Transgenic mouse model of stunned myocardium

Science

Volumn 287, Issue 5452, 2000, Pages 488-491

  Murphy, Anne M ^a   Kögler, Harald ^a   Georgakopoulos, Dimitrios ^a   McDonough, Jason L ^b   Kass, David A ^a   Van Eyk, Jennifer E ^b   Marbán, Eduardo ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ALPHA ACTIN; MESSENGER RNA; MYOSIN HEAVY CHAIN; TROPONIN I;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; HEART FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CONTRACTILITY; HUMAN; HUMAN TISSUE; MOUSE; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; STUNNED HEART MUSCLE; TRANSGENIC MOUSE;

ADRENERGIC BETA-AGONISTS; ANIMALS; CALCIUM; CARDIOMEGALY; DILATATION, PATHOLOGIC; DISEASE MODELS, ANIMAL; HEART RATE; HEART VENTRICLES; HUMANS; ISOPROTERENOL; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROFILAMENTS; MYOCARDIAL CONTRACTION; MYOCARDIAL STUNNING; MYOCARDIUM; MYOFIBRILS; TROPONIN I; VENTRICULAR FUNCTION, LEFT;

ANIMALIA; MUS MUSCULUS;

EID: 17944384116     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.287.5452.488     Document Type: Article

References (43)

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43. The care of the animals and participation of human subjects in this study was in accordance with institutional and IACUC (Institutional Animal Care and Use Committee) guidelines. We thank J. Robinson and L. Jones for technical assistance, R. Hruban for reviewing the cardiac pathology, C. Ropchan for obtaining the human samples, D. Judge and J. Weiss for assistance with the echocardiography, and M. J. Murphy for support. Supported by an American Heart Association grant-in-aid and NIH grant HL 63038 to A.M.M., NIH grant HL 44065 and the Michel Mirowski M.D. Professorship of Cardiology to E.M., grant KO1873/1-1 of the Deutsche Forschungsgemeinschaft to H.K., and a Heart and Stroke Foundation of Canada (T-3759) and Medical Research Council of Canada (MT-14375) to J.E.V.E., who is an Ontario Heart and Stroke Scholar. J.L.M. is a Heart and Stroke Foundation of Canada Research Trainee.