Induction of specific human primary immune responses to a Semliki Forest virus-based tumor vaccine in a Trimera mouse model

Cancer Immunology, Immunotherapy

Volumn 54, Issue 5, 2005, Pages 489-498

  Ni, Bing ^a   Gao, Wenda ^b   Zhu, Bo ^a   Lin, Zhihua ^a   Jia, Zhengcai ^a   Zhou, Wei ^a   Zhao, Jianping ^a   Wang, Li ^a   Wu, Yuzhang ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

MAGE 3; Semliki Forest virus; Trimera; Vaccine

Indexed keywords

CANCER ANTIBODY; CANCER VACCINE; CHROMIUM 51; DNA VACCINE; MELANOMA ANTIGEN 3; MELANOMA ANTIGEN 3 ANTIBODY; MELANOMA VACCINE; PLASMID DNA; UNCLASSIFIED DRUG; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DETECTION; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; BONE MARROW; CANCER IMMUNIZATION; CHROMIUM 51 RELEASE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DIABETES MELLITUS; DRUG EFFICACY; DRUG POTENCY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL MODEL; HAMSTER; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; IN VIVO STUDY; INTERMETHOD COMPARISON; IRRADIATION; LETHALITY; MALE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SCID MOUSE; SEMLIKI FOREST ALPHAVIRUS; T LYMPHOCYTE ACTIVATION; TUMOR IMMUNITY; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS RECOMBINANT;

ANIMALS; ANTIBODIES, NEOPLASM; ANTIGENS, NEOPLASM; CANCER VACCINES; GENETIC VECTORS; HUMANS; IMMUNOGLOBULIN G; LEUKOCYTES, MONONUCLEAR; MALE; MICE; NEOPLASM PROTEINS; PLASMIDS; SEMLIKI FOREST VIRUS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION; VACCINES, DNA;

EID: 17444386323     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-004-0591-z     Document Type: Article

References (47)

1. Asselin-Paturel C, Lassau N, Guinebretiere JM et al (1999) Transfer of the murine interleukin-12 gene in vivo by a Semliki Forest virus vector induces B16 tumor regression through inhibition of tumor blood vessel formation monitored by Doppler ultrasonography. Gene Ther 6:606-615
2. Berglund P, Smerdou C, Fleeton MN, Tubulekas I, Liljestrom P (1998) Enhancing immune responses using suicidal DNA vaccines. Nat Biotechnol 16:562-565
3. Berglund P, Fleeton MN, Smerdou C, Liljestrom P (1999) Immunization with recombinant Semliki Forest virus induces protection against influenza challenge in mice. Vaccine 17:497-507
4. Bocher WO, Marcus H, Shakarchy R et al (1999) Antigen-specific B and T cells in human/mouse radiation chimera following immunization in vivo. Immunology 96:634-641
5. Bocher WO, Dekel B, Schwerin W et al (2001) Induction of strong hepatitis B virus (HBV) specific T helper cell and cytotoxic T lymphocyte responses by therapeutic vaccination in the trimera mouse model of chronic HBV infection. Eur J Immunol 31:2071-2079
6. Bosma GC, Custer RP, Bosma MJ (1983) A severe combined immunodeficiency mutation in the mouse. Nature 301:527-530
7. Brown JP, Klitzman JM, Hellstrom I, Nowinski RC, Hellstrom KE (1978) Antibody response of mice to chemically induced tumors. Proc Natl Acad Sci U S A 75:955-958
8. Ciernik IF, Berzofsky JA, Carbone DP (1996) Induction of cytotoxic T lymphocytes and antitumor immunity with DNA vaccines expressing single T cell epitopes. J Immunol 156:2369-2375
9. Curcio C, Di Carlo E, Clynes R et al (2003) Nonredundant roles of antibody, cytokines, and perforin in the eradication of established Her-2/neu carcinomas. J Clin Invest 111:1161-1170
10. Daemen T, Pries F, Bungener L et al (2000) Genetic immunization against cervical carcinoma: induction of cytotoxic T lymphocyte activity with a recombinant alphavirus vector expressing human papillomavirus type 16 E6 and E7. Gene Ther 7:1859-1866
11. Daemen T, Riezebos-Brilman A, Bungener L et al (2003) Eradication of established HPV16-transformed tumours after immunisation with recombinant Semliki Forest virus expressing a fusion protein of E6 and E7. Vaccine 21:1082-1088
12. Fischer C, Gudat F, Stulz P et al (1997) High expression of MAGE-3 protein in squamous-cell lung carcinoma. Int J Cancer 71:1119-1121
13. Fleeton MN, Liljestrom P, Sheahan BJ, Atkins GJ (2000) Recombinant Semliki Forest virus particles expressing louping ill virus antigens induce a better protective response than plasmid-based DNA vaccines or an inactivated whole particle vaccine. J Gen Virol 81:749-758
14. Frolov I, Schlesinger S (1994) Comparison of the effects of Sindbis virus and Sindbis virus replicons on host cell protein synthesis and cytopathogenicity in BHK cells. J Virol 68:1721-1727
15. Garcia S, Dadaglio G, Gougeon ML (1997) Limits of the human-PBL-SCID mice model: severe restriction of the V beta T-cell repertoire of engrafted human T cells. Blood 89:329-336
16. Gaugler B, Van den Eynde B, van der Bruggen P et al (1994) Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. J Exp Med 179:921-930
17. Hughes RM (2004) Strategies for cancer gene therapy. J Surg Oncol 85:28-35
18. Ifversen P, Martensson C, Danielsson L et al (1995) Induction of primary antigen-specific immune reponses in SCID-hu-PBL by coupled T-B epitopes. Immunology 84:111-116
19. Kuroki M, Shibaguchi H, Imakiire T et al (2003) Immunotherapy and gene therapy of cancer using antibodies or their genes against tumor-associated antigens. Anticancer Res 23:4377-4381
20. Liljestrom P, Garoff H (1991) A new generation of animal cell expression vectors based on the Semliki Forest virus replicon. Biotechnology (N Y) 9:1356-1361
21. Lubin I, Segall H, Marcus H et al (1994) Engraftment of human peripheral blood lymphocytes in normal strains of mice. Blood 83:2368-2381
22. Luo Y, O'Hagan D, Zhou H et al (2003) Plasmid DNA encoding human carcinoembryonic antigen (CEA) adsorbed onto cationic microparticles induces protective immunity against colon cancer in CEA-transgenic mice. Vaccine 21:1938-1947
23. Marcus H, David M, Canaan A et al (1995) Human/mouse radiation chimera are capable of mounting a human primary humoral response. Blood 86:398-406
24. Martin T, Parker SE, Hedstrom R et al (1999) Plasmid DNA malaria vaccine: the potential for genomic integration after intramuscular injection. Hum Gene Ther 10:759-768
25. Mor G, Singla M, Steinberg AD et al (1997) Do DNA vaccines induce autoimmune disease? Hum Gene Ther 8:293-300
26. Morris-Downes MM, Phenix KV, Smyth J et al (2001) Semliki Forest virus-based vaccines: persistence, distribution and pathological analysis in two animal systems. Vaccine 19:1978-1988
27. Mosier DE, Gulizia RJ, Baird SM, Wilson DB (1988) Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 335:256-259
28. Nishiyama T, Tachibana M, Horiguchi Y et al (2001) Immunotherapy of bladder cancer using autologous dendritic cells pulsed with human lymphocyte antigen-A24-specific MAGE-3 peptide. Clin Cancer Res 7:23-31
29. Nonoyama S, Smith FO, Ochs HD (1993) Specific antibody production to a recall or a neoantigen by SCID mice reconstituted with human peripheral blood lymphocytes. J Immunol 151:3894-3901
30. Real FX, Mattes MJ, Houghton AN et al (1984) Class 1 (unique) tumor antigens of human melanoma: identification of a 90,000 dalton cell surface glycoprotein by autologous antibody. J Exp Med 160:1219-1233
31. Reisner Y, Dagan S (1998) The Trimera mouse: generating human monoclonal antibodies and an animal model for human diseases. Trends Biotechnol 16:242-246
32. Reynolds SR, Zeleniuch-Jacquotte A, Shapiro RL et al (2003) Vaccine-induced CD8+ T-cell responses to MAGE-3 correlate with clinical outcome in patients with melanoma. Clin Cancer Res 9:657-662
33. Roks AJ, Henning RH, Buikema H et al (2002) Recombinant Semliki Forest virus as a vector system for fast and selective in vivo gene delivery into balloon-injured rat aorta. Gene Ther 9:95-101
34. Russo V, Traversari C, Verrecchia A et al (1995) Expression of the MAGE gene family in primary and metastatic human breast cancer: implications for tumor antigen-specific immunotherapy. Int J Cancer 64:216-221
35. Sadanaga N, Nagashima H, Mashino K et al (2001) Dendritic cell vaccination with MAGE peptide is a novel therapeutic approach for gastrointestinal carcinomas. Clin Cancer Res 7:2277-2284
36. Segall H, Lubin I, Marcus H, Canaan A, Reisner Y (1996) Generation of primary antigen-specific human cytotoxic T lymphocytes in human/mouse radiation chimera. Blood 88:721-730
37. Smyth MJ, Kershaw MH, Trapani JA (1997) Xenospecific cytotoxic T lymphocytes: potent lysis in vitro and in vivo. Transplantation 63:1171-1178
38. Tary-Lehmann M, Lehmann PV, Schols D, Roncarolo MG, Saxon A (1994) Anti-SCID mouse reactivity shapes the human CD4+ T cell repertoire in hu-PBL-SCID chimeras. J Exp Med 180:1817-1827
39. Thurner B, Haendle I, Roder C et al (1999) Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma. J Exp Med 190:1669-1678
40. Traggiai E, Chicha L, Mazzucchelli L et al (2004) Development of a human adaptive immune system in cord blood cell-trans-planted mice. Science 304:104-107
41. van der Bruggen P, Bastin J, Gajewski T et al (1994) A peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE-3. Eur J Immunol 24:3038-3043
42. Vignuzzi M, Gerbaud S, van der Werf S, Escriou N (2001) Naked RNA immunization with replicons derived from poliovirus and Semliki Forest virus genomes for the generation of a cytotoxic T cell response against the influenza A virus nucleoprotein. J Gen Virol 82:1737-1747
43. Xiong C, Levis R, Shen P et al (1989) Sindbis virus: an efficient, broad host range vector for gene expression in animal cells. Science 243:1188-1191
44. Yamanaka R, Zullo SA, Ramsey J et al (2001) Induction of therapeutic antitumor antiangiogenesis by intratumoral injection of genetically engineered endostatin-producing Semliki Forest virus. Cancer Gene Ther 8:796-802
45. Zhou X, Berglund P, Rhodes G et al (1994) Self-replicating Semliki Forest virus RNA as recombinant vaccine. Vaccine 12:1510-1514
46. Zhou X, Berglund P, Zhao H, Liljestrom P, Jondal M (1995) Generation of cytotoxic and humoral immune responses by nonreplicative recombinant Semliki Forest virus. Proc Natl Acad Sci U S A 92:3009-3013
47. Zhu B, Chen Z, Cheng X et al (2003) Identification of HLA-A*0201-restricted cytotoxic T lymphocyte epitope from TRAG-3 antigen. Clin Cancer Res 9:1850-1857