CD11b limits bacterial outgrowth and dissemination during murine pneumococcal pneumonia

Journal of Infectious Diseases

Volumn 191, Issue 10, 2005, Pages 1755-1760

  Rijneveld, Anita W ^a   De Vos, Alex F ^a   Florquin, Sandrine ^a   Verbeek, J Sjef ^b   Van Der Poll, Tom ^a,c  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD11 ANTIGEN; LYMPHOCYTE ANTIBODY;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BACTERIAL GROWTH; BACTERIAL VIRULENCE; CD11B GENE; CONTROLLED STUDY; GENE; INFLAMMATION; LEUKOCYTE COUNT; LOBAR PNEUMONIA; LUNG LAVAGE; LUNG PARENCHYMA; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE; WILD TYPE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD11B; CYTOKINES; GENE EXPRESSION; LUNG; MACROPHAGES; MICE; MICE, KNOCKOUT; NEUTROPHILS; PNEUMONIA, PNEUMOCOCCAL; STREPTOCOCCUS PNEUMONIAE;

EID: 18544383759     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/429633     Document Type: Article

References (17)

1. Doerschuk CM, Tasaka S, Wang Q. CD11/CD18-dependent and -independent neutrophil emigration in the lungs: how do neutrophils know which route to take? Am J Respir Cell Mol Biol 2000; 23:133-6.
2. Bartlett JG, Dowell SF, Mandell LA, File TM Jr, Musher DM, Fine MJ. Practice guidelines for the management of community-acquired pneumonia in adults. Infectious Diseases Society of America. Clin Infect Dis 2000; 31:347-82.
3. Doerschuk CM, Winn RK, Coxson HO, Harlan JM. CD18-dependent and -independent mechanisms of neutrophil emigration in the pulmonary and systemic microcirculation of rabbits. J Immunol 1990; 144:2327-33.
4. Mizgerd JP, Horwitz BH, Quillen HC, Scott ML, Doerschuk CM. Effects of CD18 deficiency on the emigration of murine neutrophils during pneumonia. J Immunol 1999; 163:995-9.
5. Rijneveld AW, Lauw FN, Schultz MJ, et al. The role of interferon-γ in murine pneumococcal pneumonia. J Infect Dis 2002; 185:91-7.
6. Gyetko MR, Sitrin RG, Fuller JA, Todd RF 3rd, Petty H, Standiford TJ. Function of the urokinase receptor (CD87) in neutrophil chemotaxis. J Leukoc Biol 1995;58:533-8.
7. Gyetko MR, Sud S, Kendall T, Fuller JA, Newstead MW, Standiford TJ. Urokinase receptor-deficient mice have impaired neutrophil recruitment in response to pulmonary Pseudomonas aeruginosa infection. J Immunol 2000; 165:1513-9.
8. Rijneveld AW, Levi M, Florquin S, Speelman P, Carmeliet P, van Der Poll T. Urokinase receptor is necessary for adequate host defense against pneumococcal pneumonia. J Immunol 2002; 168:3507-11.
9. Coxon A, Rieu P, Barkalow FJ, et al. A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity 1996; 5:653-66.
10. Knapp S, Leemans JC, Florquin S, et al. Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia. Am J Respir Crit Care Med 2003; 167:171-9.
11. Knapp S, Wieland CW, van 't Veer C, et al. Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense. J Immunol 2004; 172:3132-8.
12. Cuzzola M, Mancuso G, Beninati C, et al. Beta 2 integrins are involved in cytokine responses to whole Gram-positive bacteria. J Immunol 2000; 164:5871-6.
13. Qin L, Quinlan WM, Doyle NA, et al. The roles of CD11/CD18 and ICAM-1 in acute Pseudomonas aeruginosa-induced pneumonia in mice. J Immunol 1996; 157:5016-21.
14. Freeman BD, Correa R, Karzai W, et al. Controlled trials of rG-CSF and CD11b-directed MAb during hyperoxia and E. coli pneumonia in rats. J Appl Physiol 1996; 80:2066-76.
15. Ross GD, Cain JA, Lachmann PJ. Membrane complement receptor type three (CR3) has lectin-like properties analogous to bovine conglutinin as functions as a receptor for zymosan and rabbit erythrocytes as well as a receptor for iC3b. J Immunol 1985; 134:3307-15.
16. Gordon DL, Johnson GM, Hostetter MK. Ligand-receptor interactions in the phagocytosis of virulent Streptococcus pneumoniae by polymorphonuclear leukocytes. J Infect Dis 1986; 154:619-26.
17. Brown JS, Hussell T, Gilliland SM, et al. The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice. Proc Natl Acad Sci USA 2002; 99:16969-74.