메뉴 건너뛰기




Volumn 122, Issue 1, 2004, Pages 71-78

N-Acetylaspartate synthase is bimodally expressed in microsomes and mitochondria of brain

Author keywords

Acetyl CoA L aspartate N acetyltransferase (NAA synthase); ANAT; Brain microsomes and mitochondria; Dithiothreitol; DTT; Endoplasmic reticulum; Enzyme property; ER; INT; Multiple sclerosis; Myelin lipid synthesis; N Acetylaspartate; N Acetylaspartate synthase

Indexed keywords

3 [(3 CHOLAMIDOPROPYL)DIMETHYLAMMONIO] 1 PROPANESULFONIC ACID; ACETYL COENZYME A SYNTHETASE; BRAIN ENZYME; DETERGENT; HYDROLASE; N ACETYLASPARTIC ACID SYNTHASE; SODIUM DIHYDROGEN PHOSPHATE; SYNTHETASE; TYLOXAPOL; UNCLASSIFIED DRUG;

EID: 1342285559     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2003.12.002     Document Type: Article
Times cited : (65)

References (63)
  • 1
    • 0020052170 scopus 로고
    • Transfer of axonally transported phospholipids into myelin isolated from rabbit optic pathway
    • Alberghina M.M., Viola M., Giuffrida A.M. Transfer of axonally transported phospholipids into myelin isolated from rabbit optic pathway. Neurochem. Res. 7:1982;139-149.
    • (1982) Neurochem. Res. , vol.7 , pp. 139-149
    • Alberghina, M.M.1    Viola, M.2    Giuffrida, A.M.3
  • 2
    • 0033570145 scopus 로고    scopus 로고
    • Dual targeting of cytochrome P4502B1 to endoplasmic reticulum and mitochondria involves a novel signal activation by cyclic AMP-dependent phosphorylation at Ser128
    • Anandatheerthavarada H.K., Biswas G., Mullick J., Sepuri N.B.V., Otvos L., Pain D., Avadhani N.G. Dual targeting of cytochrome P4502B1 to endoplasmic reticulum and mitochondria involves a novel signal activation by cyclic AMP-dependent phosphorylation at Ser128. EMBO J. 18:1999;5494-5504.
    • (1999) EMBO J. , vol.18 , pp. 5494-5504
    • Anandatheerthavarada, H.K.1    Biswas, G.2    Mullick, J.3    Sepuri, N.B.V.4    Otvos, L.5    Pain, D.6    Avadhani, N.G.7
  • 3
    • 0034057202 scopus 로고    scopus 로고
    • Improved recovery of highly enriched mitochondrial fractions from small brain tissue samples
    • Anderson M.F., Sims N.R. Improved recovery of highly enriched mitochondrial fractions from small brain tissue samples. Brain Res. Protoc. 5:2000;95-101.
    • (2000) Brain Res. Protoc. , vol.5 , pp. 95-101
    • Anderson, M.F.1    Sims, N.R.2
  • 5
    • 0023256232 scopus 로고
    • Purification of NADPH:cytochrome c (cytochrome P-450) reductase from hamster liver microsomes by detergent extraction and affinity chromatography
    • Ardies C.M., Lasker J.M., Bloswick B.P., Lieber C.S. Purification of NADPH:cytochrome c (cytochrome P-450) reductase from hamster liver microsomes by detergent extraction and affinity chromatography. Anal. Biochem. 162:1987;39-46.
    • (1987) Anal. Biochem. , vol.162 , pp. 39-46
    • Ardies, C.M.1    Lasker, J.M.2    Bloswick, B.P.3    Lieber, C.S.4
  • 6
    • 0025295740 scopus 로고
    • Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: Assessment of the load of disease
    • Arnold D.L., Matthews P.M., Francis G., Antel J. Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: assessment of the load of disease. Magn. Reson. Med. 14:1990;154-159.
    • (1990) Magn. Reson. Med. , vol.14 , pp. 154-159
    • Arnold, D.L.1    Matthews, P.M.2    Francis, G.3    Antel, J.4
  • 7
    • 0033914812 scopus 로고    scopus 로고
    • Functions of N-acetyl-L-aspartate and N-acetyl-L-aspartylglutamate in the vertebrate brain: Role in glial cell-specific signaling
    • Baslow M.H. Functions of N-acetyl-L-aspartate and N-acetyl-L- aspartylglutamate in the vertebrate brain: role in glial cell-specific signaling. J. Neurochem. 75:2000;453-459.
    • (2000) J. Neurochem. , vol.75 , pp. 453-459
    • Baslow, M.H.1
  • 8
    • 0037409849 scopus 로고    scopus 로고
    • N-acetylaspartate in the vertebrate brain: Metabolism and function
    • Baslow M.H. N-acetylaspartate in the vertebrate brain: metabolism and function. Neurochem. Res. 28:2003;941-953.
    • (2003) Neurochem. Res. , vol.28 , pp. 941-953
    • Baslow, M.H.1
  • 9
    • 0031243417 scopus 로고    scopus 로고
    • Canavan disease: Analysis of the nature of the metabolic lesions responsible for development of the observed clinical symptoms
    • Baslow M.H., Resnick T.R. Canavan disease: analysis of the nature of the metabolic lesions responsible for development of the observed clinical symptoms. J. Mol. Neurosci. 9:1997;109-126.
    • (1997) J. Mol. Neurosci. , vol.9 , pp. 109-126
    • Baslow, M.H.1    Resnick, T.R.2
  • 10
    • 0033384017 scopus 로고    scopus 로고
    • Expression of aspartoacylase activity in cultured rat macroglial cells is limited to oligodendrocytes
    • Baslow M.H., Suckow R.F., Sapirstein V., Hungund B.L. Expression of aspartoacylase activity in cultured rat macroglial cells is limited to oligodendrocytes. J. Mol. Neurosci. 13:1999;47-53.
    • (1999) J. Mol. Neurosci. , vol.13 , pp. 47-53
    • Baslow, M.H.1    Suckow, R.F.2    Sapirstein, V.3    Hungund, B.L.4
  • 11
  • 12
    • 0033961818 scopus 로고    scopus 로고
    • In vitro expression of N-acetyl aspartate by oligodendrocytes: Implications for proton magnetic resonance spectroscopy signal in vivo
    • Bhakoo K.K., Pearce D. In vitro expression of N-acetyl aspartate by oligodendrocytes: implications for proton magnetic resonance spectroscopy signal in vivo. J. Neurochem. 74:2000;254-262.
    • (2000) J. Neurochem. , vol.74 , pp. 254-262
    • Bhakoo, K.K.1    Pearce, D.2
  • 13
    • 0034790687 scopus 로고    scopus 로고
    • Developmental and regional distribution of aspartoacylase in rat brain tissue
    • Bhakoo K.K., Craig T.J., Styles P. Developmental and regional distribution of aspartoacylase in rat brain tissue. J. Neurochem. 79:2001;211-220.
    • (2001) J. Neurochem. , vol.79 , pp. 211-220
    • Bhakoo, K.K.1    Craig, T.J.2    Styles, P.3
  • 14
    • 0024325294 scopus 로고
    • N-acetyl-L-aspartic acid: A literature review of a compound prominent in 1H-NMR spectroscopic studies of brain
    • Birken D.L., Oldendorf W.H. N-acetyl-L-aspartic acid: a literature review of a compound prominent in 1H-NMR spectroscopic studies of brain. Neurosci. Biobehav. 13:1989;23-31.
    • (1989) Neurosci. Biobehav. , vol.13 , pp. 23-31
    • Birken, D.L.1    Oldendorf, W.H.2
  • 15
    • 0036136536 scopus 로고    scopus 로고
    • N-acetylaspartate is an axon-specific marker of mature white matter in vivo: A biochemical and immunohistochemical study on the rat optic nerve
    • Bjartmar C., Battistuta J., Terada N., Dupree E., Trapp B.D. N-acetylaspartate is an axon-specific marker of mature white matter in vivo: a biochemical and immunohistochemical study on the rat optic nerve. Ann. Neurol. 51:2002;51-58.
    • (2002) Ann. Neurol. , vol.51 , pp. 51-58
    • Bjartmar, C.1    Battistuta, J.2    Terada, N.3    Dupree, E.4    Trapp, B.D.5
  • 16
    • 0036386840 scopus 로고    scopus 로고
    • In-vivo proton MR-spectroscopy of the human brain: Assessment of N-acetylaspartate (NAA) reduction as a marker for neurodegeneration
    • Block W., Traber F., Flacke S., Jessen F., Pohl C., Schild H. In-vivo proton MR-spectroscopy of the human brain: assessment of N-acetylaspartate (NAA) reduction as a marker for neurodegeneration. Amino Acids. 23:2002;317-323.
    • (2002) Amino Acids , vol.23 , pp. 317-323
    • Block, W.1    Traber, F.2    Flacke, S.3    Jessen, F.4    Pohl, C.5    Schild, H.6
  • 17
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 18
    • 0026317199 scopus 로고
    • N-acetyl-L-aspartate is a major source of acetyl groups for lipid synthesis during rat brain development
    • Burri R., Steffen C., Herschkowitz N. N-acetyl-L-aspartate is a major source of acetyl groups for lipid synthesis during rat brain development. Dev. Neurosci. 13:1991;403-411.
    • (1991) Dev. Neurosci. , vol.13 , pp. 403-411
    • Burri, R.1    Steffen, C.2    Herschkowitz, N.3
  • 19
    • 0037430931 scopus 로고    scopus 로고
    • Fatty acid synthesizing enzymes intrinsic to myelin
    • Chakraborty G., Ledeen R. Fatty acid synthesizing enzymes intrinsic to myelin. Mol. Brain Res. 112:2003;46-52.
    • (2003) Mol. Brain Res. , vol.112 , pp. 46-52
    • Chakraborty, G.1    Ledeen, R.2
  • 20
    • 0034890751 scopus 로고    scopus 로고
    • Intraneuronal N-acetylaspartate supplies acetyl groups for myelin lipid synthesis: Evidence for myelin-associated aspartoacylase
    • Chakraborty G., Mekala P., Yahya D., Wu G., Ledeen R.W. Intraneuronal N-acetylaspartate supplies acetyl groups for myelin lipid synthesis: evidence for myelin-associated aspartoacylase. J. Neurochem. 78:2001;736-745.
    • (2001) J. Neurochem. , vol.78 , pp. 736-745
    • Chakraborty, G.1    Mekala, P.2    Yahya, D.3    Wu, G.4    Ledeen, R.W.5
  • 21
    • 0031731910 scopus 로고    scopus 로고
    • N-acetyl aspartate: A marker for neuronal loss or mitochondrial dysfunction
    • Clark J.B. N-acetyl aspartate: a marker for neuronal loss or mitochondrial dysfunction. Dev. Neurosci. 20:1998;271-276.
    • (1998) Dev. Neurosci. , vol.20 , pp. 271-276
    • Clark, J.B.1
  • 22
    • 0013957861 scopus 로고
    • Acetate metabolism in the nervous system. N-acetyl-L-aspartic acid and the biosynthesis of brain lipids
    • D'Adamo A.F., Yatsu F.M. Acetate metabolism in the nervous system. N-acetyl-L-aspartic acid and the biosynthesis of brain lipids. J. Neurochem. 13:1966;961-963.
    • (1966) J. Neurochem. , vol.13 , pp. 961-963
    • D'Adamo, A.F.1    Yatsu, F.M.2
  • 23
    • 0015611504 scopus 로고
    • The occurrence of N-acetylaspartate amidohyddrolase (aminoacylase II) in the developing rat
    • D'Adamo A.F., Smith J.C., Woiler C. The occurrence of N-acetylaspartate amidohyddrolase (aminoacylase II) in the developing rat. J. Neurochem. 20:1973;1275-1278.
    • (1973) J. Neurochem. , vol.20 , pp. 1275-1278
    • D'Adamo, A.F.1    Smith, J.C.2    Woiler, C.3
  • 25
    • 0017881056 scopus 로고
    • Axon-myelin transfer of phospholipid components in the course of their axonal-transport as visualized by radioautography
    • Droz B., Di Giamberardino L., Koenig H.L., Boyenval J., Hassig R. Axon-myelin transfer of phospholipid components in the course of their axonal-transport as visualized by radioautography. Brain Res. 155:1978;347-353.
    • (1978) Brain Res. , vol.155 , pp. 347-353
    • Droz, B.1    Di Giamberardino, L.2    Koenig, H.L.3    Boyenval, J.4    Hassig, R.5
  • 28
    • 0032695778 scopus 로고    scopus 로고
    • Maturation of frataxin within mammalian and yeast mitochondria: One-step processing by matrix processing peptidase
    • Gordon D.M., Shi Q., Dancis A., Pain D. Maturation of frataxin within mammalian and yeast mitochondria: one-step processing by matrix processing peptidase. Hum. Mol. Genet. 8:1999;2255-2262.
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 2255-2262
    • Gordon, D.M.1    Shi, Q.2    Dancis, A.3    Pain, D.4
  • 29
    • 0025959891 scopus 로고
    • Purification, characterization and localization of aspartoacylase from bovine brain
    • Kaul R., Casanova J., Johnson A.B., Tang P., Matalon R. Purification, characterization and localization of aspartoacylase from bovine brain. J. Neurochem. 56:1991;129-135.
    • (1991) J. Neurochem. , vol.56 , pp. 129-135
    • Kaul, R.1    Casanova, J.2    Johnson, A.B.3    Tang, P.4    Matalon, R.5
  • 30
    • 0037434071 scopus 로고    scopus 로고
    • Developmental increase of aspartoacylase in oligodendrocytes parallels CNS myelination
    • Kirmani B.F., Jacobowitz D.M., Namboodiri M.A.A. Developmental increase of aspartoacylase in oligodendrocytes parallels CNS myelination. Dev. Brain Res. 140:2003;105-115.
    • (2003) Dev. Brain Res. , vol.140 , pp. 105-115
    • Kirmani, B.F.1    Jacobowitz, D.M.2    Namboodiri, M.A.A.3
  • 31
    • 0036788406 scopus 로고    scopus 로고
    • Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time
    • Kuhlmann T., Lingfeld G., Bitsch A., Schuchardt J., Bruck W. Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time. Brain. 125:2002;2202-2212.
    • (2002) Brain , vol.125 , pp. 2202-2212
    • Kuhlmann, T.1    Lingfeld, G.2    Bitsch, A.3    Schuchardt, J.4    Bruck, W.5
  • 32
    • 0002726230 scopus 로고
    • Enzymes and receptors of myelin
    • R.E. Martenson. Boca Raton, FL: CRC Press
    • Ledeen R.W. Enzymes and receptors of myelin. Martenson R.E. Myelin: Biology and Chemistry. 1992;531-570 CRC Press, Boca Raton, FL.
    • (1992) Myelin: Biology and Chemistry , pp. 531-570
    • Ledeen, R.W.1
  • 33
    • 0020566047 scopus 로고
    • Axon-myelin transfer of glycerol-labeled lipids and inorganic phosphate during axonal transport
    • Ledeen R.W., Haley J.E. Axon-myelin transfer of glycerol-labeled lipids and inorganic phosphate during axonal transport. Brain Res. 269:1983;267-275.
    • (1983) Brain Res. , vol.269 , pp. 267-275
    • Ledeen, R.W.1    Haley, J.E.2
  • 34
    • 0026879564 scopus 로고
    • Axon-myelin transfer of phospholipids and phospholipid precursors. Labeling of myelin phosphoinositides through axonal transport
    • Ledeen R.W., Golly F., Haley J.E. Axon-myelin transfer of phospholipids and phospholipid precursors. Labeling of myelin phosphoinositides through axonal transport. Mol. Neurobiol. 6:1992;179-190.
    • (1992) Mol. Neurobiol. , vol.6 , pp. 179-190
    • Ledeen, R.W.1    Golly, F.2    Haley, J.E.3
  • 36
    • 0015334640 scopus 로고
    • Modification of the Lowry procedure for analysis of proteolipid protein
    • Lees M., Paxman S. Modification of the Lowry procedure for analysis of proteolipid protein. Anal. Biochem. 47:1972;184-192.
    • (1972) Anal. Biochem. , vol.47 , pp. 184-192
    • Lees, M.1    Paxman, S.2
  • 39
    • 0037108846 scopus 로고    scopus 로고
    • A radiometric assay for aspartoacylase activity in cultured oligodendrocytes
    • Madhavarao C.N., Hammer J.A., Quarles R.H., Namboodiri M.A.A. A radiometric assay for aspartoacylase activity in cultured oligodendrocytes. Anal. Biochem. 308:2002;314-319.
    • (2002) Anal. Biochem , vol.308 , pp. 314-319
    • Madhavarao, C.N.1    Hammer, J.A.2    Quarles, R.H.3    Namboodiri, M.A.A.4
  • 40
    • 0035072775 scopus 로고    scopus 로고
    • Absence of N-acetylaspartate in the human brain: Impact on neurospectroscopy?
    • Martin E., Capone A., Schneider J., Hennig J., Thiel T. Absence of N-acetylaspartate in the human brain: impact on neurospectroscopy? Ann. Neurol. 49:2001;518-521.
    • (2001) Ann. Neurol. , vol.49 , pp. 518-521
    • Martin, E.1    Capone, A.2    Schneider, J.3    Hennig, J.4    Thiel, T.5
  • 42
    • 0028842858 scopus 로고
    • Canavan disease: From spongy degeneration to molecular analysis
    • Matalon R., Michals K., Kaul R. Canavan disease: from spongy degeneration to molecular analysis. J. Pediatr. 127:1995;511-517.
    • (1995) J. Pediatr. , vol.127 , pp. 511-517
    • Matalon, R.1    Michals, K.2    Kaul, R.3
  • 43
    • 0028978583 scopus 로고
    • N-acetylaspartate as an acetyl source in the nervous system
    • Mehta V., Namboodiri M.A.A. N-acetylaspartate as an acetyl source in the nervous system. Mol. Brain Res. 31:1995;151-157.
    • (1995) Mol. Brain Res. , vol.31 , pp. 151-157
    • Mehta, V.1    Namboodiri, M.A.A.2
  • 44
    • 0028978706 scopus 로고
    • Differential distribution of N-acetyl-aspartylglutamic acid and N-acetylaspartate immunoreactivities in rat brain
    • Moffett J.R., Namboodiri M.A.A. Differential distribution of N-acetyl-aspartylglutamic acid and N-acetylaspartate immunoreactivities in rat brain. J. Neurocytol. 24:1995;409-433.
    • (1995) J. Neurocytol. , vol.24 , pp. 409-433
    • Moffett, J.R.1    Namboodiri, M.A.A.2
  • 45
  • 47
    • 0033943840 scopus 로고    scopus 로고
    • N-acetylaspartylglutamate: The most abundant peptide neurotransmitter in the mammalian central nervous system
    • Neale J.H., Bzdega T., Wroblewska B. N-acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system. J. Neurochem. 75:2000;443-452.
    • (2000) J. Neurochem. , vol.75 , pp. 443-452
    • Neale, J.H.1    Bzdega, T.2    Wroblewska, B.3
  • 48
    • 0000072448 scopus 로고
    • Isolation and characterization of myelin
    • P. Morell. New York, NY: Plenum
    • Norton W.T., Cammer W. Isolation and characterization of myelin. Morell P. Myelin. 1984;147-195 Plenum, New York, NY.
    • (1984) Myelin , pp. 147-195
    • Norton, W.T.1    Cammer, W.2
  • 49
    • 0018622817 scopus 로고
    • Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport
    • Patel T.B., Clark J.B. Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport. Biochem. J. 184:1979;539-546.
    • (1979) Biochem. J. , vol.184 , pp. 539-546
    • Patel, T.B.1    Clark, J.B.2
  • 50
    • 0037174926 scopus 로고    scopus 로고
    • Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation
    • Robin M.-A., Anandatheerthavarada H.K., Biswas G., Sepuri N.B.V., Gordon D.M., Pain D., Avadhani N.G. Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation. J. Biol. Chem. 277:2002;40583-40593.
    • (2002) J. Biol. Chem. , vol.277 , pp. 40583-40593
    • Robin, M.-A.1    Anandatheerthavarada, H.K.2    Biswas, G.3    Sepuri, N.B.V.4    Gordon, D.M.5    Pain, D.6    Avadhani, N.G.7
  • 51
    • 0032516912 scopus 로고    scopus 로고
    • A GTP-dependent "push" is generally required for efficient protein translocation across the mitochondrial inner membrane into the matrix
    • Sepuri N.B.V., Gordon D.M., Pain D. A GTP-dependent "push" is generally required for efficient protein translocation across the mitochondrial inner membrane into the matrix. J. Biol. Chem. 273:1998;20941-20950.
    • (1998) J. Biol. Chem. , vol.273 , pp. 20941-20950
    • Sepuri, N.B.V.1    Gordon, D.M.2    Pain, D.3
  • 52
    • 0029055754 scopus 로고
    • Evidence that phosphatidylserine is imported into mitochondria via a mitochondria-associated membrane and that the majority of mitochondrial phosphatidylethanolamine is derived from decarboxylation of phosphatidylserine
    • Shiao Y.J., Lupo G., Vance J.E. Evidence that phosphatidylserine is imported into mitochondria via a mitochondria-associated membrane and that the majority of mitochondrial phosphatidylethanolamine is derived from decarboxylation of phosphatidylserine. J. Biol. Chem. 270:1995;11190-11198.
    • (1995) J. Biol. Chem. , vol.270 , pp. 11190-11198
    • Shiao, Y.J.1    Lupo, G.2    Vance, J.E.3
  • 53
    • 0026000851 scopus 로고
    • Immunocytochemical localization of N-acetylaspartate with monoclonal antibodies
    • Simmons M.D., Frondoza C.G., Coyle J.T. Immunocytochemical localization of N-acetylaspartate with monoclonal antibodies. Neuroscience. 45:1991;37-45.
    • (1991) Neuroscience , vol.45 , pp. 37-45
    • Simmons, M.D.1    Frondoza, C.G.2    Coyle, J.T.3
  • 54
    • 0025239273 scopus 로고
    • Isolation of subcellular organelles
    • Storrie B., Madden E.A. Isolation of subcellular organelles. Methods Enzymol. 182:1990;203-225.
    • (1990) Methods Enzymol. , vol.182 , pp. 203-225
    • Storrie, B.1    Madden, E.A.2
  • 55
    • 0000356642 scopus 로고
    • Studies on the distribution of N-acetyl-L-aspartic acid in brain
    • Tallan H.H. Studies on the distribution of N-acetyl-L-aspartic acid in brain. J. Biol. Chem. 224:1957;41-45.
    • (1957) J. Biol. Chem. , vol.224 , pp. 41-45
    • Tallan, H.H.1
  • 58
    • 0023853678 scopus 로고
    • Deposition and transfer of axonally transported phospholipids in rat sciatic nerve
    • Toews A.D., Armstrong R., Ray R., Gould R.M., Morell P. Deposition and transfer of axonally transported phospholipids in rat sciatic nerve. J. Neurosci. 8:1988;593-601.
    • (1988) J. Neurosci. , vol.8 , pp. 593-601
    • Toews, A.D.1    Armstrong, R.2    Ray, R.3    Gould, R.M.4    Morell, P.5
  • 59
    • 0022196667 scopus 로고
    • N-Acetylation of L-aspartate in the nervous system: Differential distribution of a specific enzyme
    • Truckenmiller M.E., Namboodiri M.A., Brownstein M.J., Neale J.H. N-Acetylation of L-aspartate in the nervous system: differential distribution of a specific enzyme. J. Neurochem. 45:1985;1658-1662.
    • (1985) J. Neurochem. , vol.45 , pp. 1658-1662
    • Truckenmiller, M.E.1    Namboodiri, M.A.2    Brownstein, M.J.3    Neale, J.H.4
  • 60
    • 0028978925 scopus 로고
    • N-acetylaspartate in neuropsychiatric disorders
    • Tsai G., Coyle J.T. N-acetylaspartate in neuropsychiatric disorders. Prog. Neurobiol. 46:1995;531-540.
    • (1995) Prog. Neurobiol. , vol.46 , pp. 531-540
    • Tsai, G.1    Coyle, J.T.2
  • 61
    • 0026633564 scopus 로고
    • Specific expression of N-acetyl-aspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro
    • Urenjak J., Williams S.R., Gadian D.G., Noble M. Specific expression of N-acetyl-aspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro. J. Neurochem. 59:1992;55-61.
    • (1992) J. Neurochem. , vol.59 , pp. 55-61
    • Urenjak, J.1    Williams, S.R.2    Gadian, D.G.3    Noble, M.4
  • 62
    • 0027450301 scopus 로고
    • Proton magnetic resonance spectroscopy unambiguously identifies different neural cell types
    • Urenjak J., Williams S.R., Gadian D.G., Noble M. Proton magnetic resonance spectroscopy unambiguously identifies different neural cell types. J. Neurosci. 13:1993;981-989.
    • (1993) J. Neurosci. , vol.13 , pp. 981-989
    • Urenjak, J.1    Williams, S.R.2    Gadian, D.G.3    Noble, M.4
  • 63
    • 0032971730 scopus 로고    scopus 로고
    • Neuronal damage in T1-hypointense multiple sclerosis lesions demonstrated in vivo using proton magnetic resonance spectroscopy
    • van Walderveen M.A., Barkhof F., Pouwels P.J.W., Schijndel R.A., Polman C.H., Castelijns J.A. Neuronal damage in T1-hypointense multiple sclerosis lesions demonstrated in vivo using proton magnetic resonance spectroscopy. Ann. Neurol. 46:1999;79-87.
    • (1999) Ann. Neurol. , vol.46 , pp. 79-87
    • Van Walderveen, M.A.1    Barkhof, F.2    Pouwels, P.J.W.3    Schijndel, R.A.4    Polman, C.H.5    Castelijns, J.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.