Interferon-beta induces the development of type 2 dendritic cells

Cytokine

Volumn 13, Issue 5, 2001, Pages 264-271

  Huang, Yu Min ^a   Hussien, Yassir ^a   Yarilin, Dmitry ^a   Xiao, Bao Guo ^a   Liu, Yong Jun ^b   Link, Hans ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Dendritic cells; IFN ; Multiple sclerosis

Indexed keywords

B7 ANTIGEN; BETA INTERFERON; CD1 ANTIGEN; CD14 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 3 RECEPTOR; INTERLEUKIN 4;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL MATURATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; MONOCYTE; MONONUCLEAR CELL; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; TH2 CELL;

EID: 0035819762     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.2000.0835     Document Type: Article

References (36)

1. Dendritic cells and the control of immunity
2. The control of T cell responses by dendritic cell subsets
3. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells
4. Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction
5. Distinct dendritic cell subsets differentially regulate the class of immune response in vivo
6. Reciprocal control of T helper cell and dendritic cell differentiation
7. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
8. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
9. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
10. The paradigm of type I and type 2 antigen-presenting cells. Implications for atopic allergy
11. Prostaglandin E2 induces the final maturation of IL-12-deficient dendritic cells: The levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation
12. Virus-specific cytotoxic T cells in multiple sclerosis
13. Exacerbations of multiple sclerosis in patients treated with gamma interferon
14. Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis
15. What is new in the treatment of multiple sclerosis?
16. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial
17. Interferon b in multiple sclerosis: Is IL-12 supression the key?
18. Type I IFNs inhibit human dendritic cell IL-12 production and Th1 cell development
19. Interferon beta induces interleukin-10 expression: Relevance to multiple sclerosis
20. In vivo effects of interferon beta-1a on immunosuppressive cytokines in multiple sclerosis
21. Selective expression of an interleukin-12 receptor component by human T helper 1 cells
22. The role of Stat4 in species-specific regulation of Th cell development by type I IFNs
23. IFN-beta differentially regulates CD40-induced cytokine secretion by human dendritic cells
24. Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells
25. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells
26. Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma
27. Introduction: TH2-inducing DC2 for immunotherapy
28. Immunobiology of dendritic cells
29. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand
30. Dendritic cell ontogeny: A human dendritic cell lineage of myeloid origin
31. Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice
32. Type I IFNs enhance the terminal differentiation of dendritic cells
33. T-cell priming by type-1 and type-2 polarized dendritic cells: The concept of a third signal
34. Human dendritic cells require exogenous interleukin-12-inducing factors to direct the development of naive T-helper cells toward the Th1 phenotype
35. IFN-beta-1b inhibits IL-12 production in peripheral blood mononuclear cells in an IL-10-dependent mechanism: Relevance to IFN-beta-1b therapeutic effects in multiple sclerosis
36. Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application