Regulation of gonadotropin-releasing hormone gene expression in vivo and in vitro

Frontiers in Neuroendocrinology

Volumn 18, Issue 2, 1997, Pages 209-245

  Gore, Andrea C ^a   Roberts, James L ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

gene expression; Gonadotropin releasing hormone (GnRH); GT1 cells; puberty; steroids

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; DOPAMINE; ENDOTHELIN; GLUTAMIC ACID; GONADORELIN; GROWTH FACTOR; INSULIN; LUTEINIZING HORMONE; MESSENGER RNA; NEUROPEPTIDE Y; NEUROTRANSMITTER; NITRIC OXIDE; NORADRENALIN; PROTEIN KINASE C; SEROTONIN; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR;

ARTICLE; GENE EXPRESSION REGULATION; GONADORELIN RELEASE; HORMONAL REGULATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PUBERTY; PULSATILE HORMONE RELEASE; SEXUAL MATURATION; TRANSCRIPTION REGULATION;

EID: 0031127757     PISSN: 00913022     EISSN: None     Source Type: Journal    
DOI: 10.1006/frne.1996.0149     Document Type: Article

References (192)

1. Abbud R, Smith M S. Do GnRH neurons express the gene for the NMDA receptor? Brain Res. 690:1995;117-120.
2. Adelman J, Mason A, Hayflick J, Seeburg P. Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat. Proc Natl Acad Sci USA. 83:1986;179-183.
3. Advis J P, Simpkins J W, Chen H T, Meites J. Relation of biogenic amines to onset of puberty in the female rat. Endocrinology. 103:1978;11-16.
4. Barraclough C A, Wise P M. The role of catecholamines in the regulation of pituitary luteinizing hormone and follicle-stimulating hormone secretion. Endocrine Rev. 3:1982;91-119.
5. Bergendahl M, Wiemann J N, Clifton D K, Huhtaniemi I, Steiner R A. Short-term starvation decreases POMC mRNA but does not alter GnRH mRNA in the brain of adult male rats. Neuroendocrinology. 56:1992;913-920.
6. L, M, Besecke, J, H, Urban, J, E, Levine, 1993, Neuropeptide Y1 receptors mediate NPY-stimulated LHRH release from superfused hypothalamic GT1-7 cells, Proc 23rd Annu Meeting Soc Neurosci, Washington, DC, 258.5, 618.
7. Besecke L M, Wolfe A M, Pierce M E, Takahashi J S, Levine J E. Neuropeptide Y stimulates LHRH release from superfused hypothalamic GT1-7 cells. Endocrinology. 135:1994;1621-1627.
8. Bourguignon J-P, Gerard A, Franchimont P. Direct activation of gonadotropin-releasing hormone secretion through different receptors to neuroexcitatory amino acids. Neuroendocrinology. 49:1989;402-408.
9. Bourguignon J-P, Gerard A, Gonzalez M-L A, Franchimont P. Acute suppression of gonadotropin-releasing hormone by insulin-like growth factor I and subproducts: An age-dependent endocrine effect. Neuroendocrinology. 58:1993;525-530.
10. Brann D W, Mahesh V B. Excitatory amino acids: Function and significance in reproduction and neuroendocrine regulation. Front Neuroendocrinol. 15:1994;3-49.
11. Bruder J M, Krebs W D, Nett T M, Wierman M E. Phorbol ester activation of the protein kinase C pathway inhibits gonadotropin-releasing hormone gene expression. Endocrinology. 131:1992;2552-2558.
12. Bruder J M, Wierman M E. Evidence for transcriptional inhibition of GnRH gene expression by phorbol ester at a proximal promoter region. Mol Cell Endocrinol. 99:1994;177-182.
13. Calogero A E, Weber R FA, D'Agata R. Effects of rat prolactin on gonadotropin-releasing hormone secretion by the explanted male rat hypothalamus. Neuroendocrinology. 57:1993;152-157.
14. Campbell G A, Kurcz M, Marshall S, Meites J. Effects of starvation in rats on serum levels of follicle stimulating hormone, luteinizing hormone, thyrotropin, growth hormone and prolactin: Response to LH-releasing hormone and thyrotropin-releasing hormone. Endocrinology. 100:1977;580-587.
15. Caraty A, Antoine C, Delaleu B, Locatelli A, Bouchard P, Gautron J-P, Evans N P, Karsch F J, Padmanabhan V. Nature and bioactivity of gonadotropin-releasing hormone (GnRH) secreted during the GnRH surge. Endocrinology. 136:1995;3452-3460.
16. Caraty A, Locatelli A. Effect of time after castration on secretion of LHRH and LH in the ram. J Reprod Fertil. 82:1988;263-269.
17. Carter D A, Li-Jin C, Murphy D. In vitro regulation of rat prolactin messenger ribonucleic acid poly (A) tail length: Modulation by bromocriptine. J Neuroendocrinol. 5:1993;201-204.
18. Carter D A, Murphy D. Regulation of vasopressin (VP) gene expression in the bed nucleus of the stria terminalis: Gonadal steroid-dependent changes in VP mRNA accumulation are associated with alterations in mRNA poly (A) tail length but are independent of the rate of VP gene transcription. J Neuroendocrinol. 5:1993;509-515.
19. Chandran U R, Attardi B, Friedman R, Dong K, Roberts J L, DeFranco D B. Glucocorticoid receptor-mediated repression of gonadotropin-releasing hormone promoter activity in GT1 hypothalamic cell lines. Endocrinology. 134:1994;1467-1474.
20. Chen W-P, Witkin J W, Silverman A-J. Gonadotropin-releasing hormone (GnRH) neurons are directly innervated by catecholamine terminals. Synapse. 3:1989;288-290.
21. Chen W P, Witkin J W, Silverman A-J. Beta-endorphin and gonadotropin-releasing hormone synaptic input to gonadotropin-releasing hormone neurosecretory cells in the male rat. J Comp Neurol. 286:1989;85-95.
22. Cho B N, Seong J Y, Cho H, Kim K. Progesterone stimulates GnRH gene expression in the hypothalamus of ovariectomized, estrogen treated adult rats. Brain Res. 652:1994;177-180.
23. Chongthammakun S, Claypool L E, Terasawa E. Ovariectomy increases in vivo luteinizing hormone-releasing hormone release in pubertal, but not prepubertal, female rhesus monkeys. J Neuroendocrinol. 5:1993;41-50.
24. Clark M E, Mellon P L. The POU homeodomain transcription factor Oct-1 is essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer. Mol Cell Biol. 15:1995;6169-6177.
25. Clarke I J. Variable patterns of gonadotropin-releasing hormone secretion during the estrogen-induced luteinizing hormone surge in ovariectomized ewes. Endocrinology. 133:1993;1624-1632.
26. Compagnone N, Fellmann D, Bugnon C, Jaquemard C. Diffusible factors from rat arcuate nucleus and Broca's diagonal band nucleus increase size and neurite outgrowth, respectively, of cultured melanin-concentrating hormone containing neurons. Brain Res. 628:1993;137-144.
27. Dluzen D E, Ramirez V D. In vivo activity of the LHRH pulse generator as determined with push-pull perfusion of the anterior pituitary gland of unrestrained intact and castrate male rats. Neuroendocrinology. 45:1987;328-332.
28. Dubey A K, Plant T M. A suppression of gonadotropin secretion by cortisol in castrated male rhesus monkeys (Macaca mulatta. Biol Reprod. 33:1985;423-431.
29. Dutlow C M, Rachman J, Jacobs T W, Millar R P. Prepubertal increases in gonadotropin-releasing hormone mRNA, gonadotropin-releasing hormone precursor, and subsequent maturation of precursor processing in male rats. J Clin Invest. 90:1992;2496-2501.
30. Emanuel R L, Girard D M, Thull D L, Majzoub J A. Regulated expression of vasopressin gene by cAMP and phorbol ester in primary rat fetal hypothalamic cultures. Mol Cell Endocrinol. 86:1992;29-36.
31. Eraly S A, Mellon P L. Regulation of gonadotropin-releasing hormone transcription by protein kinase C is mediated by evolutionarily conserved promoter-proximal elements. Mol Endocrinol. 9:1995;848-859.
32. Evans N P, Dahl G E, Glover B H, Karsch F J. Central regulation of pulsatile gonadotropin-releasing hormone (GnRH) secretion by estradiol during the period leading up to the preovulatory GnRH surge in the ewe. Endocrinology. 134:1994;1806-1811.
33. Favit A, Wetsel W C, Negro-Vilar A. Differential expression of gamma-aminobutyric acid receptors in immortalized luteinizing hormone-releasing hormone neurons. Endocrinology. 133:1993;1983-1989.
34. Findell P R, Wong K H, Jackman J K, Daniels D V. Beta 1-adrenergic and dopamine (D1)-receptors coupled to adenylyl cyclase activation in GT1 gonadotropin-releasing hormone neurosecretory cells. Endocrinology. 132:1993;682-688.
35. Fink G. Feedback actions of target hormones on hypothalamus and pituitary with special reference to gonadal steroids. Annu Rev Physiol. 41:1979;571-585.
36. Fremeau R TJ, Autelitano D J, Blum M, Wilcox J, Roberts J L. Intervening sequence specific in situ hybridization: Detection of the pro-opiomelanocortin gene primary transcript in individual neurons. Mol Brain Res. 6:1989;197-201.
37. Fuxe K, Hokfelt T, Lofstrom A, Johansson O, Agnati L, Everett B, Goldstein M, Jeffcoate S, White N, Eneroth P, Gustafsson J, Skett P. On the role of neurotransmitters and hypothalamic hormones and their interactions in hypothalamic and extrahypothalamic control of pituitary function and sexual behavior. Subcellular Mechanisms in Reproductive Neuroendocrinology. 1976;Elsevier, Amsterdam. p. 193-246.
38. Gallo R V. Further studies on norepinephrine-induced suppression of pulsatile luteinizing hormone release in ovariectomized rats. Neuroendocrinology. 39:1984;120-125.
39. Gay V L, Plant T M. NDLMacaca mulatta. Endocrinology. 120:1987;2289-2296.
40. Goldsmith P C, Song T. The gonadotropin-releasing hormone containing ventral hypothalamic tract in the fetal rhesus monkey (Macaca mulatta. J Comp Neurol. 237:1987;130-149.
41. Goldsmith P C, Thind K K, Perera A D, Plant T M. Glutamate-immunoreactive neurons and their gonadotropin-releasing hormone-neuronal interactions in the monkey hypothalamus. Endocrinology. 134:1994;858-868.
42. Gonzalez-Manchon C, Bilezikjian L M, Corrigan A Z, Mellon P L, Vale W. Activin-A modulates gonadotropin-releasing hormone secretion from a gonadotropin-releasing hormone-secreting neuronal cell line. Neuroendocrinology. 54:1991;373-377.
43. A, C, Gore, M, Blum, J, L, Roberts, 1995, Developmental changes in mouse GnRH gene expression: Transcriptional and post-transcriptional regulation, Proc 25th Annu Meeting Soc Neurosci, San Diego, CA, 264.
44. Gore A C, Ho A, Roberts J L. Translational efficiency of gonadotropin-releasing hormone messenger RNA is negatively regulated by phorbol ester in GT1-7 cells. Endocrinology. 136:1995;1620-1625.
45. Gore A C, Mitsushima D, Terasawa E. A possible role of neuropeptide Y in the control of the onset of puberty in female rhesus monkeys. Neuroendocrinology. 58:1993;23-34.
46. Gore A C, Roberts J L. Regulation of gonadotropin-releasing hormone gene expression by the excitatory amino acids kainic acid andNDL. Endocrinology. 134:1994;2026-2031.
47. Gore A C, Roberts J L. Regulation of gonadotropin-releasing hormone gene expression in the rat during the luteinizing hormone surge. Endocrinology. 136:1995;889-896.
48. Gore A C, Terasawa E. A role for norepinephrine in the control of puberty in the female rhesus monkey,Macaca mulatta. Endocrinology. 129:1991;3009-3017.
49. Gore A C, Wu T, Rosenberg J J, Roberts J L. Gonadotropin-releasing hormone and NMDA-R1 gene expression and colocalization change during puberty in female rats. J Neurosci. 16:1996;5281-5289.
50. Grattan D R, Park S K, Selmanoff M. Orchidectomy and NMDA increase GnRH secretion as measured by push-pull perfusion of rat anterior pituitary. Am J Physiol. 268:1995;E685-E692.
51. Greenberg M E, Greene L A, Ziff E B. Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells. J Biol Chem. 260:1985;14101-14110.
52. Gruenewald D A, Matsumoto A M. Reduced gonadotropin-releasing hormone gene expression with fasting in the male rat brain. Endocrinology. 132:1993;480-482.
53. Hales T G, Kim H, Longoni B, Olsen R W, Tobin A J. Immortalized hypothalamic GT1-7 neurons express functional gamma-aminobutyric acid type A receptors. Mol Pharmacol. 42:1992;197-202.
54. Hayflick J S, Adelman J P, Seeburg P H. The complete nucleotide sequence of the human gonadotropin-releasing hormone gene. Nucleic Acids Res. 17:1989;6403-6404.
55. Herbison A E, Dyer R G. Effect on luteinizing hormone secretion of GABA receptor modulation in the medial preoptic area at the time of the proestrous luteinizing hormone surge. Neuroendocrinology. 53:1991;317-320.
56. Hiney J K, Ojeda S R, Dees W L. Insulin-like growth factor I: A possible metabolic signal involved in the regulation of female puberty. Neuroendocrinology. 54:1991;420-423.
57. A, Ho, A, C, Gore, J, L, Roberts, 1994, Post-transcriptional regulation of the GnRH gene in GT1-7 cells, Proc 24th Annu Meeting Soc Neurosci, 272.7.
58. Hoffman G E, Wray S, Goldstein M. Relationship of catecholamines and LHRH: Light microscopic study. Brain Res Bull. 9:1982;417-430.
59. Horvath T L, Naftolin F, Leranth C. Luteinizing hormone-releasing hormone and gamma-aminobutyric acid neurons in the medial preoptic area are synaptic targets of dopamine axons originating in anterior periventricular areas. J Neuroendocrinol. 5:1993;71-79.
60. Jacobson W, Wilkinson M, Gibson C J. Effects of the noradrenergic neurotoxin DSP4 on growth and the gonadal steroid- and PMSG-induced release of LH in the prepubertal female rat. Brain Res Bull. 20:1988;643-649.
61. Jakubowski M, Blum M, Roberts J L. Postnatal development of gonadotropin-releasing hormone and cyclophilin gene expression in the female and male rat brain. Endocrinology. 128:1991;2702-2708.
62. Jakubowski M, Roberts J L. Processing of gonadotropin-releasing hormone gene transcripts in the rat brain. J Biol Chem. 269:1994;4078-4083.
63. Jennes L, Stumpf W E, Tappaz M. Anatomical relationships of dopaminergic and GABAergic systems with the GnRH systems in the septo-hypothalamic area: Immunohistochemical studies. Exp Brain Res. 50:1983;91-99.
64. Kalra S P, Kalra P S. Neural regulation of luteinizing hormone secretion in the rat. Endocrine Rev. 4:1983;311-351.
65. Kalra S P, Kalra P S. Do testosterone and estradiol-17beta enforce inhibition or stimulation of luteinizing hormone-releasing hormone secretion? Biol Reprod. 41:1989;559-570.
66. Kang S H, Seong J Y, Cho S, Cho H, Kim K. Acute increase of GABAergic neurotransmission exerts a stimulatory effect on GnRH gene expression in the preoptic/anterior hypothalamic area of ovariectomized, estrogen- and progesterone-treated adult female rats. Neuroendocrinology. 61:1995;486-492.
67. Kelly M J, Garrett J, Bosch M A, Roselli C E, Douglass J, Adelman J P, Ronnekleiv O K. Effects of ovariectomy on GnRH mRNA, proGnRH and GnRH levels in the preoptic hypothalamus of the female rat. Neuroendocrinology. 49:1989;88-97.
68. Kepa J K, Wang C, Neeley C I, Raynolds M V, Gordon D F, Wood W M, Wierman M E. Structure of the rat gonadotropin releasing hormone (GnRH) gene promoter and functional analysis in hypothalamic cells. Nucleic Acids Res. 20:1992;1393-1399.
69. Kim K, Jarry H, Knoke I, Seong J Y, Leonhardt S, Wuttke W. Competitive PCR for quantitation of gonadotropin-releasing hormone mRNA level in a single micropunch of the rat preoptic area. Mol Cell Endocrinol. 97:1993;153-158.
70. Kim K, Lee B J, Cho B N, Kang S S, Choi W S, Park S D, Lee C C, Cho W K, Wuttke W. Blockade of noradrenergic neurotransmission with diethyldithiocarbamic acid decreases the mRNA level of gonadotropin-releasing hormone in the hypothalamus of ovariectomized, steroid-treated prepubertal rats. Neuroendocrinology. 59:1994;539-544.
71. Kim K, Lee B J, Park Y, Cho W K. Progesterone increases messenger ribonucleic acid (mRNA) encoding luteinizing hormone releasing hormone (LHRH) level in the hypothalamus of ovariectomized estradiol-primed prepubertal rats. Mol Brain Res. 6:1989;151-158.
72. Kim K. A partial blockade of catecholaminergic neurotransmission with 6-hydroxydopamine decreases mRNA level of gonadotropin releasing hormone in the male rat hypothalamus. Neuroendocrinology. 58:1993;146-152.
73. Kiss J, Halasz B. Demonstration of serotonergic axons terminating on luteinizing hormone-releasing hormone neurons in the preoptic area of the rat using a combination of immunocytochemistry and high resolution autoradiography. Neuroscience. 61:1985;265-275.
74. Kokoris G J, Lam N Y, Ferin M, Silverman A J, Gibson M J. Transplanted gonadotropin-releasing hormone neurons promote pulsatile luteinizing hormone secretion in congenitally hypogonadal (hpg) male mice. Neuroendocrinology. 48:1988;45-52.
75. Krey L C, Silverman A-J. Luteinizing hormone releasing hormone. Krieger D, Brownstein M, Martin J. Brain Peptides. 1983;687-709 Wiley, New York.
76. Krsmanovic L Z, Stojilkovic S S, Balla T, Al-Damluji S, Weiner R I, Catt K J. Receptors and neurosecretory actions of endothelin in hypothalamic neurons. Proc Natl Acad Sci USA. 88:1991;11124-11128.
77. Krsmanovic L Z, Stojilkovic S S, Merelli F, Dufour S M, Virmani M A, Catt K J. Calcium signaling and episodic secretion of gonadotropin-releasing hormone in hypothalamic neurons. Proc Natl Acad Sci USA. 89:1992;8462-8466.
78. Lamberts R, Vijayan E, Graf M, Mansky T, Wuttke W. Involvement of preoptic-anterior hypothalamic GABA neurons in the regulation of pituitary LH and prolactin release. Exp Brain Res. 52:1983;356-362.
79. Lee B J, Kim K, Cho W K. Activation of intracellular pathways with forskolin and phorbol ester increases LHRH mRNA level in the rat hypothalamus superfused in vitro. Mol Brain Res. 8:1990;185-191.
80. Lee W-S, Smith M S, Hoffman G E. Luteinizing hormone-releasing hormone neurons express Fos protein during the proestrous surge of luteinizing hormone. Proc Natl Acad Sci USA. 87:1990;5163-5167.
81. AB. Neuroendocrinology. 61:1995;655-662.
82. Leranth C, MacLusky N J, Shanabrough M, Naftolin F. Immunohistochemical evidence for synaptic connections between pro-opiomelanocortin-immunoreactive axons and LH-RH neurons in the preoptic area of the rat. Brain Res. 449:1988;167-176.
83. Leranth C, MacLusky N J, Sakamoto H, Shanobrough M, Naftolin F. Neuroendocrine glutamic acid decarboxylase-containing axons synapse on LHRH neurons in the rat medial preoptic area. Neuroendocrinology. 40:1985;536-539.
84. Levine J E, Ramirez V D. Luteinizing hormone-releasing hormone release during the rat estrous cycle and after ovariectomy, as estimated with push-pull cannulae. Endocrinology. 111:1982;1439-1448.
85. Li S, Garcia de Yebenes E, Pelletier G. Effects of dehydroepiandrosterone (DHEA) on GnRH gene expression in the rat brain as studied by in situ hybridization. Peptides. 16:1995;425-430.
86. Li S, Pelletier G. Dopamine regulation of gonadotropin-releasing hormone (GnRH) gene expression in the female rat brain. Neurosci Lett. 146:1992;207-210.
87. Li S, Pelletier G. Role of dopamine in the regulation of gonadotropin-releasing hormone in the male rat brain as studied by in situ hybridization. Endocrinology. 131:1992;395-399.
88. Li S, Pelletier G. Chronic administration of muscimol and pentobarbital decreases gonadotropin-releasing hormone mRNA levels in the male rat hypothalamus determined by quantitative in situ hybridization. Neuroendocrinology. 58:1993;136-139.
89. Li S, Pelletier G. Inhibitory effect of the potential endogenous benzodiazepine receptor ligand, octadecaneuropeptide (ODN), on gonadotropin-releasing hormone gene expression in the male rat brain. NeuroReport. 6:1995;1354-1356.
90. Li W, Pelletier G. Opioid regulation of gonadotropin-releasing hormone gene expression in the male rat brain as studied by in situ hybridization. NeuroReport. 4:1993;331-333.
91. Liaw J-J, Barraclough C A. NDL. Mol Brain Res. 17:1993;112-118.
92. Ma Y J, Junier M-P, Costa M E, Ojeda S R. Transforming growth factor-alpha gene expression in the hypothalamus is developmentally regulated and linked to sexual maturation. Neuron. 9:1992;657-670.
93. MacLusky N J, Naftolin F, Leranth C. Immunocytochemical evidence for direct synaptic connections between corticotropin-releasing hormone (CRH) and gonadotropin-releasing hormone (GnRH)-containing neurons in the preoptic area of the rat. Brain Res. 439:1988;391-395.
94. Maggi R, Pimpinelli F, Martini L, Piva F. Inhibition of luteinizing hormone-releasing hormone secretion by delta-opioid agonists in GT1-1 neuronal cells. Endocrinology. 136:1995;5177-5181.
95. Mahachoklertwattana P, Black S M, Kaplan S L, Bristow J D, Grumbach M M. Nitric oxide synthesized by gonadotropin-releasing hormone neurons is a mediator ofND. Endocrinology. 135:1994;1709-1712.
96. Mahachoklertwattana P, Sanchez J, Kaplan S L, Grumbach M M. ND. Endocrinology. 134:1994;1023-1030.
97. Malik K F, Silverman A-J, Morrell J I. Gonadotropin-releasing hormone mRNA in the rat: Distribution and neuronal content over the estrous cycle and after castration of males. Anat Rec. 231:1991;457-466.
98. Marks D L, Lent K L, Rossmanith W G, Clifton D K, Steiner R A. Activation-dependent regulation of galanin gene expression in gonadotropin-releasing hormone neurons in the female rat. Endocrinology. 134:1994;1991-1998.
99. Marks D L, Smith M S, Vrontakis M, Clifton D K, Steiner R A. Regulation of galanin gene expression in gonadotropin-releasing hormone neurons during the estrous cycle of the rat. Endocrinology. 132:1993;1836-1844.
100. Martinez de la Escalera G, Choi A LH, Weiner R I. Beta 1-adrenergic regulation of the GT1 gonadotropin-releasing hormone (GnRH) neuronal cell lines: Stimulation of GnRH release via receptors positively coupled to adenylate cyclase. Endocrinology. 131:1992;1397-1402.
101. Martinez de la Escalera G, Choi A LH, Weiner R I. Generation and synchronization of gonadotropin-releasing hormone (GnRH) pulses: Intrinsic properties of the GT1-1 GnRH neuronal cell line. Proc Natl Acad Sci USA. 89:1992;1852-1855.
102. Martinez de la Escalera G, Choi A LH, Weiner R I. Biphasic gabaergic regulation of GnRH secretion in GT1 cell lines. Neuroendocrinology. 59:1994;420-425.
103. Martinez de la Escalera G, Choi A LH, Weiner R I. Signaling pathways involved in GnRH secretion in GT1 cells. Neuroendocrinology. 61:1995;310-317.
104. Martinez de la Escalera G, Gallo F, Choi A LH, Weiner R I. Dopaminergic regulation of the GT1 gonadotropin-releasing hormone (GnRH) neuronal cell lines: Stimulation of GnRH release via D1-receptors positively coupled to adenylate cyclase. Endocrinology. 131:1992;2965-2971.
105. Mason A J, Hayflick J S, Zoeller R T, Young W S III, Phillips H S, Nikolics K, Seeburg P H. A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mice. Science. 234:1986;1366-1371.
106. J, A, Maurer, S, Wray, 1995, LHRH gene expression in postnatal CNS slice explant cultures: Examination of LHRH mRNA turnover, Proc 25th Annu Meeting Soc Neurosci, San Diego, CA, 745.11, 1898.
107. McShane T M, Petersen S L, McCrone S, Keisler D H. Influence of food restriction on neuropeptide Y, proopiomelanocortin, and luteinizing hormone-releasing hormone gene expression in sheep hypothalami. Biol Reprod. 49:1993;831-839.
108. Melcangi R, Galbiati M, Messi E, Piva F, Martini L, Motta M. Type 1 astrocytes influence luteinizing hormone-releasing hormone release from the hypothalamic cell line GT1-1: Is transforming growth factor-beta the principle involved? Endocrinology. 136:1995;679-686.
109. Mellon P L, Windle J J, Goldsmith P C, Padula C A, Roberts J L, Weiner R I. Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron. 5:1990;1-10.
110. Merchenthaler I, Setalo G, Petrusz P, Negro-Vilar A, Flerko B. Identification of hypophysiotropic luteinizing hormone-releasing hormone (LHRH) neurons by combined retrograde labeling and immunocytochemistry. Exp Clin Endocrinol. 94:1989;133-140.
111. Michels K M, Saavedra J M. Differential development of insulin-like growth factor-1 binding in the hypothalamus of hamster and rat. Brain Res Dev Brain Res. 62:1991;215-221.
112. Milenkovic L, D'Angelo G, Kelly P A, Weiner R I. Inhibition of gonadotropin-releasing hormone release by prolactin from GT1 neuronal cell lines through prolactin receptors. Proc Natl Acad Sci USA. 91:1994;1244-1247.
113. Mitsushima D, Hei D L, Terasawa E. Gamma-aminobutyric acid is an inhibitory neurotransmitter restricting the release of luteinizing hormone-releasing hormone before the onset of puberty. Proc Natl Acad Sci USA. 91:1994;395-399.
114. Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg P H. Heteromeric NMDA receptors: Molecular and functional distinction of subtypes. Science. 256:1992;1217-1221.
115. Moretto M, Lopez F J, Negro-Vilar A. Endothelin-3 stimulates luteinizing hormone-releasing hormone (LHRH) secretion from LHRH neurons by a prostaglandin-dependent mechanism. Endocrinology. 132:1993;789-794.
116. Moretto M, Lopez F J, Negro-Vilar A. Nitric oxide regulates luteinizing hormone-releasing hormone secretion. Endocrinology. 133:1993;2399-2402.
117. Negro-Vilar A, Ojeda S R, McCann S M. Catecholaminergic modulation of LHRH release by median eminence terminals in vitro. Endocrinology. 104:1979;1749-1757.
118. Noris G, Hol D, Clapp C, Martinez de la Escalera G. Histamine directly stimulates gonadotropin-releasing hormone secretion from GT1-1 cells via H1 receptors coupled to phosphoinositide hydrolysis. Endocrinology. 136:1995;2967-2974.
119. Nyberg C L, Srivastava V, Hiney J, Lara F, Dees W L. ND. Endocrinology. 136:1995;2874-2880.
120. Ojeda S R, Urbanski H F, Costa M E, Hill D F, Moholt-Siebert M. Involvement of transforming growth factor alpha in the release of luteinizing hormone-releasing hormone from the developing female hypothalamus. Proc Natl Acad Sci USA. 87:1990;9698-9702.
121. Olson B R, Scott D C, Wetsel W C, Elliot S J, Tomic M, Stojilkovic S, Nieman L K, Wray S. Effects of insulin-like growth factors I and II and insulin on the immortalized hypothalamic GT1-7 cell line. Neuroendocrinology. 62:1995;155-165.
122. Orstead K M, Spies H G. Inhibition of hypothalamic gonadotropin-releasing hormone release by endogenous opioid peptides in the female rabbit. Neuroendocrinology. 46:1987;14-23.
123. Park O-K, Gugneja S, Mayo K E. Gonadotropin-releasing hormone gene expression during the rat estrous cycle: Effects of pentobarbital and ovarian steroids. Endocrinology. 127:1990;365-372.
124. Park O-K, Ramirez V D. Spontaneous changes in LHRH release during the rat estrous cycle, as measured with repetitive push-pull perfusions of the pituitary gland in the same female rats. Neuroendocrinology. 50:1989;66-72.
125. Park Y, Park S D, Cho W K, Kim K. Testosterone stimulates LH-RH-like mRNA level in the rat hypothalamus. Brain Res. 451:1988;255-260.
126. Pau K-Y F, Berria M, Hess D L, Spies H G. Preovulatory gonadotropin-releasing hormone surge in ovarian-intact rhesus macaques. Endocrinology. 133:1993;1650-1656.
127. Pau K-Y F, Spies H G. Estrogen-dependent effects of norepinephrine on hypothalamic gonadotropin-releasing hormone release in the rabbit. Brain Res. 399:1986;15-23.
128. 3335. Endocrinology. 137:1996;234-239.
129. Petersen S L, McCrone S, Keller M, Gardner E. Rapid increases in LHRH mRNA levels following NMDA. Endocrinology. 129:1991;1679-1681.
130. Petersen S L, McCrone S, Keller M, Shores S. Effects of estrogen and progesterone on luetinizing hormone-releasing hormone messenger ribonucleic acid levels: Consideration of temporal and neuroanatomical variables. Endocrinology. 136:1995;3604-3610.
131. Petersen S L, McCrons S, Coy D, Adelman J P, Mahan L C. GABAA receptor subunit mRNAs in cells of the preoptic area: Colocalization with LHRH mRNA using dual-label in situ hybridization histochemistry. Endocrine J. 1:1993;29-34.
132. Petraglia F, Sutton S, Vale W, Plotsky P. Corticotropin-releasing factor decreases plasma luteinizing hormone levels in female rats by inhibiting gonadotropin-releasing hormone release into hypophysial-portal circulation. Endocrinology. 120:1987;1083-1087.
133. Plant T M. Puberty in primates. Knobil E, Neill J. The Physiology of Reproduction. 1988;1763-1788 Raven Press, New York.
134. Porkka-Heiskanen T, Urban J H, Turek F W, Levine J E. Gene expression in a subpopulation of luteinizing hormone-releasing hormone (LHRH) neurons prior to the preovulatory gonadotropin surge. J Neurosci. 14:1994;5548-5558.
135. Ramaley J A. Development of gonadotropin regulation in the prepubertal mammal. Biol Reprod. 20:1979;1-31.
136. Rivest S, Lee S, Attardi B, Rivier C. The chronic intracerebroventricular infusion of interleukin-1 beta alters the activity of the hypothalamic-pituitary-gonadal axis of cycling rats. I. Effect on LHRH and gonadotropin biosynthesis and secretion. Endocrinology. 133:1993;2424-2430.
137. Rivier C, Vale W. Cytokines act within the brain to inhibit LH secretion and ovulation in the rat. Endocrinology. 127:1990;849-856.
138. Roberts J L, Dutlow C M, Jakubowski M, Blum M, Millar R P. Estradiol stimulates preoptic area-anterior hypothalamic proGnRH-GAP gene expression in ovariectomized rats. Mol Brain Res. 6:1989;127-134.
139. J, L, Roberts, S, Wray, J, J, Rosenberg, A, C, Gore, 1995, GnRH mRNA is rapidly turned overin vivo, Proc 25th Annu Meeting Soc Neurosci, San Diego, CA, 745.710.
140. Roselli C E, Kelly M J, Ronnekleiv O K. Testosterone regulates progonadotropin-releasing hormone levels in the preoptic area and basal hypothalamus of the male rat. Endocrinology. 126:1990;1080-1086.
141. Rothfeld J M, Hejtmancik J F, Conn P M, Pfaff D W. LHRH messenger RNA in neurons in the intact and castrate male rat forebrain, studied by in situ hybridization. Exp Brain Res. 67:1987;113-118.
142. Rothfeld J M, Hejtmancik J F, Conn P M, Pfaff D W. In situ hybridization for LHRH mRNA following estrogen treatment. Mol Brain Res. 6:1989;121-125.
143. Sagrillo C A, Grattan D R, McCarthy M M, Selmanoff M. Hormonal and neurotransmitter regulation of GnRH gene expression and related reproductive behaviors. Behav Genet. 26:1996;241-277.
144. Sarkar D K, Chiappa S A, Fink G, Sherwood N M. Gonadotropin-releasing hormone surge in pro-oestrous rats. Nature. 264:1976;461-463.
145. Sarkar D K, Fink G. Luteinizing hormone releasing factor in pituitary stalk plasma from long-term ovariectomized rats: Effects of steroids. J Endocrinol. 86:1980;511-524.
146. Scott R EM, Autelitano D J, Lugo D I, Blum M, Roberts J L, Pintar J E. Developmental changes in levels of proopiomelanocortin intron A-containing heterogeneous nuclear RNA and mature messenger RNA in the anterior and neurointermediate lobes of the rat pituitary. Mol Endocrinol. 8:1990;812-820.
147. Seeburg P H, Adelman J P. Characterization of cDNA for precursor of human luteinizing hormone releasing hormone. Nature. 311:1984;666-668.
148. Selmanoff M, Shu C, Petersen S L, Barraclough C A, Zoeller R T. Single cell levels of hypothalamic messenger ribonucleic acid encoding luteinizing hormone-releasing hormone in intact, castrated and hyperprolactinemic male rats. Endocrinology. 128:1991;459-466.
149. Selmanoff M K, Goldman B D, Ginsburg B E. Developmental changes in serum luteinizing hormone, follicle stimulating hormone and androgen levels in males of two inbred mouse strains. Endocrinology. 100:1977;122-127.
150. Seong J Y, Lee Y K, Lee C C, Kim K. NMDA receptor antagonist decreases the progesterone-induced increase in GnRH gene expression in the rat hypothalamus. Neuroendocrinology. 58:1993;234-239.
151. Sherman T G, Watson S J. Differential expression of vasopressin alleles in Brattleboro heterozygote. J Neurosci. 8:1988;3797-3811.
152. Sherwood N M, Chiappa S A, Sarkar D K, Fink G. Gonadotropin-releasing hormone (GnRH) in pituitary stalk blood from proestrous rats: Effects of anesthetics and relationship between stored and released GnRH and luteinizing hormone. Endocrinology. 107:1980;1410-1417.
153. S, H, Shin, C, Howitt, J, V, Milligan, A paradoxical castration effect on LHRH levels in male rat hypothalamus and serum, Life Sci, 14, 2491, 2496.
154. Silverman A-J, Antunes J L, Abrams G M, Nilaver G, Thau R, Robinson J A, Ferin M, Krey L C. The luteinizing hormone-releasing hormone pathways in rhesus (Macaca mulattaMacaca nemestrina. J Comp Neurol. 211:1982;309-317.
155. Smyth C, Wilkinson M. A critical period for glutamate receptor-mediated induction of precocious puberty in female rats. J Neuroendocrinol. 6:1994;275-284.
156. Sortino M A, Aleppo G, Scapagnini U, Canonico P L. Involvement of nitric oxide in the regulation of gonadotropin-releasing hormone release from the GT1-1 neuronal cell line. Endocrinology. 134:1994;1782-1787.
157. i. Neuroendocrinology. 59:1994;309-317.
158. Steele M K, Stephenson K N, Meredith J M, Levine J E. Effects of angiotensin II on LHRH release, as measured by in vivo microdialysis of the anterior pituitary gland of conscious female rats. Neuroendocrinology. 55:1992;276-281.
159. Y, Sun, A, C, Gore, J, L, Roberts, 1996, Regulation of gonadotropin-releasing hormone (GnRH) gene expression by glutamate in male and female rats, Proc 10th Annu Meeting Endocrine Soc, San Francisco, CA, P1-390, 232.
160. Sutton S W, Mitsugi N, Plotsky P M, Sarkar D K. Neuropeptide Y (NPY): A possible role in the initiation of puberty. Endocrinology. 123:1988;2152-2154.
161. Terasawa E, Krook C, Hei D L, Gearing M, Schultz N J, Davis G A. Norepinephrine is a possible neurotransmitter stimulating pulsatile release of luteinizing hormone releasing hormone in the rhesus monkey. Endocrinology. 123:1988;1808-1816.
162. Thind K K, Goldsmith P C. Glutamate and GABAergic neurointeractions in the monkey hypothalamus: A quantitative immunomorphological study. Neuroendocrinology. 61:1995;471-485.
163. Toranzo D, Dupont E, Simard J, Labrie C, Couet J, Labrie F, Pelletier G. Regulation of pro-gonadotropin-releasing hormone gene expression by sex steroids in the brain of male and female rats. Mol Endocrinol. 3:1989;1748-1756.
164. Tsai P-S, Werner S, Weiner R I. Basic fibroblast growth factor is a neurotrophic factor in GT1 gonadotropin-releasing hormone neuronal cell lines. Endocrinology. 136:1995;3831-3838.
165. Tsuruo Y, Kawano H, Hisano S, Kagotani Y, Daikoku S, Zhang T, Yanaihara N. Substance P-containing neurons innervating LHRH-containing neurons in the septo-preoptic area of rats. Neuroendocrinology. 53:1991;236-245.
166. Tsuruo Y, Kawano H, Kagotani Y, Hisano S, Daikoku S, Chihara K, Zhang T, Yanaihara N. Morphological evidence for neuronal regulation of LHRH containing neurons by neuropeptide Y in the rat septo-preoptic area. Neurosci Lett. 110:1990;261-266.
167. Urbanski H F, Fahy M M, Daschel M, Meshul C. ND. J Reprod Fertil. 100:1994;5-9.
168. Urbanski H F, Ojeda S R. A role ofND. Endocrinology. 126:1990;1774-1776.
169. van den Pol A N, Wuarin J-P, Dudek F E. Glutamate, the dominant excitatory transmitter in neuroendocrine regulation. Science. 250:1990;1276-1278.
170. Watanabe G, Terasawa E. In Vivo release of luteinizing hormone releasing hormone increases with puberty in the female rhesus monkey. Endocrinology. 125:1989;92-99.
171. Weesner G D, Bergen H T, Pfaff D W. Differential regulation of luteinizing hormone-releasing hormone and galanin messenger ribonucleic acid levels by alpha1-adrenergic agents in the ovariectomized rat. J Neuroendocrinol. 4:1992;331-336.
172. Weesner G D, Krey L C, Pfaff D W. Alpha 1 adrenergic regulation of estrogen-induced increases in luteinizing hormone-releasing hormone mRNA levels and release. Mol Brain Res. 17:1993;77-82.
173. Weiner R, Wetsel W, Goldsmith P, Martinez de la Escalera G, Windle J, Padula C, Choi C, Negro-Vilar A, Mellon P. Gonadotropin-releasing hormone neuronal cell lines. Front Neuroendocrinol. 13:1992;95-119.
174. Wetsel W C. Immortalized hypothalamic luteinizing hormone-releasing hormone (LHRH) neurons: A new tool for dissecting the molecular and cellular basis of LHRH physiology. Cell Mol Neurobiol. 15:1995;43-78.
175. Wetsel W C, Eraly S A, Whyte D B, Mellon P L. Regulation of gonadotropin-releasing hormone by protein kinase-A and -C in immortalized hypothalamic neurons. Endocrinology. 132:1993;2360-2370.
176. Wetsel W C, Valenca M M, Merchenthaler I, Liposits Z, Lopez F J, Weiner R I, Mellon P L, Negro-Vilar A. Intrinsic pulsatile secretory activity of immortalized luteinizing hormone-releasing hormone-secreting neurons. Proc Natl Acad Sci USA. 89:1992;4149-4153.
177. Wiemann J N, Clifton D K, Steiner R A. Gonadotropin-releasing hormone messenger ribonucleic acid levels are unaltered with changes in the gonadal hormone milieu of the adult male rat. Endocrinology. 127:1990;523-532.
178. Wierman M E, Bruder J M, Kepa J K. Regulation of gonadotropin-releasing hormone (GnRH) gene expression in hypothalamic neuronal cells. Cell Mol Neurobiol. 15:1995;79-88.
179. Wilson T, Treisman R. Removal of poly (A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences. Nature. 336:1988;396-399.
180. Woller M J, Terasawa E. Infusion of neuropeptide Y into the stalk-median eminence stimulates in vivo release of luteinizing hormone-releasing hormone in gonadectomized rhesus monkeys. Endocrinology. 128:1991;1144-1150.
181. K, H, Wong, L, E, Kendall, P, R, Findell, 1991, Immortalized hypothalamic GnRH neurons (GT1 cells) possess alpha-2 adrenergic receptors, Proc 22nd Annu Meeting Soc Neurosci, 73, 461.
182. Wray S, Hoffman G. Postnatal morphological changes in rat LHRH neurons correlated with sexual maturation. Neuroendocrinology. 43:1986;93-97.
183. Wray S, Zoeller R T, Gainer H. Differential effects of estrogen on luteinizing hormone-releasing hormone gene expression in slice explant cultures prepared from specific rat forebrain regions. Mol Endocrinol. 3:1989;1197-1206.
184. Xia L, Van Vugt D, Alston E J, Luckhaus J, Ferin M. A surge of gonadotropin-releasing hormone accompanies the estradiol-induced gonadotropin surge in the rhesus monkey. Endocrinology. 131:1992;2812-2820.
185. T, Yeo, K, Dong, Z, Zeng, K, Yu, M, Blum, J, Roberts, 1993, Transcriptional and post-transcriptional regulation of gonadotropin-releasing hormone gene expression by the activation of protein kinase C pathway in a mouse hypothalamic GT1 cell line, Proc 23rd Annu Meeting Soc Neurosci, 258.4, 618.
186. Yeo T T, Gore A C, Blum M, Roberts J L. Protein synthesis-dependent and independent mechanisms for the regulation of GnRH RNA transcript levels by PMA in GT1 cells. Mol Brain Res. 1997.
187. Yeo T TS, Gore A C, Jakubowski M, Dong K, Blum M, Roberts J L. Characterization of gonadotropin-releasing hormone gene transcripts in a mouse hypothalamic neuronal GT1 cell line. Mol Brain Res. 42:1996;255-262.
188. Yoon M, Lee D K, Ryu K, Lee C C, Kim K. Effect of testosterone and its metabolites on LHRH and LH gene expression in castrated adult rats. Neuroendocrinol Lett. 16:1994;97-102.
189. Yu K-L, Yeo T TS, Dong K-W, Jakubowski M, Lackner-Arkin C, Blum M, Roberts J L. Second messenger regulation of mouse gonadotrophin-releasing hormone gene expressin in immortalized mouse hypothalamic GT1-3 cells. Mol Cell Endocrinol. 102:1994;85-92.
190. Zingg H H, Lefebvre D L, Almazan G. Regulation of poly (A) tail size of vasopressin mRNA. J Biol Chem. 263:1988;11041-11043.
191. Zoeller R T, Seeburg P H, Young W S III. In situ hybridization histochemistry for messenger ribonucleic acid (mRNA) encoding gonadotropin-releasing hormone (GnRH): Effect of estrogen on cellular levels of GnRH mRNA in female rat brain. Endocrinology. 122:1988;2570-2577.
192. Zoeller R T, Young W S III. Changes in cellular levels of messenger ribonucleic acid encoding gonadotropin-releasing hormone in the anterior hypothalamus of female rats during the estrous cycle. Endocrinology. 123:1988;1688-1689.