Determination of chlorpyrifos, chlorpyrifos oxon, and 3,5,6-trichloro- 2-pyridinol in rat and human blood

Journal of Analytical Toxicology

Volumn 22, Issue 3, 1998, Pages 203-210

  Brzak, Kathy A ^a   Harms, Daniel W ^a   Bartels, Michael J ^a   Nolan, Richard J ^a  

^a DOW CHEMICAL COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORPYRIFOS; DRUG METABOLITE; HEXANE; METHANOL; PYRIDINOL;

ARTICLE; DRUG DETERMINATION; GAS CHROMATOGRAPHY; HUMAN; HYDROLYSIS; IONIZATION; MASS SPECTROMETRY; METABOLITE; NONHUMAN; QUANTITATIVE DIAGNOSIS; RAT;

EID: 0031867567     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/22.3.203     Document Type: Article

References (11)

1. R.J. Weir. Organic phosphates. In Patty's Industrial Hygiene and Toxicology, 4th ed., Vol. 2, Part A. G.D. Clayton and F.E. Clayton, Eds. John Wiley & Sons, New York, NY, 1993, pp 720-751.
2. R.J. Nolan, D.L. Rick, N.L. Freshour, and J.H. Saunders. Chlorpyrifos: pharmacokinetics in human volunteers. Toxicol. Appl. Pharmacol. 73: 8-15 (1984).
3. M.J. Bartels and P.E. Kastl. Analysis of 3,5,6-trichloropyridinol in human urine using negative-ion chemical ionization gas chromatography-mass spectrometry. J. Chromatogr. B. 575: 69-74 (1992).
4. J.E. Chambers and R.L. Carr. Inhibition patterns of brain acetylcholinesterase and hepatic and plasma aliesterases following exposures to three phosphorothionate insecticides and their oxons in rats. Fund. Appl. Toxicol. 21: 111-119 (1993).
5. C.S. Forsyth and J.E. Chambers. Activation and degradation of the phosphorothionate insecticides parathion and EPN by rat brain. Biochem. Pharmacol. 38: 1597-1603 (1989).
6. L.G. Sultatos, L.G. Costa, and S.D. Murphy. Determination of organophosphorus insecticides, their oxygen analogs and metabolites by high pressure liquid chromatography. Chromatographia 15: 669-671 (1982).
7. V. Drevenkar, Z. Vasilic, B. Stengl, Z. Frobe, and V. Rumenjak. Chlorpyrifos metabolites in serum and urine of poisoned persons. Chem.-Biol. Interactions 87: 315-322 (1993).
8. M.P. Barbalas and W.A. Garland. A computer program for the deconvolution of mass spectral peak abundance data from experiments using stable isotopes. J. Pharm. Sci. 80: 922-927 (1991).
9. A.L. Lehninger. Biochemistry, 2nd ed. Worth, New York, NY, 1995, Ch. 8, pp 183-216.
10. A.L. Pond, C.P. Coyne, H.W. Chambers, and J.E. Chambers. Identification and isolation of two rat serum proteins with A-esterase activity toward paraoxon and chlorpyrifos oxon. Biochem. Pharmacol. 52(2): 363-369 (1996).
11. L.G. Sultatos. Metabolic activation of the organophosphorus insecticides chlorpyrifos and fenitrothion by perfused rat liver. Toxicology 68: 1-9 (1991).