Divergence from the germ-line sequence in unmutated chronic lymphocytic leukemia is due to somatic mutation rather than polymorphisms [3]

Blood

Volumn 102, Issue 8, 2003, Pages 3075-

  Davis, Zadie A ^b   Orchard, Jenny A ^b   Corcoran, Martin M ^b   Oscier, David G ^a  

^a ROYAL BOURNEMOUTH HOSPITAL   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

BASE PAIRING; CHRONIC LYMPHATIC LEUKEMIA; GENE SEQUENCE; GENETIC POLYMORPHISM; GERM LINE; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; LETTER; LEUKEMIA CELL; POINT MUTATION; PRIORITY JOURNAL; PROGNOSIS; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SOMATIC HYPERMUTATION; SOMATIC MUTATION;

EID: 0141992960     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-08-2696     Document Type: Letter

References (7)

1. Matsuda F, Shin EK, Nagaoka H, et al. Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy-chain locus. Nat Genet. 1993;3:88-94.
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3. Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94:1848-1854.
4. Krober A, Seiler T, Benner A, et al. V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood. 2002;100:1410-1416.
5. Lin K, Sherrington PD, Dennis M, Matrai Z, Cawley JC, Pettitt AR. Relationship between p53 dysfunction, CD38 expression, and IgV(H) mutation in chronic lymphocytic leukemia. Blood. 2002;100:1404-1409.
6. Krober A, Benner A, Buhler A, Dohner H, Stilgenbauer S. Multivariate survival analysis of VH genes in CLL:V3-21 and V3-23 are prognostic factors independently of the VH mutation status [abstract]. Blood. 2002;100:196a.
7. Tobin G, Thunberg U, Johnson A, et al. Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia. Blood. 2002;99:2262-2264.