Phosphorylation of connexin43 and inhibition of gap junctional communication in 12-O-tetradecanoylphorbol-13-acetate-exposed R6 fibroblasts: Minor role of protein kinase CβI and μ

Carcinogenesis

Volumn 22, Issue 2, 2001, Pages 221-231

  Husøy, Trine ^a,b   Cruciani, Véronique ^a   Sanner, Tore ^a   Mikalsen, Svein Ole ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; COMPLEMENTARY DNA; CONNEXIN 43; ISOENZYME; LY 379196; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

ANIMAL CELL; ARTICLE; CELL COMMUNICATION; CONTROLLED STUDY; DNA SEQUENCE; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; EXPOSURE; FIBROBLAST; GAP JUNCTION; GENETIC CODE; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

EID: 19244369265     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/22.2.221     Document Type: Article

References (54)

1. Junctional intercellular communication and the control of growth
2. Role of connexin genes in growth control
3. The role of gap junction membrane channels in development
4. Molecular cloning and functional expression of the mouse gap junction gene connexin-57 in human HeLa cells
5. Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines
6. Role of Cx43 phosphorylation and MAP kinase activation in EGF induced enhancement of cell communication in human kidney epithelial cells
7. A characterization of pervanadate, an inducer of cellular tyrosine phosphorylation and inhibitor of gap junctional intercellular communication
8. A characterization of permolybdate and its effect on cellular tyrosine phosphorylation, gap junctional intercellular communication and phosphorylation status of the gap junction protein, connexin43
9. Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter
10. Tumour promoters inhibit metabolic cooperation in cocultures of epidermal and 3T3 cells
11. 125I]EGF binding in hamster fibroblasts
12. Effects of peroxisome proliferators and 12-O-tetradecanoyl phorbol-13-acetate on intercellular communication and connexin43 in two hamster fibroblast systems
13. Phorbol ester induces phosphorylation and down-regulation of connexin 43 in WB cells
14. Effects of five phorbol esters on gap junctional intercellular communication, morphological transformation and epidermal growth factor binding in Syrian hamster embryo cells
15. Rapid inhibition of intercellular communication between BALB/c 3T3 cells by diacylglycerol, a possible endogenous functional analogue of phorbol esters
16. Contrasting duration of inhibition of cell-cell communication in primary mouse epidermal cells by phorbol 12,13-dibutyrate and by bryostatin 1
17. Rat connexin43: Regulation by phosphorylation in heart
18. TPA increases conductance but decreases permeability in neonatal rat cardiomyocyte gap junction channels
19. PKCv, a new member of the protein kinase C family, composes a fourth subfamily with PKCμ
20. Characterization of activators and inhibitors of protein kinase Cμ
21. Overproduction of protein kinase C causes disordered growth control in rat fibroblasts
22. Expression of four protein kinase C isoforms in rat fibroblasts. Distinct subcellular distribution and regulation by calcium and phorbol esters
23. Phorbol ester activation of the isotypes of protein kinase C from bovine and rat brain
24. 1, γ, δ and ε by phorbol esters of different biological activities
25. 12-Deoxyphorbol-13-O-phenylacetate-20-acetate is not protein kinase C-β isoenzyme-selective in vivo
26. Selective inhibition of protein kinase C isoenzymes by the indolocarbazole Gö 6976
27. (S) -13-[(dimethylamino)methyl] -10,11,14,15 -tetrahydro -4,9:16,21 -dimetheno-1H, 13H-dibenzo[e,k]pyrrolo [3,4-h][1,4,13]oxadiazacyclo -hexadecene-1,3(2H) -dione (LY333531) and related analogues: Isozyme protein kinase Cβ
28. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor
29. +-ATPase activity
30. Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis
31. Protein kinase C-β contributes to NADPH oxidase activation in neutrophils
32. The protein kinase C β-specific inhibitor LY379196 blocks TPA-induced monocytic differentiation of HL60 cells
33. Stimulated phosphorylation of intracellular connexin43
34. Two inhibitors of gap junctional intercellular communication, TPA and endosulfan: Different effects on phosphorylation of connexin 43 in the rat liver epithelial cell line, IAR 20
35. Inhibition of rat liver gap junction intercellular communication by tumor-promoting agents in vivo. Association with aberrant localization of connexin proteins
36. Differential effect of subcellular localization of communication impairing gap junction protein connexin43 on tumor cell growth in vivo
37. Selective gap-junctional communication capacity of transformed and non-transformed rat liver epithelial cell lines
38. Selective lack of intercellular communication between transformed and nontransformed cells as a common property of chemical and oncogene transformation of BALB/c 3T3 cells
39. Immunological demonstration of protein kinase Cμ in murine tissues and various cell lines. Differential recognition of phosphorylated forms and lack of down-regulation upon 12-O-tetradecanolyphorphol-13-acetate treatment of cells
40. A fluorescence photobleaching assay of gap junction-mediated communication between human cells
41. Determination of the specific substrate sequence motifs of protein kinase C isozymes
42. The differential effects of 12-O-tetradecanoylphorbol-13-acetate on the gap junctions and connexins of the developing mammalian lens
43. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C
44. Inhibition of protein kinase C μ by various inhibitors. Differentiation from protein kinase C isoenzymes
45. The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1β (Rsk-2) and p70 S6 kinase
46. The protein kinase C inhibitors bisindolylmaleimide I (GF 109203X) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity
47. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
48. 11 protein, phosphatidylinositol 3-kinase β, and protein kinase Cε
49. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
50. Potentiation of insulin-induced phosphatidylinositol-3 kinase activity by phorbol ester is mediated by protein kinase C ε
51. Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase
52. Phosphatases involved in modulation of gap junctional intercellular communication and dephosphorylation of connexin43 in hamster fibroblasts: 2B or not 2B?
53. Differential effects of two protein kinase C inhibitors, calphostin C and Gö6976, on pineal cyclic nucleotide accumulation
54. Effect of cAMP elevating compounds on inhibition of gap junctional communication and induction of morphological transformation in Syrian hamster embryo cells