Enhanced ability of danispletim and myelopoietin-1 to suppress apoptosis in human hematopoietic cells

Leukemia

Volumn 15, Issue 8, 2001, Pages 1203-1216

  McCubrey, J A ^a   Blalock, W L ^a   Saleh, O ^a   Pearce, M ^a   Burrows, C ^a   Steelman, L S ^a   Lee, J T ^a   Franklin, R A ^a   Oberhaus, S M ^a   Moye, P W ^a   Doshi, P D ^b   McKearn, J P ^b  

^a EAST CAROLINA UNIVERSITY   (United States)

^b PFIZER INC   (United States)

Author keywords

Apoptosis; Cytokines; Redox potential; Signal transduction

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOKINE; DANIPLESTIM; FREE RADICAL; LIPOCORTIN 5; MYELOPOIETIN 1; PROPIDIUM IODIDE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 3; UNCLASSIFIED DRUG; HEMOPOIETIC GROWTH FACTOR; HYBRID PROTEIN; INTERLEUKIN 3; MYELOPOIETIN; PEPTIDE;

APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL LINE; CELL POPULATION; CELL RESPIRATION; CONTROLLED STUDY; DRUG EFFECT; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NICK END LABELING; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; CELL DIFFERENTIATION; CELL LINEAGE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; PATHOLOGY; STEM CELL MOBILIZATION;

APOPTOSIS; CELL DIFFERENTIATION; CELL LINEAGE; GRANULOCYTE COLONY STIMULATING FACTOR, RECOMBINANT; HEMATOPOIESIS; HEMATOPOIETIC CELL GROWTH FACTORS; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; INTERLEUKIN-3; PEPTIDES; RECOMBINANT FUSION PROTEINS;

EID: 17944368285     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402167     Document Type: Article

References (49)

1. Signal transduction, cell cycle regulatory and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: Possible sites for intervention with anti-neoplastic drugs
2. The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors
3. Heat shock proteins - Modulators of apoptosis in tumour cells
4. Cell death beyond apoptosis
5. Suppression of apoptosis: Role in cell growth and neoplasia
6. Drug-resistance enables selective killing of resistant leukemia cells: Exploiting of drug resistance instead of reversal
7. Apoptosis: The biochemistry and molecular biology of programmed cell death
8. Apoptosis: Mechanisms and roles in pathology
9. Exposure of phosphatidyl serine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
10. Serine/threonine phosphorylation in cytokine signal transduction
11. Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors
12. Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines
13. Mitogen-activated protein kinase pathway is dispensable for microtubule-active drug-induced Raf-1/Bcl-2 phosphorylation and apoptosis in leukemic cells
14. Serine phosphorylation of death agonist Bad in response to survival factor results in binding to 14-3-3 not Bcl-xL
15. Kinases: Positive and negative regulators of apoptosis
16. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
17. Acceleration of hematopoietic reconstitution with a synthetic cytokine (SC-55494) after radiation-induced bone marrow aplasia
18. Saturation mutagenesis of human interleukin-3
19. Potent interleukin 3 receptor agonist with selectively enhanced hematopoietic activity relative to recombinant human interleukin 3
20. The receptor binding site of human interleukin-3 defined by mutagenesis and molecular modeling
21. Phage presentation and affinity selection of a deletion mutant of human interleukin-3
22. Multiple conformations of a human interleukin-3 variant
23. Administration of daniplestim and granulocyte colony-stimulating factor for the mobilization of hematopoietic progenitor cells in nonhuman primates
24. Combination therapy for radiation-induced bone marrow aplasia in nonhuman primates using synthokine SC-55494 and recombinant human granulocyte colony-stimulating factor
25. Circular permutation of the granulocyte colony-stimulating factor receptor agonist domain of myelopoietin
26. Circular permutation of granulocyte colony-stimulating factor
27. Myelopoietin, a chimeric agonist of human interleukin 3 and granulocyte colony-stimulating factor receptors, mobilizes CD34+ cells that rapidly engraft lethally x-irradiated nonhuman primates
28. Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells
29. Oncogenic effects of overexpression of the interleukin-3 receptor on hematopoietic cells
30. Differential effects of retroviral long terminal repeats on interleukin-3 gene expression and autocrine transformation
31. Characterization of proteins binding specifically to the interleukin 3 (IL-3) mRNA 3′ untranslated region in IL-3-dependent and autocrine transformed cells
32. Synergy between Raf and BCL2 in abrogating the cytokine-dependency of hematopoietic cells
33. Differential abilities of activated Raf oncoproteins to abrogate cytokine-dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells
34. Effects of deregulated Raf activation on integrin and cytokine-receptor expression and the induction of apoptosis in hematopoietic cells
35. Diptheria toxin fused to human interleukin-3 is toxic to blasts from patients with myeloid leukemias
36. Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine-dependency of human and murine hematopoietic cells
37. Differential abilities of the Raf family of protein kinases to abrogate cytokine-dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism
38. + bone marrow cells
39. Apoptotic regulation in primitive hematopoietic precursors
40. Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells
41. Phosphatidylinositol 3-kinase is involved in the protection of primary cultured human erythroid precursor cells from apoptosis
42. Role of intracellular redox status in apoptosis induction of human T-cell leukemia virus type 1-infected lymphocytes by 13-cis-retinoic acid
43. Isolation and characterization of daunorubicin-resistant AML-2 sublines
44. Receptor binding and signaling characteristics of MPO-1 (SC-68420) - Multifunctional IL-3 and G-CSF receptor agonist
45. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB
46. Involvement of two NF-kappa B binding elements in tumor necrosis factor alpha-, CD40-, and Epstein-Barr virus latent membrane protein l-mediated induction of the cellular inhibitor of apoptosis protein 2 gene
47. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor
48. Functions of lipid rafts in biological membranes
49. Functional rafts in cell membranes