Generation of primary antigen-specific human cytotoxic T lymphocytes in human/mouse radiation chimera

Blood

Volumn 88, Issue 2, 1996, Pages 721-730

  Segall, Harry ^a   Lubin, Ido ^a   Marcus, Hadar ^a   Canaan, Alon ^a   Reisner, Yair ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANTIBODY RESPONSE; ANTIGEN SPECIFICITY; ARTICLE; CHIMERA; COMBINED IMMUNODEFICIENCY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; IMMUNOMODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0030001039     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.2.721.bloodjournal882721     Document Type: Article

References (47)

1. Carlsson R, Martensson C, Kalliomaki S, Ohlin M, Borrebaeck CA: Human peripheral blood lymphocytes transplanted into SCID mice constitute an in vivo culture system exhibiting several parameters found in a normal humoral immune response and are a source of immunocytes for the production of human monoclonal antibodies. J Immunol 148:1065, 1992
2. Duchosal MA, Eming SA, McConahey PJ, Dixon FJ: The hu-PBL-SCID mouse model. Long-term human serologic evolution associated with the xenogeneic transfer of human peripheral blood leukocytes into SCID mice. Cell Immunol 139:468, 1992
3. Hesselton RM, Koup RA, Cromwell MA, Graham BS, Johns M, Sullivan JL: Human peripheral blood xenografts in the SCID mouse: Characterization of immunologic reconstitution. J Infect Dis 168:630, 1993
4. Martino G, Anastasi J, Feng J, McShan C, DeGroot L, Quintans J, Grimaldi LM: The fate of human peripheral blood lymphocytes after transplantation into SCID mice. Eur J Immunol 23:1023, 1993
5. Mosier DE, Gulizia RJ, Baird SM, Wilson DB: Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 335:256, 1988
6. Mosier DE: Adoptive transfer of human lymphoid cells to severely immunodencient mice: Models for normal human immune function, autoimmunity, lymphomagenesis, and AIDS. Adv Immunol 50:303, 1991
7. Pfeffer K, Heeg K, Bubeck R, Conradt P, Wagner H: Adoptive transfer of human peripheral blood lymphocytes (PBL) in scid mice. Curr Top Microbiol Immunol 152:211, 1989
8. Torbett BE, Picchio G, Mosier DE: hu-PBL-SCID mice: A model for human immune function, AIDS, and lymphomagenesis. Immunol Rev 124:139, 1991
9. Mazingue C, Cottrez F, Auriault C, Cesbron JY, Capron A: Obtention of a human primary humoral response against schistosome protective antigens in severe combined immunodeficiency mice after the transfer of human peripheral blood mononuclear cells. Eur J Immunol 21:1763, 1991
10. Neil GA, Sammons DW: Immunization of SCID-Hu mice and generation of anti-hepatitis B surface antigen-specific hybridomas by electrofusion. Hum Antibodies Hybridomas 3:201, 1992
11. Aaberge IS, Michaelsen TE, Rolstad AK, Groeng EC, Solberg P, Lovik M: SCID-Hu mice immunized with a pneumococcal vaccine produce specific human antibodies and show increased resistance to infection. Infect Immunol 60:4146, 1992
12. Tary LM, Saxon A: Human mature T cells that are anergic in vivo prevail in SCID mice reconstituted with human peripheral blood. J Exp Med 175:503, 1992
13. + T cell repertoire in hu-PBL-SCID chimeras. J Exp Med 180:1817, 1994
14. Kollmann TR, Pettoello MM, Zhuang X, Kim A, Hachamovitch M, Smarnworawong P, Rubinstein A, Goldstein H: Disseminated human immunodeficiency virus 1 (HIV-1) infection in SCID-hu mice after peripheral inoculation with HIV-1. J Exp Med 179:513, 1994
15. Aldrovandi GM, Feuer G, Gao L, Jamieson B, Kristeva M, Chen IS, Zack JA: The SCID-hu mouse as a model for HIV-1 infection. Nature 363:732, 1993
16. Mosier DE, Gulizia RJ, Baird SM, Wilson DB, Spector DH, Spector SA: Human immunodeficiency virus infection of human-PBL-SCID mice. Science 251:791, 1991
17. Malkovska V, Cigel F, Storer BE: Human T cells in hu-PBL-SCID mice proliferate in response to Daudi lymphoma and confer anti-tumour immunity. Clin Exp Immunol 96:158, 1994
18. Shiroki R, Poindexter NJ, Mohanakumar T, Scharp DW: Rejection of human islet allografts in human lymphocyte-reconstituted severe combined immunodeficient mice. Transplant Proc 26:716, 1994
19. Alegre ML, Peterson LJ, Jeyarajah DR, Weiser M, Bluestone JA, Thistlethwaite JR: Severe combined immunodeficient mice engrafted with human splenocytes have functional human T cells and reject human allografts. J Immunol 153:2738, 1994
20. Lubin I, Segall H, Marcus H, David M, Kulova L, Steinitz M, Erlich P, Gan J, Reisner Y: Engraftment of human peripheral blood lymphocytes in normal strains of mice. Blood 83:2368, 1994
21. Karn J: Control of human immunodeficiency virus replication by the tat, rev, nef and protease genes. Curr Opin Immunol 3:526, 1991
22. Hadida F, Parrot A, Kieny MP, Sadat SB, Mayaud C, Debre P, Autran B: Carboxyl-terminal and central regions of human immunodeficiency virus-1 NEF recognized by cytotoxic T lymphocytes from lymphoid organs. An in vitro limiting dilution analysis. J Clin Invest 89:53, 1992
23. + cytotoxic T lymphocytes protect human peripheral blood leukocyte-severe combined immunodeficient mice from HIV-1 infection by an HLA-unrestricted mechanism. J Immunol 153:4826, 1994
24. Carlson IH: New markers in serum for lymphocyte activation for predicting allograft rejection. Neopterin and soluble interleukin-2 receptor. Clin Lab Med 12:99, 1992
25. Zerler B: The soluble interleukin-2 receptor as a marker for human neoplasia and immune status. Cancer Cells 3:471, 1991
26. Obara T, Vodian MA, Kung PC: Clinical significance of soluble interleukin 2 receptor for monitoring the diseases associated with activated lymphocytes and viral infections. J Clin Lab Anal 6:423, 1992
27. Sandhu J, Shpitz B, Gallinger S, Hozumi N: Human primary immune response in SCID mice engrafted with human peripheral blood lymphocytes. J Immunol 152:3806, 1994
28. Fisch P, Malkovsky M, Kovats S, Sturm E, Braakman E, Klein BS, Voss SD, Morrissey LW, DeMars R, Welch WJ, Bolhuis RL, Sondel PM: Recognition by human V gamma 9/V delta 2 T cells of a GroEL homolog on Daudi Burkitt's lymphoma cells. Science 250:1269, 1990
29. Fisch P, Oettel K, Fudim N, Surfus JE, Malkovsky M, Sondel PM: MHC-unrestricted cytotoxic and proliferative responses of two distinct human gamma/delta T cell subsets to Daudi cells. J Immunol 148:2315, 1992
30. Sturm E, Braakman E, Fisch P, Vreugdenhil RJ, Sondel P, Bolhuis RL: Human V gamma 9-V delta 2 T cell receptor-gamma delta lymphocytes show specificity to Daudi Burkitt's lymphoma cells. J Immunol 145:3202, 1990
31. Dallman MJ: Cytokines as mediators of organ graft rejection and tolerance. Curr Opin Immunol 5:788, 1993
32. Kalams SA, Walker BD: The cytotoxic T-lymphocyte response in HIV-1 infection. Clin Lab Med 14:271, 1994
33. Hoffenbach A, Langlade DP, Dadaglio G, Vilmer E, Michel F, Mayaud C, A uB, Plata F: Unusually high frequencies of HIV-specific cytotoxic T lymphocytes in humans. J Immunol 142:452, 1989
34. Walker BD, Chakrabarti S, Moss B, Paradis TJ, Flynn T, Durno AG, Blumberg RS, K aJ, Hirsch MS, Schooley RT: HIV-specific cytotoxic T lymphocytes in seropositive individuals. Nature 328:345, 1987
35. Nixon DF, Townsend AR, Elvin JG, Rizza CR, Gallwey J, McMichael AJ: HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides. Nature 336:484, 1988
36. McElrath MJ, Corey L, Greenberg PD: Evaluation of cytotoxic T cell responses to candidate HIV-1 vaccines in HIV-1-uninfected individuals. Aids Res Hum Retroviruses 10:S69, 1994 (suppl 2)
37. McElrath MJ, Hoffman M, Kluckling S, Corey L, Greenberg PD: HIV-infected macrophages as efficient stimulator cells for detection of cytotoxic T cell responses to HIV in seronegative and seropositive vaccine recipients. Aids Res Hum Retroviruses 10:541, 1994
38. McElrath MJ, Corey L, Berger D, Hoffman MC, Klucking S, Dragavon J, Peterson E, Greenberg PD: Immune responses elicited by recombinant vaccinia-human immunodeficiency virus (HIV) envelope and HIV envelope protein: Analysis of the durability of responses and effect of repeated boosting. J Infect Dis 169:41, 1994
39. Mosier DE, Gulizia RJ, MacIsaac PD, Corey L, Greenberg PD: Resistance to human immunodeficiency virus 1 infection of SCID mice reconstituted with peripheral blood leukocytes from donors vaccinated with vaccinia gp160 and recombinant gp160. Proc Natl Acad Sci USA 90:2443, 1993
40. Michel F, Hoffenbach A, Langlade-Demoyen P, Guy B, Girard M, Lecocq JP, Wain-Hobson S, Kieny MP, Plata F: HIV-specific T lymphocyte immunity in mice immunized with a recombinant vaccinia virus. Eur J Immunol 18:1917, 1988
41. Borst J, van de Griend RJ, van Oostveen JW, Ang SL, Melief CJ, Seidman JG, Bolhuis RL: A T-cell receptor gamma/CD3 complex found on cloned functional lymphocytes. Nature 325:683, 1987
42. - clones expressing the putative T cell receptor gamma gene product. Analysis of the activation pathways leading to interleukin 2 production and triggering of the lytic machinery. J Exp Med 166:277, 1987
43. Hoffman RW, Bluestone JA, Leo O, Shaw S: Lysis of anti-T3-bearing murine hybridoma cells by human allospecific cytotoxic T cell clones and inhibition of that lysis by anti-T3 and anti- LFA-1 antibodies. J Immunol 135:5, 1985
44. Siliciano RF, Pratt JC, Schmidt RE, Ritz J, Reinherz EL: Activation of cytolytic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein. Nature 317:428, 1985
45. Hammond SA, Bollinger RC, Stanhope PE, Quinn TC, Schwartz D, Clements ML, Siliciano RF: Comparative clonal analysis of human immunodeficiency virus type 1 (HIV-1)-specific CD4+ and CD8+ cytolytic T lymphocytes isolated from seronegative humans immunized with candidate HTV-1 vaccines. J Exp Med 176:1531, 1992
46. Zarling JM, Eichberg JW, Moran PA, McClure J, Sridhar P, Hu SL: Proliferative and cytotoxic T cells to AIDS virus glycoproteins in chimpanzees immunized with a recombinant vaccinia virus expressing AIDS virus envelope glycoproteins. J Immunol 139:988, 1987
47. Koenig S, Earl P, Powell D, Pantaleo G, Merli S, Moss B, Fauci AS: Group-specific, major histocompatibility complex class I-restricted cytotoxic responses to human immunodeficiency virus 1 (HIV-1) envelope proteins by cloned peripheral blood T cells from an HJV-1-infected individual. Proc Natl Acad Sci USA 85:8638, 1988