PKCν, a new member of the protein kinase C family, composes a fourth subfamily with PKCμ

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1450, Issue 1, 1999, Pages 99-106

  Hayashi, Akiko ^a   Seki, Naohiko ^a,b   Hattori, Atsushi ^a,c   Kozuma, Sumie ^a   Saito, Toshiyuki ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b KAZUSA DNA RESEARCH INSTITUTE   (Japan)

^c Aisin Cosmos R and D Co   (Japan)

Author keywords

2p21; Chromosome mapping; Cysteine rich motif; PH domain; PKC ; PKD; Protein kinase C

Indexed keywords

COMPLEMENTARY DNA; PROTEIN KINASE C; ISOENZYME; MESSENGER RNA; PROTEIN KINASE C NU;

ARTICLE; CELL DIFFERENTIATION; CHROMOSOME 2P; DATA BASE; DNA DETERMINATION; ENZYME ACTIVITY; GENE MAPPING; HUMAN; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; TISSUE SPECIFICITY; AMINO ACID SEQUENCE; BIOSYNTHESIS; CHEMISTRY; CHROMOSOME MAP; COMPARATIVE STUDY; GENETICS; MOLECULAR GENETICS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; BASE SEQUENCE; BLOTTING, NORTHERN; CHROMOSOME MAPPING; DATABASES; DNA, COMPLEMENTARY; HUMANS; ISOENZYMES; MOLECULAR SEQUENCE DATA; PROTEIN KINASE C; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ALIGNMENT;

EID: 0033528865     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4889(99)00040-3     Document Type: Article

References (22)

1. Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science. 258:1992;607-614.
2. Bell R.M., Burns D.J. Lipid activation of protein kinase C. J. Biol. Chem. 266:1991;4661-4664.
3. Hug H., Sarre T.F. Protein kinase C isoenzymes: divergence in signal transduction? Biochem. J. 291:1993;329-343.
4. Dekker L.V., Parker P.J. Protein kinase C - a question of specificity. Trends Biochem. Sci. 19:1994;73-77.
5. Knopf J.L., Lee M.H., Sultzman L.A., Kriz R.W., Loomis C.R., Hewick R.M., Bell R.M. Cloning and expression of multiple protein kinase C cDNAs. Cell. 46:1986;491-502.
6. Johannes F.J., Prestle J., Eis S., Oberhagemann P., Pfizenmaier K. PKCμ is a novel, atypical member of the protein kinase C family. J. Biol. Chem. 269:1994;6140-6148.
7. Valverde A.M., Sinnett-Smith J., Van Lint J., Rozengurt E. Molecular cloning and characterization of protein kinase D: A target for diacylglycerol and phorbol esters with a distinctive catalytic domain. Proc. Natl. Acad. Sci. USA. 91:1994;8572-8576.
8. Dieterich S., Herget T., Link G., Bottinger H., Pfizenmaier K., Johannes F.J. In vitro activation and substrates of recombinant, baculovirus expressed human protein kinase Cμ FEBS Lett. 381:1996;183-187.
9. Van Lint J.V., Sinnett-Smith J., Rozengurt E. Expression and characterization of PKD, a phorbol ester and diacylglycerol-stimulated serine protein kinase. J. Biol. Chem. 270:1995;1455-1461.
10. Hanks S.K., Quinn A.M., Hunter T. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science. 241:1988;42-52.
11. Haslam R.J., Koide H.B., Hemmings B.A. Pleckstrin domain homology. Nature. 363:1993;309-310.
12. Mayer B.J., Ren R., Clark K.L., Baltimore D. A putative modular domain present in diverse signaling proteins. Cell. 73:1993;629-630.
13. Gibson T.J., Hyvonen M., Musacchio A., Saraste M., Birney E. PH domain: the first anniversary. Trends. Biochem. Sci. 19:1994;349-353.
14. Lemmon M.A., Ferguson K.M., Schlessinger J. PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell. 85:1996;621-624.
15. Van Lint J., Ni Y., Valius M., Merlevede W., Vandenheede J.R. Platelet-derived growth factor stimulates protein kinase D through the activation of phospholipase Cγ and protein kinase C. J. Biol. Chem. 273:1998;7038-7043.
16. Iglesias T., Rozengurt E. Protein kinase D activation by mutations within its pleckstrin homology domain. J. Biol. Chem. 273:1998;410-416.
17. Saito T., Seki N., Ishii H., Ohira M., Hayashi A., Kozuma S., Hori T. Complementary DNA cloning and chromosomal mapping of a novel phosphatidylinositol kinase gene. DNA Res. 4:1997;301-305.
18. Saito T., Seki N., Ohira M., Hayashi A., Kozuma S., Hattori A., Hori T. Assignment of the ZIP kinase gene to human chromosome 19p13.3 by somatic hybrid analysis and fluorescence in-situ hybridization. J. Hum. Genet. 43:1998;209-211.
19. Seki N., Nimura Y., Ohira M., Saito T., Ichimiya S., Nomura N., Nakagawara A. Identification and chromosome assignment of a human gene encoding a novel phosphatidylinositol-3 kinase. DNA Res. 4:1997;355-358.
20. Seki N., Hayashi A., Abe M., Araki R., Fujimori A., Fukumura R., Hattori A., Kozuma S., Ohira M., Hori T., Saito T. Chromosomal assignment of the gene for human DNA-PKcs interacting protein (KIP) on chromosome 15q25.3-q26.1 by somatic hybrid analysis and fluorescence in situ hybridization. J. Hum. Genet. 43:1998;275-277.
21. Zugaza J.L., Sinnett-Smith J., Van Lint J., Rozengurt E. Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway. EMBO J. 15:1996;6220-6230.
22. Chen X., Knauf J.A., Gonsky R., Wang M., Lai E.H., Chissoe S., Fagin J.A., Korenberg J.R. From amplification to gene in thyroid cancer: a high-resolution mapped bacterial-artificial-chromosome resource for cancer chromosome aberrations guides gene discovery after comparative genome hybridization. Am. J. Hum. Genet. 63:1998;625-637.