Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease

Molecular Therapy

Volumn 11, Issue 5, 2005, Pages 745-753

  Klugmann, Matthias ^a,d   Leichtlein, Claudia B ^a   Symes, C Wymond ^a   Serikawa, Tadao ^b   Young, Deborah ^a   During, Matthew J ^a,c  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b KYOTO UNIVERSITY   (Japan)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Adeno associated virus; Aspartoacylase; Canavan disease; Demyelination; Epilepsy; Gene therapy; Leukodystrophy; N acetylaspartate; Oligodendrocyte

Indexed keywords

ASPARTOACYLASE; CAPSID PROTEIN; N ACETYLASPARTIC ACID;

ADENO ASSOCIATED VIRUS; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANAVAN DISEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEMYELINATING DISEASE; DEMYELINATION; ELECTROENCEPHALOGRAM; ENZYME ACTIVITY; FEMALE; GENE THERAPY; IMMUNOHISTOCHEMISTRY; LOCOMOTION; MALE; MOTOR DYSFUNCTION; MYELINATION; NONHUMAN; OLIGODENDROGLIA; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SEIZURE; VIRAL GENE DELIVERY SYSTEM; VIRUS RECOMBINANT;

AMIDOHYDROLASES; ANIMALS; ASPARTIC ACID; CANAVAN DISEASE; CENTRAL NERVOUS SYSTEM; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; MALE; MOTOR NEURONS; MYELIN SHEATH; RATS; SEIZURES;

ADENO-ASSOCIATED VIRUS;

EID: 17644419965     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2005.01.006     Document Type: Article

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