B Cell Receptor (BCR) cross-talk: IL-4 creates an alternate pathway for BCR-induced ERK activation that is phosphatidylinositol 3-kinase independent

Journal of Immunology

Volumn 174, Issue 9, 2005, Pages 5375-5381

  Guo, Benchang ^a   Rothstein, Thomas L ^a,b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; RAF PROTEIN; STAT6 PROTEIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; ENZYME ACTIVATION; IMMUNE RESPONSE; MACROMOLECULE; MALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; SIGNAL TRANSDUCTION;

EID: 17844410418     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.9.5375     Document Type: Article

References (54)

1. Benschop, R. J., and J. C. Cambier. 1999. B cell development: signal transduction by antigen receptors, and their surrogates. Curr. Opin. Immunol. 11:143.
2. King, I., B., and J. G. Monroe. 2000. Immunobiology of the immature B cell: plasticity in the B-cell antigen receptor-induced response fine tunes negative selection. Immunol. Rev. 176:86.
3. Niiro, H., and E. A. Clark. 2002. Regulation of B-cell fate by antigen-receptor signals. Nat. Rev. Immunol. 2:945.
4. Johnson, G. L., and R. Lapadat. 2002. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911.
5. Fruman, D. A., A. B. Satterthwaite, and O. N. Witte. 2000. Xid-like phenotypes: a B cell signalosome takes shape. Immunity 13:1.
6. Li, Q., and I. M. Verma. 2002. NF-κB regulation in the immune system. Nat. Rev. Immunol. 2:725.
7. Han, A., K. Saijo, I. Mecklenbrauker, A. Tarakhovsky, and M. C, Nussenzweig. 2003. Bam32 links the B cell receptor to BRK and JNK and mediates B cell proliferation but not survival. Immunity 19:621.
8. Gaide, O., B. Favier, D. F. Legler, D. Bonnet, B. Brissoni, S. Valitutti, C. Bron, J. Tschopp, and M. Thome. 2002. CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-κB activation. Nat. Immunol. 3:836.
9. Jun, J. E., L. E. Wilson, C. G. Vinuesa, S. Lesage, M. Blery, L. A. Miosge, M. C. Cook, E. M. Kucharska, H. Hara, J. M. Penninger, et al. 2003. Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity 18:751.
10. Hara, H., T. Wada, C. Bakal, I. Kozieradzki, S. Suzuki, N. Suzuki, M. Nghiem, E. K. Griffiths, C. Krawczyk, B. Bauer, et al. 2003. The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity 18:763.
11. Niiro, H., and E. A. Clark. 2003. Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1. Immunity 19:637.
12. Ueda, Y., S. Hirai, S. Osada, A. Suzuki, K. Mizuno, and S. Ohno. 1996. Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J. Biol. Chem. 271:23512.
13. Li, Y. Y., M. Baccam, S. B. Waters, J. E. Pessin, G. A. Bishop, and G. A. Koretzky. 1996. CD40 ligation results in protein kinase C-independent activation of ERK and JNK in resting murine splenic B cells. J. Immunol. 157:1440.
14. Marais, R., Y. Light, C. Mason, H. Paterson, M. F. Olson, and C. J. Marshall. 1998. Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. Science 280:109.
15. 2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B cell antigen receptor. J. Exp. Med. 188:1287.
16. Sakata, N., H. Kawasome, N. Terada, P. Gerwins, G. L. Johnson, and E. W. Gelfand. 1999. Differential activation and regulation of mitogen-activated protein kinases through the antigen receptor and CD40 in human B cells. Eur. J. Immunol. 29:2999.
17. Jacob, A., D. Cooney, M. Pradhan, and K. M. Coggeshall. 2002. Convergence of signaling pathways on the activation of ERK in B cells. J. Biol. Chem. 277:23420.
18. Mizuno, T., and T. L. Rothstein. 2003. Cutting edge: CD40 engagement eliminates the need for Bruton's tyrosine kinase in B cell receptor signaling for NF-κB. J. Immunol. 170:2806.
19. Paul, W. E. 1997. Interleukin 4: signalling mechanisms and control of T cell differentiation. Ciba Found. Symp. 204:208.
20. Paul, W. E., and J. Ohara. 1987. B-cell stimulatory factor-1/interleukin 4. Annu. Rev. Immunol. 5:429.
21. Nelms, K., A. D. Keegan, J. Zamorano, J. J. Ryan, and W. E. Paul. 1999. The IL-4 receptor: signaling mechanisms and biologic functions. Annu. Rev. Immunol. 17:701.
22. Smerz-Bertling, C., and A. Duschl. 1995. Both interleukin 4 and interleukin 13 induce tyrosine phosphorylation of the 140-kDa subunit of the interleukin 4 receptor. J. Biol. Chem. 270:966.
23. Hou, J., U. Schindler, W. J. Henzel, T. C. Ho, M. Brasseur, and S. L. McKnight. 1994. An interleukin-4-induced transcription factor: IL-4 Slat. Science 265:1701.
24. Sun, X. J., L. M. Wang, Y. Zhang, L. Yenush, M. G. Myers, Jr., E. Glasheen, W. S. Lane, J. H. Pierce, and M. F. White. 1995. Role of IRS-2 in insulin and cytokine signalling. Nature 377:173.
25. Kaplan, M. H., U. Schindler, S. T. Smiley, and M. J. Grusby. 1996. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4:313.
26. Shimoda, K., J. van Deursen, M. Y. Sangster, S. R. Sarawar, R. T. Carson, R. A. Tripp, C. Chu, F. W. Quelle, T. Nosaka, D. A. Vignali, et al. 1996. Lack of IL-4-indiiced Th2 respond and IgE class switching in mice with disrupted Stat6 gene. Nature 380:630.
27. Takeda, K., T. Tanaka, W. Shi, M. Matsumoto, M. Minami, S. Kashiwamura, K, Nakanishi, N. Yoshida, T. Kishimoto, and S. Akira. 1996. Essential role of Stat6 in IL-4 signalling. Nature 380:627.
28. Rothstein, T. L., J. K. Wang, D. J. Panka, L. C. Foote, Z. Wang, B. Stanger, H. Cui, S. T. Ju, and A. Marshak-Rothstein. 1995. Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells. Nature 374:163.
29. Schneider, T. J., D. Grillot, L. C. Foote, G. E. Nunez, and T. L. Rothstein. 1997. Bcl-x protects primary B cells against Fas-mediated apoptosis. J. Immunol. 159:4834.
30. Liu, J. L., T. C. Chiles, R. J. Sen, and T. L. Rothstein. 1991. Inducible nuclear expression of NF-κB in primary B cells stimulated through the surface Ig receptor. J. Immunol. 146:1685.
31. Jamieson, C., F. Mauxion, and R. Sen. 1989. Identification of a functional NF-κB binding site in the murine T cell receptor β2 locus. J. Exp. Med. 170:1737.
32. Petro, J. B., and W. N. Khan. 2001. Phospholipase C-γ2 couples Bruton's tyrosine kinase to the NF-κB signaling pathway in B lymphocytes. J. Biol. Chem. 276:1715.
33. Pogue, S. L., T. Kurosaki, J. Bolen, and R. Herbst. 2000. B cell antigen receptor-induced activation of Akt promotes B cell survival and is dependent on Syk kinase. J. Immunol. 165:1300.
34. Andrews, R., L. Rosa, M. Daines, and G. Khurana Hershey. 2001. Reconstitution of a functional human type II IL-4/IL-13 receptor in mouse B cells: demonstration of species specificity. J. Immunol. 166:1716.
35. Crews, C. M., A. Alessandrini, and R. L. Erikson. 1992. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science 258:478.
36. Piatelli, M. J., C. Doughty, and T. C. Chiles. 2002. Requirement for a hsp90 chaperone-dependent MEK1/2-ERK pathway for B cell antigen receptor-induced cyclin D2 expression in mature B lymphocytes. J. Biol. Chem. 277:12144.
37. Favata, M. F., K. Y. Horiuchi, E. J. Manos, A. J. Daulerio, D. A. Stradley, W. S. Feeser, D. E. Van Dyk, W. J. Pitts, R. A. Earl, F. Hobbs, et al. 1998. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J. Biol. Chem. 273:18623.
38. Richards, J. D., S. H. Dave, C. H. Chou, A. A. Mamchak, and A. L. DeFranco. 2001. Inhibition of the MEK/ERK signaling pathway blocks a subset of B cell responses to antigen. J. Immunol. 166:3855.
39. Iritani, B. M., K. A. Forbush, M. A. Farrar, and R. M. Perlmutter. 1997. Control of B cell development by Ras-mediated activation of Raf. EMBO J. 16:7019.
40. Tordai, A., R. A. Franklin, H. Patel, A. M. Gardner, G. L. Johnson, and E. W. Gelfand. 1994. Cross-linking of surface IgM stimulates the Ras/Raf-1/ MEK/MAPK cascade in human B lymphocytes. J. Biol. Chem. 269:7538.
41. Howard, M., J. Farrar, M. Hilfiker, B. Johnson, K. Takatsu, T. Hamaoka, and W. E. Paul. 1982. Identification of a T cell-derived b cell growth factor distinct from interleukin 2. J. Exp. Med. 155:914.
42. Brown, M. A., J. H. Pierce, C. J. Watson, J. Falco, J. N. Ihle, and W. E. Paul. 1987. B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells. Cell 50:809.
43. Seder, R. A., W. E. Paul, A. M. Dvorak, S. J. Sharkis, A. Kagey-Sobotka, Y. Niv, F. D. Finkelman, S, A. Barbieri, S. J. Galli, and M. Flaut 1991. Mouse splenic and bone marrow cell populations that express high-affinity Fcε receptors and produce interleukin 4 are highly enriched in basophils. Proc. Natl. Acad. Sci. USA 88:2835.
44. pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179:1285.
45. Moqbel, R., S. Ying, J. Barkans, T. M. Newman, P. Kimmitt, M. Wakelin, L. Taborda-Barata, Q. Meng, C. J. Corrigan, S. R. Durham, et al. 1995. Identification of messenger RNA for IL-4 in human eosinophils with granule localization and release of the translated product. J. Immunol. 155:4939.
46. Moriyama, M., T. Yamochi, K. Semba, T. Akiyama, and S. Mori. 1997. BCL-6 is phosphorylated at multiple sites in its serine- and proline-clustered region by mitogen-activated protein kinase (MAPK) in vivo. Oncogene 14:2465.
47. Niu, H., B. H. Ye, and R. Dalla-Favera. 1998. Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. Genes Dev. 12:1953.
48. Fukuda, T., T. Yoshida, S. Okada, M. Hatano, T. Miki, K. Ishibashi, S. Okabe, H. Koseki, S. Hirosawa, M. Taniguchi, et al. 1997. Disruption of the Bcl6 gene results in an impaired germinal center formation. J. Exp. Med. 186:439.
49. Tunyaplin, C., A. L. Shaffer, C. D. Angelin-Duclos, X. Yu, L. M. Staudt, and K. L. Calame. 2004. Direct repression of prdm 1 by Bcl-6 inhibits plasmacytic differentiation. J. Immunol. 173:1158.
50. Foote, L. C., R. G. Howard, A. Marshak-Rothstein, and T. L. Rothstein. 1996. IL-4 induces Fas resistance in B cells. J. Immunol. 157:2749.
51. DiPiro, J. T., T. R. Howdieshell, J. K. Goddard, D. B. Callaway, R. G. Hamilton, and A. R. Mansberger, Jr. 1995. Association of interleukin-4 plasma levels with traumatic injury and clinical, course. Arch. Surg. 130:1159.
52. Song, G. Y., C. S. Chung, I. H. Chaudry, and A. Ayala. 2000. IL-4-induced activation of the Stat6 pathway contributes to the suppression of cell-mediated immunity and death in sepsis. Surgery 128:133.
53. Torre, D., R. Tambini, S. Aristodemo, G. Gavazzeni, A. Goglio, C. Cantamessa, A. Pugliese, and G. Biondi. 2000. Anti-inflammatory response of IL-4, IL-10 and TGF-β in patients with systemic inflammatory response syndrome. Mediators Inflamm. 9:193.
54. Mizuno T., and T. L. Rothstein. 2005. B cell receptor cross-talk: CD40 engagement creates an alternate pathway for B cell receptor signaling that activates IKK/IκBα/NF-κB without the need for PI3K and PLCγ. J. Immunol. In press.