Curcumin blocks interleukin-1 (IL-1) signaling by inhibiting the recruitment of the IL-1 receptor-associated kinase IRAK in murine thymoma EL-4 cells

Journal of Nutrition

Volumn 135, Issue 8, 2005, Pages 1859-1864

  Jurrmann, Nadine ^a,b   Brigelius Flohé, Regina ^a,b   Böl, Gaby Fleur ^a  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b UNIVERSITY OF POTSDAM   (Germany)

Author keywords

Curcumin; Interleukin 1 receptor associated kinase; Redox regulation; Thiol modification

Indexed keywords

CURCUMIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1;

ALKYLATION; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; MICHAEL ADDITION; NONHUMAN; OXIDATION; PROTEIN MODIFICATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMOMA;

MURINAE;

EID: 19344366664     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/135.8.1859     Document Type: Article

References (50)

1. Cheng, A. L., Hsu, C. H., Lin, J. K., Hsu, M. M., Ho, Y. F., Shen, T. S., Ko, J. Y., Lin, J. T., Lin, B. R. et al. (2001) Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 21: 2895-2900.
2. 2 production and COX-2 expression in human blood. Proc. Am. Assoc. Cancer Res. 42: 17-18.
3. Huang, H. C., Jan, T. R. & Yeh, S. F. (1992) Inhibitory effect of curcumin, an anti-inflammatory agent, on vascular smooth muscle cell proliferation. Eur. J. Pharmacol. 221: 381-384.
4. Huang, T. S., Lee, S. C. & Lin, J. K. (1991) Suppression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells. Proc. Natl. Acad. Sci. U.S.A. 88: 5292-5296.
5. Chen, Y. R. & Tan, T. H. (1998) Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin. Oncogene 17: 173-178.
6. Khar, A., Ali, A. M., Pardhasaradhi, B. V., Begum, Z. & Anjum, R. (1999) Antitumor activity of curcumin is mediated through the induction of apoptosis in AK-5 tumor cells. FEBS Lett. 445: 165-168.
7. Anto, R. J., Mukhopadhyay, A., Denning, K. & Aggarwal, B. B. (2002) Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl. Carcinogenesis 23: 143-150.
8. Jana, N. R., Dikshit, P., Goswami, A. & Nukina, N. (2004) Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway. J. Biol. Chem. 279: 11680-11685.
9. Jiang, M. C., Yang-Yen, H. F., Yen, J. J. & Lin, J. K. (1996) Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines. Nutr. Cancer 26: 111-120.
10. Woo, J. H., Kim, Y. H., Choi, Y. J., Kim, D. G., Lee, K. S., Bae, J. H., Min do, S., Chang, J. S., Jeong, Y. J., et al. (2003) Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis 24: 1199-1208.
11. Chan, M. M., Huang, H. I., Fenton, M. R. & Fong, D. (1998) In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties. Biochem. Pharmacol. 55: 1955-1962.
12. Hong, J., Bose, M., Ju, J., Ryu, J. H., Chen, X., Sang, S., Lee, M. J. & Yang, C. S. (2004) Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase. Carcinogenesis 25: 1671-1679.
13. Huang, M. T., Lysz, T., Ferraro, T., Abidi, T. F., Laskin, J. D. & Conney, A. H. (1991) Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res. 51: 813-819.
14. Singh, S. & Aggarwal, B. B. (1995) Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane). J. Biol. Chem. 270: 24995-25000.
15. Jobin, C., Bradham, C. A., Russo, M. P., Juma, B., Narula, A. S., Brenner, D. A. & Sartor, R. B. (1999) Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. J. Immunol. 163: 3474-3483.
16. Kumar, A., Dhawan, S., Hardegen, N. J. & Aggarwal, B. B. (1998) Curcumin (diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activation. Biochem. Pharmacol. 55: 775-783.
17. Plummer, S. M., Holloway, K. A., Manson, M. M., Munks, R. J., Kaptein, A., Farrow, S. & Howells, L. (1999) Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex. Oncogene 18: 6013-6020.
18. Morin, D., Barthelemy, S., Zini, R., Labidalle, S. & Tillement, J. P. (2001) Curcumin induces the mitochondrial permeability transition pore mediated by membrane protein thiol oxidation. FEBS Lett. 495: 131-136.
19. Dinkova-Kostova, A. T., Massiah, M. A., Bozak, R. E., Hicks, R. J. & Talalay, P. (2001) Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups. Proc. Natl. Acad. Sci. U.S.A. 98: 3404-3409.
20. Dinkova-Kostova, A. T. & Talalay, P. (1999) Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes. Carcinogenesis 20: 911-914.
21. Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D. & Yamamoto, M. (1999) Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 13: 76-86.
22. Balogun, E., Hoque, M., Gong, P., Killeen, E., Green, C. J., Foresti, R., Alam, J. & Motterlini, R. (2003) Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem. J. 371: 887-895.
23. Zhang, D. D. & Hannink, M. (2003) Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol. Cell. Biol. 23: 8137-81351.
24. Dinarello, C. A. (1996) Biologic basis for interleukin-1 in disease. Blood 87: 2095-2147.
25. Sims, J. E., Gayle, M. A., Slack, J. L., Alderson, M. R., Bird, T. A., Giri, J. G., Colotta, F., Re, F., Mantovani, A., et al. (1993) Interleukin 1 signaling occurs exclusively via the type I receptor. Proc. Natl. Acad. Sci. U.S.A. 90: 6155-6159.
26. Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S. & Cao, Z. (1997) MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7: 837-847.
27. Burns, K., Clatworthy, J., Martin, L., Martinon, F., Plumpton, C., Maschera, B., Lewis, A., Ray, K., Tschopp, J. & Volpe, F. (2000) Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat. Cell. Biol. 2: 346-351.
28. Martin, M., Böl, G.-F., Eriksson, A., Resch, K. & Brigelius-Flohé, R. (1994) Interleukin-1-induced activation of a protein kinase co-precipitating with the type I interleukin-1 receptor in T cells. Eur. J. Immunol. 24: 1566-1571.
29. Cao, Z., Henzel, W. J. & Gao, X. (1996) IRAK: a kinase associated with the interleukin-1 receptor. Science (Washington, DC) 271: 1128-1131.
30. Li, S., Strelow, A., Fontana, E. J. & Wesche, H. (2002) IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc. Natl. Acad. Sci. U.S.A. 99: 5567-5572.
31. Kollewe, C., Mackensen, A. C., Neumann, D., Knop, J., Cao, P., Li, S., Wesche, H. & Martin, M. U. (2004) Sequential autophosphorylation steps n the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling. J. Biol. Chem. 279: 5227-5236.
32. Böl, G.-F., Jurrmann, N. & Brigelius-Flohé, R. (2003) Recruitment of the interleukin-1 receptor (IL-1RI)-associated kinase IRAK to the IL-1RI is radox regulated. Biol. Chem. 384: 609-617.
33. Friedrichs, B., Müller, C. & Brigelius-Flohé, R. (1998) Inhibition of tumor necrosis factor-alpha- and interleukin-1-induced endothelial E-selectin expression by thiol-modifying agents. Arterioscler. Thromb. Vasc. Biol. 18:1829-1837.
34. Brigelius-Flohé, R., Banning, A., Kny, M. & Böl, G.-F. (2004) Redox events in interleukin-1 signaling. Arch. Biochem. Biophys. 423: 66-73.
35. Gitler, C., Mogyoros, M. & Kalef, E. (1994) Labeling of protein vicinal dithiols: role of protein-S2 to protein-(SH)2 conversion in metabolic regulation and oxidative stress. Methods Enzymol. 233: 403-415.
36. Greenwood, F. C., Hunter, W. M. & Glover, J. S. (1963) The preparation of I-131-labelled human growth hormone of high specific radioactivity. Biochem. J. 89: 114-123.
37. Ross, K., Yang, L., Dower, S., Volpe, F. & Guesdon, F. (2002) Identification of threonine 66 as a functionally critical residue of the interleukin-1 receptor-associated kinase. J. Biol. Chem. 277: 37414-37421.
38. Singh, S. & Aggarwal, B. B. (1995) Protein-tyrosine phosphalase inhibitors block tumor necrosis factor-dependent activation of the nuclear transcription factor NF-kappa B. J. Biol. Chem. 270: 10631-10639.
39. Witek-Zawada, B. & Koj, A. (2003) Regulation of expression of stromelysin-1 by proinflammatory cytokines in mouse brain astrocytes. J. Physiol. Pharmacol. 54: 489-496.
40. Wuyts, W. A., Vanaudenaerde, B, M., Dupont, L. J., Demedts, M. G. & Verleden, G. M. (2003) Involvement of p38 MAPK, JNK, p42/p44 ERK and NF-kappaB in IL-1 beta-induced chemokine release in human airway smooth muscle cells. Respir. Med. 97: 811-817.
41. Bamba, S., Andoh, A., Yasui, H., Araki, Y., Bamba, T. & Fujiyama, Y. (2003) Matrix metalloproteinase-3 secretion from human colonic sub-epithelial myofibroblasts: role of interleukin-17. J. Gastroenterol. 38: 548-554.
42. Kim, H. Y., Park, E. J., Joe, E. H. & Jou, I. (2003) Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia. J. Immunol. 171: 6072-6079.
43. Kojima, H., Takeuchi, M., Ohta, T., Nishida, Y., Arai, N., Ikeda, M., Ikegami, H. & Kurimoto, M. (1998) Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells. Biochem. Biophys. Res. Commun. 244: 183-186.
44. Vig, E., Green, M., Liu, Y., Donner, D. B., Mukaida, N., Goebl, M. G. & Harrington, M. A. (1999) Modulation of tumor necrosis factor and interleukin-1-dependent NF-kappaB activity by mPLK/IRAK. J. Biol. Chem. 274: 13077-13084.
45. Mamidipudi, V., Li, X. & Wooten, M. W. (2002) Identification of interleukin 1 receptor-associated kinase as a conserved component in the p75-neurotrophin receptor activation of nuclear factor-kappa B. J. Biol. Chem. 277: 28010-28018.
46. Iwasaki, A. & Medzhitov, R. (2004) Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 5: 987-995.
47. Böl, G.-F., Kreuzer, O. J. & Brigelius-Flohé, R. (2000) Translocation of the interleukin-1 receptor-associated kinase-1 (IRAK-1) into the nucleus. FEBS Lett. 477: 73-78.
48. Knop, J. & Martin, M. U. (1999) Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity. FEBS Lett. 448: 81-85.
49. Maschera, B., Ray, K., Burns, K. & Volpe, F. (1999) Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB. Biochem. J. 339: 227-231.
50. Huang, Y., Li, T., Sane, D. C. & Li, L. (2004) IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression. J. Biol. Chem. 279: 51697-51703.