Effects of deregulated Raf activation on integrin, cytokine-receptor expression and the induction of apoptosis in hematopoietic cells

Leukemia

Volumn 14, Issue 11, 2000, Pages 1921-1938

  Weinstein Oppenheimer, C ^a,b   Steelman, L S ^a   Algate, P A ^c   Blalock, W L ^a   Burrows, C ^a   Hoyle, P E ^a   Lee, J T ^a   Moye, P W ^a   Shelton, J G ^a   Franklin, R ^a   McCubrey, J A ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

^b UNIVERSIDAD DE VALPARAÍSO   (Chile)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Apoptosis; Autocrine transformation; Differentiation; GM CSF expression; Integrins; Raf

Indexed keywords

CD11B ANTIGEN; CD18 ANTIGEN; CELL ADHESION MOLECULE; COMPLEMENTARY DNA; CYTOKINE; CYTOKINE RECEPTOR; ESTRADIOL; ESTROGEN RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HORMONE BINDING PROTEIN; INTEGRIN; INTERLEUKIN 3; MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; RAF PROTEIN; REGULATOR PROTEIN; RETINOIC ACID; THYMIDINE; TRITIUM;

ANIMAL CELL; APOPTOSIS; ARTICLE; BONE MARROW CELL; CATALYSIS; CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CELL MATURATION; CELL STRUCTURE; CELL SURFACE; CELL TRANSFORMATION; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; ENZYME ACTIVITY; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN DOMAIN; PROTEIN EXPRESSION; REGULATORY MECHANISM;

EID: 0033759376     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401926     Document Type: Article

References (44)

1. Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: Possible sites for intervention with anti-neoplastic drugs
2. Abnormal activation of cytokine gene expression by intracisternal type A particle transposition: Effects of mutations which result in autocrine growth factor stimulation and malignant transformation
3. Regulation of interleukin 3 expression in normal and autocrine transformed hematopoietic cells
4. Regulation of the interleukin (IL-3) receptor by IL-3 in the fetal liver-derived FL5.12 cell line
5. Cytokine receptors and signal transduction
6. Oncogenic effects of overexpression of the interleukin-3 receptor on hematopoietic cells
7. Growth factor-dependent hemopoietic precursor cell lines
8. Enrichment of hematopoietic precursor cells and cloning of multipotential B lymphocyte precursors
9. Abrogation of factor-dependence in two IL-3-dependent cell lines can occur by two distinct mechanisms
10. Retroviral infection can abrogate the factor-dependency of hematopoietic cells by autocrine and non-autocrine mechanisms depending on the presence of a functional viral oncogene
11. Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3 or erythropoietin
12. Autocrine growth factor secretion after transformation of human cytokine dependent cells by viral and cellular oncogenes
13. Cytokine-dependent engraftment of human myeloid leukemic cell lines in immunosuppressed mice
14. Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells
15. A conditionally-active form of MEK1 results in autocrine transformation of human and mouse hematopoeitic cells
16. Effects of deregulated Raf and MEK1 expression on the cytokine dependency of hematopoietic cells
17. Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells
18. Signaling through the hematopoietic cytokine receptors
19. Signal transduction by the high-affinity GM-CSF receptor: Two distinct cytoplasmic regions of the common beta subunit responsible for the different signaling
20. Suppression of apoptotic death in hematopoietic cells by signaling through the IL-3/GM-CSF receptors
21. The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- And chemosensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity
22. Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase
23. Raf revealed in life-or-death-decisions
24. Endothelial apoptosis in B-Raf-deficient mice
25. C-raf-1 protein kinase is essential for mouse development
26. Differential effects of viral and cellular oncogenes on the growth factor-dependency of hematopoietic cells
27. Conditionally oncogenic forms of the A-raf and B-raf protein kinases display different biological and biochemical properties in NIH 3T3 cells
28. Mutations of critical amino acids affect the biological and biochemical properties of oncogenic A-Raf and Raf-1
29. Differential abilities of the Raf family of protein of kinases to abrogate cytokine-dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism
30. Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells
31. Serine/threonine phosphorylation in cytokine signal transduction
32. Viral models for understanding chronic myelogenous leukemia
33. The role of TEL fusion genes in pediatric leukemias
34. Growth promoting effects of insulin-like growth factor-1 on hematopoietic cells: Overexpression of introduced IGF-1 receptor abrogates IL-3-dependency of murine factor dependent cells by a ligand-dependent mechanism
35. Overexpression of protein kinase C isoform epsilon but not delta in human interleukin-3-dependent cells suppresses apoptosis and induces bcl-2 expression
36. Autocrine transformation of human hematopoietic cells after transfection with an activated granulocyte/macrophage colony stimulating factor gene
37. The effect of activating mutations on dimerization, tyrosine phosphorylation and internalization of the macrophage colony stimulating factor receptor
38. A phosphatidylinositol 3-kinase-dependent pathway that differentially regulates c-Raf and A-Raf
39. Constitutive expression of the promyelocytic leukemia-associated oncogene PML-RARα in TF-1 cells: Isform-specific and retinoic acid dependent effects on growth, bcl-2 expression, and apoptosis
40. The human beta 2 integrin CD18 promoter consists of two inverted Ets cis elements
41. Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene
42. The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression
43. Cell-surface differentiation in the mouse. Characterization of 'jumping' and 'lineage' antigens using xenogeneic rat monoclonal antibodies
44. Characterization of subsets of bone marrow-derived macrophages by flow cytometric analysis