CCR5 antagonists: Bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 4, 2002, Pages 677-679

  Lynch, Christopher L ^a   Gentry, Amy L ^a   Hale, Jeffrey J ^a   Mills, Sander G ^a   MacCoss, Malcolm ^a   Malkowitz, Lorraine ^a   Springer, Martin S ^a   Gould, Sandra L ^a   DeMartino, Julie A ^a   Siciliano, Salvatore J ^a   Cascieri, Margaret A ^a   Doss, George ^a   Carella, Anthony ^a   Carver, Gwen ^a   Holmes, Karen ^a   Schleif, William A ^a   Danzeisen, Renee ^a   Hazuda, Daria ^a   Kessler, Joseph ^a   Lineberger, Janet ^a   Miller, Michael ^a   Emini, Emilio A ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENE DERIVATIVE; ANTIVIRUS AGENT; BLOCKING AGENT; CHEMOKINE RECEPTOR CCR5; ISOXAZOLIDINE DERIVATIVE; NITRONE; PYRROLIDINE DERIVATIVE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; FUSED HETEROCYCLIC RINGS; ISOXAZOLE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYCLOADDITION; DRUG POTENCY; DRUG RECEPTOR BINDING; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; PHARMACOPHORE; RECEPTOR AFFINITY; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; MICROBIOLOGICAL EXAMINATION; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-HIV AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; HIV-1; HUMANS; ISOXAZOLES; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; PROTEIN BINDING; PYRROLIDINES; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 18244396143     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00835-6     Document Type: Article

References (15)