The Groucho-like transcription factor UNC-37 functions with the neural specificity gene unc-4 to govern motor neuron identity in C. elegans

Development

Volumn 124, Issue 9, 1997, Pages 1699-1709

  Pflugrad, Amy ^a   Meir, James Y J ^a   Barnes, Thomas M ^b   Miller III, David M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

C. elegans; Groucho; Motor neuron; Neural specificity; Unc 37; Unc 4

Indexed keywords

HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; EMBRYO; GENE EXPRESSION REGULATION; MISSENSE MUTATION; MOTONEURON; MUTANT; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BASE SEQUENCE; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CONSERVED SEQUENCE; GENES, HELMINTH; HELMINTH PROTEINS; HOMEODOMAIN PROTEINS; HUMANS; INTERNEURONS; MOLECULAR SEQUENCE DATA; MOTOR NEURONS; MOVEMENT; MUSCLE PROTEINS; MUTAGENESIS, SITE-DIRECTED; NERVOUS SYSTEM PHYSIOLOGY; NUCLEAR PROTEINS; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SYNAPSES; TRANSCRIPTION FACTORS;

ANIMALIA; CAENORHABDITIS ELEGANS;

EID: 0031001187     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Altschul, S. F., Gish, W., Miller, W., Myers, E. W. and Lipman, D. J. (1990). Basic local alignment search tool. J. Mol. Biol. 215, 403-410.
2. Barnes, T. M., Jin, Y., Horvitz, H. R., Ruvkun, G. and Hekimi, S. (1996). The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (Stomatin) and nonspecific lipid transfer protein. J. Neurochem. 67, 46-57.
3. Barstead, R. J. and Waterston, R. H. (1989). The basal component of the nematode dense-body is vinculin. J. Biol. Chem. 264, 10177-10188.
4. Blumenthal, T. (1995). Trans-splicing and polycistronic transcription in Caenorhabditis elegans. Trends Genet. 11, 132-136.
5. Brenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94.
6. Chalfie, M., Tu, Y., Euskirchen, G., Ward, W. W. and Prasher, D. C. (1994). Green fluorescent protein as a marker for gene expression. Science 263, 802-805.
7. Clark, D.V, Suleman, D. S., Beckenbach, K. A., Gilchrist, E. J. and Baillie, D. L. (1995). Molecular cloning and characterization of the dpy-20 gene of Caenorhabditis elegans. Mol. Gen. Genet. 247, 367-378.
8. Coulson A., Huynh C., Kozono Y., and Shownkeen R. (1995). The physical map of the Caenorhabditis elegans genome. In C. elegans: Modern Biological Analysis of an Organism. (ed. H.F. Epstein and D. C. Shakes) Methods in Cell Biology 48, 533-550.
9. Dehni, G., Liu, Y., Husain, J. and Stifani, S. (1995). TLE expression correlates with mouse embryonic segmentation, neurogenesis, and epithelial determination. Mechanisms of Development 53, 369-381.
10. Delidakis, C., Preiss, A., Hartley, D. A. and Artavanis-Tsakonas, S. (1991). Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster. Genetics 129, 803-823.
11. Dynlacht, B. D., Weinzierl, R. O., Admon, A. and Tjian R. (1993). The dTAFII80 subunit of Drosophila TFIID contains beta-transducin repeats. Nature 363, 176-179, 1993
12. Finney, M. and Ruvkun, G. (1990). The unc-86 gene product couples cell lineage and cell identity in C. elegans. Cell 63, 895-905.
13. Fischer-Vize, J. A., Vize, P. D. and Rubin, G. M. (1992). A unique mutation in the Enhancer of split gene complex affects the fates of the mystery cells in the developing Drosophila eye. Development 115, 89-101.
14. Fisher, A. L., Ohsako. S. and Caudy, M. (1996). The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain. Mol. Cell. Biol. 16, 2670-2677.
15. Francis, R., Barton, M. K., Kimble, J. and Schedl, T. (1995). gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegans. Genetics 139, 579-606.
16. Harlow, E. and Lane, D. (1988). Antibodies: A Laboratory Manual Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
17. Hartley, D. A., Preiss, A. and Artavanis-Tsakonas, S. (1988). A deduced gene product from the Drosophila neurogenic locus, enhancer of split, shows homology to mammalian G-protein beta subunit. Cell 55, 785-795.
18. Heitzler, P., Bourouis, M., Ruel, L., Carteret, C. and Simpson, P. (1996). Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila. Development 122, 161-71.
19. Kelly, W. G., Xu, S. Q., Montgomery, M. K. and Fire, A. (1997). Distinct requirements for somatic and germline expression of a generally expressed C. elegans gene. Genetics in press.
20. Kimble, J. (1981). Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans. Dev. Biol. 87, 286-300.
21. Komachi, K., Redd, M. J. and Johnson, A. D. (1994). The WD repeats of Tup1 interact with the homeo domain protein alpha2. Genes Dev. 8, 2857-2867.
22. Koop, K. E., MacDonald, L. M. and Lobe, C. G. (1996). Transcripts of Grg4, a murine groucho-related gene, are detected in adjacent tissues to other murine neurogenic gene homologues during embryonic development. Mech. Dev. 59, 73-87
23. McKim, K., Starr, S. T. and Rose, A. M. (1992). Genetic and molecular analysis of the dpy-14 region in Caenorhabditis elegans. Mol. Gen. Genet. 233, 241-251.
24. Mello, C. C., Kramer, J. M., Stinchcomb, D. and Ambros, V. (1991). Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10, 3959-3970.
25. Miller, D. M., Shen, M. M., Shamu, C. E., Bürglin, T. R., Ruvkun, G., Dubois, M. L., Ghee, M. and Wilson, L. (1992). C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons. Nature 355, 841-845.
26. Miller, D. M., III, Niemeyer, C. J. and Chitkara, P. (1993). Dominant unc-37 mutations suppress the movement defect of a homeodomain mutation in unc-4, a neural specificity gene in Caenorhabditis elegans. Genetics 135, 741-753.
27. Miller, D.M., III and Niemeyer, C.J. (1995). Expression of the unc-4 homeoprotein in C. elegans motor neurons specifies presynaptic input. Development 121, 2877-2886.
28. Miller, D. M., III and Shakes, D. C. (1995). Immunofluorescence Microscopy. In C. elegans: Modern Biological Analysis of an Organism (ed. H. F. Epstein and D. C. Shakes) Methods in Cell Biology. 48, 365-392.
29. Miller, D. M., Stockdale, F. and Karn, J. (1986). Immunological identification of the genes encoding the four myosin heavy chains of Caenorhabditis elegans. Proc. Nat. Acad. Sci. USA 83, 2305-230.
30. Miyasaka, H., Choudry, B. K., Hou, E. W., and Li, S. S.-L. (1993). Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. Ear. J. Biochem. 216, 343-352.
31. Neer, E. J., Schmidt, C. J., Nambudripad, R. and Smith, T. F. (1994). The ancient regulatory-protein family of WD-repeat proteins. Nature 371, 297-300
32. Paroush, Z., Finley, R. L., Kidd, T., Wainwright, S. M., Ingham, P. W., Brent, R. and Ish-Horowicz, D. (1994). Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins. Cell 79, 805-815.
33. Pinto, M. and Lobe, C. G. (1996). Products of the grg (Groucho-related gene) family can dimerize throught the amino-terminal Q domain. J. Biol. Chem. 271, 33026-33031.
34. Rovescalli, A. C., Asoh, S. and Nirenberg, M. (1996). Cloning and characterization of four murine homeobox genes. Proc. Natl. Acad. Sci. USA 93, 10691-10696.
35. Saito, T., Lo, L., Anderson, D. J. and Mikoshiba, K. (1996). Identification of a novel paired homeodomain protein related to C. elegans UNC-4 as a potential downstream target of MASH1. Dev. Biol. 180, 143-155
36. Sambrook, J., Fritsch, E. F. and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual. New York: Cold Spring Harbor Laboratory.
37. Schmidt, C. J. and Sladek, T. E. (1993). A rat homolog of the Drosophila enhancer of split (groucho) locus lacking WD-40 repeats. J. Bio. Chem. 268, 25681-25686.
38. Smith, D. B. and Johnson, K. S. (1988).Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67, 31-40.
39. Sondek, J., Bohm, A., Lambright, D. G., Hamm, H. E. and Sigler, P. B. (1996). Crystal structure of a G-protein beta gamma dimer at 2.1A resolution. Nature 379, 369-374.
40. Stifani, S., Blaumueller, C. M., Redhead, N. J., Hill, R. E. and Artavanis-Tsakonas, S. (1992). Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins. Nature Genetics 2, 119-127.
41. Sulston, J. E. and Horvitz, H. R. (1977). Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev. Biol. 56, 110-156.
42. Tata, F. and Hartley, D. A. (1993). The role of the Enhancer of split complex during cell fate determination in Drosophila.Development Supplement, 139-148.
43. Tzamarias, D. and Struhl, K. (1995). Distinct TPR motifs of Cyc8 are involved in recruiting the cyc8-Tup1 corepressor complex to differentially regulated promoters. Genes Dev. 9, 821-831.
44. Wall, M. A., Coleman, D. E., Lee, E., Iniguez-Lluhi, J. A., Posner, B. A., Gilman, A. G., and Sprang, S. R. (1995). The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell 83, 1047-1058 (1995).
45. White, J. G., Southgate, E., Thomson, J. N. and Brenner, S. (1986). The structure of the nervous system of the nematode Caenorhabditis elegans. Phil. Trans. R. Soc. Land. B 314, 1-340.
46. White, J. G., Southgate, E. and Thomson, J. N.(1992). Mutations in the Caenorhabditis elegans unc-4 gene alter the synaptic input to ventral cord motor neurons. Nature 355, 838-841.
47. Williams, B. D., Schrank, B., Huynh, C., Shownkeen, R. and Waterston, R. H. (1992). A genetic-mapping system in Caenorhabditis elegans based on polymorphic sequence-tagged sites. Genetics 131, 609-624.