Myelopoietin, a chimeric agonist of human interleukin 3 and granulocyte colony-stimulating factor receptors, mobilizes CD34+ cells that rapidly engraft lethally X-irradiated nonhuman primates

Experimental Hematology

Volumn 27, Issue 10, 1999, Pages 1557-1568

  MacVittie, Thomas J ^a   Farese, Ann M ^a   Davis, Thomas A ^b   Lind, Lisa B ^a   McKearn, John P ^c  

^a UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTER   (United States)

^b NAVAL MEDICAL RESEARCH INSTITUTE   (United States)

^c MONSANTO COMPANY   (United States)

Author keywords

CD34+ cells; Leukapheresis; Mobilization; Myelopoietin; Nonhuman primate; Transplantation

Indexed keywords

CD34 ANTIGEN; COLONY STIMULATING FACTOR RECEPTOR; CYTOKINE; DANIPLESTIM; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 3 RECEPTOR; MYELOPOIETIN; SC 55494; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COLONY FORMING CELL; COLONY FORMING UNIT GM; CONTROLLED STUDY; HEMATOPOIESIS; IMMUNOPHENOTYPING; LEUKAPHERESIS; MALE; MEGAKARYOCYTE; NONHUMAN; PRIMATE; PRIORITY JOURNAL; RHESUS MONKEY; SUBCUTANEOUS DRUG ADMINISTRATION; X IRRADIATION;

ANIMALS; ANTIGENS, CD34; AREA UNDER CURVE; BLOOD CELL COUNT; CELL DIVISION; DRUG COMBINATIONS; FILGRASTIM; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; INTERLEUKIN-3; LEUKOCYTES; MACACA MULATTA; MALE; PEPTIDES; RECEPTORS, GRANULOCYTE COLONY-STIMULATING FACTOR; RECEPTORS, INTERLEUKIN-3; RECOMBINANT FUSION PROTEINS; TIME FACTORS; TRANSPLANTATION CONDITIONING;

EID: 0032836512     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(99)00092-2     Document Type: Article

References (67)

1. Siena S., Bregni M., Brando B., Ravagnani F., Bonadonna G., Gianni A.M. Circulation of CD34-positive hematopoietic stem cells in peripheral blood of high-dose cyclophosphamide treated patients. enhancement by intravenous recombinant human GM-CSF Blood. 74:1989;1905.
2. Sheridan W.P., Begley G., Juttner C.A., Szer J., To L.B., Maher D., McGrath K.M., Morstyn G., Fox R.M. Effect of peripheral blood progenitor cells mobilized by filgrastim (G-CSF) on platelet recovery after high dose chemotherapy. Lancet. 339:1992;640.
3. Chao N.J., Schriber J.R., Grimes K., Long G.D., Negrin R.S., Raimondi C.M., Horning S.J., Brown S.L., Miller L., Blume K.G. Granulocyte colony-stimulating factor "mobilized" peripheral blood progenitor cells accelerate granulocyte and platelet recovery after high-dose chemotherapy. Blood. 81:1993;2031.
4. Korbling M., Przepiorka D., Huh Y.O., Engel H., van Besien K., Giralt S., Andersson B., Kleine H.D., Seong D., Deisseroth A.B., Andreeff M., Champlin R. Allogeneic blood stem cell transplantation for refractory leukemia and lymphoma. potential advantage of blood over marrow allografts Blood. 85:1995;1659.
5. Bensinger W.I., Weaver C.H., Appelbaum F.R., Rowley S., Demirer T., Sanders J., Storb R., Buckner C.D. Transplantation of allogeneic peripheral blood stem cells mobilized by recombinant human granulocyte colony stimulating factor. Blood. 85:1995;1655.
6. Schmitz N., Dreger P., Suttorp M., Rohwedder E.B., Haferlach T., Loffler H., Hunter A., Russell N.H. Primary transplantation of allogeneic peripheral blood progenitor cells mobilized by Filgrastim (granulocyte colony stimulating factor). Blood. 85:1995;1666.
7. To L.B., Dyson P.G., Branford A.L. Peripheral blood stem cells collected in very early remission produce rapid and sustained autologous haemopoietic reconstitution in acute non-lymphoblastic leukemia. Bone Marrow Transplant. 2:1987;103.
8. Schwartzberg L., Birch R., Blanco R., Wittlin F., Muscato J., Tauer K. Rapid and sustained hematopoietic reconstitution by peripheral blood stem cell infusion alone following high-dose chemotherapy. Bone Marrow Transplant. 11:1993;369.
9. Schwartzberg L.S., Birch R., Hazelton B., Tauer K.W., Lee P., Altemose R. Peripheral blood stem cell mobilization by chemotherapy with and without recombinant human granulocyte colony-stimulating factor. J Hematother. 1:1992;317.
10. Elias A.D., Ayash L., Anderson K.C., Hunt M., Wheeler C., Schwartz G., Tepler I., Mazanet R., Lynch C., Pap S., Pelaez J., Reich E.et al. Mobilization of peripheral blood progenitor cells by chemotherapy and granulocyte-macrophage colony-stimulating factor for hematologic support after high-dose intensification for breast cancer. Blood. 79:1992;3036.
11. Haas R., Ho A.D., Bredthauer U., Cayeux S., Egerer G., Knauf W., Hunstein W. Successful autologous transplantation of blood stem cells mobilized with recombinant human granulocyte-macrophage colony-stimulating factor. Exp Hematol. 18:1990;94.
12. To L.B., Sheppard K.M., Haylock D.N., Dyson P.G., Charles P., Thorp D.L., Dale B.M., Dart G.W., Roberts M.M., Sage R.E. Single high doses of cyclophosphamide enable the collection of high numbers of hemopoietic stem cells from the peripheral blood. Exp Hematol. 18:1990;442.
13. Socinski M.A., Elias A., Schnipper L., Cannistra S.A., Antman K.S., Griffin J.D. Granulocyte-macrophage colony stimulating factor expands the circulating haemopoietic progenitor cell compartment in man. Lancet. 5:1988;1194.
14. Lane T.A., Law P., Maruyama M., Young D., Burgess J., Mullen M., Mealiffe M., Terstappen L.W.M.M., Hardwick A., Moubayed M., Oldham F.et al. Harvesting and enrichment of hematooietic progenitor cells mobilized into the peripheral blood of normal donors by granulocyte-macrophage colony-stimulating factor (GM-CSF) or G- CSF. potential role in allogeneic marrow transplantation Blood. 85:1995;275.
15. Gasparetto C., Smith C., Gillio A., Stoppa A.M., Moore M.A.S., O'Reilly R.J. Enrichment of peripheral blood stem cells in a primate model following administration of a single dose of rh-IL-1. Bone Marrow Transplant. 14:1994;717.
16. Geissler K., Peschel C., Niederwieser D., Strobl H., Goldschmitt J., Ohler L., Bettelheim P., Kalhs P., Huber C., Lechner K., Hocker P., Kolbe K. Potentiation of granulocyte colony-stimulating factor-induced mobilization of circulating progenitor cells by seven-day pretreatment with interleukin-3. Blood. 87:1996;2732.
17. Brugger W., Bross K., Frisch J., Dern P., Weber B., Mertelsmann R., Kanz L. Mobilization of peripheral blood progenitor cells by sequential administration of interleukin-3 and granulocyte-macrophage colony stimulating factor following polychemotherapy with etoposide, ifosfamide, and cisplatin. Blood. 79:1992;1193.
18. Gianni A.M., Siena S., Bregni M., Tarella C., Stern A.C., Pileri A., Bonadonna G. Granulocyte-macrophage colony-stimulating factor to harvest circulating haematopoietic stem cells for autotransplantation. Lancet. 2:1989;580.
19. Donahue R.E., Kirby M.R., Metzger M.E., Agricola B.A., Sellers S.E., Cullis H.M. Peripheral blood CD34+ cells differ from bone marrow CD34+ cells in Thy-1 expression and cell cycle status in nonhuman primates mobilized or not mobilized with granulocyte colony-stimulating factor and/or stem cell factor. Blood. 87:1996;1644.
20. Moskowitz C.H., Stiff P., Gordon M.S., McNiece I., Ho A.D., Costa J.J., Broun E.R., Bayer R.A., Wyres M., Hill J., Jelaca-Maxwell K., Nichols C.R.et al. Recombinant methionyl human stem cell factor and filgrastim for peripheral blood progenitor cell mobilization and transplantation in non-Hodgkin's lymphoma patients. results of a phase I/II trial Blood. 89:1997;3136.
21. McNiece I.K., Briddell R.A., Hartley C.A., Smith K.A., Andrews R.G. Stem cell factor enhances in vivo effects of granulocyte colony stimulating factor for stimulating mobilization of peripheral blood progenitor cells. Stem Cells. 11:1993;36.
22. Geissler K., Valent P., Mayer P., Liehl E., Hinterberger W., Lechner K., Bettelheim P. Recombinant human IL-3 expands the pool of circulating hematopoietic progenitor cells in primates. Synergism with recombinant human granulocyte-macrophage colony stimulating factor. Blood. 75:1990;2305.
23. Andrews R.G., Briddell R.A., Knitter G.H., Opie T., Bronsden M., Myerson D., Appelbaum F.R., McNiece I.K. In vivo synergy between recombinant human stem cell factor and recombinant human granulocyte colony-stimulating factor in baboons. enhanced circulation of progenitor cells Blood. 84:1994;800.
24. Mauch P., Lamont C., Neben T.Y., Quinto C., Goldman S.J., Witsell A. Hematopoietic stem cells in the blood after stem cell factor and interleukin-11 administration. evidence for different mechanisms of mobilization Blood. 86:1995;4674.
25. Sudo Y., Shimazaki C., Ashihara E., Kikuta T., Hirai H., Sumikuma T., Yamagata N., Goto H., Inaba T., Fujita N., Nakagawa M. Synergistic effect of FLT-3 ligand on the granulocyte colony-stimulating factor-induced mobilization of hematopoietic stem cells and progenitor cells into blood in mice. Blood. 89:1997;3186.
26. Molineux G., McCrea C., Yan X.-Q., Kerzic P., McNiece I. Flt-3 ligand synergizes with granulocyte colony-stimulating factor to increase neutrophil numbers and to mobilize peripheral blood stem cells with long-term repopulating potential. Blood. 89:1997;3998.
27. Brasel K., McKenna H.J., Charrier K., Morrissey P.J., Williams D.E., Lyman S.D. Flt3 ligand synergizes with granulocyte-macrophage colony-stimulating factor or granulocyte colony-stimulating factor to mobilize hematopoietic progenitor cells into the peripheral blood of mice. Blood. 90:1997;3781.
28. Papayannopoulou T., Nakamoto B., Andrews R.G., Lyman S.D., Lee M.Y. In vivo effects of Flt3/Flk2 ligand on mobilization of hematopoietic progenitors in primates and potent synergistic enhancement with granulocyte colony-stimulating factor. Blood. 90:1997;620.
29. Laterveer L., Lindley I.J.D., Heemskerk D.P.M., Camps J.A.J., Pauwels E.K.J., Willemze R., Fibbe W.E. Rapid mobilization of hematopoietic progenitor cells in rhesus monkeys by a single intravenous injection of interleukin-8. Blood. 87:1996;781.
30. Laterveer L., Zijlmans J.M.J.M., Lindley I.J.D., Hamilton M.S., Willemze R., Fibbe W.E. Improved survival of lethally irradiated recipient mice transplanted with circulating progenitor cells mobilized by IL-8 after pretreatment with stem cell factor. Exp Hematol. 24:1996;1387.
31. Monahan J.B., Hood W.F., Joy W.D., Caparon M.H., Paik K., Goldberg S.B., Klein B.K., Staten N.R., Pegg L.E., Bauer S.C., Mina M.S., Abrams M.A.et al. Functional characterization of SC 68420 - a multifunctional agonist which activates both IL3 and G-CSF receptors. Blood. 86:1995;154a. (abstr).
32. McKearn J.P., Hood W.F., Monahan J.B., Joy W.D., Caparon M.H., Paik K., Bauer S.C., Lee S.C., Goldberg S.B., Klein B.K., Staten N.R., Pegg L.E.et al. Myelopoietin - a multifunctional agonist of human IL-3 and G-CSF receptors. Blood. 86:1995;259a. (abstr).
33. Kahn L.E., Farese A.M., MacVittie T.J., Strauss-Schoenberger N.J., Minster N.I., Lind L.B., McKearn J.P., Streeter P.R. Progenipoietin-G promotes in vivo expansion of hematopoietic progenitor cells in mice and nonhuman primates. Blood. 90:1997;58a. (abstr).
34. Thomas J.W., Baum C.M., Hood W.F., Klein B., Monahan J.B., Paik K., Staten N., Abrams M., McKearn J.P. Potent interleukin 3 receptor agonist with selectively enhanced hematopoietic activity relative to recombinant human interleukin 3. Proc Natl Acad Sci U S A. 92:1995;3779.
35. The Institute of Laboratory Animal Resources, National Research Council. Guide for the Care and Use of Laboratory Animals. Washington, DC: National Institutes of Health, 86-23.
36. van Gils F., Budel L., Burger H., van Leen R., Lowenberg B., Wagemaker G. Interleukin-3 (IL-3) receptors on rhesus monkey cells. species specificity of human IL-3, binding characteristics, and lack of competition with GM-CSF Exp Hematol. 22:1994;248.
37. Burger H., van Leen R., Dorssers L.C.J., Persoon N.L.M., Wagemaker G. Species specificity of human interleukin-3 demonstrated by cloning and expression of the homologous rhesus monkey (Macaca mulatta) gene. Blood. 76:1990;2229.
38. Klein B., Thomas J., Klover J., Shieh J.J., Donnelly A., Abegg A., Dacquel-Smith L., Webster H., Farese A., MacVittie T., McKearn J. Comparison of daniplestim and human interleukin-3. impact of structure on functional activity Blood. 92:1998;174b. (abstr).
39. Farese A.M., Herodin F., Grab L.B., Varma N., Baum C., Burton E., McKearn J.P., MacVittie T.J. Therapeutic efficacy of synthokine SC-55494 in a nonhuman primate model of high dose, sublethal, radiation-induced marrow aplasia. Blood. 84:1994;28a. (abstr).
40. Andrews R.G., Briddell R.A., Knitter G.H., Rowley S.D., Appelbaum F.R., McNiece I. Rapid engraftment by peripheral blood progenitor cells mobilized by recombinant human stem cell factor and recombinant human granulocyte colony-stimulating factor in nonhuman primates. Blood. 85:1995;15.
41. Farese A.M., Herodin F., Grab L.B., Varma N., Baum C., Burton E., McKearn J.P., MacVittie T.J. Acceleration of hematopoietic reconstitution with a synthetic cytokine (SC-55494) after radiation-induced marrow aplasia. Blood. 87:1996;581.
42. Yan X.-Q., Briddell R., Hartley C., Stoney G., Samal B., McNiece I. Mobilization of long-term hematopoietic reconstituting cells in mice by the combination of stem cell factor plus granulcoyte colony-stimulating factor. Blood. 84:1994;795.
43. Glaspy J., McNiece I., LeMaistre F., Menchaca D., Briddell R.A., Lill M., Jones R., Tami J., Morstyn G., Brown S., Shpall E.J. Effects of stem cell factor (rhSCF) and Filgrastim (rhG-CSF) on the mobilization of peripheral blood progenitor cells (PBPC) and hematological recovery post transplant. preliminary phase I/II study results Br J Haematol. 87:1994;156.
44. Begley C.G., Basser R., Mansfield R., Thompson B., Parker J., Layton J., To B., Cebon J., Sheridan W.P., Fox R.M., Green M.D. Enhanced levels and enhanced clonogenic capacity of blood progenitor cells following administration of stem cell factor plus granulocyte colony-stimulating factor to humans. Blood. 90:1997;3378.
45. Shpall E., Wheeler C.A., Turner S.A., Yanovich S., Brown R.A., Pecora A.L., Shea T.C., Mangan K.F., Williams S.F., LeMaistre C.F., Long G.D., Jones R.et al. A randomized phase 3 study of peripheral blood progenitor cell mobilization with stem cell factor and filgrastim in high-risk breast cancer patients. Blood. 93:1999;2491.
46. Basser R., To L.B., Begley C.G., Maher D., Juttner C., Cebon J., Mansfield R., Duggan G., Szer J., Collins J., Schwartz B., Marty J.et al. Rapid hematopoietic recovery after multicycle high-dose chemotherapy. enhancement of filgrastim-induced progenitor-cell mobilization by recombinant human stem-cell factor J Clin Oncol. 16:1998;1899.
47. Weaver C.H., Hazelton B., Birch R., Palmer P., Allen C., Schwartzberg L., West W. An analysis of the engraftment kinetics as a function of the CD34 content of peripheral blood progenitor cell collections in 692 patients after the administration of myeloablative chemotherapy. Blood. 86:1995;3961.
48. Kiss J.E., Rybka W.B., Winkelstein A., deMagalhaes-Silverman M., Lister J., D'Andrea P., Ball E.D. Relationship of CD34+ cell dose to early and late hematopoiesis following autologous peripheral blood stem cell transplantation. Bone Marrow Transplant. 19:1997;303.
49. Dercksen M.W., Rodenhuis S., Dirkson M.K.A., Schaasberg W.P., Baars J.W., van der Wall E., Slaper-Cortenbach I.C.M., Pinedo H.M., Von dem Borne A.E.G., van der Schoot C.E., Gerritsen W.R. Subsets of CD34+ cells and rapid hematopoietic recovery after peripheral blood stem cell transplantation. J Clin Oncol. 13:1995;1922.
50. Bertolini F., Battaglia M., Pedrazzoli P., Da Prada G.A., Lanza A., Soligo D., Caneva L., Sarina B., Murphy S., Thomas T., della Cuna G.R. Megakaryocytic progenitors can be generated ex vivo and safely administered to autologous peripheral blood progentior cell transplant recipients. Blood. 89:1997;2679.
51. Gehling U.M., Ryder J.W., Hogan C.J., Hami L., McNiece I., Franklin W., Williams S., Helm K., King J., Shpall E.J. Ex vivo expansion of megakaryocyte progenitors. effect of various growth factor combinations on CD34+ progenitor cells from bone marrow and G-CSF-mobilized peripheral blood Exp Hematol. 25:1997;1125.
52. Emerson S.G. Ex vivo expansion of hematopoietic precursors, progenitors, and stem cells. the next generation of cellular therapeutics Blood. 87:1996;3082.
53. Haylock D.N., To L.B., Dowse T.L., Juttner C.A., Simmons P.J. Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage. Blood. 80:1992;1405.
54. Strunk D., Rappersberger K., Egger C., Strobl H., Kromer E., Elbe A., Maurer D., Stingl G. Generation of human dendritic cells/Langerhans cells from circulating CD34+ hematopoieitic progenitor cells. Blood. 87:1996;1292.
55. Szabolcs P., Moore M.A.S., Young J.W. Expansion of immunostimulatory dendritic cells among the myeloid progeny of human CD34+ bone marrow precursors cultured with c-kit ligand, granulocyte-macrophage colony-stimulating factors, and TNF-α J Immunol. 154:1995;5851.
56. Duhrsen U., Villeval J.-L., Boyd J., Kannourakis G., Morstyn G., Metcalf D. Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients. Blood. 72:1988;2074.
57. Siena S., Bregni M., Bonsi L., Sklenar I., Bagnara G.P., Bonadonna G., Gianni A.M. An increase in peripheral blood megakaryocyte progentors following cancer therapy with high-dose cyclophosphamide and hematopoietic growth factors. Exp Hematol. 21:1993;1583.
58. Dyson P.G., Jackson K.A., McClure B.J., Rawling T.P., To L.B. Increased levels of megakaryocyte progenitors in peripheral blood mobilised by chemotherapy and/or haemopoietic growth factor protocols. Bone Marrow Transplant. 18:1996;705.
59. Takamatsu Y., Harada M., Teshima T., Makino S., Inaba S., Akashi K., Shibuya T., Niho Y. Relationship of infused CFU-GM and CFU-Mk mobilised by chemotherapy with or without G-CSF to platelet recovery after autologous blood stem cell transplantation. Exp Hematol. 23:1995;8.
60. Grigg A.P., Roberts A.W., Raunow H., Houghton S., Layton J.E., Boyd A.W., McGrath K.M., Maher D. Optimizing dose and scheduling of filgrastim (granulocyte colony-stimulating factor) for mobilization and collection of peripheral blood progenitor cells in normal volunteers. Blood. 86:1995;4437.
61. Tanaka R., Matsudaira T., Aizawa J., Ebihara Y., Muraoka K., Tsuji K., Ikebuchi K., Kodama K., Takaku F., Nakahata T. Characterization of peripheral blood progenitor cells (PBPC) mobilized by filgrastim (rHuG-CSF) in normal volunteers. dose-effect relationship for filgrastim with the character of mobilized PBPC Br J Haematol. 92:1996;795.
62. Prosper F., Stroncek D., McCarthy J.B., Verfaillie C.M. Mobilization and homing of peripheral blood progenitors is related to reversible downregulation of α4β1 integrin expression and function. J Clin Invest. 101:1998;2456.
63. 2/M phases of the cell cycle. Blood. 92:1998;842.
64. Leavesley D.I., Oliver J.M., Swart B.W., Berndt M.C., Haylock D.N., Simmons P.J. Signals from platelet/endothelial cell adhesion molecule enhance the adhesive activity of the very late antigen-4 integrin of human CD34+ hemopoietic progenitor cells. J Immunol. 153:1994;4673.
65. Papayannopoulou T., Priestley G.V., Nakamoto B. Anti-VLA4/VCAM-1-induced mobilization requires cooperative signaling through the kit/mkit ligand pathway. Blood. 91:1998;2231.
66. Woulfe S.L., Streeter P.R., Kahn L.E., Minster N.I., MacVittie T.J., Farese A.M., McKearn J.P. Expansion of functionally competent multi-lineage hematopoietic cells using the novel chimeric hematopoietic growth factor, progenipoietin. Blood. 92:1998;377a. (abstr).
67. Glaspy J.A., Shpall E.J., LeMaistre C.F., Briddell R.A., Menchaca D.M., Turner S.A., Lill M., Chap L., Jones R., Wiers M.D., Sheridan W.P., McNiece I.K. Peripheral blood progenitor cell mobilization using stem cell factor in combination with filgrastim in breast cancer patients. Blood. 90:1997;2939.