Antigen-specific B and T cells in human/mouse radiation chimera following immunization in vivo

Immunology

Volumn 96, Issue 4, 1999, Pages 634-641

  Bocher W O ^a   Marcus, H ^a   Shakarchy, R ^a   Dekel, B ^a   Shouval, D ^b   Galun, E ^b   Reisner, Yair ^a,b  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 4; MEMBRANE ANTIGEN; MONOCLONAL ANTIBODY; TETANUS TOXOID;

ADOPTIVE IMMUNOTHERAPY; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION CHIMERA; SCID MOUSE; T LYMPHOCYTE; VACCINATION;

ADOPTIVE TRANSFER; ANIMALS; B-LYMPHOCYTES; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; HEPATITIS B SURFACE ANTIGENS; HUMANS; IMMUNIZATION; IMMUNOGLOBULIN G; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; MICE, SCID; RADIATION CHIMERA; T-LYMPHOCYTES; TETANUS TOXOID;

EID: 0032955324     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1999.00704.x     Document Type: Article

References (42)

1. 1. Bosma G.C., Custer R.P. & Bosma M.J. (1983) A severe combined immunodeficiency mutation in the mouse. Nature 301, 527.
2. 2. Mosier D.E., Gulizia R.J., Baird S.M. & Wilson D.B. (1988) Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 335, 256.
3. 3. Albert S.E., McKerlie C., Pester A. et al. (1997) Time-dependent induction of protective anti-influenza immune responses in human peripheral blood lymphocyte/SCID mice. J Immunol 159, 1393.
4. 4. Markham R.B. & Donnenberg A.D. (1992) Effect of donor and recipient immunization protocols on primary and secondary human antibody responses in SCID mice reconstituted with human peripheral blood mononuclear cells. Infect Immun 60, 2305.
5. 5. Sandhu J., Shpitz B., Gallinger S. & Hozumi N. (1994) Human primary immune response in SCID mice engrafted with human peripheral blood lymphocytes. J Immunol 152, 3806.
6. 6. Nonoyama S., Smith F.O. & Ochs H.D. (1993) Specific antibody production to a recall or a neoantigen by SCID mice reconstituted with human peripheral blood lymphocytes. J Immunol 151, 3894.
7. 7. Malkovska V., Cigel F. & Storer B.E. (1994) Human T cells in hu-PBL-SCID mice proliferate in response to Daudi lymphoma and confer anti-tumour immunity. Clin Exp Immunol 96, 158.
8. 8. Ahedi M.R., Christensson B., Islam K.B., Hammarstrom L. & Smith C.I. (1992) Immunoglobulin production in severe combined immunodeficient (SCID) mice reconstituted with human peripheral blood mononuclear cells. Eur J Immunol 22, 823.
9. 9. Murphy W.J., Bennett M., Anver M.R., Baseler M. & Longo D.L. (1992) Human-mouse lymphoid chimeras: host-vs.-graft and graft-vs.-host reactions. Eur J Immunol 22, 1421.
10. 10. Hoffmann F.G., Kranz B., Gall C. & Thierfelder S. (1992) Peritoncal sanctuary for human lymphopoiesis in SCID mice injected with human peripheral blood lymphocytes from Epstein Barr virus-negative donors. Eur J Immunol 22, 3161.
11. 11. Saxon A., Macy E., Denis K., Tary Lehmann M., Witte O. & Braun J. (1991) Limited B cell repertoire in severe combined immunodeficient mice engrafted with peripheral blood mononuclear cells derived from immunodeficient or normal humans. J Clin Invest 87, 658.
12. 12. Garcia S., Dadaglio G. & Gougeon M.L. (1997) Limits of the human-PBL-SCID mice model: severe restriction of the Vβ T-cell repertoire of engrafted human T cells. Blood 89, 329.
13. + T cell repertoire in hu-PBL-SCID chimeras. J Exp Med 180, 1817.
14. 14. Ifversen P., Martensson C., Danielsson L., Ingvar C., Carlsson R. & Borrebaeck C.A. (1995) Induction of primary antigen-specific immune reponses in SCID-hu-PBL by coupled T-B epitopes. Immunology 84, 111.
15. 15. Simpson E., Farrant J. & Chandler P. (1991) Phenotypic and functional studies of human peripheral blood lymphocytes engrafted in scid mice. Immunol Rev 124, 97.
16. 16. Tary Lehmann M. & Saxon A. (1992) Human mature T cells that are anergic in vivo prevail in SCID mice reconstituted with human peripheral blood. J Exp Med 175, 503.
17. 17. Lubin I., Segall H., Marcus H. et al. (1994) Engraftment of human peripheral blood lymphocytes in normal strains of mice. Blood 83, 2368.
18. 18. Burakova T., Marcus H., Canaan A. et al. (1997) Engrafted human T and B lymphocytes form mixed follicles in lymphoid organs of human/mouse and human/rat chimera. Transplantation 63, 1166.
19. 19. Marcus H., Burakova T., Shezen E., et al. (1996) Human→mouse radiation chimera do not develop Epstein Barr virus lymphoma. Immunol Lett 49, 155.
20. 20. Mosier D.E., Picchio G.R., Baird S.M., Kobayashi R. & Kipps T.J. (1992) Epstein Barr virus-induced human B-cell lymphomas in SCID mice reconstituted with human peripheral blood leukocytes. Cancer Res 52 (19S), 5552S.
21. 21. Marcus H., David M., Canaan A. et al. (1995) Human/mouse radiation chimera are capable of mounting a human primary humoral response. Blood 86, 398.
22. 22. Segall H., Lubin I., Marcus H., Canaan A. & Reisner Y. (1996) Generation of primary antigen-specific human cytotoxic T lymphocytes in human/mouse radiation chimera. Blood 88, 721.
23. 23. Böcher W.O., Herzog H.S., Herr W. et al. (1996) Regulation of the neutralizing anti-hepatitis B surface (HBs) antibody response in vitro in HBs vaccine recipients and patients with acute or chronic hepatitis B virus (HBV) infection. Clin Exp Immunol 105, 52.
24. 24. El Ghazali G.E., Paulie S., Andersson G. et al. (1993) Number of interleukin-4-and interferon-γ-secreting human T cells reactive with tetanus toxoid and the mycobacterial antigen PPD or phytohemagglutinin: distinct response profiles depending on the type of antigen used for activation. Eur J Immunol 23, 2740.
25. 25. Shultz L.D., Schweilzer P.A., Christianson S.W. et al. (1995) Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J Immunol 154, 180.
26. 26. Eren R., Lubin I., Terkieltaub D. et al. (1998) Human monoclonal antibodies specific to hepatitis B virus generated in a human/mouse radiation chimera: the trimera system. Immunology 93, 154.
27. 27. Amadori A., Veronesi A., Coppola V., Indraccolo S., Mion M. & Chieco Bianchi L. (1996) The hu-PBL-SCID mouse in human lymphocyte function and lymphomagenesis studies: achievements and caveats. Semin Immunol 8, 249.
28. 28. Coppola V., Veronesi A., Indraccolo S. et al (1998) Lymphoproliferative disease in human peripheral blood mononuclear cell-Injected SCID mice. IV. Differential activation of human Th1 and Th2 lymphocytes and influence of the atopic status on lymphoma development. J Immunol 160, 2514.
29. 29. Williams S.S., Umemoto T., Kida H., Repasky E.A. & Bankert R.B. (1992) Engraftment of human peripheral blood leukocytes into severe combined immunodeficient mice results in the long term and dynamic production of human xenoreactive antibodies. J Immunol 149, 2830.
30. 30. Hesselton R.M., Koup R.A., Cromwell M.A., Graham B.S., Johns M. & Sullivan J.L. (1993) Human peripheral blood xenografts in the SCID mouse: characterization of immunologic reconstitution. J Infect Dis 168, 630.
31. 31. Armstrong N., Cigel F., Borcherding W., Hong R. & Malkovska V. (1992) In vitro preactivated human T cells engraft in SCID mice and migrate to murine lymphoid tissues. Clin Exp Immunol 90, 476.
32. 32. Sylvan S.P. & Hellstrom U.B. (1990) HBsAg-induced interferon-γ secretion in T cells from asymptomatic HBsAg carriers and HB-immune donors in vitro. Immunology 70, 197.
33. 33. Petrovsky N. & Harrison L.C. (1995) Cytokine-based human whole blood assay for the detection of antigen-reactive T cells. J Immunol Methods 186, 37.
34. + T cells requires repeated antigenic stimulation. Cell Immunol 152, 18.
35. 35. Löhr H.F., Schlaak J.F., Gerken G., Fleischer B., Dienes H.P. & Meyer Zum Büschenfelde K.H. (1994) Phenotypical analysis and cytokine release of liver-infiltrating and peripheral blood T lymphocytes from patients with chronic hepatitis of different etiology. Liver 14, 161.
36. 36. Böcher W.O., Herzog-Hauff S., Meyer Zum Büschenfelde K.H. & Löhr H.F. (1998) Kinetics of hepatitis B surface (HBs) specific immune responses in acute and chronic hepatitis B or after HBs vaccination. Stimulation of the in vitro antibody response by interferon-γ. Hepatology in press.
37. 37. Borzi R.M., Dal Monte P., Honorati M.C. & Facchini A. (1992) IgG subclass distribution of anti-HBs antibodies following vaccination with cDNA HBsAg. J Immunol Methods 146, 17.
38. 38. Persson M.A., Brown S.E., Steward M.W. et al. (1988) IgG subclass-associated affinity differences of specific antibodies in humans. J Immunol 140, 3875.
39. 39. Kawano Y. & Noma T. (1996) Role of interleukin-2 and interferon-γ in inducing production of IgG subclasses in lymphocytes of human newborns. Immunology 88, 40.
40. 40. Kawano Y., Noma T. & Yata J. (1994) Regulation of human IgG subclass production by cytokines. IFN-gamma and IL-6 act antagonistically in the induction of human IgG1 but additively in the induction of IgG2. J Immunol 153, 4948.
41. 41. Kitani A. & Strober W. (1993) Regulation of C gamma subclass germ-line transcripts in human peripheral blood B cells. J Immunol 151, 3478.
42. 42. Reisner Y. & Dagan S. (1998) The trimera mouse: a novel system for the generation of human monoclonal antibodies and models for human diseases. Trends Biotechnol 16, 242.