메뉴 건너뛰기




Volumn 20, Issue 2, 2005, Pages 91-96

Cholesterol and apolipoprotein E in Alzheimer's disease

Author keywords

Alzheimer's disease; Amyloid peptide; Apolipoprotein E; Cholesterol

Indexed keywords

24 HYDROXYCHOLESTEROL; AMYLOID A PROTEIN; AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; ARGININE; C REACTIVE PROTEIN; CHOLESTEROL; CHOLESTEROL DERIVATIVE; CYSTEINE; CYTOKINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; OXYSTEROL; PRAVASTATIN; SIMVASTATIN; UNCLASSIFIED DRUG;

EID: 17444406613     PISSN: 15333175     EISSN: None     Source Type: Journal    
DOI: 10.1177/153331750502000208     Document Type: Article
Times cited : (34)

References (63)
  • 1
    • 0037418570 scopus 로고    scopus 로고
    • Alzheimer disease: Current concepts and emerging diagnostic and therapeutic strategies
    • Clark C, Karlawish J: Alzheimer disease: Current concepts and emerging diagnostic and therapeutic strategies. Ann Intern Med. 2003; 138: 400-410.
    • (2003) Ann Intern Med , vol.138 , pp. 400-410
    • Clark, C.1    Karlawish, J.2
  • 2
    • 0037349681 scopus 로고    scopus 로고
    • Pharmacotherapy for Alzheimer's disease: 2002
    • Knopman D: Pharmacotherapy for Alzheimer's disease: 2002. Clinical Neuropharmacol. 2003; 26: 93-101.
    • (2003) Clinical Neuropharmacol , vol.26 , pp. 93-101
    • Knopman, D.1
  • 3
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe D: The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science. 2002; 297: 353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.2
  • 4
    • 0034049944 scopus 로고    scopus 로고
    • Proteolytic processing and cell biological functions of the amyloid precursor protein
    • De Strooper B, Annaert W: Proteolytic processing and cell biological functions of the amyloid precursor protein. J Cell Sci. 2000; 113:1857-1870.
    • (2000) J Cell Sci. , vol.113 , pp. 1857-1870
    • De Strooper, B.1    Annaert, W.2
  • 5
    • 0042810567 scopus 로고    scopus 로고
    • Cholesterol, A beta and Alzheimer's disease
    • Hartmann T: Cholesterol, A beta and Alzheimer's disease. Trend Neurosci. 2001; 24: S45-S48.
    • (2001) Trend Neurosci , vol.24
    • Hartmann, T.1
  • 6
    • 0035940542 scopus 로고    scopus 로고
    • Cholesterol and neuropathologic markers of AD: A population-based autopsy study
    • Launer L, White L, Petrovitch H, et al.: Cholesterol and neuropathologic markers of AD: A population-based autopsy study. Neurology. 2001; 57: 1447-1452.
    • (2001) Neurology , vol.57 , pp. 1447-1452
    • Launer, L.1    White, L.2    Petrovitch, H.3
  • 7
  • 8
    • 0345669752 scopus 로고    scopus 로고
    • Alzheimer's disease: The cholesterol connection
    • Puglielli L, Tanzi R, Kovacs D: Alzheimer's disease: The cholesterol connection. Nat Neurosci. 2003; 6: 345-351.
    • (2003) Nat Neurosci , vol.6 , pp. 345-351
    • Puglielli, L.1    Tanzi, R.2    Kovacs, D.3
  • 9
    • 0035083555 scopus 로고    scopus 로고
    • Cholesterol metabolism in the brain
    • Dietschy JM, Turley SD: Cholesterol metabolism in the brain. Curr Opin Lipidol. 2001; 12: 105-112.
    • (2001) Curr Opin Lipidol , vol.12 , pp. 105-112
    • Dietschy, J.M.1    Turley, S.D.2
  • 10
    • 0031848338 scopus 로고    scopus 로고
    • Cholesterol homeostasis in human brain: Turnover of 24S- hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation
    • Björkhem I, Lütjohann D, Diczfalusy U, et al.: Cholesterol homeostasis in human brain: Turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. J Lipid Res. 1998; 39: 1594-1600.
    • (1998) J Lipid Res , vol.39 , pp. 1594-1600
    • Björkhem, I.1    Lütjohann, D.2    Diczfalusy, U.3
  • 11
    • 2342471420 scopus 로고    scopus 로고
    • The blood-brain barrier. An overview: Structure, regulation, and clinical implications
    • Ballabh P, Braun A, Nedergaard M: The blood-brain barrier. An overview: Structure, regulation, and clinical implications. Neurobiol Dis. 2004; 16: 1-13.
    • (2004) Neurobiol Dis , vol.16 , pp. 1-13
    • Ballabh, P.1    Braun, A.2    Nedergaard, M.3
  • 12
    • 2442557294 scopus 로고    scopus 로고
    • Brain cholesterol: Long secret life behind a barrier
    • Bjorkhem I, Meaney S: Brain cholesterol: Long secret life behind a barrier. Arterioscler Thromb Vasc Biol. 2004; 24: 806-815.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 806-815
    • Bjorkhem, I.1    Meaney, S.2
  • 13
    • 0031976318 scopus 로고    scopus 로고
    • Serum total cholesterol, apolipoprotein E 4, and Alzheimer's disease
    • Notkola I-L, Sulkava R, Pekkanen J, et al.: Serum total cholesterol, apolipoprotein E 4, and Alzheimer's disease. Neuroepidemiology. 1998; 17: 14-20.
    • (1998) Neuroepidemiology , vol.17 , pp. 14-20
    • Notkola, I.-L.1    Sulkava, R.2    Pekkanen, J.3
  • 14
    • 0035954333 scopus 로고    scopus 로고
    • Midlife vascular risk factors and late-life mild cognitive impairment. A population-based study
    • Kivipelto M, Helkala E-L, Hänninen T, et al.: Midlife vascular risk factors and late-life mild cognitive impairment. A population-based study. Neurology. 2001; 56: 1683-1689.
    • (2001) Neurology , vol.56 , pp. 1683-1689
    • Kivipelto, M.1    Helkala, E.-L.2    Hänninen, T.3
  • 15
    • 0033772113 scopus 로고    scopus 로고
    • Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
    • Wolozin B, Kellman W, Ruosseau P, et al.: Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch Neurol. 2000; 57: 1439-1443.
    • (2000) Arch Neurol , vol.57 , pp. 1439-1443
    • Wolozin, B.1    Kellman, W.2    Ruosseau, P.3
  • 16
    • 0034638746 scopus 로고    scopus 로고
    • Statins and the risk of dementia
    • Jick H, Zornberg G, Jick S, et al.: Statins and the risk of dementia. Lancet. 2000; 356: 1627-1631.
    • (2000) Lancet , vol.356 , pp. 1627-1631
    • Jick, H.1    Zornberg, G.2    Jick, S.3
  • 17
    • 0001504829 scopus 로고    scopus 로고
    • Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo
    • Fassbender K, Simons M, Bergmann C, et al.: Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc Natl Acad Sci USA. 2001; 98: 5856-5861.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5856-5861
    • Fassbender, K.1    Simons, M.2    Bergmann, C.3
  • 18
    • 0028177562 scopus 로고
    • Induction of Alzheimer-like b-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol
    • Sparks D, Scheff S, Hunsaker J, et al.: Induction of Alzheimer-like b-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol. Exper Neurol. 1994; 126: 88-94.
    • (1994) Exper Neurol , vol.126 , pp. 88-94
    • Sparks, D.1    Scheff, S.2    Hunsaker, J.3
  • 19
    • 0032568552 scopus 로고    scopus 로고
    • Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
    • Simons M, Keller P, De Strooper B, et al: Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci USA. 1998; 95: 6460-6464.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6460-6464
    • Simons, M.1    Keller, P.2    De Strooper, B.3
  • 20
    • 0034990260 scopus 로고    scopus 로고
    • Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide
    • Buxbaum J, Geoghagen N, Friedhoff L: Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide. J Alz Dis. 2001; 3: 221-229.
    • (2001) J Alz Dis , vol.3 , pp. 221-229
    • Buxbaum, J.1    Geoghagen, N.2    Friedhoff, L.3
  • 21
    • 0033833354 scopus 로고    scopus 로고
    • Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
    • Refolo L, Malester B, LaFrancois J, et al.: Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol Dis. 2000; 7: 321-331.
    • (2000) Neurobiol Dis , vol.7 , pp. 321-331
    • Refolo, L.1    Malester, B.2    LaFrancois, J.3
  • 22
    • 0029671454 scopus 로고    scopus 로고
    • Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein
    • Bodovitz S, Klein W: Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein. J Biol Chem. 1996; 271: 4436-4440.
    • (1996) J Biol Chem , vol.271 , pp. 4436-4440
    • Bodovitz, S.1    Klein, W.2
  • 23
    • 0037627924 scopus 로고    scopus 로고
    • Effective strategies for long-term statin use
    • Fonarow G, Watson K: Effective strategies for long-term statin use. Am J Cardiol. 2003; 92(1A): 27i-34i.
    • (2003) Am J Cardiol , vol.92 , Issue.1 A
    • Fonarow, G.1    Watson, K.2
  • 24
    • 0037262480 scopus 로고    scopus 로고
    • Treatment with simvastatin in patients with Alzheimer's disease lowers both alpha- And beta-cleaved amyloid precursor protein
    • Sjogren M, Gustafsson K, Syversen S, et al.: Treatment with simvastatin in patients with Alzheimer's disease lowers both alpha- and beta-cleaved amyloid precursor protein. Dement Geriatr Cog Dis. 2003; 16(1): 25-30.
    • (2003) Dement Geriatr Cog Dis , vol.16 , Issue.1 , pp. 25-30
    • Sjogren, M.1    Gustafsson, K.2    Syversen, S.3
  • 25
    • 0037159224 scopus 로고    scopus 로고
    • Effects of statins on human cerebral cholesterol metabolism and secretion of Alzheimer amyloid peptide
    • Fassbender K, Stroik M, Bertsch T, et al.: Effects of statins on human cerebral cholesterol metabolism and secretion of Alzheimer amyloid peptide. Neurology. 2002; 59: 1257-1258.
    • (2002) Neurology , vol.59 , pp. 1257-1258
    • Fassbender, K.1    Stroik, M.2    Bertsch, T.3
  • 26
    • 0033984125 scopus 로고    scopus 로고
    • The evolving role of statins in the management of atherosclerosis
    • Vaughan C, Gotto A, Basson C: The evolving role of statins in the management of atherosclerosis. J Am Coll Cardiol. 2000; 35: 1-10.
    • (2000) J Am Coll Cardiol , vol.35 , pp. 1-10
    • Vaughan, C.1    Gotto, A.2    Basson, C.3
  • 27
  • 28
    • 0642370860 scopus 로고    scopus 로고
    • Changes in apolipoprotein e expression in response to dietary and pharmacological modulation of cholesterol
    • Petanceska S, DeRosa S, Sharma A, et al.: Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol. J Molec Neurosci. 2003; 20: 395-406.
    • (2003) J Molec Neurosci , vol.20 , pp. 395-406
    • Petanceska, S.1    DeRosa, S.2    Sharma, A.3
  • 29
    • 0037388527 scopus 로고    scopus 로고
    • Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease
    • Vega G, Weiner M, Lipton A, et al.: Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease. Arch Neurol. 2003; 60: 510-515.
    • (2003) Arch Neurol , vol.60 , pp. 510-515
    • Vega, G.1    Weiner, M.2    Lipton, A.3
  • 30
    • 4544255297 scopus 로고    scopus 로고
    • Differential expression of cholesterol hydroxylases in Alzheimer's disease
    • Brown J, Theisler C, Silberman S, et al.: Differential expression of cholesterol hydroxylases in Alzheimer's disease. J Biol Chem. 2004; 279: 34674-34681.
    • (2004) J Biol Chem , vol.279 , pp. 34674-34681
    • Brown, J.1    Theisler, C.2    Silberman, S.3
  • 31
    • 0242288696 scopus 로고    scopus 로고
    • Brain cholesterol, statins and Alzheimer's Disease
    • Kirsch C, Eckert G, Koudinov A, et al.: Brain cholesterol, statins and Alzheimer's Disease. Pharmacopsychiatry. 2003; 36 Suppl 2: S113-S119.
    • (2003) Pharmacopsychiatry , vol.36 , Issue.2 SUPPL.
    • Kirsch, C.1    Eckert, G.2    Koudinov, A.3
  • 32
    • 3042640736 scopus 로고    scopus 로고
    • High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs
    • Lutjohann D, Stroick M, Bertsch T, et al.: High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs. Steroids. 2004; 69: 431-438.
    • (2004) Steroids , vol.69 , pp. 431-438
    • Lutjohann, D.1    Stroick, M.2    Bertsch, T.3
  • 33
    • 0033594903 scopus 로고    scopus 로고
    • cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain
    • Lund E, Guileyardo J, Russell D: cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc Natl Acad Sci USA. 1999; 96: 7238-7243.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7238-7243
    • Lund, E.1    Guileyardo, J.2    Russell, D.3
  • 34
    • 0035985702 scopus 로고    scopus 로고
    • Oxysterols in human circulation: Which role do they have?
    • Bjorkhem I, Meaney S, Diczfalusy U: Oxysterols in human circulation: Which role do they have? Curr Opin Lipidol. 2002; 13: 247-253.
    • (2002) Curr Opin Lipidol , vol.13 , pp. 247-253
    • Bjorkhem, I.1    Meaney, S.2    Diczfalusy, U.3
  • 35
    • 0343775806 scopus 로고    scopus 로고
    • Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients
    • Lutjohann D, Papassotiropoulos A, Bjorkhem I, et al.: Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients. J Lipid Res. 2000; 41: 195-198.
    • (2000) J Lipid Res , vol.41 , pp. 195-198
    • Lutjohann, D.1    Papassotiropoulos, A.2    Bjorkhem, I.3
  • 36
    • 0004821712 scopus 로고    scopus 로고
    • Plasma 24S-hydroxycholesterol: A peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease
    • Papassotiropoulos A, Lutjohann D, Bagli M, et al.: Plasma 24S-hydroxycholesterol: A peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease. Neuroreport. 2000; 11:1959-1962.
    • (2000) Neuroreport , vol.11 , pp. 1959-1962
    • Papassotiropoulos, A.1    Lutjohann, D.2    Bagli, M.3
  • 37
    • 0242383365 scopus 로고    scopus 로고
    • 24S-hydroxycholesterol: A marker of brain cholesterol metabolism
    • Lutjohann D, von Bergmann K: 24S-hydroxycholesterol: A marker of brain cholesterol metabolism. Pharmacopsychiatry. 2003; 36 Suppl 2: S102-S106.
    • (2003) Pharmacopsychiatry , vol.36 , Issue.2 SUPPL.
    • Lutjohann, D.1    Von Bergmann, K.2
  • 38
    • 3042770616 scopus 로고    scopus 로고
    • The cellular biochemistry of cholesterol and statins: Insights into the pathophysiology and therapy of Alzheimer's disease
    • Wolozin B, Brown J, Theisler C, et al.: The cellular biochemistry of cholesterol and statins: Insights into the pathophysiology and therapy of Alzheimer's disease. CNS Drug Review. 2004; 10: 127-146.
    • (2004) CNS Drug Review , vol.10 , pp. 127-146
    • Wolozin, B.1    Brown, J.2    Theisler, C.3
  • 39
    • 0037227538 scopus 로고    scopus 로고
    • Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism
    • Papassotiropoulos A, Streffer J, Tsolaki M, et al.: Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism. Arch Neurol. 2003; 60: 29-35.
    • (2003) Arch Neurol , vol.60 , pp. 29-35
    • Papassotiropoulos, A.1    Streffer, J.2    Tsolaki, M.3
  • 40
    • 0037008389 scopus 로고    scopus 로고
    • Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease
    • Desai P, DeKosky S, Kamboh M: Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease. Neurosci Lett. 2002; 328: 9-12.
    • (2002) Neurosci Lett , vol.328 , pp. 9-12
    • Desai, P.1    DeKosky, S.2    Kamboh, M.3
  • 41
    • 0036384169 scopus 로고    scopus 로고
    • Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease
    • Kolsch H, Lutjohann D, Ludwig M, et al.: Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease. Mol Psychiatry. 2002; 7: 899-902.
    • (2002) Mol Psychiatry , vol.7 , pp. 899-902
    • Kolsch, H.1    Lutjohann, D.2    Ludwig, M.3
  • 42
    • 0021704422 scopus 로고
    • Plasma lipoproteins: Apolipoprotein structure and function
    • Mahley R, Innerarity T, Rall S, et al.: Plasma lipoproteins: Apolipoprotein structure and function. J Lipid Res. 1984; 25:1277-1294.
    • (1984) J Lipid Res , vol.25 , pp. 1277-1294
    • Mahley, R.1    Innerarity, T.2    Rall, S.3
  • 43
    • 0019783892 scopus 로고
    • Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms
    • Weisgraber K, Rall S, Mahley R: Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms. J Biol Chem. 1981; 256: 9077-9083.
    • (1981) J Biol Chem , vol.256 , pp. 9077-9083
    • Weisgraber, K.1    Rall, S.2    Mahley, R.3
  • 44
    • 0024473341 scopus 로고
    • Genetic basis of lipoprotein disorders
    • Breslow JL: Genetic basis of lipoprotein disorders. J Clin Invest. 1989; 84: 373-380.
    • (1989) J Clin Invest , vol.84 , pp. 373-380
    • Breslow, J.L.1
  • 45
    • 0035997373 scopus 로고    scopus 로고
    • Lipoprotein receptors in the nervous system
    • Herz J, Bock H: Lipoprotein receptors in the nervous system. Ann Rev Biochem. 2002; 71: 405-434.
    • (2002) Ann Rev Biochem , vol.71 , pp. 405-434
    • Herz, J.1    Bock, H.2
  • 46
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder E, Saunders A, Strittmatter W, et al.: Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993; 261: 921-923.
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.1    Saunders, A.2    Strittmatter, W.3
  • 47
    • 0030005627 scopus 로고    scopus 로고
    • Apolipoprotein E alleles as risk factors in Alzheimer's disease
    • Roses A: Apolipoprotein E alleles as risk factors in Alzheimer's disease. Ann Rev Med. 1996; 47: 487-500.
    • (1996) Ann Rev Med , vol.47 , pp. 487-500
    • Roses, A.1
  • 48
    • 0030823158 scopus 로고    scopus 로고
    • Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis
    • APOE and Alzheimer Disease Meta Analysis Consortium
    • Farrer L, Cupples L, Haines J, et al.: Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA. 1997; 278: 1349-1356.
    • (1997) JAMA , vol.278 , pp. 1349-1356
    • Farrer, L.1    Cupples, L.2    Haines, J.3
  • 49
    • 0027365822 scopus 로고
    • Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein-E genotype in late-onset Alzheimer disease
    • Schmechel DE, Saunders AM, Strittmatter WJ, et al.: Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein-E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci USA. 1993; 90: 9649-9653.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9649-9653
    • Schmechel, D.E.1    Saunders, A.M.2    Strittmatter, W.J.3
  • 50
    • 0033595026 scopus 로고    scopus 로고
    • APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: The Cache County Study
    • Breitner J, Wyse B, Anthony J, et al.: APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: The Cache County Study. Neurology. 1999; 53: 321-331.
    • (1999) Neurology , vol.53 , pp. 321-331
    • Breitner, J.1    Wyse, B.2    Anthony, J.3
  • 51
    • 0028973776 scopus 로고
    • Apolipoprotein E epsilon 4 allele and the lifetime risk of Alzheimer's disease. What physicians know, and what they should know
    • Seshadri S, Drachman D, Lippa C: Apolipoprotein E epsilon 4 allele and the lifetime risk of Alzheimer's disease. What physicians know, and what they should know. Arch Neurol. 1995; 52: 1074-1079.
    • (1995) Arch Neurol , vol.52 , pp. 1074-1079
    • Seshadri, S.1    Drachman, D.2    Lippa, C.3
  • 52
    • 0031839545 scopus 로고    scopus 로고
    • Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: The Rotterdam Study
    • Slooter A, Cruts M, Kalmijn S, et al.: Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: The Rotterdam Study. Arch Neurol. 1998; 55: 964-968.
    • (1998) Arch Neurol , vol.55 , pp. 964-968
    • Slooter, A.1    Cruts, M.2    Kalmijn, S.3
  • 53
    • 4143063440 scopus 로고    scopus 로고
    • Apolipoprotein E dose-dependent modulation of beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease
    • DeMattos R: Apolipoprotein E dose-dependent modulation of beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. J Molec Neurosci. 2004; 23: 255-262.
    • (2004) J Molec Neurosci , vol.23 , pp. 255-262
    • DeMattos, R.1
  • 54
    • 0028173205 scopus 로고
    • Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments
    • Ma J, Yee A, Brewer B, et al.: Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Nature. 1994; 372: 92-94.
    • (1994) Nature , vol.372 , pp. 92-94
    • Ma, J.1    Yee, A.2    Brewer, B.3
  • 55
    • 0028986408 scopus 로고
    • Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein
    • Castano E, Prelli F, Wisniewski T, et al.: Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein. Eur Bio chem J. 1995; 306: 599-604.
    • (1995) Eur Bio Chem J , vol.306 , pp. 599-604
    • Castano, E.1    Prelli, F.2    Wisniewski, T.3
  • 56
    • 0033593027 scopus 로고    scopus 로고
    • Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease
    • Bales K, Verina T, Cummins D, et al: Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. Proc Natl Acad Sci USA. 1999; 96: 15233-15238.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 15233-15238
    • Bales, K.1    Verina, T.2    Cummins, D.3
  • 57
    • 9144224765 scopus 로고    scopus 로고
    • ApoE and clusterin cooperatively suppress Abeta levels and deposition. Evidence that ApoE regulates extracellular Abeta metabolism in vivo
    • DeMattos R, Cirrito J, Parsadanian M, et al.: ApoE and clusterin cooperatively suppress Abeta levels and deposition. Evidence that ApoE regulates extracellular Abeta metabolism in vivo. Neuron. 2004; 41:193-202.
    • (2004) Neuron , vol.41 , pp. 193-202
    • DeMattos, R.1    Cirrito, J.2    Parsadanian, M.3
  • 58
    • 0037172815 scopus 로고    scopus 로고
    • Inhibition of apolipoprotein E-related neurotoxicity by glycosaminoglycans and their oligosaccharides
    • Bazin H, Marques M, Owens A, et al.: Inhibition of apolipoprotein E-related neurotoxicity by glycosaminoglycans and their oligosaccharides. Biochemistry. 2002; 41: 8203-8211.
    • (2002) Biochemistry , vol.41 , pp. 8203-8211
    • Bazin, H.1    Marques, M.2    Owens, A.3
  • 59
    • 8644247543 scopus 로고    scopus 로고
    • New and confirmatory evidence of an association between APOE genotype and baseline C-reactive protein in dyslipidemic individuals
    • Judson R, Brain C, Dain B, et al.: New and confirmatory evidence of an association between APOE genotype and baseline C-reactive protein in dyslipidemic individuals. Atherosclerosis. 2004; 177:345-351.
    • (2004) Atherosclerosis , vol.177 , pp. 345-351
    • Judson, R.1    Brain, C.2    Dain, B.3
  • 60
    • 9644267020 scopus 로고    scopus 로고
    • The apolipoprotein E polymorphism is associated with circulating C-reactive protein (the Ludwigshafen risk and cardiovascular health study)
    • Marz W, Scharnagl H, Hoffmann M, et al.: The apolipoprotein E polymorphism is associated with circulating C-reactive protein (the Ludwigshafen risk and cardiovascular health study). Eur Heart J. 2004; 25: 2109-2119.
    • (2004) Eur Heart J , vol.25 , pp. 2109-2119
    • Marz, W.1    Scharnagl, H.2    Hoffmann, M.3
  • 61
    • 0034704261 scopus 로고    scopus 로고
    • Human neurons generate C-reactive protein and amyloid P: Upregulation in Alzheimer's disease
    • Yasojima K, Schwab C, McGeer EG et al.: Human neurons generate C-reactive protein and amyloid P: upregulation in Alzheimer's disease. Brain Res. 2000; 887: 80-89.
    • (2000) Brain Res , vol.887 , pp. 80-89
    • Yasojima, K.1    Schwab, C.2    McGeer, E.G.3
  • 62
    • 0034575124 scopus 로고    scopus 로고
    • Apolipoprotein E: Far more than a lipid transport protein
    • Mahley R, Rall S: Apolipoprotein E: far more than a lipid transport protein. Ann Rev Genom Hum Genet. 2000; 1: 507-537.
    • (2000) Ann Rev Genom Hum Genet , vol.1 , pp. 507-537
    • Mahley, R.1    Rall, S.2
  • 63
    • 0023860891 scopus 로고
    • Apolipoprotein E polymorphism and arteriosclerosis
    • Davignon J, Gregg R, Sing C: Apolipoprotein E polymorphism and arteriosclerosis. Arteriosclerosis. 1988; 8: 1-21.
    • (1988) Arteriosclerosis , vol.8 , pp. 1-21
    • Davignon, J.1    Gregg, R.2    Sing, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.