Synthesis and pharmacology of the baclofen homologues 5-amino-4-(4- chlorophenyl)pentanoic acid and the R- and S-enantiomers of 5-amino-3-(4- chlorophenyl)pentanoic acid

Journal of Medicinal Chemistry

Volumn 42, Issue 11, 1999, Pages 2053-2059

  Karla, Rolf ^b   Ebert, Bjarke ^a   Thorkildsen, Christian ^a   Herdeis, Claus ^b   Johansen, Tommy N ^a   Nielsen, Birgitte ^a   Krogsgaard Larsen, Povl ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 5 AMINO 3 (4 CHLOROPHENYL)PENTANOIC ACID; 5 AMINO 4 (4 CHLOROPHENYL)PENTANOIC ACID; BACLOFEN; UNCLASSIFIED DRUG; VALERIC ACID;

ANIMAL TISSUE; ARTICLE; DRUG BINDING; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; GUINEA PIG; NONHUMAN; REACTION ANALYSIS; RECEPTOR AFFINITY; STEREOCHEMISTRY;

ANIMALS; BACLOFEN; BINDING, COMPETITIVE; BRAIN; GABA AGENTS; GUINEA PIGS; ILEUM; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PENTANOIC ACIDS; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; RECEPTORS, GABA-B; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTIC MEMBRANES;

EID: 0033519740     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990076+     Document Type: Article

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