Sequence and expression pattern of a novel human orphan G-protein- coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain

Genomics

Volumn 65, Issue 2, 2000, Pages 121-128

  Bräuner Osborne, Hans ^a   Krogsgaard Larsen, Povl ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; GUANINE NUCLEOTIDE BINDING PROTEIN; METABOTROPIC RECEPTOR; RECEPTOR SUBTYPE; RETINOIC ACID; SIGNAL PEPTIDE;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CHROMOSOME 16P; CODON; EXPRESSED SEQUENCE TAG; LUNG PARENCHYMA; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PHYLOGENY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

EID: 19244382287     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.2000.6164     Document Type: Article

References (34)

1. Altschul S. F., Gish W., Miller W., Myers E. W., Lipman D. J. Basic local alignment search tool. J. Mol. Biol. 215:1990;403-410.
2. B receptors: Drugs meet clones. Curr. Opin. Neurobiol. 8:1998;345-350.
3. Bräuner-Osborne H., Brann M. R. Pharmacology of muscarinic acetylcholine receptor subtypes (m1-m5): High throughput assays in mammalian cells. Eur. J. Pharmacol. 295:1996;93-102.
4. Bräuner-Osborne H., Jensen A. A., Sheppard P. O., O'Hara P., Krogsgaard-Larsen P. The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain. J. Biol. Chem. 274:1999;18382-18386.
5. Brown E. M. Physiology and pathophysiology of the extracellular calcium-sensing receptor. Am. J. Med. 106:1999;238-253.
6. Cheng Y., Lotan R. Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor. J. Biol. Chem. 273:1998;35008-35015.
7. Chung D. S., Traynelis S. F., Murphy T. J., Conn P. J. 4-Methylhomoibotenic acid activates a novel metabotropic glutamate receptor coupled to phosphoinositide hydrolysis. J. Pharmacol. Exp. Ther. 283:1997;742-749.
8. Dohlman H. G., Thorner J., Caron M. G., Lefkowitz R. J. Model systems for the study of seven-transmembrane-segment receptors. Annu. Rev. Biochem. 60:1991;653-688.
9. Flor P. J., Lindauer K., Püttner I., Rüegg D., Lukic S., Knöpfel T., Kuhn R. Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2. Eur. J. Neurosci. 7:1995;622-629.
10. B receptor extracellular domain support a Venus flytrap mechanism for ligand binding. J. Biol. Chem. 274:1999;13362-13369.
11. Hart A. C., Kramer H., Van Vactor D. L. Jr., Paidhungat M., Zipursky S. L. Induction of cell fate in the Drosophila retina: The bride of sevenless protein is predicted to contain a large extracellular domain and seven transmembrane segments. Genes Dev. 4:1990;1835-1847.
12. Jayawickreme C. K., Kost T. A. Gene expression systems in the development of high-throughput screens. Curr. Opin. Biotechnol. 8:1997;629-634.
13. Josefsson L. G. Evidence for kinship between diverse G-protein coupled receptors. Gene. 239:1999;333-340.
14. Karla R., Ebert B., Thorkildsen C., Herdeis C., Johansen T. N., Nielsen B., Krogsgaard-Larsen P. Synthesis and pharmacology of the baclofen homologues 5-amino-4-(4-chlorophenyl)pentanoic acid and the R- and S-enantiomers of 5-amino-3-(4-chlorophenyl)pentanoic acid. J. Med. Chem. 42:1999;2053-2059.
15. Kolakowski L. F. GCRDb: A G-protein-coupled receptor database. Recept. Channels. 2:1994;1-7.
16. Kozak M. Structural features in eukaryotic mRNAs that modulate the initiation of translation. J. Biol. Chem. 266:1991;19867-19870.
17. Kyte J., Doolittle R. F. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157:1982;105-132.
18. Makoff A., Volpe F., Lelchuk R., Harrington K., Emson P. Molecular characterization and localization of human metabotropic glutamate receptor type 3. Brain Res. Mol. Brain Res. 40:1996;55-63.
19. B receptors make it to the top - As dimers. Trends Pharmacol. Sci. 20:1999;87-89.
20. Nielsen H., Engelbrecht J., Brunak S., von Heijne G. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Protein Eng. 10:1997;1-6.
21. O'Hara P. J., Sheppard P. O., Thøgersen H., Venezia D., Haldeman B. A., McGrane V., Houamed K. M., Thomsen C., Gilbert T. L., Mulvihill E. R. The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins. Neuron. 11:1993;41-52.
22. Pedersen A. G., Nielsen H. Neural network prediction of translation initiation sites in eukaryotes: Perspectives for EST and genome analysis. ISMB. 5:1997;226-233.
23. Pellicciari R., Costantino G. Metabotropic G-protein-coupled glutamate receptors as therapeutic targets. Curr. Opin. Chem. Biol. 3:1999;433-440.
24. Pellicciari R., Marinozzi M., Costantino G., Natalini B., Moroni F., Pellegrini-Giampietro D. (2R,1′S,2′R,3′S)-2-(2′-Carboxy-3′- phenylcyclopropyl)-glycine (PCCG-13), the first potent and selective competitive antagonist of phospholipase D-coupled metabotropic glutamate receptors: asymmetric synthesis and preliminary biological properties. J. Med. Chem. 42:1999;2716-2720.
25. Perrière G., Gouy M. WWW-Query: An on-line retrieval system for biological sequence banks. Biochimie. 78:1996;364-369.
26. Pi M., Hinson T. K., Quarles L. D. Failure to detect the extracellular calcium-sensing receptor (CaSR) in human osteoblast cell lines. J. Bone Miner. Res. 14:1999;1310-1319.
27. Pin J.-P., Duvoisin R. The metabotropic glutamate receptors: Structure and functions. Neuropharmacology. 34:1995;1-26.
28. Probst W. C., Snyder L. A., Schuster D. I., Brosius J., Sealfon S. C. Sequence alignment of the G-protein coupled receptor superfamily. DNA Cell Biol. 11:1992;1-20.
29. Saitou N., Nei M. The neighbor-joining method: A new method for reconstructing phylogenetic trees. Mol. Biol. Evol. 4:1987;406-425.
30. Savarese T. M., Fraser C. M. In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors. Biochem. J. 283:1992;1-19.
31. Sonnhammer E. L. L., von Heijne G., Krogh A. A hidden Markov model for predicting transmembrane helices in protein sequences. Glasgow J., Littlejohn T., Major F., Lathrop R., Sankoff D., Sensen C. Proceedings of the Sixth International Conference on Intelligent Systems for Molecular Biology. 1998;175-182 AAAI Press, Menlo Park.
32. Thompson J. D., Higgins D. G., Gibson T. J. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:1994;4673-4680.
33. Tirindelli R., Mucignat-Caretta C., Ryba N. J. Molecular aspects of pheromonal communication via the vomeronasal organ of mammals. Trends Neurosci. 21:1998;482-486.
34. Wilson S., Bergsma D. J., Chambers J. K., Muir A. I., Fantom K. G., Ellis C., Murdock P. R., Herrity N. C., Stadel J. M. Orphan G-protein-coupled receptors: the next generation of drug targets? Br. J. Pharmacol. 125:1998;1387-1392.