Artificial mutations and natural variations in the CD46 molecules from human and monkey cells define regions important for measles virus binding

Journal of Virology

Volumn 71, Issue 8, 1997, Pages 6144-6154

  Hsu, Eric C ^a,b   Dörig, Ruth E ^c,d   Sarangi, Farida ^b   Marcil, Anne ^c   Iorio, Caterina ^b   Richardson, Christopher D ^a,b,e  

^a UNIVERSITY OF TORONTO   (Canada)

^b AMGEN INC   (United States)

^c NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^d MCGILL UNIVERSITY   (Canada)

^e PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE COFACTOR PROTEIN; VIRUS RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BABOON; CERCOPITHECIDAE; CONTROLLED STUDY; ERYTHROCYTE; HUMAN; HUMAN CELL; MACACA; MEASLES VIRUS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RHESUS MONKEY; STRUCTURE ACTIVITY RELATION; VIRUS ADSORPTION; VIRUS CELL INTERACTION;

EID: 1842367272     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.8.6144-6154.1997     Document Type: Article

References (83)

1. Adams, E. M., M. C. Brown, M. Nunge, M. Krych, and J. P. Atkinson. 1991. Contribution of the repeating domains of membrane cofactor protein (MCP; CD46) of the complement system to ligand binding and cofactor activity. J. Immunol. 147:3005-3011.
2. Albrecht, P., D. Lorenz, M. J. Klutch, J. H. Vickers, and F. A. Ennis. 1980. Fatal measles infection in marmosets: pathogenesis and prophylaxis. Infect. Immun. 27:969-978.
3. Albrecht, P., D. Lorenz, and M. J. Klutch. 1981. Encephalitogenicity of measles virus in marmosets. Infect. Immun. 34:581-587.
4. Alkhatib, G., and D. Briedis. 1986. The predicted primary structure of measles virus hemagglutinin. Virology 150:479-490.
5. Arthos, J., K. C. Deen, M. A. Chaikin, J. A. Fornwald, G. Sathe, Q. J. Sattentau, P. R. Clapham, R. A. Weiss, J. S. McDougal, C. Pietropaolo, R. Axel, A. Truneh, P. J. Maddon, and R. W. Sweet. 1989. Identification of the residue in human CD4 critical for the binding of HIV. Cell 57:469-481.
6. Ashkenazi, A., L. G. Presta, S. A. Marsters, T. R. Camerato, K. A. Rosenthal, B. M. Fendly, and D. J. Capon. 1990. Mapping the CD4 binding site for human immunodeficiency virus by alanine-scanning mutagenesis. Proc. Natl. Acad. Sci. USA 87:7150-7154.
7. Barlow, P., A. Steinkasserer, D. B. Norman, B. Kieffer, A. P. Wiles, R. B. Sim, and I. D. Campbell. 1993. Solution structure of a pair of complement modules by nuclear magnetic resonance. J. Mol. Biol. 232:268-284.
8. Bartz, R., U. Brinckmann, L. M. Dunster, B. Rima, V. ter Meulen, and J. Schneider-Schaulies. 1996. Mapping amino acids of the measles virus hemagglutinin responsible for receptor (CD46) down-regulation. Virology 224: 334-337.
9. Bowman, M. R., K. D. MacFerrin, S. L. Schreiber, and S. J. Burakoff. 1990. Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules. Proc. Natl. Acad. Sci. USA 87:9052-9056.
10. Brodsky, M. H., M. Warton, R. M. Myers, and D. R. Littman. 1990. Analysis of the site in CD4 that binds to the HIV envelope glycoprotein. J. Immunol. 144:3078-3086.
11. Buchholz, C. J., U. Schneider, P. Devaux, D. Gerlier, and R. Cattaneo. 1996. Cell entry by measles virus: long hybrid receptors uncouple binding from membrane fusion. J. Virol. 70:3716-3723.
12. Cho, S.-W., T. J. Oglesby, B.-L. Hsi, E. M. Adams, and J. P. Atkinson. 1991. Characterization of three monoclonal antibodies to membrane co-factor protein (MCP) of the complement system and quantification of MCP by radioassay. Clin. Exp. Immunol. 83:257-261.
13. Clayton, L. K., R. E. Hussey, R. Steinbrich, H. Ramachandran, V. Husain, and E. L. Reinherz. 1988. Substitution of murine for human CD4 residues identifies amino acids critical for HIV-gp120 binding. Nature 335:363-366.
14. Devaux, P., B. Loveland, D. Christiansen, J. Milland, and D. Gerlier. 1996. Interactions between the ectodomains of haemagglutinin and CD46 as a primary step in measles virus entry. J. Gen. Virol. 77:1477-1481.
15. Dörig, R. E., A. Marcil, A. Chopra, and C. D. Richardson. 1993. The human CD46 is a receptor for measles virus (Edmonston strain). Cell 75:295-305.
16. Dörig, R. E., A. Marcil, and C. D. Richardson. 1994. CD46, a primate-specific receptor for measles virus. Trends Microbiol. 2:312-318.
17. Earl, P. L., O. Elroy-Stein, and B. Moss. 1995. Expression of proteins in mammalian cells using vaccinia viral vectors, p. 16.15-16.19. In F. M. Ausubel. R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology. John Wiley & Sons, New York, N.Y.
18. Enders-Ruckle, G. 1965. Methods of determining immunity, duration, and character of immunity resulting from measles. Arch. Gesamte Virusforsch. 16:182-207.
19. Fraser, K. B., and S. J. Martin. 1978. Measles virus and its biology. Academic Press Inc. (London), Ltd, London, United Kingdom.
20. Funahashi, S., and T. Kitawaki. 1963. Studies on measles virus hemagglutination. Biken J. 6:73-96.
21. Gerlier, D., B. Loveland, G. Varior-Krishnan, B. Thorley, I. F. C. McKenzie, and C. Rabourdin-Combe. 1994. Measles virus receptor properties are shared by several CD46 isoforms differing in extracellular regions and cytoplasmic tails. J. Gen. Virol. 75:2163-2171.
22. Gerlier, D., G. Varior-Krishnan, and P. Devaux. 1995. CD46-mediated virus entry: a first key to host-range specificity. Trends Microbiol. 3:338-345.
23. Gould, E. A., S. L. Cosby, and P. V. Shirodaria. 1976. Salt-dependent haemagglutinating measles virus in SSPE. J. Gen. Virol. 33:139-142.
24. Graves, M., S. Silver, and P. W. Choppin. 1978. Measles virus polypeptide synthesis in infected cells. Virology 86:254-263.
25. Griffin, D. E., and W. J. Bellini. 1996. Measles virus, p. 1267-1312. In B. N. Fields, D. M. Knipe, P. M. Howley, R. M. Chanock, J. L. Melnick, T. P. Monath, B. Roizman, and S. E. Straus (ed.), Virology, 3rd ed. Lippincott-Raven Publishers, New York, N.Y.
26. Gubler, U., and B. J. Hoffman. 1983. A simple and very efficient method for generating cDNA libraries. Gene 25:263-269.
27. Harlow, E., and D. Lane. 1988. Antibodies: a laboratory manual, p. 55-137. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
28. Hirano, A., S. Yant, K. Iwata, J. Kortesarfaty, T. Seya, S. Nagasawa, and T. C. Wong. 1996. Human cell-receptor CD46 is down-regulated through recognition of a membrane-proximal region of the cytoplasmic domain in persistent measles virus infection. J. Virol. 70:6929-6936.
29. Hsu, E. C., F. Sarangi, and C. D. Richardson. Unpublished data.
30. Iwata, K., T. Seya, Y. Yanagi, J. M. Pesando, P. M. Johnson, M. Okabe, S. Ueda, H. Ariga, and S. Nagasawa. 1995. Diversity of sites for measles virus binding and for inactivation of complement C3b and C4b on membrane cofactor protein CD46. J. Biol. Chem. 270:15148-15152.
31. Jameson, B. A., P. E. Rao, L. I. Kong, B. H. Hahn, G. M. Shaw, L. E. Hood, and S. B. H. Kent. 1988. Location and chemical synthesis of a binding site for HIV-1 on the CD4 protein. Science 240:1335-1339.
32. Karp, C. L., M. Wysocka, L. M. Wahl, J. M. Ahearn, P. J. Cuomo, B. Sherry, G. Trinchieri, and D. E. Griffin. 1996. Mechanism of suppression of cell-mediated immunity by measles virus. Science 273:228-231.
33. Kobune, F., H. Sakata, and A. Sugiura. 1990. Marmoset lymphoblastoid cells as a sensitive host for isolation of measles virus. J. Virol. 64:700-705.
34. Kobune, F., H. Takahashi, K. Terao, T. Ohkawa, Y. Ami, Y. Suzaki, N. Nagata, H. Sakata, K. Yamanouchi, and K. Chieko. 1996. Nonhuman primate models of measles. Lab. Anim. Sci. 46:315-320.
35. Krantic, S., C. Gimenez, and C. Rabourdin-Combe. 1995. Cell-to-cell contact via measles virus haemagglutinin-CD46 interaction triggers CD46 down-regulation. J. Gen. Virol. 76:2793-2800.
36. Lalumiére, M., and C. D. Richardson. 1995. Production of recombinant baculoviruses using rapid screening vectors that contain the gene for β-galactosidase, p. 161-177. In C. D. Richardson (ed.), Baculovirus expression protocols. Humana Press, Totowa, N.J.
37. Lebon, P., A. Protat, and P. Molinie. 1975. L-Arginine elution of measles virus adsorbed on monkey erythrocytes. Infect. Immun. 11:1407-1408.
38. Levy, J. A. 1994. HIV and the pathogenesis of AIDS, p. 35-36. ASM Press, Washington, D.C.
39. Lifson, J. D., K. M. Hwang, P. L. Nara, B. Fraser, M. Padgett, N. M. Dunlop, and L. E. Eiden. 1988. Synthetic CD4 peptide derivatives that inhibit HIV infection and cytopathicity. Science 241:712-716.
40. Liszewski, M. K., T. W. Post, and J. P. Atkinson. 1991. Membrane cofactor protein (MCP of CD46): newest member of the regulators of complement activation gene cluster. Annu. Rev. Immunol. 9:431-455.
41. Liszewski, M. K., and J. P. Atkinson. 1992. Membrane cofactor protein. Curr. Top. Microbiol. Immunol. 178:45-60.
42. Maisner, A., J. Schneider-Schaulies, M. K. Liszewski, J. P. Atkinson, and G. Herrler. 1994. Binding of measles virus to membrane cofactor protein (CD46): importance of disulfide bonds and N-glycans for the receptor function. J. Virol. 68:6299-6304.
43. Maisner, A., and G. Herrler. 1995. Membrane cofactor protein with different types of N-glycans can serve as measles virus receptor. Virology 210:479-481.
44. Maisner, A., M. K. Liszewski, J. P. Atkinson, and G. Herrler. 1996. Oligosaccharide in SCR-2 is required for measles virus binding and infection. J. Virol. 70:4973-4977.
45. Malvoisin, E., and T. F. Wild. 1993. Measles virus glycoproteins: studies on the structure and interaction of the haemagglutinin and fusion proteins. J. Gen. Virol. 74:2365-2372.
46. Manchester, M., M. K. Liszewski, J. P. Atkinson, and M. B. A. Oldstone. 1994. Multiple isoforms of CD46 (membrane cofactor protein) serve as receptors for measles virus. Proc. Natl. Acad. Sci. USA 91:2161-2165.
47. Manchester, M., A. Valsamakis, R. Kaufman, M. K. Liszewski, J. Alvarez, J. P. Atkinson, D. M. Lublin, and M. B. A. Oldstone. 1995. Measles virus and C3 binding sites are distinct on membrane cofactor protein (CD46). Proc. Natl. Acad. Sci. USA 92:2303-2307.
48. Mizukami, T., T. R. Fuerst, E. A. Berger, and B. Moss. 1988. Binding region for human immunodeficiency virus (HIV) and epitopes for HIV-blocking monoclonal antibodies of the CD4 molecule defined by site-directed mutagenesis. Proc. Natl. Acad. Sci. USA 85:9273-9277.
49. Naniche, D., T. F. Wild, C. Rabourdin-Combe, and D. Gerlier. 1993. Measles virus haemagglutinin induces down-regulation of gp57/67, a molecule involved in virus binding. J. Gen. Virol. 74:1073-1079.
50. Naniche, D., G. Varior-Krishnan, F. Cervoni, T. F. Wild, B. Rossi, C. Rabourdin-Combe, and D. Gerlier. 1993. Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus. J. Virol. 67:6025-6032.
51. Napier, J. R., and P. H. Napier. 1994. The natural history of the primates, p. 14. MIT Press, Cambridge, Mass.
52. Nickells, M. W., and J. P. Atkinson. 1990. Characterization of CR1-and membrane cofactor protein-like proteins of two primates. J. Immunol. 144: 4262-4268.
53. Norrby, E. 1962. Hemagglutination by measles virus. I. The production of hemagglutinin in tissue culture and the influence of different conditions on the hemagglutinating system. Arch. Gesamte Virusforsch. 12:153-163.
54. Norrby, E. 1962. Hemagglutination by measles virus. II. Properties of the hemagglutinin and of the receptors on the erythrocytes. Arch. Gesamte Virusforsh. 12:164-172.
55. Norrby, E. 1963. Hemagglutination by measles virus. III. Identification of two different hemagglutinins. Virology 19:147-157.
56. Norrby, E., and M. N. Oxman. 1990. Measles virus, p. 1013-1044. In B. N. Fields, D. M. Knipe, R. M. Chanock, M. S. Hirsch, J. L. Melnick, T. P. Monath, and B. Roizman (ed.), Virology, 2nd ed. Raven Press, New York, N.Y.
57. Periés, J. R., and C. Chany. 1961. Activité hémagglutinante et hémolytique du virus morbilleux. C. R. Acad. Sci. 251:820-821.
58. Periés, J. R., and C. Chany. 1961. Mécanisme de l'action hémagglutinante des cultures de virus morbilleux. C. R. Acad. Sci. 252:2956-2957.
59. Periés, J. R., and C. Chany. 1962. Studies on measles viral hemagglutination. Proc. Soc. Exp. Biol. Med. 110:477-482.
60. Peterson, A., and B. Seed. 1988. Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4. Cell 54:65-72.
61. Petty, K. J. 1995. Metal-chelate affinity chromatography, p. 10.11.10-10.11.24. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular virology. John Wiley & Sons, New York, N.Y.
62. Post, T. W., M. K. Liszewski, E. M. Adams, I. Tedja, E. A. Miller, and J. P. Atkinson. 1991. Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produce multiple isoforms that correlate with protein phenotype. J. Exp. Med. 174:93-102.
63. Purcell, D. F. J., S. M. Russell, N. J. Deacon, M. A. Brown, D. J. Hooker, and I. F. C. McKenzie. 1991. Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation. Immunogenetics 33:335-344.
64. Repke, H., D. Gabuzda, G. Palu, R. Emmrich, and J. Sodrosky. 1992. Effect of CD4 synthetic peptides on HIV type 1 envelope glycoprotein function. J. Immunol. 149:1809-1816.
65. Richardson, C. D., A. Scheid, and P. W. Choppin. 1980. Specific inhibition of paramyxovirus and myxovirus replication by oligopeptides with ammo acid sequences similar to those at the N-termini of F1 and HA2 viral polypeptides. Virology 105:205-222.
66. Richardson, C. D., A. Berkovich, S. Rozenblatt, and W. J. Bellini. 1985. Use of antibodies directed against synthetic peptides for identifying cDNA clones, establishing reading frames, and deducing the gene order of measles virus. J. Virol. 54:186-193.
67. Richardson, C. D., D. Hull, P. Greer, K. Hasel, A. Berkovich, G. Englund, W. Bellini, B. Rima, and R. Lazzarini. 1986. The nucleotide sequence of the mRNA encoding the fusion protein of measles virus (Edmonston strain): a comparison of fusion proteins from several different paramyxoviruses. Virology 155:508-523.
68. Richardson, C. D., M. Banville, M. Lalumiére, J. Vialard, and E. A. Meighen. 1992. Bacterial luciferase produced with rapid screening baculovirus vectors is a sensitive reporter for infection of insect cells and larvae. Intervirology 34:213-227.
69. Rosanoff, E. I. 1961. Hemagglutination and hemadsorption of measles virus. Proc. Soc. Exp. Biol. Med. 106:563-567.
70. Rota, J. S., K. B. Hummel, P. A. Rota, and W. J. Bellini. 1992. Genetic variability of the glycoprotein genes of current wild-type measles isolates. Virology 188:135-142.
71. Russell, S. M., R. L. Sparrow, I. F. McKenzie, and D. F. Purcell. 1992. Tissue-specific and allelic expression of the complement regulator CD46 is controlled by alternative splicing. Eur. J. Immunol. 22:1513-1518.
72. Sattentau, Q. J., A. G. Dalgleish, R. A. Weiss, and P. C. L. Beverley. 1986. Epitopes of the CD4 antigen and HIV infection. Science 234:1120-1123.
73. Schneider-Schaulies J., L. M. Dunster, F. Kobune, B. Rima, and V. ter Meulen. 1995. Differential downregulation of CD46 by measles virus strains. J. Virol. 69:7257-7259.
74. Schneider-Schaulies, J., J.-J. Schnorr, U. Brinnckmann, L. M. Dunster, K. Baczko, U. G. Liebert, S. Schneider-Schaulies, and V. ter Meulen. 1995. Receptor usage and differential downregulation of CD46 by measles virus wild-type and vaccine strains. Proc. Natl. Acad. Sci. USA 92:3943-3947.
75. Schneider-Schaulies, J., J.-J. Schnorr, J. Schlender, L. M. Dunster, S. Schneider-Schaulies, and V. ter Meulen. 1996. Receptor (CD46) modulation and complement-mediated lysis of uninfected cells after contact with measles virus-infected cells. J. Virol. 70:255-263.
76. Shirodaria, P. V., E. Dermott, and E. A. Gould. 1976. Some characteristics of salt-dependent haemagglutinating measles viruses. J. Gen. Virol. 33:107-115.
77. Tabor, S., and C. C. Richardson. 1985. A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. Proc. Natl. Acad. Sci. USA 82:1074-1078.
78. ter Meulen, V., and M. A. Billeter. 1995. Measles virus. Curr. Top. Microbiol. Immunol. 191:1-192.
79. Tsui, P., R. W. Sweet, G. Sathe, and M. Rosenberg. 1992. An efficient phage plaque screen for the random mutational analysis of the interaction of HIV-1 gp120 with human CD4. J. Biol. Chem. 267:9361-9367.
80. Vialard, J., M. Lalumiere, T. Vernet, D. Briedis, G. Alkhatib, D. Henning, D. Levin, and C. D. Richardson. 1990. Synthesis of the membrane fusion and hemagglutinin proteins of measles virus, using a novel baculovirus vector containing the β-galactosidase gene. J. Virol. 64:37-50.
81. Vialard, J. E., and C. D. Richardson. 1993. The 1,629-nucleotide open reading frame located downstream of the Autographa californica nuclear polyhedrosis virus polyhedrin gene encodes a nucleocapsid-associated phosphoprotein. J. Virol. 67:5859-5866.
82. Wild, T. F., E. Malvoisin, and R. Buckland. 1991. Measles virus: both the haemagglutinin and fusion glycoproteins are required for fusion. J. Gen. Virol. 72:439-442.
83. Zhang, X., M. Gaubin, L. Briant, V. Srikantan, R. Murali, U. Saragovi, D. Weiner, C. Devaux, M. Autiero, D. Piatier-Tonneau, and M. I. Greene. 1997. Synthetic CD4 exocyclics inhibit binding of human immunodeficiency virus type 1 envelope to CD4 and virus replication in T lymphocytes. Nat. Biotech. 15:150-154.