Targeted and restricted complement activation on acrosome-reacted spermatozoa

Journal of Clinical Investigation

Volumn 115, Issue 5, 2005, Pages 1241-1249

  Riley Vargas, Rebecca C ^a   Lanzendorf, Susan ^a   Atkinson, John P ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; C REACTIVE PROTEIN; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C2; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3B; COMPLEMENT FACTOR H; MEMBRANE COFACTOR PROTEIN; MOLECULAR MARKER;

ACROSOME; ARTICLE; CELL VIABILITY; COMPLEMENT ACTIVATION; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; NONHUMAN; OVARY FOLLICLE FLUID; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN RESTRICTION; PROTEIN TARGETING; SPERMATOZOON;

EID: 18144454192     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI23213     Document Type: Article

References (62)

1. Seya, T., Turner, J., and Atkinson, J.P. 1986. Purification and characterization of a membrane protein (gp45-70) that is a cofactor for cleavage of C3b and C4b. J. Exp. Med. 163:837-855.
2. Ballard, L.L., Bora, N.S., Yu, G.H., and Atkinson, J.P. 1988. Biochemical characterization of membrane cofactor protein of the complement system. J. Immunol. 141:3923-3929.
3. Seya, T., and Atkinson, J.P. 1989. Functional properties of membrane cofactor protein of complement. Biochem. J. 264:581-588.
4. Oglesby, T.J., Allen, C.J., Liszewski, M.K., White, D.J., and Atkinson, J.P. 1992. Membrane cofactor protein (CD46) protects cells from complement-mediated attack by an intrinsic mechanism. J. Exp. Med. 175:1547-1551.
5. Dorig, R.E., Marcil, A., Chopra, A., and Richardson, C.D. 1993. The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell. 75:295-305.
6. Naniche, D., et al. 1993. Human membrane cofactor ptotein (CD46) acts as a cellular receptor for measles virus. J. Virol. 67:6025-6032.
7. Manchester, M., Liszewski, M.K., Atkinson, J.P., and Oldstone, M.B.A. 1994. Multiple isoforms of CD46 (membrane cofactor protein) serve as receptors for measles virus. Proc. Natl. Acad. Sci. U. S. A. 91:2161-2165.
8. Santoro, F., et al. 1999. CD46 is a cellular receptor for human herpesvirus 6. Cell. 99:817-827.
9. Segerman, A., et al. 2003. Adenovirus type 11 uses CD46 as a cellular receptor. J. Virol. 77:9183-9191.
10. Gaggar, A., Shayakhmetov, D.M., and Lieber, A. 2003. CD46 is a cellular receptor for group B adenoviruses. Nat. Med. 9:1408-1412.
11. Okada, N., Liszewski, M.K., Atkinson, J.P., and Caparon, M. 1995. Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus. Proc. Natl. Acad. Sci. U. S. A. 92:2489-2493.
12. Kallstrom, H., Liszewski, M.K., Atkinson, J.P., and Jonsson, A.B. 1997. Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria. Mol. Microbiol. 25:639-647.
13. Riley-Vargas, R.C., and Atkinson, J.P. 2003. Expression of membrane cofactor protein (MCP; CD46) on spermatozoa: just a complement inhibitor? Modern Aspects of Immunobiology. 3:75-78.
14. + cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature. 421:388-392.
15. Richards, A., et al. 2003. Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome. Proc. Natl. Acad. Sci. U. S. A. 100:12966-12971.
16. Noris, M., et al. 2003. Familial haemolytic uraemic syndrome and an MCP mutation. Lancet. 362:1542-1547.
17. Cervoni, F., et al. 1992. Identification and characterization of membrane cofactor protein (MCP) on human spermatozoa. J. Immunol. 148:1431-1437.
18. Riley, R.C., Kemper, C., Leung, M., and Atkinson, J.P. 2002. Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa. Mol. Reprod. Dev. 62:534-546.
19. Anderson, D.J., Michaelson, J.S., and Johnson, P.M. 1989. Trophoblast/leukocyte-common antigen is expressed by human testicular germ cells and appears on the surface of acrosome-reacted sperm. Biol. Reprod. 41:285-293.
20. Fenichel, P., et al. 1990. Localization and characterization of the acrosomal antigen recognized by GB24 on human spermatozoa. Mol. Reprod. Dev. 27:173-178.
21. Kitamura, M., et al. 1997. Possible association of infertility with sperm-specific abnormality of CD46. J. Reprod. Immunol. 33:83-88.
22. Nomura, M., et al. 2001. Genomic analysis of idiopathic infertile patients with sperm-specific depletion of CD46. Exp. Clin. Immunogenet. 18:42-50.
23. Jiang, H., and Pillai, S. 1998. Complement regulatory proteins on the sperm surface: relevance to sperm motility. Am. J. Reprod. Immunol. 39:243-248.
24. Inoue, N., et al. 2003. Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm. Mol. Cell. Biol. 23:2614-2622.
25. Mizuno, M., Harris, C.L., and Morgan, B.P. 2004. Immunohistochemical analysis of membrane complement regulatory proteins in rat testis: unique roles for DAF and MCP in spermatozoal function? Abstracts from the XXth International Complement Workshop, 172. Mol. Immunol. 41:280.
26. Hosokawa, M., Nonaka, M., Okada, N., and Okada, H. 1996. Molecular cloning of guinea pig membrane cofactor protein: preferential expression in testis. J. Immunol. 157:4946-4952.
27. Foley, S., Li, B., Dehoff, M., Molina, M., and Holers, V.M. 1993. Mouse Crry/p65 is a regulator of the alternative pathway of complement activation. Eur. J. Immunol. 23:1381-1384.
28. Xu, C., et al. 2000. A critical role for the murine complement regulator Crry in fetomaternal tolerance. Science. 287:498-501.
29. Anderson, D.J., Abbott, A.F., and Jack, R.M. 1993. The role of complement component C3b and its receptors in sperm-oocyte interaction. Proc. Natl. Acad. Sci. U. S. A. 90:10051-10055.
30. Taylor, C.T., Biljan, M.M., Kingsland, C.R., and Johnson, P.M. 1994. Inhibition of human spermatozoon-oocyte interaction in vitro by monoclonal antibodies to CD46 (membrane cofactor protein). Hum. Reprod. 9:907-911.
31. D'Cruz, O.J., Lambert, H., and Haas, G.G., Jr. 1997. Expression of CD15 (Lewisx) antigen on human sperm and its role in sperm-egg interaction. Am. J. Reprod. Immunol. 37:172-183.
32. Riley, R.C., Tannenbaum, P.L., Abbott, D.H., and Atkinson, J.P. 2002. Cutting edge. Inhibiting measles virus infection but promoting reproduction: an explanation for splicing and tissue-specific expression of CD46. J. Immunol. 169:5405-5409.
33. Hsu, E.G., et al. 1997. Artificial mutations and natural variations in the CD46 molecules from human and monkey cells define regions important for measles virus binding. J. Virol. 71:6144-6154.
34. Adams, E., Brown, M.C., Nunge, M., Krych, M., and Atkinson, J.P. 1991. Contribution of the repeating domains of membrane cofactor protein (CD46) of the complement system to ligand binding and cofactor activity. J. Immunol. 147:3005-3011.
35. Iwata, K., et al. 1995. Diversity of sites for measles virus binding and for inactivation of complement C3b and C4b on membrane cofactor protein CD46. J. Biol. Chem. 270:15148-15152.
36. Vanderpuye, O.A., Labarrere, C.A., and McIntyre, J.A. 1992. The complement system in human reproduction. Am. J. Reprod. Immunol. 27:145-155.
37. Clarke, G.N., Hsieh, C., Koh, S.H., and Cauchi, M.N. 1984. Sperm antibodies, immunoglobulins, and complement in human follicular fluid. Am. J. Reprod. Immunol. 5:179-181.
38. Perricone, R., et al. 1992. Functionally active complement: is present in human ovarian follicular fluid and can be activated by seminal plasma. Clin. Exp. Immunol. 89:154-157.
39. Perricone, R., et al. 1990. Complement, complement activation and anaphylatoxins in human ovarian follicular fluid. Clin. Exp. Immunol. 82:359-362.
40. Cervoni, F., et al. 1993. Expression of decay accelerating factor (CD55) of the complement system on human spermatozoa. J. Immunol. 151:939-948.
41. Fenichel, P., et al. 1994. Expression of the complement regulatory protein CD59 on human spermatozoa: characterization and role in gametic interaction. Mol. Reprod. Dev. 38:338-346.
42. Mold, C., Gewurz, H., and Du Clos, T.W. 1999. Regulation of complement activation by C-reactive protein. Immunopharmacology. 42:23-30.
43. Jilma, B., et al. 1997. Menstrual cycle-associated changes in blood levels of interleukin-6, alpha1 acid glycoprotein, and C-reactive protein. J. Lab. Clin. Med. 130:69-75.
44. Orvieto, R., et al. 2004. C-reactive protein levels in patients undergoing controlled ovarian hyperstimulation for IVF cycle. Hum. Reprod. 19:357-359.
45. Liszweski, M.K., et al. 2000. Dissecting sites important for complement regulatory activity in membrane cofactor protein (MCP; CD46). J. Biol. Chem. 275:37692-37701.
46. Barilla-LaBarca, M.L., Liszewski, M.K., Lambris, J.D., Hourcade, D., and Atkinson, J.P. 2002. Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells. J. Immunol. 168:6298-6304,
47. Gershov, D., Kim, S., Brot, N., and Elkon, K.B. 2000. C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity [erratum 2001, 193:1439]. J. Exp. Med. 192:1353-1364.
48. Vogelpoel, F.R., et al. 1987. Antibody and complement-binding activity of viable and nonviable human spermatozoa. Arch. Androl. 18:189-197.
49. Cervoni, F., et al. 1992. Identification and characterization of membrane cofactor protein on human spermatozoa. J. Immunol. 148:1431-1437.
50. Clark, R.A., and Klebanoff, S.J. 1976. Generation of a neutrophil chemotactic agent by spermatozoa: role of complement and regulation by seminal plasma factors. J. Immunol. 117:1378-1386.
51. Vogelpoel, F.R., and Verhoef, J. 1985. Activation of polymorphonuclear leukocytes by spermatozoa. Arch. Androl. 14:123-131.
52. Lee, Y.-L., et al. 2004. The embryotrophic activity of oviductal cell-derived complement C3b and iC3b, a novel function of complement protein in reproduction. J. Biol. Chem. 279:12763-12768.
53. Wessels, M.R., et al. 1995. Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity. Proc. Natl. Acad. Sci. U. S. A. 92:11490-11494.
54. Circolo, A., et al. 1999. Genetic disruption of the murine complement C3 promoter region generates deficient mice with extrahepatic expression of C3 mRNA. Immunopharmacology. 42:135-149.
55. Fischer, M., et al. 1996. Regulation of the B cell response to T-dependent antigens by classical pathway complement. J. Immunol. 157:549-556.
56. He, Z.Y., et al. 2003. None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion. Dev. Biol. 254:226-237.
57. Schorey, J.S., Carroll, M.C., and Brown, E.J. 1997. A macrophage invasion mechanism of pathogenic mycobacteria. Science. 277:1091-1093.
58. Seya, T., et al. 1991. Preferential inactivation of the C5 convertase of the alternative complement pathway by factor I and membrane cofactor protein (MCP). Mol. Immunol. 28:1137-1147.
59. Kurita-Taniguchi, M., et al. 2002. Molecular assembly of CD46 with CD9, alpha 3-beta 1 integrin and protein tyrosine phosphatase SHP-1 in human macrophages through differentiation by GM-CSF. Mol. Immunol. 38:689-700.
60. Lozahic, S., et al. 2000. CD46 (membrane cofactor protein) associates with multiple beta 1 integrins and tetraspans. Eur. J. Immunol. 30:900-907.
61. LeNaour, F., Rubinstein, E., Jasmin, C., Prenant, M., and Boucheix, C. 2000. Severely reduced female fertility in CD9-deficient mice. Science. 287:319-321.
62. Miyado, K., et al. 2000. Requirement of CD9 on the egg plasma membrane for fertilization. Science. 287:321-324.