Regulation of HSF1-responsive gene expression by N-terminal truncated form of p73α

Biochemical and Biophysical Research Communications

Volumn 317, Issue 3, 2004, Pages 865-872

  Tanaka, Yasuharu ^a   Kameoka, Masanori ^a   Itaya, Asako ^a   Ota, Katsuya ^a   Yoshihara, Koichiro ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

Np73; DNp73; Heat shock factor; Heat shock protein; HSF; Hsp; p53; p73; TAp73

Indexed keywords

HEAT SHOCK PROTEIN 70; HEAT SHOCK TRANSCRIPTION FACTOR 1; PROLINE; PROTEIN P73; TRANSACTIVATOR PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EMBRYO; GENE ACTIVATION; GENE ACTIVITY; GENE EXPRESSION REGULATION; HEAT SHOCK RESPONSE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN FUNCTION; REPORTER GENE; SIGNAL TRANSDUCTION;

BASE SEQUENCE; CELL LINE, TUMOR; DNA PRIMERS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GENES, TUMOR SUPPRESSOR; HUMANS; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 1842689284     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.03.124     Document Type: Article

References (33)

1. Kaghad M., Bonnet H., Yang A., Creancier L., Biscan J.-C., Valent A., Minty A., Chalon P., Lelias J.-M., Dumont X., Ferrara P., McKeon F., Caput D. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell. 90:1997;809-819.
2. de Laurenzi V., Constanzo A., Barcaroli D., Terrinoni A., Falco M., Annicchiarico-Petruzzelli M., Levrero M., Melino G. Two new splice variants, γ and δ, with different transcriptional activity. J. Exp. Med. 188:1998;1763-1768.
3. Zaika A.I., Kovalev S., Marchenko N.D., Moll U.M. Overexpression of the wild type p73 gene in breast cancer tissues and cell lines. Cancer Res. 59:1999;3257-3263.
4. de Laurenzi V., Catani M.V., Terrinoni A., Corazzari M., Melino G., Costanzo A., Levrero M., Knight R.A. Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants ε and ζ Cell Death Differ. 6:1999;389-390.
5. Ueda Y., Hijikata M., Takagi S., Chiba T., Shimotohno K. New p73 variants with altered C-terminal structures have varied transcriptional activities. Oncogene. 18:1999;4993-4998.
6. Fontemaggi G., Kelar I., Amariglio N., Rechavi G., Krishnamurthy J., Strano S., Sacchi A., Givol D., Blandino G. Identification of direct p73 target genes combining DNA microarray and chromatin immunoprecipitation analyses. J. Biol. Chem. 277:2002;43359-43368.
7. Pozniak C.D., Radinovic S., Yang A., McKeon F., Kaplan D.R., Miller F.D. An anti-apoptotic role for the p53 family member, p73, during developmental neuron death. Science. 289:2000;304-306.
8. Sayan A.E., Sayan B.S., Findikli N., Ozturk M. Acquired expression of transcriptionally active p73 in hepatocellular carcinoma cells. Oncogene. 20:2001;5111-5117.
9. Ishimoto O., Kawahara C., Enjo K., Obinata M., Nukiwa T., Ikawa S. Possible oncogenic potential of Np73: a newly identified isoform of human p73. Cancer Res. 62:2002;636-641.
10. Grob T.J., Novak U., Maisse C., Barcaroli D., Lüthi A.U., Pirnia F., Hügli B., Graber H.U., de Laurenzi V., Fey M.F., Melino G., Tobler A. Human ΔNp73 regulates a dominant negative feedback loop for TAp73 and p53. Cell Death Differ. 8:2001;1213-1223.
11. Yang A., Walker N., Bronson R., Kaghad M., Oosterwegel M., Bonnin J., Vagner C., Bonnet H., Dikkes P., Sharpe A., McKeon F., Caput D. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature. 404:2000;99-103.
12. Nakagawa T., Takahashi M., Ozaki T., Watanabe K., Todo S., Mizuguchi H., Hayakawa T., Nakagawara A. Autoinhibitory regulation of p73 by ΔNp73 to modulate cell survival and death through a p73-specific target element within the ΔNp73 promoter. Mol. Cell. Biol. 22:2002;2575-2585.
13. Kartasheva N.N., Contente A., Lenz-Stöppler C., Roth J., Dobbelstein M. p53 induces the expression of its antagonist p73ΔN, establishing an autoregulatory feedback loop. Oncogene. 21:2002;4715-4727.
14. Pozniak C.D., Barnabé-Heider F., Rymer V.V., Lee A.F., Sadikot A.F., Miller F.D. p73 is required for survival and maintenance of CNS neurons. J. Neurosci. 22:2002;9800-9809.
15. Stiewe T., Theseling C.C., Pützer B.M. Transactivation-deficient ΔTA-p73 inhibits p53 by direct competition for DNA binding. J. Biol. Chem. 277:2002;14177-14185.
16. Tanaka Y., Kameoka M., Ota K., Itaya A., Ikuta K., Yoshihara K. Establishment of persistent infection with HIV-1 abrogates the caspase-3-dependent apoptotic signaling pathway in U937 cells. Exp. Cell Res. 247:1999;514-524.
17. Mathew A., Shi Y., Jolly C., Morimoto R.I. Analysis of the mammalian heat-shock response. Methods Mol. Biol. 99:2000;217-255.
18. Kameoka M., Tanaka Y., Ota K., Itaya A., Yoshihara K. Poly(ADP-ribose) polymerase is involved in PMA-induced activation of HIV-1 in U1 cells by modulating the LTR function. Biochem. Biophys. Res. Commun. 262:1999;285-289.
19. Morimoto R.I. Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev. 12:1998;3788-3796.
20. Pirkkala L., Nykänen P., Sistonen L. Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J. 15:2001;1118-1131.
21. Holmberg C.I., Tran S.E.F., Erikosson J.E., Sistonen L. Multisite phosphorylation provides sophisticated regulation of transcription factors. Trends Biochem. Sci. 27:2002;619-627.
22. Holmberg C.I., Hietakangas V., Mikhailov A., Rantanen J.O., Kallio M., Meinander A., Hellman J., Morrice N., MacKintosh C., Morimoto R.I., Eriksson J.E., Sistonen L. Phosphrylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. EMBO J. 20:2001;3800-3810.
23. Hong Y., Rogers R., Matunis M.J., Mayhew C.N., Goodson M., Park-Sarge O.-K., Sarge K.D. Regulation of heat shock transcription factor 1 by stress-induced SUMO-1 modification. J. Biol. Chem. 276:2001;40263-40267.
24. Hietakangas V., Ahiskog J.K., Jakobsson A.M., Hellesuo M., Sahlberg N.M., Holmberg C.I., Mikhailov A., Palvimo J.J., Pirkkala L., Sistonen L. Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1. Mol. Cell. Biol. 23:2003;2953-2968.
25. Agoff S.N., Hou J., Linzer D.I.H., Wu B. Regulation of the human hsp70 promoter by p53. Science. 259:1993;84-87.
26. Mitsudomi T., Steinberg S.M., Nau M.M., Carbone D., D'Amico D., Bodner S., Oie H.K., Linnoila R.I., Mulshine J.L., Minna J.D., Gazadar A.F. p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features. Oncogene. 7:1992;171-180.
27. Yuan Z.-M., Shioya H., Ishiko T., Sun X., Gu J., Huang Y.Y., Lu H., Kharbanda S., Weichselbaum R., Kufe D. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature. 399:1999;814-817.
28. Chi S.-W., Ayed A., Arrowsmith C.H. Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain. EMBO J. 18:1999;4438-4445.
29. Thanos C.D., Bowie J.U. p53 family members p63 and p73 are SAM domain-containing proteins. Protein Sci. 8:1999;1708-1710.
30. Ozaki T., Naka M., Takada N., Tada M., Sakiyama S., Nakagawara A. Deletion od the COOH-terminal region of p73α enhances both its transactivation function and DNA-binding activity but inhibits induction of apoptosis in mammalian cells. Cancer Res. 59:1999;5902-5907.
31. Beere H.M., Wolf B.B., Cain K., Mosser D.D., Mahboubi A., Kuwata T., Tailor P., Morimoto R.I., Cohen G.M., Green D.R. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat. Cell Biol. 2:2000;469-475.
32. Saleh A., Srinivasula S.M., Balkir L., Robbins P.D., Alnemri E.S. Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat. Cell Biol. 2:2000;469-475.
33. Kartasheva N.N., Lenz-Bauer C., Hartmann O., Schäfer H., Eilers M., Dobbelstein M. ΔNp73 can modulate the expression of various genes in a p53-independent fashion. Oncogene. 22:2003;8246-8254.