Important secondary metabolites and essential oils of species within the Anthemideae (Asteraceae)

Journal of Herbs, Spices and Medicinal Plants

Volumn 11, Issue 1-2, 2004, Pages 1-46

  Teixeira Da Silva, Jaime A ^a   Yonekura, Lina ^b   Kaganda, Joyceline ^c   Mookdasanit, Juta ^d   Nhut, Duong T ^e   Afach, Ghanwa ^a  

^a KAGAWA UNIVERSITY   (Japan)

^b INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA   (Brazil)

^c Tanzania Food and Nutrition Centre   (Tanzania)

^d KASETSART UNIVERSITY   (Thailand)

^e Dalat Institute of Biology   (Viet Nam)

Author keywords

Achillea; Anthemis; Artemisia; Chamomile; Chrysanthemum; Feverfew; Medicinal plant; Pyrethrin; Santolina; Tanacetum

Indexed keywords

ACHILLEA AGERATUM EXTRACT; ACHILLEA CAPILLARIS EXTRACT; ACHILLEA FILIPENDULINA EXTRACT; ACHILLEA MILLEFOLIUM EXTRACT; ACHILLEA SETACEA EXTRACT; ACHILLEA TERETIFOLIA EXTRACT; ANTHEMIS DRACUNCULUS EXTRACT; ARCTIUM LAPPA EXTRACT; ARTEMISIA ABSINTHIUM EXTRACT; ARTEMISIA ABYSSINICA EXTRACT; ARTEMISIA ANNUA EXTRACT; ARTEMISIA ASIATICA EXTRACT; ARTEMISIA ATRATA EXTRACT; ARTEMISIA DOUGLASIANA EXTRACT; ARTEMISIA EXTRACT; ARTEMISIA GIRALDI EXTRACT; ARTEMISIA JUDAICA EXTRACT; ARTEMISIA MOLINEIRI EXTRACT; ARTEMISIA MONGOLICA EXTRACT; ARTEMISIA PALLENS EXTRACT; ARTEMISIA PRINCEPS EXTRACT; ARTEMISIA SANTOLINA EXTRACT; ARTEMISIA SCOPARIA EXTRACT; ARTEMISIA SIEVERSIANA EXTRACT; ARTEMISIA VESTITA EXTRACT; ASTERACEAE EXTRACT; BALSAMITA MAJOR EXTRACT; CHRYSANTHEMUM CINERARIAEFOLIUM EXTRACT; CHRYSANTHEMUM CORONARIUM EXTRACT; CHRYSANTHEMUM MORIFOLIUM EXTRACT; ESSENTIAL OIL; MATRICARIA CHAMOMILLA EXTRACT; MATRICARIA MATRICARIOIDES EXTRACT; PLANT EXTRACT; SANTOLINA CANESCENS EXTRACT; SANTOLINA OBLONGFOLIA EXTRACT; SANTOLINA OBLONGIFOLIA EXTRACT; SANTOLINA ROSMARINIFOLIA EXTRACT; TANACETUM ARGYROPHYLLUM EXTRACT; TANACETUM DENSUM EXTRACT; TANACETUM EXTRACT; TANACETUM MICROPHYLLUM EXTRACT; TANACETUM PARTHENIUM EXTRACT; TANACETUM VULGARE EXTRACT; UNCLASSIFIED DRUG;

SECONDARY METABOLITE;

ALTERNATIVE MEDICINE; ASTERACEAE; DRUG ACTIVITY; ECONOMIC ASPECT; MEDICINAL PLANT; METABOLITE; NONHUMAN; PLANT ROOT; REVIEW; TRADITIONAL MEDICINE;

ACHILLEA; ANTHEMIDEAE; ANTHEMIS; ARTEMISIA; ASTERACEAE; CHRYSANTHEMUM; SANTOLINA; TANACETUM; TANACETUM PARTHENIUM;

EID: 18644385030     PISSN: 10496475     EISSN: None     Source Type: Journal    
DOI: 10.1300/J044v11n01_01     Document Type: Review

References (115)

1. Aggarwal, K.K., A.K. Tripathi, V. Prajapati, and S. Kumar. 2001. Toxicity of 1,8-cineole towards three species of stored product coleopterans. Insect Sci. Appl. 21:155-160.
2. Ahmad, V.U., M.A. Khan, F.T. Baqai, and R.B. Tareen. 1995. Santoflavone, a 5-deoxyflavonoid from Achillea santolina. Phytochemistry 38:1305-1307.
3. Ahmadi, L., M. Mirza, and F. Shahmir. 2002. The volatile constituents of Artemisia marschaliana Sprengel and its secretory elements. Flav. Frag. J. 17:141-143.
4. Ahmed, A.A., and M.A.A. Elela. 1999. Highly oxygenated bisabolenes and an acetylene from Matricaria aurea. Phytochemistry 51:551-554.
5. Akihisa, T., K. Yasukawa, H. Oinuma, Y. Kasahara, S. Yamanouchi, M. Takido, K. Kumaki, and T. Tamura. 1996. Triterpene alcohols from the flowers of Compositae and their anti-inflammatory effects. Phytochemistry 43:1255-1260.
6. Akihisa, T., Y. Inoue, K. Yasukawa, Y. Kasahara, S. Yamanouchi, K. Kumaki, and T. Tamura. 1998. Widespread occurrence of syn-alkane-6,8-diols in the flowers of the Compositae. Phytochemistry 49:1637-1640.
7. Aljančić, I., V. Vajs, N. Menković, I. Karadzić, N. Juranić, S. Milosavicević, S. Macura. 1996. Flavones and sesquiterpene lactones from Achillea atrata subsp. multifida: Antimicrobial activity. J. Nat. Prod. 62:909-911.
8. Al Kurdi, R., H. Khlaif, and D. Al Eissawi. 2000. Effectiveness of selected plant extracts in inhibiting Agrobacterium tumefaciens in vitro and in suppressing tumor formation on tomato roots in greenhouse. Dirasat Agric. Sci. 27:10-19.
9. Alvarez-Castellanos, P.P., C.D. Bishop, and M.J. Pascual-Villalobos. 2001. Antifungal activity of the essential oil of flowerheads of garland chrysanthemum (Chrysanthemum coronarium) against agricultural pathogens. Phytochemistry 57:99-102.
10. Alzoreky, N.S., and K. Nakahara. 2002. Antibacterial activity of extracts from some edible plants commonly consumed in Asia. Intl. J. Food Microbiol. 80:223-230.
11. Appendino, G., P. Gariboldi, G.M. Nano, and P. Tétényi. 1984. Tetrahydrofuran-type terpenoids from Tanacetum vulgare. Phytochemistry 23:2545-2551.
12. Bandonienė, D., A. Pukalskas, P.R. Venskutonis, and D. Gruzdienė. 2000. Preliminary screening of antioxidant activity of some plant extracts in rapeseed oil. Food Res. Intl. 33:785-791.
13. Barrero, A.F., M.M. Herrador, J. Quilez, R.R.A. Manzaneda, D. Portal, J.A. Gavin, D.G. Gravalos, M.S.J. Simmonds, and W.M. Blaney. 1999. Bioactive sesquiterpenes from Santolina rosmarinifolia subsp. canescens. A conformational analysis of the germacrene ring. Phytochemistry 51:529-541.
14. Başer, K.H.C., B. Demirci, N. Tabanca, T. Özek, and N. Gören. 2001. Composition of the essential oils of Tanacetum armenum (DC.) Schultz Bip., T. balsamita L., T. chiliophyllum (Fisch. & Mey) Schultz Bip. var. chiliophyllum and T. haradjani (Rech. Fil.) Grierson and the enantiomeric distribution of camphor and carvone. Flav. Frag. J. 16:195-200.
15. Bear, S., J. Cott, and M.C. Tims. 2001. Herbmed®. Accessed April 23, 2003 at http://www.herbmed.org.
16. Bilia, A.R., D. Lazari, L. Messori, V. Taglioli, C. Temperini, and F.F. Vincieri. 2002. Simple and rapid physico-chemical methods to examine action of antimalarial drugs with hemin. Its application to Artemisia annua constituents. Life Sci. 70:769-778.
17. Bremer, K. 1994. Asteraceae: Cladistics and classification. Timber Press, Portland, Oregon. pp. 435-478.
18. Burkhardt, P.R., K. Burkhardt, C.A. Haenggeli, and T. Landis. 1999. Plant-induced seizures: Reappearance of an old problem. J. Neurol. 246:667-670.
19. Bylaitė, E., R. Venskutonis, J.P. Roozen, and M.A. Posthumus. 2000. Composition of essential oil of costmary [Balsamita major (L.) Desf.] at different growth phases. J. Agric. Food Chem. 48:2409-2414.
20. Cai, Y., J.W. Jia, J. Crock, Z.X. Lin, X.Y. Chen, and R. Croteau. 2002. A cDNA clone for β-caryophyllene synthase from Artemisia annua. Photochemistry 61:523-529.
21. Chen, D.H., C.J. Liu, H.C. Ye, G.F. Li, B.Y. Liu, Y.L. Meng, and X.Y. Chen. 2000a. Ri-mediated transformation of Artemisia annua with a recombinant farnesyl diphosphate synthase gene for artemisinin production. Plant Cell Tiss. Org. Cult. 57:157-162.
22. Chen, D.H., H.C. Ye, and G.F. Li. 2000b. Expression of a chimeric farnesyl diphosphate synthase gene in Artemisia annua L. transgenic plants via Agrobacterium tumefaciens-mediated transformation. Plant Sci. 155:179-185.
23. Chenshu, A., X. Wang, X. Yuan, B. Zhao, and Y. Wang. 2003. Optimization of cryopreservation of Artemisia annua L. callus. Biotechnol. Lett. 25:35-38.
24. Chialva, F., F. Monguzzi, P. Manitto, and A. Akgül. 1993. Essential oil constituents of Achillea biebersteinii Afan. J. Ess. Oil Res. 5:87-88.
25. de Logu, A., G. Loy, M.L. Pellerano, L. Bonsignore, and M.L. Schivo. 2000. Inactivation of HSV-1 and HSV-2 and prevention of cell-to-cell virus spread by Santolina insularis essential oil. Antiviral Res. 48:177-185.
26. de Vincenzi, M., M. Silano, F. Maialetti, and B. Scazzocchio. 2000. Constituents of aromatic plants: II. estragole. Fitoterapia 71:725-729.
27. Dunkel, F.V., and L.J. Sears. 1998. Fumigant properties of physical preparations from mountain big sagebrush, Artemisia tridentata Nutt. Ssp. vaseyana (Rydb.) beetle for stored grain insects. J. Stored Prod. Res. 34:307-321.
28. Figueiredo, A.C., J.G. Barroso, L.G. Pedro, S.S. Fontinha, A. Looman, and J.J.C. Scheffer 1994. Composition of the essential oil of Artemisia argentea L'Hér., an endemic species of the Madeira archipelago. Flav. Frag. J. 9:229-232.
29. Flickinger, E.A., T.F. Hatch, R.C. Wofford, C.M. Grieshop, S.M. Murray, and G.C. Fahey. 2002. In vitro fermentation properties of selected fructooligosaccharide-containing vegetables and in vivo colonic microbial populations are affected by the diets of healthy human infants. J. Nutr. 132:2188-2194.
30. Fukuda, K., Y. Hibiya, M. Mutoh, Y. Ohno, K. Yamashita, S. Akao, and H. Fujiwara. 2000. Inhibition of parthenolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1. Biochem. Pharmacol. 60:595-600.
31. Gambelunghe, C., and P. Melai. 2002. Absinthe: Enjoying a new popularity among young people? Forens. Sci. Intl. 130:183-186.
32. Glasl, S., A. Presser, D. Gunbilig, I. Werner, S. Narantuya, E. Haslinger, J. Jurenitsch, and W. Kubelka. 2001. Highly hydroxylated guaianolides of Achillea asiatica and Middle European Achillea species. Phytochemistry 58:1189-1194.
33. Guarrera, P.M. 1999. Traditional antihelmintic, antiparasitic and repellant uses of plants in Central Italy. J. Ethnopharmacol. 68:183-192.
34. Gupta, S.K., P. Singh, P. Bajpai, G. Ram, D. Singh, M.M. Gupta, D.C. Jain, S.P. Khanuja, and S. Kumar. 2002. Morphogenetic variation for artemisin and volatile oil in Artemisia annua. Industr. Crop Prod. 16:217-224.
35. Hao, J.Y., W. Han, S.D. Huang, B.Y. Xue, and X. Deng. 2002. Microwave-assisted extraction of artemisinin from Artemisia annua L. Sep. Purif. Technol. 28:191-196.
36. Hendriks, H., R. Bos, and H.J. Woerdenbag. 1996. The essential oil of Tanacetum parthenium (L.) Schultz-Bip. Flav. Frag. J. 11:367-371.
37. Hitmi, A., H. Sallanon, and C. Barthomeuf. 1997. Cryopreservation of Chrysanthemum cinerariaefolium Vis. cells and its impact on their pyrethrin biosynthesis ability. Plant Cell Rep. 17:60-64.
38. Hitmi, A., C. Barthomeuf, and H. Sallanon. 2001. Effects of plant growth regulators on the growth and pyrethrin production by cell cultures of Chrysanthemum cinerariaefolium. Austr. J. Bot. 49:81-88.
39. Höld, K.M., N.S. Sirisoma, T. Ikeda, T. Narahashi, and J.E. Casida. 2000. α-Thujone (the active component of absinthe): γ-aminobutyric acid type A receptor modulation and metabolic detoxification. Proc. Natl. Acad. Sci. USA 97:3826-3831.
40. Justesen, U., and P. Knuthsen. 2001. Composition of flavonoids in fresh herbs and calculation of flavonoid intake by use of herbs in traditional Danish dishes. Food Chem. 73:245-250.
41. Juteau, F., V. Masotti, J.M. Bessière, and J. Viano. 2002. Antibacterial and antioxidant activities of Artemisia annua essential oil. Fitoterapia 73:532-535.
42. Kalemba, D. 1999. Constituents of the essential oil of Artemisia asiatica Nakai. Flav. Frag. J. 14:173-176.
43. Kasahara, K., and K. Nishibori. 1995. The suppressing effect of garland chrysanthemum on the odour of nishibori soup stock. Fish. Sci. 61:672-674.
44. Katsuda, Y. 1999. Development of and future prospects for pyrethroid chemistry. Pest. Sci. 55:775-782.
45. Kawamoto, H., Y. Asada, H. Sekine, and T. Furuya. 1998. Biotransformation of artemisinic acid by cultured cells of Artemisia annua. Phytochemistry 48:1329-1333.
46. Kazarinova, N.V., and K.G. Tkachenko. 2000. Medicinal plants in treatment of different forms of tuberculosis. Rast. Res. 36:92-106.
47. Khan, M.M.A.A., D.C. Jain, R.S. Bhakuni, M. Zaim, and R.S. Thakur. 1991. Occurrence of some antiviral sterols in Artemisia annua. Plant Sci. 75:161-165.
48. Kim, J.T., J.Y. Park, H.S. Seo, H.G. Oh, J.W. Noh, J.H. Kim, D.Y. Kim, and H.J. Youn. 2002. In vitro antiprotozoal effects of artemisinin on Neospora caninum. Vet. Parasitol. 103:53-63.
49. Kim, K.S., S. Lee, J.S. Shin, S.H. Shim, and B.K. Kim. 2003. Arteminin, a new coumarin from Artemisia apiacea. Fitoterapia 73:266-268.
50. Kim, M.K., M.J. Kim, D.H. Shin, C.G. Song, and H.S. Lee. 2001. Growth-inhibiting effects of vegetable extracts on beneficial and harmful human intestinal bacteria. Agric. Chem. Biotechnol. 44:65-70.
51. Kiran, U., and D.D. Patra. 2003. Influence of natural essential oils and their by-products as nitrification retarders in regulating nitrogen utilization for Japanese mint in sandy loam soils of subtropical central India. Agric. Ecosyst. Env. 94:237-245.
52. Kiriamiti, H.K., S. Camy, C. Gourdon, and J.S. Condoret. 2003. Pyrethrin extraction from pyrethrum flowers using carbon dioxide. J. Supercrit. Fluid. 26:193-200.
53. Kishore, N., N.K. Dubey, J.P.N. Chansouria. 2001. Antimycotic activity of the essential oil of Artemisia nilagirica. Flav. Frag. J. 16:61-63.
54. Klayman, D. L. 1993. Artemisia annua. From weed to respectable antimalarial plant. Chapter 17. In D.A. Kinghorn, ed. Human medicinal agents from plants. ACS Symposium Series 534.
55. Lebedev, A.A., E.A. Batakov, V.A. Kurkin, E.A. Lebedeva, G.G. Zapesochnaya, E.V. Avdeeva, G.V. Simonova, and A.V. Volotsueva. 2001. The antioxidative activity of a complex hepatoprotective preparation silybokhol. Rast. Res. 37:69-75.
56. 6 content of spices. J. Food Comp. Anal. 14:163-167.
57. Lin, S.C., C.H. Lin, C.C. Lin, Y.H. Lin, C.F. Chen, I.C. Chen, and L.Y. Wang. 2002. Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride. J. Biomed. Sci. 9:401-409.
58. Liu, C.Z., C. Guo, Y.C. Wang, and F. Ouyang. 2002. Effect of light irradiation on hairy root growth and artemisin biosynthesis of Artemisia annua L. Proc. Biochem. 38:581-585.
59. Liu, C.Z., C. Guo, Y.C. Wang, and F. Ouyang. 2003. Comparison of various bioreactors on growth and artemisinin biosynthesis of Artemisia annua L. shoot cultures. Proc. Biochem. 39(1):45-49.
60. Lourenço, P.M.L., A.C. Figueiredo, J.G. Barroso, L.G. Pedro, M.M. Oliverira, S.G. Deans, and J.J.C. Scheffer. 1999. Essential oils from hairy root cultures and from plant roots of Achillea millefolium. Phytochemistry 51:637-642.
61. Lydon, J., J.R. Teasdale, and P.K. Chen. 1997. Allelopathic activity of annual wormwood (Artemisia annua) and the role of artemisinin. Weed Sci. 45:807-811.
62. Máday, E., É. Szöke, Z. Muskath, and E. Lemberkoviès. 1999. A study of the production of essential oils in chamomile hairy root cultures. Europ. J. Drug Metab. Pharmacokin. 24:303-308.
63. Mansilla, H., and J.A. Palenzuela. 1999. Minor eudesmanolides from Artemisia canariensis. Phytochemistry 51:995-997.
64. Mehlführer, M., K. Troll, J. Jurenitsch, H. Auer, and W. Kubelka. 1997. Betaines and free proline within the Achillea millefolium group. Phytochemistry 44:1067-1069.
65. Morán, A., M.L. Martín, M.J. Montero, A.V. Ortiz de Urbina, M.A. Sevilla, and L. San Roman. 1989. Analgesic, antipyretic and anti-inflammatory activity of the essential oil of Artemisia caerulescens subsp. gallica. J. Ethnopharmacol. 27:307-317.
66. Mueller, M.S., I.B. Karhagomba, H.M. Hirt, and E. Wemakor. 2000. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: Agricultural, chemical and clinical aspects. J. Ethnopharmacol. 73:487-493.
67. Murayama, T., H. Yada, M. Kobori, H. Shinmoto, and T. Tsushida. 2002. Evaluation of three antioxidants and their identification and radical scavenging activities in edible chrysanthemums. J. Jap. Soc. Hort. Sci. 71:236-242.
68. Muyima, N.Y.O., G. Zulu, T. Bhengu, and D. Popplewell. 2002. The potential application of some novel essential oils as natural cosmetic preservatives in an aqueous cream formulation. Flav. Frag. J. 17:258-266.
69. Navarro, V., M.L. Villarreal, G. Rojas, and X. Lazoya. 1996. Antimicrobial evaluation of some plants used in Mexican traditional medicine for the treatment of infectious diseases. J. Ethnopharmacol. 53:143-147.
70. Nin, S., A. Bennici, G. Roselli, D. Mariotti, and S. Schiff. 1997. Agrobacterium-mediated transformation of Artemisia absinthium L. (wormwood) and production of secondary metabolites. Plant Cell Rep. 16:725-730.
71. Palá, P.J., N.A. Velasco, A.M.J. Pérez, V.P. Ramos, C.F. Gómez, and J. Sanz. 1999. Essential oil of Santolina rosmarinifolia L. ssp. rosmarinifolia: First isolation of capillene, a diacetylene derivative. Flav. Frag. J. 14:131-134.
72. Paniego, N.B., and A.M. Giulietti. 1996. Artemisinin production by Artemisia annua L.-transformed organ cultures. Enz. Microb. Toxicol. 18:526-530.
73. Perez, M.P., and M.J. Pascual-Villalobos. 1999. Effects of the essential oil of flower heads of Chrysanthemum coronarium L. on white fly and stored product pests. Invest. Agr. Prod. Protec. Veg. 14:249-258.
74. Pieman, A.K. 1986. Biological activities of sesquiterpene lactones. Biochem. System. Ecol. 14:255-281.
75. Povetjeva, T.N., V.G. Pashinsky, V.V. Dudko, T.G. Horuzhaja, V.N. Zhdanov, T.A. Kanakina, O.V. Pershina, and O.V. Turliantseva. 2001. Antiinflammatory properties of Arctium tomentosum Mill. Roots and leaves dry extracts. Rast. Res. 37:80-85.
76. 2 extraction of essential oil and oleoresin from chamomile (Chamomilla recutita [L.] Rauschert). J. Supercrit. Fluid. 21:245-256.
77. Pujar, P.P., D.D. Sawaikar, S.R. Rojatkar, and B.A. Nagasampagi. 2000. A new germacranolide from Artemisia pallens. Fitoterapia 71:590-592.
78. Quarengui, M.V., M.L. Tereschuk, M.D. Baigori, and L.R. Abdala. 2000. Antimicrobial activity of flowers from Anthemis cotula. Fitoterapia 71:710-712.
79. Rao, S., and G.A. Ravishankar. 2002. Plant cell cultures: Chemical factories of secondary metabolites. Biotechnol. Adv. 20:101-153.
80. Ravid, U., E. Putievsky, and I. Katzir. 1993. Determination of the enatiomeric composition of (1R)(dextro)-and (1S)(levo)-camphor in essential oils of some Lamiaceae and Compositae herbs. Flav. Frag. J. 8:225-228.
81. Rezaeipoort, R., S. Saeidnia, and M. Kamalinejad. 1999. Immunosuppressive activity of Achillea talagonica on humoral immune responses in experimental animals. J. Ethnopharmacol. 65:273-276.
82. Saadali, B., D. Boriky, M. Blaghen, M. Vanhaelen, and M. Talbi. 2001. Alkamides from Artemisia dracunculus. Photochemistry 58:1083-1086.
83. 2 and anti-inflammatory activity of Santolina chamaecyparissus. Life Sci. 66:35-40.
84. Sallal, A.K.J., and A. Alkofahi. 1996. Inhibition of the haemolytic activities of snake and scorpion venoms in vitro with plant extracts. Biomed. Lett. 53:211-215.
85. Sashida, Y., H. Nakata, H. Shimomura, and M. Kagaya. 1983. Sesquiterpene lactones from pyrethrum flowers. Phytochemistry 22:1219-1222.
86. Schillberg, S., N. Emans, R. Fischer. 2002. Antibody molecular farming in plants and plant cells. Phytochem. Rev. 1:45-54.
87. Seidakhmetova, R.B., A.A. Bejsenbaieva, G.A. Atazhanova, I.M. Sulejmenov, R.N. Pak, A.T. Kuliiasov, and S.M. Adekenov. 2002. Chemical composition and biological activity of the essential oil of Artemisia glabella. Khim. Farm. Z. 36:27-30.
88. Shi, G., X. Guo, T. Wu, and B. Xue. 1999. Antioxidation of water extract from Artemisia capillaris Thunb. in vitro. J. Plant Res. Env. 8:7-10.
89. Shinmoto, H., T. Kimura, M. Suzuki, and K. Yamagishi. 2001. Antitumor activity of vegetables harvested in Tohoku region. J. Jpn. Soc. Food. Sci. Technol. 48:787-790.
90. Soliman, K.M., and R.I. Badeaa. 2002. Effect of oil extracted from some medicinal plants on different mycotoxigenic fungi. Food Chem. Toxicol. 40:1669-1675.
91. Srivastava, H.K. 1999. Genetic diversity and enhancement for antimalarial compound in Artemisia annua. Proc. Natl. Acad. Sci. India Sect. B Biol. Sci. 69:13-26.
92. Stojakowska, A., and W. Kisiel. 1997. Production of parthenolide in organ cultures of feverfew. Plant Cell Tiss. Org. Cult. 47:159-162.
93. Stojakowska, A., J. Malarz, and W. Kisiel. 2002. Salicylate and methyl jasmonate differentially influence diacetylene accumulation pattern in transformed roots of feverfew. Plant Sci. 163:1147-1152.
94. Storer, J.R., and H.F. van Emden. 1995. Antibiosis and antixenosis of chrysanthemum cultivars to the aphid Aphis gossypii. Entomol. Exp. Appl. 77:307-314.
95. Tan, R.X., H. Lu, J.L. Wolfender, T.T. Yu, W.F. Zheng, L. Yang, S. Gafner, and K. Hostettmann. 1999. Mono- and sesquiterpenes and antifungal constituents from Artemisia species. Planta Med. 65:64-67.
96. Tellez, M.R., C. Canel, A.M. Rimando, and S.O. Duke. 1999. Differential accumulation of isoprenoids in glanded and glandless Artemisia annua L. Phytochemistry 52:1035-1040.
97. Teoh K.H., P.J. Weathers, R.D. Cheetham, and D.B. Walcerz. 1996. Cryopreservation of transformed (hairy) roots of Artemisia annua. Cryobiology 33:106-117.
98. Thomas, O.O. 1989. Anticoagulant and antifibrinolytic properties of Tanacetum corymbosum. Fitoterapia 60:231-234.
99. Tkachenko, K.G., N.V. Kazarinova, L.M. Muzychenko, A.M. Shurgaya, O.V. Pavlova, and N.G. Safonova. 1999. Sanation properties of essential oils of some plant species. Rast. Res. 35:11-24.
100. Tsevegsuren, N., W.W. Christie, and D. Lösel. 1998. Tanacetum (Chrysanthemum) corymbosum seed oil-a rich source of a novel conjugated acetylenic acid. Lipids 33:723-727.
101. Ukiya, M., T. Akihisa, H. Tokuda, H. Suzuki, T. Mukainaka, E. Ichiishi, K. Yasukawa, Y. Kasahara, and H. Nishino. 2002. Constituents of Compositae plants III. Anti-tumor promoting effects and cytotoxic activity against human cancer cell lines of triterpene diols and triols from edible chrysanthemum flowers. Cancer Lett. 177:7-12.
102. Valecha, N., S. Biswas, V. Badoni, K.S. Bhandari, and O.P Sati. (1994.) Antimalarial activity of Artemisia japonica, Artemisia maritima and Artemisia nilegarica. Indian J. Pharmacol. 26:144-146.
103. Valenti, D., A. de Logu, G. Loy, C. Sinico, L. Bonsignore, F. Cottiglia, D. Garau, and A.M. Fadda. 2001. Liposome-incorporated Santolina insularis essential oil: Preparation, characterization and in vitro antiviral activity. J. Liposome Res. 11:73-90.
104. van Agtmael, M.A., T.A. Eggelte, and C.J. van Boxtel 1999. Artemisinin drugs in the treatment of malaria: From medicinal herb to registered medication. TIPS 20:199-205.
105. Vergauwe, A., E. van Geldre, D. Inzé, M. van Montagu, and E. van den Eeckhout. 1996. The use of amoxillin and ticarcillin in combination with a β-lactamase inhibitor as decontaminating agents in the Agrobacterium tumefaciens-mediated transformation of Artemisia annua L. J. Biotechnol. 52:89-95.
106. Verpoorte, R., A. Contin, and J. Memelink. 2002. Biotechnology for the production of plant secondary metabolites. Phytochem. Rev. 1:13-25.
107. Wake, G., J. Court, A. Pickering, R. Lewis, R. Wilkins, and E. Perry. 2000. CNS acetylcholine receptor activity in European medicinal plants traditionally used to improve failing memory. J. Ethnopharmacol. 69:105-114.
108. Weisbord, S.D., J.B. Soule, and P.L. Kimmel. 1997. Poison on line acute renal failure caused by oil of wormwood purchased through the Internet. New England J. Med. 337:825-827.
109. WHO. 1998. Roll back malaria. A global partnership. Geneva, WHO.
110. Williams, C.A., J.B. Harbourne, H. Geiger, and J.R.S. Hoult. 1999. Variations in lipophylic and polar flavonoids in the genus Tanacetum. Phytochemistry 52:1301-1306.
111. Yano, K., and T. Ishizu. 1994. Capillen a seed germination inhibitor from Artemisia capillaris roots. Phytochemistry 37:689-690.
112. Youn, H.J., and J.W. Noh. 2001. Screening of the anticoccidial effects of herb extracts against Eimeria tenella. Vet. Parasitol. 96:257-263.
113. Yun, K.W., B.S. Kil, D.M. Han. 1993. Phytotoxic and antimicrobial activity of volatile constituents of Artemisia princeps var. orientalis. J. Chem. Ecol. 19:2757-2763.
114. Zheng, M. 1988. An experimental study of antiviral action of 472 herbs on Herpes Simplex Virus. J. Trad. Chin. Med. 8:203-206.
115. Ziyyat, A., A. Legssyer, H. Mekhfi, A. Dassouli, M. Serhrouchni, and W. Benjelloun. 1997. Phytotherapy of hypertension and diabetes in oriental Morocco. J. Ethnopharmacol. 58:45-54.