A POP-1 repressor complex restricts inappropriate cell type-specific gene transcription during Caenorhabditis elegans embryogenesis

EMBO Journal

Volumn 20, Issue 24, 2001, Pages 7197-7208

  Calvo, Dominica ^a,b   Victor, Martin ^a,b   Gay, Frédérique ^a   Sui, Guangchao ^a   Po Shan Luke, Margaret ^a   Dufourcq, Pascale ^a   Wen, Gengyun ^a   Maduro, Morris ^b   Rothman, Joel ^b   Shi, Yang ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

C.elegans embryonic development; CBP 1; Histone acetylase; Histone deacetylase; Transcriptional repression

Indexed keywords

GENE PRODUCT; HISTONE ACETYLTRANSFERASE; HISTONE ACETYLTRANSFERASE CBP1; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; PROTEIN END1; PROTEIN POP1; PROTEIN UNC37; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CAENORHABDITIS ELEGANS; CELL LINEAGE; COMPLEX FORMATION; EMBRYO DEVELOPMENT; ENDODERM; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DNA-BINDING PROTEINS; GATA TRANSCRIPTION FACTORS; HELMINTH PROTEINS; HIGH MOBILITY GROUP PROTEINS; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ARACHNIDA; CAENORHABDITIS; CAENORHABDITIS ELEGANS; HEXAPODA; INVERTEBRATA;

EID: 18244392455     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.24.7197     Document Type: Article

References (38)

1. The CBP co-activator is a histone acetyltransferase
2. The Yin-Yang of TCF/β-catenin signaling
3. β-catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator
4. SKN-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C.elegans embryo
5. The genetics of Caenorhabditis elegans
6. Groucho/TLE family proteins and transcriptional repression
7. A functional interaction between the histone deacetylase Rpd3 and the corepressor Groucho in Drosophila development
8. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
9. Groucho proteins: Transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates
10. Analysis of Groucho-histone interactions suggests mechanistic similarities between Groucho- and Tup-mediated repression
11. The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p
12. A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT
13. The TBP-like factor CeTLF is required to activate RNA polymerase II transcription during C.elegans embryogenesis
14. Distinct β-catenins mediate adhesion and signalling functions in C.elegans
15. Segregation of developmental potential in early embryos of Caenorhabditis elegans
16. POP-1 and anterior-posterior fate decisions in C.elegans embryos
17. Pop-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C.elegans embryos
18. Restriction of mesoendoderm to a single blastomere by the combined action of SKN-1 and a GSK-3β homolog is mediated by MED-1 and -2 in C.elegans
19. MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans
20. The maternal-to-zygotic transition in embryonic patterning of Caenorhabditis elegans
21. The transcriptional coactivators p300 and CBP are histone acetyltransferases
22. The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3
23. The Groucho-like transcription factor UNC-37 functions with the neural specificity gene unc-4 to govern motor neuron identity in C.elegans
24. Establishment of initial asymmetry in early Caenorhabditis elegans embryos
25. Wnt signaling and an APC related gene specify endoderm in early C.elegans
26. WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C.elegans
27. TCF transcription factors: Molecular switches in carcinogenesis
28. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
29. Specification of cell fates in the early embryo
30. Stimulation of p300-mediated transcription by the kinase MEKK1
31. A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans
32. Transcriptional repression by YY1, a human GLI-Kruppel related protein, and relief of repression by adenovirus E1A protein
33. The embryonic cell lineage of the nematode Caenorhabditis elegans
34. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p
35. Wnt signaling polarizes an early C.elegans blastomere to distinguish endoderm and mesoderm
36. A conserved transcription motif suggesting functional parallels between C.elegans SKN-1 and Cap'n'Collar-related proteins
37. Reprogramming of early embryonic blastomeres into endodermal progenitors by a Caenorhabditis elegans GATA factor
38. end-1 encodes an apparent GATA factor that specifies the endoderm precursor in Caenorhabditis elegans embryos