Optimized regulation of gene expression using artificial transcription factors

Molecular Therapy

Volumn 5, Issue 6, 2002, Pages 685-694

  Yaghmai, Reza ^a   Cutting, Garry R ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Artificial genes; Gene activation; Gene expression regulation; Gene therapy; Genetic transcription; Transactivators; Transcription factors; Zinc fingers

Indexed keywords

DNA; REPRESSOR PROTEIN; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN; HYBRID PROTEIN;

ARTICLE; CELL TYPE; CONTROLLED STUDY; CYTOMEGALOVIRUS; DNA BINDING MOTIF; GENE EXPRESSION REGULATION; GENE TARGETING; GENE THERAPY; GENETIC ENGINEERING; HUMAN; HUMAN CELL; NONHUMAN; PROMOTER REGION; ROUS SARCOMA ONCOVIRUS; SAFETY; SIMIAN VIRUS 40; GENE VECTOR; GENETICS; KINETICS; METABOLISM; PROTEIN ENGINEERING; PROTEIN TERTIARY STRUCTURE;

CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS; ONCOVIRINAE; RICE STRIPE VIRUS; ROUS SARCOMA VIRUS; SIMIAE; SIMIAN VIRUS 40; SYNTHETIC CONSTRUCT;

CYTOMEGALOVIRUS; GENE EXPRESSION REGULATION; GENETIC VECTORS; KINETICS; PROMOTER REGIONS (GENETICS); PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SIMIAN VIRUS 40; TRANSCRIPTION FACTORS; ZINC FINGERS;

EID: 0035989012     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2002.0610     Document Type: Article

References (53)

1. Initial sequencing and analysis of the human genome
2. The sequence of the human genome
3. Gene therapy-promises, problems and prospects
4. Molecular genetics of the RNA polymerase II general transcriptional machinery
5. Transcriptional activation by recruitment
6. Mechanisms of transcriptional activation: Differences and similarities between yeast, Drosophila, and man
7. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
8. Composite co-activator ARC mediates chromatin-directed transcriptional activation
9. Chromosome territories, nuclear architecture and gene regulation in mammalian cells
10. Nuclear visions: Functional flexibility from structural instability
11. RNA polymerase II and the integration of nuclear events
12. The enhanceosome and transcriptional synergy
13. Expressing the human genome
14. Design of novel sequence-specific DNA-binding proteins
15. Zinc finger proteins as designer transcription factors
16. Regulation of the MDR1 gene by transcriptional repressors selected using peptide combinatorial libraries
17. Improved DNA binding specificity from polyzinc finger peptides by using strings of two-finger units
18. Design and selection of novel Cys2His2 zinc finger proteins
19. Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A
20. Synthetic zinc finger transcription factor action at an endogenous chromosomal site. Activation of the human erythropoietin gene
21. Positive and negative regulation of endogenous genes by designed transcription factors
22. Identification of ligands and coligands for the ecdysone-regulated gene switch
23. Tet repressor-based system for regulated gene expression in eukaryotic cells: Principles and advances
24. The impact of mammalian gene regulation concepts on functional genomic research, metabolic engineering, and advanced gene therapies
25. Negative effect of the transcriptional activator GAL4
26. Different activation domains stimulate transcription from remote ('enhancer') and proximal ('promoter') positions
27. Transcriptional activation by artificial recruitment in yeast is influenced by promoter architecture and downstream sequences
28. Transcriptional activation by artificial recruitment in mammalian cells
29. Use of a zinc-finger consensus sequence frame-work and specificity rules to design specific DNA binding proteins
30. Structure-based design of transcription factors
31. Design of polydactyl zinc-finger proteins for unique addressing within complex genomes
32. Design of polyzinc finger peptides with structured linkers
33. Getting a handhold on DNA: Design of poly-zinc finger proteins with femtomolar dissociation constants
34. A 2.2 Å resolution crystal structure of a designed zinc finger protein bound to DNA
35. Transcriptional repression by zinc finger peptides. Exploring the potential for applications in gene therapy
36. Imposing specificity by localization: Mechanism and evolvability
37. Cooperative DNA binding of the yeast transcriptional activator GAL4
38. A synergistic increase in potency of a multimerized VP16 transcriptional activation domain
39. Synergistic and promoter-selective activation of transcription by recruitment of transcription factors TFIID and TFIIB
40. Herpes simplex virus type 1 ICP4 promotes transcription preinitiation complex formation by enhancing the binding of TFIID to DNA
41. A general mechanism for transcriptional synergy by eukaryotic activators
42. The initiation accuracy of the SV40 early transcription is determined by the functional domains of two TATA elements
43. Eukaryotic transcription: An interlaced network of transcription factors and chromatin-modifying machines
44. Sequence requirements for plasmid nuclear import
45. Virtually unidirectional binding of TBP to the AdMLP TATA box within the quaternary complex with TFIIA and TFIIB
46. The structural basis for the oriented assembly of a TBP/TFB/promoter complex
47. Human general transcription factor TFIIB: Conformational variability and interaction with VP16 activation domain
48. The conformation of the transcription factor TFIIB modulates the response to transcriptional activators in vivo
49. Intramolecular interaction of yeast TFIIB in transcription control
50. Activation of gene expression by small molecule transcription factors
51. Redesigning the DNA-binding specificity of a zinc finger protein: A data base-guided approach
52. A short amino acid sequence able to specify nuclear location
53. Kruppel-associated boxes are potent transcriptional repression domains