Analysis of VH gene sequences using two web-based immunogenetics resources gives different results, but the affinity maturation status of chronic lymphocytic leukaemia clones as assessed from either of the resulting data sets has no prognostic significance

Leukemia

Volumn 19, Issue 5, 2005, Pages 741-749

  Lane, B S ^a   Mensah, A A ^a   Lin, K ^a   Pettitt, A R ^a   Sherrington, P D ^a  

^a ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Affinity maturation; CLL; Ig genes; Prognosis

Indexed keywords

CD38 ANTIGEN; PROTEIN P53; ADENOSINE DIPHOSPHATE RIBOSYL CYCLASE; CD38 PROTEIN, HUMAN; IMMUNOGLOBULIN FRAGMENT; IMMUNOGLOBULIN HEAVY CHAIN; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN;

ANTIGEN EXPRESSION; ARTICLE; CANCER GROWTH; CANCER SURVIVAL; CHRONIC LYMPHATIC LEUKEMIA; COHORT ANALYSIS; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC DATABASE; HUMAN; IMMUNOGENETICS; LEUKEMIA CELL; MOLECULAR CLONING; PRIORITY JOURNAL; PROGNOSIS; PROTEIN FUNCTION; STATISTICAL MODEL; AGED; BIOLOGY; CELL CLONE; COMPARATIVE STUDY; COMPUTER INTERFACE; FEMALE; GENETICS; MALE; METHODOLOGY; MORTALITY; MUTATION; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; REPRODUCIBILITY; STATISTICS; SURVIVAL;

ADP-RIBOSYL CYCLASE; AGED; ANTIGENS, CD; ANTIGENS, CD38; CLONE CELLS; COMPUTATIONAL BIOLOGY; DATABASES, GENETIC; DNA MUTATIONAL ANALYSIS; FEMALE; HUMANS; IMMUNOGENETICS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN HEAVY CHAINS; LEUKEMIA, LYMPHOCYTIC, CHRONIC; MALE; MEMBRANE GLYCOPROTEINS; MUTATION; PROGNOSIS; REPRODUCIBILITY OF RESULTS; SURVIVAL ANALYSIS; TUMOR SUPPRESSOR PROTEIN P53; USER-COMPUTER INTERFACE;

EID: 18644378420     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2403720     Document Type: Article

References (39)

1. Rozman C, Montserrat E. Chronic lymphocytic leukaemia. N Engl J Med 1995: 333: 1052-1057.
2. Caligaris-Capio F, Hamblin TJ. B-cell chronic lymphocytic leukaemia: a bird of a different feather. J Clin Oncol 1999; 17: 399-408.
3. H mutation in chronic lymphocytic leukaemia. Blood 2002; 100: 1404-1409.
4. H gene mutation in B-cell chronic lymphocytic leukemia. Blood 2001; 97: 1902.
5. Damle RN, Wasil T, Fais F. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999; 94: 1840-1847.
6. Ibrahim S, Keating M, Do KA, O'Brien S, Huh YO, Jilani I et al. CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia. Blood 2001; 98: 181-186.
7. H genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999; 94: 1848-1854.
8. Oscier DG, Gardiner AC, Mould SJ, Glide S, Davis ZA, Ibbotson RE et al. Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors. Blood 2002; 100: 1177-1184.
9. Neuberger MS, Ehrenstein MR, Rada C, Sale J, Batista FD, Williams G et al. Memory in the B-cell compartment: antibody affinity maturation. Philos Trans R Soc London B 2000; 355: 357-360.
10. Schroder AE, Greiner A, Seyfert C, Berek C. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane in patients with rheumatoid arthritis. Proc Natl Acad Sci USA 1996; 93: 221-225.
11. Matsumoto M, Lo SF, Carruthers CJL, Min J, Mariathasan S, Huang G et al. Affinity maturation without germinal centres in lymphotoxin-α-deficient mice. Nature 1996; 382: 462-466.
12. Fais F, Ghiotto F, Hashimoto S, Sellars B, Valetto A, Allen SL et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 1998; 102: 1515-1525.
13. Rosenwald A, Alizadeh AA, Widhopf G, Simon R, Davis RE, Yu X et al. Relation of gene expression phenotype to iummunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med 2001; 194: 1639-1647.
14. Klein U, Tu Y, Stolovitzky GA, Keller JL, Haddad Jr J, Miljkovic V et al. Transcriptional analysis of the B cell germinal centre reaction. Proc Natl Acad Sci USA 2003; 100: 2639-2644.
15. Damle RN, Ghiotto F, Valetto A, Albesiano E, Fais F, Yan XJ et al. B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes. Blood 2002; 99: 4087-4093.
16. Chiorazzi N, Ferrarini M. B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor. Annu Rev Immunol 2003; 21: 841-894.
17. Chang B, Casali P. The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement. Immunol Today 1994; 15: 367-373.
18. Wagner SD, Neuberger MS. Somatic hypermutation of immunoglobulin genes. Annu Rev Immunol 1996; 14: 441-457.
19. Keppler TB. Codon bias and plasticity in immunoglobulins. Mol Biol Evol 1997; 14: 637-643.
20. Lossos IS, Tibshirani R, Narasimhan B, Levy R. The inference of antigen selection on Ig genes. J Immunol 2000; 165: 5122-5126.
21. Dörner T, Brezinschek H-P, Brezinschek RI, Foster SJ, Domiati-Saad R, Lipsky PE. Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes. J Immunol 1997; 158: 2779-2789.
22. Dyer MJS, Oscier DG. The configuration of the immunoglobulin genes in B cell chronic lymphocytic leukemia. Leukemia 2002; 16: 973-984.
23. Lefranc M-P. IMGT, the international ImMunoGeneTics database®. Nucleic Acids Res 2003; 31: 307-310.
24. H segments. J Mol Biol 1992; 227: 799-817.
25. K. EMBO J 1995; 14: 4628-4638.
26. λ repertoire. J Mol Biol 1996; 264: 220-232.
27. Kabat E, Wu T, Reid-Miller M, Perry H, Gottesman K. Sequences of Proteins of Immunological Interest, Public Health Service National Institutes of Health, US Department of Health and Human Services 1991. Bethesda Maryland, USA.
28. Lefranc M-P. The IMGT unique numbering for immunoglobulins, T cell receptors and Ig-like domains. Immunologist 1999; 7: 132-136.
29. H3-21 gene segment. Blood 2003; 102: 1145-1146.
30. Davis ZA, Orchard JA, Corcoran MM, Oscier DG. Divergence from the germ-line sequence in unmutated chronic lymphocytic leukemia is due to somatic mutation rather than polymorphisms. Blood 2003; 102: 3075.
31. H-gene is mutated? Leukemia 2004; 18: 882-883.
32. Hans-Helmar A, Werner M (http://www.dnaplot.de).
33. Pettitt AR, Sherrington PD, Stewart G, Cawley JC, Taylor AM, Stankovic T. p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation. Blood 2001; 98: 814-822.
34. H gene mutations in chronic lymphocytic leukemia B cells are consistent with the canonical somatic hypermutation process. Blood 2004; 103: 3490-3495.
35. Kröber A, Benner A, Bühler A, Döhner H, Stilgenbauer S. Multivariate survival analysis of specific VH-genes in CLL: V3-21 and V3-23 are prognostic factors independently of the VH mutation status. Blood 2002; 100: 738.
36. H gene mutations in B cell chronic lymphocytic leukaemia according to antigen-driven selection identifies subgroups with different prognosis and usage of the canonical somatic hypermutation machinery. Br J Haematol 2004; 126: 29-42.
37. Pettitt AR, Sherrington PD, Allsup DJ, Matrai Z, Cawley JC, Zuzel M. Natural history of chronic lymphocytic leukaemia: current thinking. In: Hamblin T, Johnson S, Miles A (eds). The Effective Management of Chronic Lymphocytic Leukaemia. UK Key Advances in Clinical Practice Series 2004. Aesculapius Medical Press, London, UK.
38. H mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood 2002; 100: 1410-1416.
39. Adams CL, Macleod MKL, Milner-White EJ, Aitken R, Garside P, Stott DI. Complete analysis of the B-cell response to a protein antigen, from in vivo germinal centre formation to 3-D modelling of affinity maturation. Immunology 2003; 108: 274-287.