. Iontophoresis of polypeptides: effect of ethanol pretreatment on human skin. J Pharm Sci 79:588-591, (1990).
71. C. L. Gay, P. G. Green, R. H. Guy, and M. L. Francoeur. Iontophoretic delivery of piroxicam across the skin in vitro. J Cont Rel 22:57-68, (1992).
72. J. E. Riviere, B. Sage, and P. L. Williams. Effects of vasoactive drugs on transdermal lidocaine iontophoresis. J Pharm Sci 80:615-620, (1991).
73. P. L. Williams and J. E. Riviere. A model describing transdermal iontophoretic delivery of lidocaine incorporating consideration of cutaneous microvascular state. J. Pharm Sci 82:1080-1084, (1993).
74. D. L. Chu, H. J. Chiou, and D. P. Wan. Characterization of transdermal delivery of nefopam hydrochloride under iontophoresis. Drug Dev Ind Pharm 20:2775-2785, (1994).
75. A. K. Banga and Y. W. Chien. Characterization of in vitro transdermal iontophoretic delivery of insulin. Drug Dev Ind Pharm 19:2069-2087, (1993).
76. R. H. Guy. Current status and future prospects of transdermal drug delivery. Pharm. Res. 13:1765-1769, (1996).
77. S. K. Gupta, S. Kumar, S. Bolton, C. R. Behl, and A. W. Malick. Optimization of iontophoretic transdermal delivery of a peptide and a non-peptide drug. J Cont Rel 30:253-261, (1994).