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Volumn 66, Issue 2 II, 2005, Pages

PPAR receptors and insulin sensitivity: New agonists in development;Récepteurs PPAR et insulinosensibilité: Nouveaux agonistes en développement

Author keywords

Fatty acids; Insulin resistance; PPAR agonists; PPAR nuclear receptors; Rexinoids; Type 2 diabetes mellitus

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 3 METHYL 7 (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 3 PROPOXY 2 NAPHTHYL) 2,4,6 OCTATRIENOIC ACID; 5 (2,4 DIOXO 5 THIAZOLIDINYLMETHYL) 2 METHOXY N [4 (TRIFLUOROMETHYL)BENZYL]BENZAMIDE; 6 [1 (5,6,7,8 TETRAHYDRO 3,5,5,8,8 PENTAMETHYL 2 NAPHTHYL)CYCLOPROPYL]NICOTINIC ACID; BALAGLITAZONE; CLX 0921; DRF 2655; E 3030; EML 4156; FIBRIC ACID DERIVATIVE; FLUORENYLMETHOXYCARBONYLLEUCINE; GLIBENCLAMIDE; GLITAZONE DERIVATIVE; GW 0072; IMIGLITAZAR; LG 100641; LIGAND; LY 465608; LY 510818; LY 510929; MURAGLITAZAR; NAVEGLITAZAR; NNC 61 0645; PAT 5A; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ANTAGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; PMT 13; RAGAGLITAZAR; RECEPTOR BLOCKING AGENT; REGLITAZAR; RETINOID X RECEPTOR; RETINOID X RECEPTOR AGONIST; REXINOID DERIVATIVE; ROSIGLITAZONE; T 0903131; TESAGLITAZAR; TY 51501; TZD 18; UNCLASSIFIED DRUG;

EID: 17744365612     PISSN: 00034266     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (10)

References (81)
  • 1
    • 0036399805 scopus 로고    scopus 로고
    • PPARγ and glucose homeostasis
    • Picard F, Auwerx J. PPARγ and glucose homeostasis. Annu Rev Nutr 2002; 22: 167-97.
    • (2002) Annu Rev Nutr , vol.22 , pp. 167-197
    • Picard, F.1    Auwerx, J.2
  • 2
    • 0035985669 scopus 로고    scopus 로고
    • New factors in the regulation of adipose differentiation and metabolism
    • Host D, Grimaldi PA. New factors in the regulation of adipose differentiation and metabolism. Curr Opinion Lipid 2002; 13: 241-5.
    • (2002) Curr Opinion Lipid , vol.13 , pp. 241-245
    • Host, D.1    Grimaldi, P.A.2
  • 3
    • 0842263981 scopus 로고    scopus 로고
    • The biology of peroxisome proliferator-activated receptors: Relationship with lipid metabolism and insulin sensitivity
    • Ferré P. The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes 2004; 53: S43-S50.
    • (2004) Diabetes , vol.53
    • Ferré, P.1
  • 4
    • 0037330414 scopus 로고    scopus 로고
    • PPARγ agonists: Adipogenic treatment of type II diabetes
    • Larsen TM, Toubro S, Astrup A. PPARγ agonists: adipogenic treatment of type II diabetes. Int J Obes 2003; 27: 147-61.
    • (2003) Int J Obes , vol.27 , pp. 147-161
    • Larsen, T.M.1    Toubro, S.2    Astrup, A.3
  • 5
    • 0037732481 scopus 로고    scopus 로고
    • The adipocyte in insulin resistance: Key molecules and the impact of the thiazolidinediones
    • Arner P. The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones. Trends Endocrinol Metab 2003; 14: 137-45.
    • (2003) Trends Endocrinol Metab , vol.14 , pp. 137-145
    • Arner, P.1
  • 6
    • 0034845086 scopus 로고    scopus 로고
    • Adipocyte metabolism and the metabolic syndrome
    • Stears AJ, Byrne CD. Adipocyte metabolism and the metabolic syndrome. Diabetes Obes Metab 2001; 3: 129-42.
    • (2001) Diabetes Obes Metab , vol.3 , pp. 129-142
    • Stears, A.J.1    Byrne, C.D.2
  • 7
    • 85082782094 scopus 로고    scopus 로고
    • Adiponectine: De l'adipocyte au muscle
    • Ferré P. Adiponectine: de l'adipocyte au muscle. Ann Endocrinol 2004; 65: 1S36-1S43.
    • (2004) Ann Endocrinol , vol.65
    • Ferré, P.1
  • 8
    • 0031898610 scopus 로고    scopus 로고
    • PPAR-γ: Adipogenic regulator and thiazolidinedione receptor
    • Spiegelman BM. PPAR-γ: adipogenic regulator and thiazolidinedione receptor. Diabetes 1998; 47: 507-14.
    • (1998) Diabetes , vol.47 , pp. 507-514
    • Spiegelman, B.M.1
  • 10
    • 0035040960 scopus 로고    scopus 로고
    • Mécanisme d'action des thiazolidinediones
    • Girard J. Mécanisme d'action des thiazolidinediones. Diabetes Metab 2001; 27: 271-8.
    • (2001) Diabetes Metab , vol.27 , pp. 271-278
    • Girard, J.1
  • 11
    • 0035124186 scopus 로고    scopus 로고
    • New oral therapies for type 2 diabetes mellitus: The glitazones or insulin-sensitizers
    • Mudaliar S, Henry RR. New oral therapies for type 2 diabetes mellitus: the glitazones or insulin-sensitizers. Annu Rev Med 2001; 52: 239-57.
    • (2001) Annu Rev Med , vol.52 , pp. 239-257
    • Mudaliar, S.1    Henry, R.R.2
  • 12
    • 2342556709 scopus 로고    scopus 로고
    • PPARγ et insulinorésistance
    • Girard J. PPARγ et insulinorésistance. Ann Endocrinol 2002; 63: 1519-1522.
    • (2002) Ann Endocrinol , vol.63 , pp. 1519-1522
    • Girard, J.1
  • 13
    • 0037026744 scopus 로고    scopus 로고
    • Rationale for and role of thiazolidinediones in type 2 diabetes mellitus
    • Lebovitz HE. Rationale for and role of thiazolidinediones in type 2 diabetes mellitus. Am J Cardiol 2002; 90 (suppl.): 34G-41G.
    • (2002) Am J Cardiol , vol.90 , Issue.SUPPL.
    • Lebovitz, H.E.1
  • 14
    • 4744369942 scopus 로고    scopus 로고
    • Place des thiazolidinediones dans le traitement du diabète de type 2
    • Blicklé JF. Place des thiazolidinediones dans le traitement du diabète de type 2. Presse Med 2004; 33: 1034-40.
    • (2004) Presse Med , vol.33 , pp. 1034-1040
    • Blicklé, J.F.1
  • 15
    • 2342451980 scopus 로고    scopus 로고
    • Thiazolidinediones et insulinosensibilité: Rôle du récepteur nucléaire PPARγ
    • Pégorier JP, Girard J. Thiazolidinediones et insulinosensibilité: rôle du récepteur nucléaire PPARγ. Ann Endocrinol 2004; 65: 65-72.
    • (2004) Ann Endocrinol , vol.65 , pp. 65-72
    • Pégorier, J.P.1    Girard, J.2
  • 16
  • 17
  • 18
    • 0034861516 scopus 로고    scopus 로고
    • A review, of rosiglitazone in type 2 diabetes mellitus
    • Werner AL, Travaglini MT. A review, of rosiglitazone in type 2 diabetes mellitus. Pharmacotherapy 2001; 21: 1082-99.
    • (2001) Pharmacotherapy , vol.21 , pp. 1082-1099
    • Werner, A.L.1    Travaglini, M.T.2
  • 19
    • 0036343675 scopus 로고    scopus 로고
    • Rosiglitazone: A review of its use in the management of type 2 diabetes mellitus
    • Wagstaff AJ, Goa KL. Rosiglitazone: A review of its use in the management of type 2 diabetes mellitus. Drugs 2002; 62: 1805-37.
    • (2002) Drugs , vol.62 , pp. 1805-1837
    • Wagstaff, A.J.1    Goa, K.L.2
  • 20
    • 3042622123 scopus 로고    scopus 로고
    • Pioglitazone, insulinosensibilité et diabète de type 2: Données récentes
    • Monnier L, Sauvanet JP. Pioglitazone, insulinosensibilité et diabète de type 2: données récentes. Ann Endocrinol 2004; 65: 136-48.
    • (2004) Ann Endocrinol , vol.65 , pp. 136-148
    • Monnier, L.1    Sauvanet, J.P.2
  • 21
    • 3042780425 scopus 로고    scopus 로고
    • Effets cardio-vasculaires de la rosiglitazone
    • Le Feuvre C. Effets cardio-vasculaires de la rosiglitazone. Presse Med 2004; 33: 735-45.
    • (2004) Presse Med , vol.33 , pp. 735-745
    • Le Feuvre, C.1
  • 22
    • 0032511580 scopus 로고    scopus 로고
    • Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38
    • UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. Br Med J 1998; 317: 703-13.
    • (1998) Br Med J , vol.317 , pp. 703-713
  • 23
    • 0036860896 scopus 로고    scopus 로고
    • Atherosclerosis in type 2 diabetes mellitus and insulin resistance: Mechanistic links and therapeutic targets
    • Plutzky J, Viberti G, Haffner S. Atherosclerosis in type 2 diabetes mellitus and insulin resistance: mechanistic links and therapeutic targets. J Diabetes Complic 2002; 16: 401-15.
    • (2002) J Diabetes Complic , vol.16 , pp. 401-415
    • Plutzky, J.1    Viberti, G.2    Haffner, S.3
  • 24
    • 0141823378 scopus 로고    scopus 로고
    • Balaglitazone, a new partial PPARγ agonist has a better cardiovascular safety profile and glycemic control compared with the full PPARγ agonist rosiglitazone
    • abstract 594-P
    • Wulff EM, Pedersen KE, Sauerberg P. Balaglitazone, a new partial PPARγ agonist has a better cardiovascular safety profile and glycemic control compared with the full PPARγ agonist rosiglitazone. Diabetes 2003; 52 (suppl.1): A138-A139 [abstract 594-P].
    • (2003) Diabetes , vol.52 , Issue.SUPPL. 1
    • Wulff, E.M.1    Pedersen, K.E.2    Sauerberg, P.3
  • 25
    • 0142058608 scopus 로고    scopus 로고
    • Balaglitazone, a new thiazolidinedione, improves glucose and lipid control in patients with type 2 diabetes
    • abstract 530-P
    • Koev D, Ionescu-Trgoviste C, Rosenthal A, et al. Balaglitazone, a new thiazolidinedione, improves glucose and lipid control in patients with type 2 diabetes. Diabetes 2003; 52 (suppl.1): A124 [abstract 530-P].
    • (2003) Diabetes , vol.52 , Issue.SUPPL. 1
    • Koev, D.1    Ionescu-Trgoviste, C.2    Rosenthal, A.3
  • 26
    • 0042888577 scopus 로고    scopus 로고
    • A novel peroxisome proliferator-activated gamma agonist, CLX-0921, has potent antihyperglycemic activity without adipogenic potential
    • Dey D, Medicherla S, Neogi P, et al. A novel peroxisome proliferator-activated gamma agonist, CLX-0921, has potent antihyperglycemic activity without adipogenic potential. Metabolism 2003; 52: 1012-8.
    • (2003) Metabolism , vol.52 , pp. 1012-1018
    • Dey, D.1    Medicherla, S.2    Neogi, P.3
  • 27
    • 0036708115 scopus 로고    scopus 로고
    • PMT13, a pyrimidone analogue of thiazolidinedione improves insulin resistance-associated disorders in animal models of type 2 diabetes
    • Chakrabarti R, Vikramadithyan RK, Kumar P, et al. PMT13, a pyrimidone analogue of thiazolidinedione improves insulin resistance-associated disorders in animal models of type 2 diabetes. Diabetes Obes Metab 2002; 4: 319-28.
    • (2002) Diabetes Obes Metab , vol.4 , pp. 319-328
    • Chakrabarti, R.1    Vikramadithyan, R.K.2    Kumar, P.3
  • 28
    • 0037960935 scopus 로고    scopus 로고
    • PAT5A: A partial agonist of peroxisome proliferator-activated receptor gamma is a potent antidiabetic thiazolidinedione yet not adipogenic
    • Misra P, Chakrabarti R, Vikramadithyan RK, et al. PAT5A: a partial agonist of peroxisome proliferator-activated receptor gamma is a potent antidiabetic thiazolidinedione yet not adipogenic. J Pharmacol Exp Ther 2003; 306: 763-71.
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 763-771
    • Misra, P.1    Chakrabarti, R.2    Vikramadithyan, R.K.3
  • 29
    • 13044286786 scopus 로고    scopus 로고
    • A peroxisome proliferator-activated receptor-γ ligand inhibits adipocyte differentiation
    • Oberfield JL, Collins JL, Holmes CP, et al. A peroxisome proliferator-activated receptor-γ ligand inhibits adipocyte differentiation. Proc Natl Acad Sci USA 1999; 96: 6102-6.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 6102-6106
    • Oberfield, J.L.1    Collins, J.L.2    Holmes, C.P.3
  • 30
    • 2642557181 scopus 로고    scopus 로고
    • A unique PPAR-γ ligand with potent insulin-sensitizing yet weak adipogenic activity
    • Rocchi S, Picard F, Vamecq J, et al. A unique PPAR-γ ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol Cell 2001; 8: 737-47.
    • (2001) Mol Cell , vol.8 , pp. 737-747
    • Rocchi, S.1    Picard, F.2    Vamecq, J.3
  • 31
    • 12444273748 scopus 로고    scopus 로고
    • Distinct properties and advantages of a novel peroxisome proliferator-activated protein-γ selective modulator
    • Berger JP, Petro AE, Macnaul KL, et al. Distinct properties and advantages of a novel peroxisome proliferator-activated protein-γ selective modulator. Mol Endocrinol 2003; 17: 662-76.
    • (2003) Mol Endocrinol , vol.17 , pp. 662-676
    • Berger, J.P.1    Petro, A.E.2    Macnaul, K.L.3
  • 32
    • 17744363455 scopus 로고    scopus 로고
    • T0903131, a selective modulator of PPAR-gamma activity, increases adiponectin levels in healthy subjects
    • abstract 656-P
    • Kersey K, Floren LC, Pendleton B, Stempien MJ, Buchanan J, Dunn F. T0903131, a selective modulator of PPAR-gamma activity, increases adiponectin levels in healthy subjects. Diabetes 2004; 53 (suppl.2): A156 [abstract 656-P].
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2
    • Kersey, K.1    Floren, L.C.2    Pendleton, B.3    Stempien, M.J.4    Buchanan, J.5    Dunn, F.6
  • 33
    • 0034993832 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: From transcriptional control to clinical practice
    • Pineda-Torra I, Chinetti G, Duval C, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice. Curr Opin Lipidol 2001; 12: 245-54.
    • (2001) Curr Opin Lipidol , vol.12 , pp. 245-254
    • Pineda-Torra, I.1    Chinetti, G.2    Duval, C.3    Fruchart, J.C.4    Staels, B.5
  • 34
    • 0037405057 scopus 로고    scopus 로고
    • Modulation of PPARgamma activity with pharmaceutical agents: Treatment of insulin resistance and atherosclerosis
    • Wang M, Tafuri S. Modulation of PPARgamma activity with pharmaceutical agents: treatment of insulin resistance and atherosclerosis. J Cell Biochem 2003; 89: 38-47.
    • (2003) J Cell Biochem , vol.89 , pp. 38-47
    • Wang, M.1    Tafuri, S.2
  • 35
    • 0033766035 scopus 로고    scopus 로고
    • A selective PPARγ modulator blocks adipocyte differentiation but stimulates glucose uptake in 3T3-L1 adipocytes
    • Mukherjee R, Hoener PA, Jow L, et al. A selective PPARγ modulator blocks adipocyte differentiation but stimulates glucose uptake in 3T3-L1 adipocytes. Mol Endocrinol 2000; 14: 1425-33.
    • (2000) Mol Endocrinol , vol.14 , pp. 1425-1433
    • Mukherjee, R.1    Hoener, P.A.2    Jow, L.3
  • 36
    • 0034695479 scopus 로고    scopus 로고
    • A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation
    • Wright HM, Clish CB, Mikami T, et al. A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation. J Biol Chem 2000; 275: 1873-7.
    • (2000) J Biol Chem , vol.275 , pp. 1873-1877
    • Wright, H.M.1    Clish, C.B.2    Mikami, T.3
  • 37
    • 85047685428 scopus 로고    scopus 로고
    • Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes
    • Yamauchi T, Waki H, Kamon J, et al. Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes. J Clin Invest 2001; 108: 1001-13.
    • (2001) J Clin Invest , vol.108 , pp. 1001-1013
    • Yamauchi, T.1    Waki, H.2    Kamon, J.3
  • 38
    • 0034607438 scopus 로고    scopus 로고
    • Effect of metformin and rosiglitazone combination therapy in patients. In patients with type 2 diabetes mellitus
    • Fonseca V, Rosenstock J, Patwardhan R, Salzman A. Effect of metformin and rosiglitazone combination therapy in patients. in patients with type 2 diabetes mellitus. JAMA 2000; 283: 1695-1702.
    • (2000) JAMA , vol.283 , pp. 1695-1702
    • Fonseca, V.1    Rosenstock, J.2    Patwardhan, R.3    Salzman, A.4
  • 39
    • 0036830104 scopus 로고    scopus 로고
    • Effects of rosiglitazone alone or in combination with atorvastatin on metabolic abnormalities in type 2 diabetes mellitus
    • Freed MI, Ratner R, Marcovina SM, et al., for the Rosiglitazone Study 108 Investigators. Effects of rosiglitazone alone or in combination with atorvastatin on metabolic abnormalities in type 2 diabetes mellitus. Am J Cardiol 2002; 90: 947-52.
    • (2002) Am J Cardiol , vol.90 , pp. 947-952
    • Freed, M.I.1    Ratner, R.2    Marcovina, S.M.3
  • 40
    • 0036095647 scopus 로고    scopus 로고
    • Antidiabétiques oraux et lipides
    • Vergès B. Antidiabétiques oraux et lipides. Ann Endocrinol 2002; 63: 1S45-1S50.
    • (2002) Ann Endocrinol , vol.63
    • Vergès, B.1
  • 41
    • 1042268743 scopus 로고    scopus 로고
    • Favorable effects of pioglitazone and metformin compared with gliclazide on lipoprotein subfractions in overweight patients with early type 2 diabetes
    • Lawrence JM, Reid J, Taylor GJ, Stirling C, Reckless JPD. Favorable effects of pioglitazone and metformin compared with gliclazide on lipoprotein subfractions in overweight patients with early type 2 diabetes. Diabetes Care 2004; 27: 41-6.
    • (2004) Diabetes Care , vol.27 , pp. 41-46
    • Lawrence, J.M.1    Reid, J.2    Taylor, G.J.3    Stirling, C.4    Reckless, J.P.D.5
  • 42
    • 26144464702 scopus 로고    scopus 로고
    • Rosiglitazone reduces novel biomarkers of cardiovascular disease in subjects with type 2 diabetes mellitus already on statin therapy
    • abstract 1124-192
    • Brunzell JD, Marconiva S, Yu D, et al. Rosiglitazone reduces novel biomarkers of cardiovascular disease in subjects with type 2 diabetes mellitus already on statin therapy. J Am Coll Cardiol 2004; 43 (Suppl.A): 236 [abstract 1124-192].
    • (2004) J Am Coll Cardiol , vol.43 , Issue.SUPPL.A , pp. 236
    • Brunzell, J.D.1    Marconiva, S.2    Yu, D.3
  • 43
    • 0034804726 scopus 로고    scopus 로고
    • Pioglitazone: Mechanism of action
    • Smith U. Pioglitazone: mechanism of action. Int J Clin Pract 2001; Suppl.121: 13-18.
    • (2001) Int J Clin Pract , Issue.SUPPL. 121 , pp. 13-18
    • Smith, U.1
  • 44
    • 0003179974 scopus 로고    scopus 로고
    • Traitement médicamenteux du diabète de type 2. Recommandations: Texte long, argumentaire
    • AFSSAPS. Traitement médicamenteux du diabète de type 2. Recommandations: texte long, argumentaire. Diabetes Metab 1999; 25(Suppl.6): 1-79.
    • (1999) Diabetes Metab , vol.25 , Issue.SUPPL. 6 , pp. 1-79
  • 45
    • 0031938673 scopus 로고    scopus 로고
    • Overview of fenofibrate
    • Packard CJ. Overview of fenofibrate. Eur Heart J 1998; 19: A62-A65.
    • (1998) Eur Heart J , vol.19
    • Packard, C.J.1
  • 46
    • 0036382889 scopus 로고    scopus 로고
    • Micronised fenofibrate. An updated review of its clinical efficacy in the management of dyslipidaemia
    • Keating GM, Ormrod D. Micronised fenofibrate. An updated review of its clinical efficacy in the management of dyslipidaemia. Drugs 2002; 62: 1909-44.
    • (2002) Drugs , vol.62 , pp. 1909-1944
    • Keating, G.M.1    Ormrod, D.2
  • 47
    • 0344874601 scopus 로고    scopus 로고
    • Fibrates in 2003: Therapeutic action in atherogenic dyslipidaemia and future perspectives
    • Chapman MJ. Fibrates in 2003: therapeutic action in atherogenic dyslipidaemia and future perspectives. Atherosclerosis 2003; 171: 1-13.
    • (2003) Atherosclerosis , vol.171 , pp. 1-13
    • Chapman, M.J.1
  • 48
    • 1842454746 scopus 로고    scopus 로고
    • Clinical interest of PPARs ligands. Particular benefit in type 2 diabetes and metabolic syndromes
    • Vergés B. Clinical interest of PPARs ligands. Particular benefit in type 2 diabetes and metabolic syndromes. Diabetes Metab 2004; 30: 7-12.
    • (2004) Diabetes Metab , vol.30 , pp. 7-12
    • Vergés, B.1
  • 49
    • 0034595980 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor a activators improve insulin sensitivity and reduce adiposity
    • Guerre-Millo M, Gervois P, Raspé E, et al. Peroxisome proliferator-activated receptor a activators improve insulin sensitivity and reduce adiposity. J Biol Chem 2000; 275: 16638-42.
    • (2000) J Biol Chem , vol.275 , pp. 16638-16642
    • Guerre-Millo, M.1    Gervois, P.2    Raspé, E.3
  • 50
    • 17744367026 scopus 로고    scopus 로고
    • Effects of PPAR-α/γ therapy on glucose/lipid metabolism, hepatic fat content, and plasma adiponectin concentration in patients with type 2 diabetes
    • abstract PS-714
    • Bajaj M, DeFronzo R, Suraamornkul S. Effects of PPAR-α/γ therapy on glucose/lipid metabolism, hepatic fat content, and plasma adiponectin concentration in patients with type 2 diabetes. Diabetologia 2004; 47 (suppl.1): A258 [abstract PS-714].
    • (2004) Diabetologia , vol.47 , Issue.SUPPL. 1
    • Bajaj, M.1    Defronzo, R.2    Suraamornkul, S.3
  • 51
    • 85083135611 scopus 로고    scopus 로고
    • The effects of dual PPARα/γ stimulation with combination of rosiglitazone and fenofibrate on metabolic parameters in type 2 diabetic patients
    • abstract PS-715
    • Seber S, Ucak S, Basat A, et al. The effects of dual PPARα/γ stimulation with combination of rosiglitazone and fenofibrate on metabolic parameters in type 2 diabetic patients. Diabetologia 2004; 47 (suppl.1): A258-A259 [abstract PS-715].
    • (2004) Diabetologia , vol.47 , Issue.SUPPL. 1
    • Seber, S.1    Ucak, S.2    Basat, A.3
  • 53
    • 0142216121 scopus 로고    scopus 로고
    • Ragaglitazar: A novel PPAR alpha-PPAR gamma agonist with lipid-lowering and insulin-sensitizing efficacy in animal models
    • Chakrabarti R, Vikramadithyan RK, Misra P, et al. Ragaglitazar: a novel PPAR alpha-PPAR gamma agonist with lipid-lowering and insulin-sensitizing efficacy in animal models. Br J Pharmacol 2003; 140: 527-37.
    • (2003) Br J Pharmacol , vol.140 , pp. 527-537
    • Chakrabarti, R.1    Vikramadithyan, R.K.2    Misra, P.3
  • 54
    • 0036847135 scopus 로고    scopus 로고
    • AZ 242, a novel PPARalpha/gamma agonist with beneficial effects on insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats
    • Ljung B, Bamberg K, Dahllof B, et al. AZ 242, a novel PPARalpha/gamma agonist with beneficial effects on insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats. J Lipid Res 2002; 43: 1855-63.
    • (2002) J Lipid Res , vol.43 , pp. 1855-1863
    • Ljung, B.1    Bamberg, K.2    Dahllof, B.3
  • 55
    • 3042634455 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) activation induces tissue-specific effects on fatty acid uptake and metabolism in vivo. A study using the novel PPARα/γ agonist tesaglitazar
    • Hegarty BD, Furler SM, Oakes ND, Kraegen EW, Cooney GJ. Peroxisome proliferator-activated receptor (PPAR) activation induces tissue-specific effects on fatty acid uptake and metabolism in vivo. A study using the novel PPARα/γ agonist tesaglitazar. Endocrinology 2004; 145: 3158-64.
    • (2004) Endocrinology , vol.145 , pp. 3158-3164
    • Hegarty, B.D.1    Furler, S.M.2    Oakes, N.D.3    Kraegen, E.W.4    Cooney, G.J.5
  • 56
    • 17644362904 scopus 로고    scopus 로고
    • Muraglitazar, a novel non-TZD dual PPARα/γ agonist, improves metabolic abnormalities in obese, severely diabetic db/db mice
    • abstract 134-OR
    • Harrity T, Chu C, Kunselman L, et al. Muraglitazar, a novel non-TZD dual PPARα/γ agonist, improves metabolic abnormalities in obese, severely diabetic db/db mice. Diabetes 2004; 53 (suppl.2): A31-A32 [abstract 134-OR].
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2
    • Harrity, T.1    Chu, C.2    Kunselman, L.3
  • 57
    • 17744363287 scopus 로고    scopus 로고
    • Glucose lowering effects of multiple administration of muraglitazar (BMS-298585), a novel PPARα/γ dual agonist, in type 2 diabetic patients
    • abstract 138-OR
    • Mosqueda-Garcia R, Frost CE, Swaminathan A, et al. Glucose lowering effects of multiple administration of muraglitazar (BMS-298585), a novel PPARα/γ dual agonist, in type 2 diabetic patients. Diabetes 2004; 53 (suppl 2): A32 [abstract 138-OR].
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2
    • Mosqueda-Garcia, R.1    Frost, C.E.2    Swaminathan, A.3
  • 58
    • 0031793850 scopus 로고    scopus 로고
    • A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-α (PPARα) and PPARγ: Effect of PPARα activation on abnormal lipid metabolism in liver of Zucker fatty rats
    • Murakami K, Tobe K, Ide T, et al. A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-α (PPARα) and PPARγ: effect of PPARα activation on abnormal lipid metabolism in liver of Zucker fatty rats. Diabetes 1998; 47: 1841-7.
    • (1998) Diabetes , vol.47 , pp. 1841-1847
    • Murakami, K.1    Tobe, K.2    Ide, T.3
  • 59
    • 17644399086 scopus 로고    scopus 로고
    • Single and multiple doses of MK-0767 (KRP-297) reduce free fatty acids and lipids in healthy subjects
    • abstract 588-P
    • Wagner J, Chun X, Rippley R, et al. Single and multiple doses of MK-0767 (KRP-297) reduce free fatty acids and lipids in healthy subjects. Diabetes 2003; 52 (suppl. 1): A137 [abstract 588-P].
    • (2003) Diabetes , vol.52 , Issue.SUPPL. 1
    • Wagner, J.1    Chun, X.2    Rippley, R.3
  • 60
    • 0032898052 scopus 로고    scopus 로고
    • Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative
    • Shibata T, Matsui K, Nagao K, Shinkai H, Yonemori F, Wakitani K. Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative. Eur J Pharmacol 1999; 364: 211-9.
    • (1999) Eur J Pharmacol , vol.364 , pp. 211-219
    • Shibata, T.1    Matsui, K.2    Nagao, K.3    Shinkai, H.4    Yonemori, F.5    Wakitani, K.6
  • 61
    • 0036224780 scopus 로고    scopus 로고
    • A tailored therapy for the metabolic syndrome: The dual peroxisome proliferator-activated receptor-α/γ agonist LY465608 ameliorates insulin resistance and diabetic hyperglycaemia while improving cardiovascular risk factors in preclinical models
    • Etgen GJ, Oldham BA, Johnson WT, et al. A tailored therapy for the metabolic syndrome: the dual peroxisome proliferator-activated receptor-α/γ agonist LY465608 ameliorates insulin resistance and diabetic hyperglycaemia while improving cardiovascular risk factors in preclinical models. Diabetes 2002; 51: 1083-7.
    • (2002) Diabetes , vol.51 , pp. 1083-1087
    • Etgen, G.J.1    Oldham, B.A.2    Johnson, W.T.3
  • 62
    • 4243334991 scopus 로고    scopus 로고
    • LY510929, a highly potent, non-TZD, PPARα/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia
    • abstract 605-P
    • Etgen GJ, Broderick C, Oldham BA, et al. LY510929, a highly potent, non-TZD, PPARα/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Diabetes 2003; 52 (suppl.1): A141 [abstract 605-P].
    • (2003) Diabetes , vol.52 , Issue.SUPPL. 1
    • Etgen, G.J.1    Broderick, C.2    Oldham, B.A.3
  • 63
    • 17744385549 scopus 로고    scopus 로고
    • Efficacy of LY519818, a novel non-TZD, PPAR γ-dominant α/γ dual agonist
    • abstract 139-OR
    • Prince M, Spicer K, Caro J, et al. Efficacy of LY519818, a novel non-TZD, PPAR γ-dominant α/γ dual agonist. Diabetes 2004; 53 (suppl 2): A33 [abstract 139-OR].
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2
    • Prince, M.1    Spicer, K.2    Caro, J.3
  • 64
    • 12144286421 scopus 로고    scopus 로고
    • A novel peroxisome proliferator-activated receptor α/γ dual agonist demonstrates favorable effects on lipid homeostasis
    • Guo Q, Sahoo SP, Wang PR, et al. A novel peroxisome proliferator- activated receptor α/γ dual agonist demonstrates favorable effects on lipid homeostasis. Endocrinology 2004; 145: 1640-8.
    • (2004) Endocrinology , vol.145 , pp. 1640-1648
    • Guo, Q.1    Sahoo, S.P.2    Wang, P.R.3
  • 65
    • 17744378975 scopus 로고    scopus 로고
    • Hypoglycemic and hypolipidemic effects of a novel dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist, E3030, in db/db mice
    • abstract 544-P
    • Inoue T, Yoshitomi H, Kasai S, et al. Hypoglycemic and hypolipidemic effects of a novel dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist, E3030, in db/db mice. Diabetes 2004; 53 (suppl.2): A129 [abstract 544-P].
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2
    • Inoue, T.1    Yoshitomi, H.2    Kasai, S.3
  • 66
    • 17744400099 scopus 로고    scopus 로고
    • Hypolipidemic effects of a novel dual PPARα/γ agonist, E3030, in beagle dogs
    • abstract 553-P
    • Kasai S, Inoue T, Yoshitomi H, et al. Hypolipidemic effects of a novel dual PPARα/γ agonist, E3030, in beagle dogs. Diabetes 2004; 53 (suppl.2): A131 [abstract 553-P].
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2
    • Kasai, S.1    Inoue, T.2    Yoshitomi, H.3
  • 67
    • 0042229358 scopus 로고    scopus 로고
    • DRF 2655: A unique molecule that reduces body weight and ameliorates metabolic abnormalities
    • Vikramadithyan RK, Hiriyan J, Suresh J, et al. DRF 2655: a unique molecule that reduces body weight and ameliorates metabolic abnormalities. Obes Res 2003; 11: 292-303.
    • (2003) Obes Res , vol.11 , pp. 292-303
    • Vikramadithyan, R.K.1    Hiriyan, J.2    Suresh, J.3
  • 68
    • 14944344498 scopus 로고    scopus 로고
    • LM 4156, a novel, balanced activator of PPAR α and γ improves dyslipidemia in fa/fa Zucker rats
    • abstract 488-P
    • Chevreuil O, Contard F, Guerrier D. LM 4156, a novel, balanced activator of PPAR α and γ improves dyslipidemia in fa/fa Zucker rats. Diabetes 2003; 52 (suppl.1): A114 [abstract 488-P].
    • (2003) Diabetes , vol.52 , Issue.SUPPL. 1
    • Chevreuil, O.1    Contard, F.2    Guerrier, D.3
  • 69
    • 85083121833 scopus 로고    scopus 로고
    • LM 4156, a novel, balanced activator of PPAR α and ψ with anti-hyperglycemic and HDL elevator properties in db/db and human apoA1 mice
    • abstract 492-P
    • Contard F, Berard I, Yvon S, Decerprit J, Guerrier D. LM 4156, a novel, balanced activator of PPAR α and ψ with anti-hyperglycemic and HDL elevator properties in db/db and human apoA1 mice. Diabetes 2003; 52 (suppl.1): A115 [abstract 492-P].
    • (2003) Diabetes , vol.52 , Issue.SUPPL. 1
    • Contard, F.1    Berard, I.2    Yvon, S.3    Decerprit, J.4    Guerrier, D.5
  • 70
    • 85083123219 scopus 로고    scopus 로고
    • TY-51501, a novel halobenzyltyrosine derivatives, ameliorates insulin resistance and up-regulates adiponectin in vivo
    • abstract 616-P
    • Satoh H, Kubota N, Terauchi Y, et al. TY-51501, a novel halobenzyltyrosine derivatives, ameliorates insulin resistance and up-regulates adiponectin in vivo. Diabetes 2003; 52 (suppl.1): A144 [abstract 616-P].
    • (2003) Diabetes , vol.52 , Issue.SUPPL. 1
    • Satoh, H.1    Kubota, N.2    Terauchi, Y.3
  • 71
    • 0037376448 scopus 로고    scopus 로고
    • Dual PPARalpha/ gamma activation provides enhanced improvement of insulin sensitivity and glycemic control in ZDF rats
    • Brand CL, Sturis J, Gotfredsen CF, et al. Dual PPARalpha/ gamma activation provides enhanced improvement of insulin sensitivity and glycemic control in ZDF rats. Am J Physiol Endocrinol Metab 2003; 284: E-841-54.
    • (2003) Am J Physiol Endocrinol Metab , vol.284
    • Brand, C.L.1    Sturis, J.2    Gotfredsen, C.F.3
  • 72
    • 85083147855 scopus 로고    scopus 로고
    • Muraglitazar, a novel PPAR alpha/ gamma dual agonist, lowers fasting plasma glucose, triglycerides, non esterified fatty acids and apolipoprotein (APO) CIII after once a day administration in type 2 diabetic patients
    • abstract PS-717
    • Gregg RE, Swaminathan A, Frost C, Nepal S, Raymond R, Mosqueda-Garcia R. Muraglitazar, a novel PPAR alpha/ gamma dual agonist, lowers fasting plasma glucose, triglycerides, non esterified fatty acids and apolipoprotein (APO) CIII after once a day administration in type 2 diabetic patients. Diabetologia 2004; 47 (suppl. 1): A259 [abstract PS-717].
    • (2004) Diabetologia , vol.47 , Issue.SUPPL. 1
    • Gregg, R.E.1    Swaminathan, A.2    Frost, C.3    Nepal, S.4    Raymond, R.5    Mosqueda-Garcia, R.6
  • 73
    • 2542462552 scopus 로고    scopus 로고
    • Ragaglitazar improves glycemic control and lipid profile in type 2 diabetic subjects
    • Saad MF, Greco S, Osei K, et al. Ragaglitazar improves glycemic control and lipid profile in type 2 diabetic subjects. Diabetes Care 2004; 27: 1324-9.
    • (2004) Diabetes Care , vol.27 , pp. 1324-1329
    • Saad, M.F.1    Greco, S.2    Osei, K.3
  • 74
    • 0037362638 scopus 로고    scopus 로고
    • PPARalpha/gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly
    • Ye JM, Iglesias MA, Watson DG, et al. PPARalpha/gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly. Am J Physiol Endocrinol Metab 2003; 284: E-531-40.
    • (2003) Am J Physiol Endocrinol Metab , vol.284
    • Ye, J.M.1    Iglesias, M.A.2    Watson, D.G.3
  • 75
    • 17744361912 scopus 로고    scopus 로고
    • Données nouvelles sur les récepteurs PPAR
    • Vidal H. Données nouvelles sur les récepteurs PPAR. Ann Endocrinol 2005; 66: 1S5-1S9.
    • (2005) Ann Endocrinol , vol.66
    • Vidal, H.1
  • 76
    • 0346788908 scopus 로고    scopus 로고
    • Roles of PPARdelta in the control of muscle development and metabolism
    • Grimaldi PA. Roles of PPARdelta in the control of muscle development and metabolism. Biochem Soc Trans 2003; 31: 1130-2.
    • (2003) Biochem Soc Trans , vol.31 , pp. 1130-1132
    • Grimaldi, P.A.1
  • 77
    • 14744277647 scopus 로고    scopus 로고
    • The effects of PPARα, δ and PPARpan™ agonists on diet-induced obesity in fat-fed AKR mice
    • abstract 565-P
    • Lewis MC, Wilson JG, Ignar DM, Oliver WR Jr. The effects of PPARα, δ and PPARpan™ agonists on diet-induced obesity in fat-fed AKR mice. Diabetes 2004; 53 (suppl. 2): A134 [abstract 565-P].
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2
    • Lewis, M.C.1    Wilson, J.G.2    Ignar, D.M.3    Oliver Jr., W.R.4
  • 78
    • 14744279323 scopus 로고    scopus 로고
    • PPARpan™ agonist treatment improves lipid utilization via tissue-specific effects on skeletal muscle and adipose tissue lipoprotein lipase activity in obese monkeys
    • abstract 666-P
    • Ortmeyer HK, Collins CA, Minnick DT, et al. PPARpan™ agonist treatment improves lipid utilization via tissue-specific effects on skeletal muscle and adipose tissue lipoprotein lipase activity in obese monkeys. Diabetes 2004; 53 (suppl. 2): A159 [abstract 666-P].
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2
    • Ortmeyer, H.K.1    Collins, C.A.2    Minnick, D.T.3
  • 79
    • 17444442152 scopus 로고    scopus 로고
    • Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists
    • Mukherjee R, Davies PJA, Crombie DL, et al. Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists. Nature 1997; 386: 407-10.
    • (1997) Nature , vol.386 , pp. 407-410
    • Mukherjee, R.1    Pja, D.2    Crombie, D.L.3
  • 80
    • 0037066766 scopus 로고    scopus 로고
    • The antidiabetic agent LG100754 sensitizes cells to low concentrations of peroxisome proliferator-activated receptor gamma ligands
    • Forman BM. The antidiabetic agent LG100754 sensitizes cells to low concentrations of peroxisome proliferator-activated receptor gamma ligands. J Biol Chem 2002; 277: 12503-6.
    • (2002) J Biol Chem , vol.277 , pp. 12503-12506
    • Forman, B.M.1
  • 81
    • 0034895388 scopus 로고    scopus 로고
    • The rexinoid LG100754 is a novel RXR: PPARgamma agonist which decreases glucose level in vivo
    • Cesario RM, Klausing K, Razzaghi H, et al. The rexinoid LG100754 is a novel RXR: PPARgamma agonist which decreases glucose level in vivo. Mol Endocrinol 2001; 15: 1360-9.
    • (2001) Mol Endocrinol , vol.15 , pp. 1360-1369
    • Cesario, R.M.1    Klausing, K.2    Razzaghi, H.3


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