A high-throughput cell-based reporter gene system for measurement of CYP1A1 induction

Journal of Pharmacological and Toxicological Methods

Volumn 47, Issue 3, 2002, Pages 143-151

  Cui, Xiaoming ^a   Palamanda, Jairam ^a   Norton, Laura ^a   Thomas, Ann ^a   Lau, Yau Yi ^a   White, Ronald E ^a   Cheng, K C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cytochrome P450 1A1; Ethoxyresorufin O demethylation activity; Methods; Rat; Reporter gene system; Safety pharmacology; Western blotting

Indexed keywords

3 INDOCARBINOL; 3 METHYLCHOLANTHRENE; ALPHA NAPHTHOFLAVONE; BETA NAPHTHOFLAVONE; CYTOCHROME P450 1A1; ETHOXYRESORUFIN DEETHYLASE; LUCIFERASE; METHANOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME INDUCTION; GENE CONTROL; LIVER MICROSOME; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; RAT; REPORTER GENE; SIGNAL TRANSDUCTION; VALIDATION PROCESS; WESTERN BLOTTING;

EID: 0036589686     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8719(02)00222-8     Document Type: Article

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