Apical trypsin increases ion transport and resistance by a phospholipase C-dependent rise of Ca2+

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 288, Issue 5 32-5, 2005, Pages

  Swystun, Veronica ^a,b   Chen, Lan ^a   Factor, Phillip ^e   Siroky, Brian ^d   Darwin Bell, P ^b,d   Matalon, Sadis ^a,b,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c University of Alabama at Birmingham   (United States)

^d University of Alabama at Birmingham   (United States)

^e NONE   (United States)

Author keywords

Chloride; Elastase; Lung fluid clearance; Short circuit current; Sodium

Indexed keywords

ALPHA 1 ANTITRYPSIN; AMILORIDE; CALCIUM ION; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID ACETOXYMETHYL ESTER; GELATIN; GLIBENCLAMIDE; IONOMYCIN; LEUKOCYTE ELASTASE; PHOSPHOLIPASE C; PHOSPHOLIPASE C INHIBITOR; PROTEINASE ACTIVATED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR AGONIST; SOYBEAN TRYPSIN INHIBITOR; THAPSIGARGIN; TRYPSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRONCHUS MUCOSA; CELL LINE; CHLORIDE CURRENT; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INFLAMMATORY CELL; ION TRANSPORT; LUNG ALVEOLUS CELL TYPE 2; LUNG ALVEOLUS EPITHELIUM; LUNG CLEARANCE; LUNG FLUID; LUNG LAVAGE; NONHUMAN; NOSE MUCOSA; PRIORITY JOURNAL; SHORT CIRCUIT CURRENT; SODIUM CURRENT; ZYMOGRAPHY;

ANIMALS; BIOLOGICAL TRANSPORT; BRONCHI; CALCIUM; CELL LINE; CELL POLARITY; ELECTRIC CONDUCTIVITY; EXTRAVASCULAR LUNG WATER; HUMANS; LEUKOCYTE ELASTASE; PHOSPHOLIPASE C; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, PAR-1; RECEPTOR, PAR-2; RESPIRATORY MUCOSA; TRYPSIN;

EID: 17444381141     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00396.2004     Document Type: Article

References (54)

1. - secretion in airway epithelia. J Biol Chem 277: 43041-43049, 2002.
2. Berdiev BK, Prat AG, Cantiello HF, Ausiello DA, Fuller CM, Jovov B, Benos DJ, and Ismailov H. Regulation of epithelial sodium channels by short actin filaments. J Biol Chem 271: 17704-17710, 1996.
3. - channel by specific protein kinases and protein phosphatases. J Biol Chem 268: 2037-2047, 2004.
4. Bradding P. The role of the mast cell in asthma: a reassessment. Curr Opin Allergy Clin Immunol 3: 45-50, 2003.
5. + transport in normal and CF human bronchial epithelial cells is inhibited by BAY 39-9437. Am J Physiol Lung Cell Mol Physiol 281: L16-L23, 2001.
6. Caldwell RA, Boucher RC, and Stutts MJ. Serine protease activation of near-silent epithelial Na+ channels. Am J Physiol Cell Physiol 286: C190-C194, 2004.
7. Cantiello HF. Role of actin filament organization in CFTR activation. Pflügers Arch 443, Suppl 1: S75-S80, 2001.
8. Chen XJ, Eaton DC, and Jain L. β-Adrenergic regulation of amiloride-sensitive lung sodium channels. Am J Physiol Lung Cell Mol Physiol 282: L609-L620, 2002.
9. Chokki M, Yamamura S, Eguchi H, Masegi T, Horiuchi H, Tanabe H, Kamimura T, and Yasuoka S. Human airway trypsin-like protease increases mucin gene expression in airway epithelial cells. Am J Respir Cell Mol Biol 30: 470-478, 2004.
10. Chow JM, Moffatt JD, and Cocks TM. Effect of protease-activated receptor (PAR)-1, -2 and -4-activating peptides, thrombin and trypsin in rat isolated airways. Br J Pharmacol 131: 1584-1591, 2000.
11. Chraibi A, Vallet V, Firsov D, Hess SK, and Horisberger JD. Protease modulation of the activity of the epithelial sodium channel expressed in Xenopus oocytes. J Gen Physiol 111: 127-138, 1998.
12. Cocks TM, Fong B, Chow JM, Anderson GP, Frauman AG, Goldie RG, Henry PJ, Carr MJ, Hamilton JR, and Moffatt JD. A protective role for protease-activated receptors in the airways. Nature 398: 156-160, 1999.
13. Compton SJ, McGuire JJ, Saifeddine M, and Hollenberg MD. Restricted ability of human mast cell tryptase to activate proteinase-activated receptor-2 in rat aorta. Can J Physiol Pharmacol 80: 987-992, 2002.
14. Corvera CU, Dery O, McConalogue K, Bohm SK, Khitin LM, Caughey GH, Payan DG, and Bunnett NW. Mast cell tryptase regulates rat colonie myocytes through proteinase-activated receptor 2. J Clin Invest 100: 1383-1393, 1997.
15. Danahay H, Withey L, Poll CT, van de Graaf SF, and Bridges RJ. Protease-activated receptor-2-mediated inhibition of ion transport in human bronchial epithelial cells. Am J Physiol Cell Physiol 280: C1455-C1464, 2001.
16. Davis IC, Sullender WM, Hickman-Davis JM, Lindsey JR, and Matalon S. Nucleotide-mediated inhibition of alveolar fluid clearance in BALB/c mice following respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol 286: L112-L120, 2004.
17. Dery O, Corvera CU, Steinhoff M, and Bunnett NW. Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am J Physiol Cell Physiol 274: C1429-C1452, 1998.
18. Donaldson SH, Hirsh A, Li DC, Holloway G, Chao J, Boucher RC, and Gabriel SE. Regulation of the epithelial sodium channel by serine proteases in human airways. J Biol Chem 277: 8338-8345, 2002.
19. + currents in Xenopus oocytes expressing α,βγrENaC. Am J Physiol Cell Physiol 274: C1417-C1423, 1998.
20. Engelhardt JF, Zepeda M, Cohn JA, Yankaskas JR, and Wilson JM. Expression of the cystic fibrosis gene in adult human lung. J Clin Invest 93: 737-749, 1994.
21. Factor P, Saldias F, Ridge K, Dumasius V, Zabner J, Jaffe HA, Blanco G, Barnard M, Mercer R, Perrin R, and Sznajder JI. Augmentation of lung liquid clearance via adenovirus-mediated transfer of a Na,K-ATPase beta1 subunit gene. J Clin Invest 102: 1421-1430, 1998.
22. Fang X, Fukuda N, Barbry P, Sartori C, Verkman AS, and Matthay MA. Novel role for CFTR in fluid absorption from the distal airspaces of the lung. J Gen Physiol 119: 199-208, 2002.
23. Garty H and Edelman IS. Amiloride-sensitive trypsinization of apical sodium channels. Analysis of hormonal regulation of sodium transport in toad bladder. J Gen Physiol 81: 785-803, 1983.
24. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450, 1985.
25. + absorption across cultured alveolar type II monolayers. Am J Physiol Lung Cell Mol Physiol 274: L369-L377, 1998.
26. + transport by basal nitric oxide. Am J Respir Cell Mol Biol 30: 720-728, 2004.
27. Hughey RP, Bruns JB, Kinlough CL, Harkleroad KL, Tong Q, Carattino MD, Johnson JP, Stockand JD, and Kleyman TR. Epithelial sodium channels are activated by furin-dependent proteolysis. J Biol Chem 279: 18111-18114, 2004.
28. Jovov B, Berdiev BK, Fuller CM, Ji HL, and Benos DJ. The serine protease trypsin cleaves C termini of beta- and gamma-subunits of epithelial Na+ channels. J Biol Chem 277: 4134-4140, 2002.
29. Kawano N, Osawa H, Ito T, Nagashima Y, Hirahara F, Inayama Y, Nakatani Y, Kimura S, Kitajima H, Koshikawa N, Miyazaki K, and Kitamura H. Expression of gelatinase A, tissue inhibitor of metalloproteinases-2, matrilysin, and trypsin(ogen) in lung neoplasms: an immunohistochemical study. Hum Pathol 28: 613-622, 1997.
30. Kawkitinarong K, Linz-McGillem L, Birukov KG, and Garcia JG. Differential regulation of human lung epithelial and endothelial barrier function by thrombin. Am J Respir Cell Mol Biol 31: 517-527, 2004.
31. Kong W, McConalogue K, Khitin LM, Hollenberg MD, Payan DG, Bohm SK, and Bunnett NW. Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2. Proc Natl Acad Sci USA 94: 8884-8889, 1997.
32. Koshikawa N, Hasegawa S, Nagashima Y, Mitsuhashi K, Tsubota Y, Miyata S, Miyagi Y, Yasumitsu H, and Miyazaki K. Expression of trypsin by epithelial cells of various tissues, leukocytes, and neurons in human and mouse. Am J Pathol 153: 937-944, 1998.
33. 3- secretion across rat fetal distal lung epithelial cells. Am J Physiol Lung Cell Mol Physlol 282: L650-L658, 2002.
34. Lee WL and Downey GP. Leukocyte elastase: physiological functions and role in acute lung injury. Am J Respir Crit Care Med 164: 896-904, 2001.
35. - in fetal rat alveolar epithelium. J Physiol 515: 669-683, 1999.
36. Matalon S and O'Brodovich H. Sodium channels in alveolar epithelial cells: molecular characterization, biophysical properties, and physiological significance. Annu Rev Physiol 61: 627-661, 1999.
37. Matthay MA, Folkesson HG, and Verkman AS. Salt and water transport across alveolar and distal airway epithelia in the adult lung. Am J Physiol Lung Cell Mol Physiol 270: L487-L503, 1996.
38. 2+ concentration in human bronchial epithelial cells. J Med Invest 50: 95-107, 2003.
39. + transport is dependent on beta2-adrenergic receptor signaling. Circ Res 94: 1091-1100, 2004.
40. Nguyen TD, Moody MW, Steinhoff M, Okolo C, Koh DS, and Bunnett NW. Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2. J Clin Invest 103: 261-269, 1999.
41. Nielsen VG, Duvall MD, Baird MS, and Matalon S. cAMP activation of chloride and fluid secretion across the rabbit alveolar epithelium. Am J Physiol Lung Cell Mol Physiol 275: L1127-L1133, 1998.
42. Palmer LG and Frindt G. Effects of cell Ca and pH on Na channels from rat cortical collecting tubule. Am J Physiol Renal Fluid Electrolyte Physiol 253: F333-F339, 1987.
43. Pereira PJ, Bergner A, Macedo-Ribeiro S, Huber R, Matschiner G, Fritz H, Sommerhoff CP, and Bode W. Human beta-tryptase is a ring-like tetramer with active sites facing a central pore. Nature 392: 306-311, 1998.
44. Sakuma T, Folkesson HG, Suzuki S, Okaniwa G, Fujimura S, and Matthay MA. Beta-adrenergic agonist stimulated alveolar fluid clearance in ex vivo human and rat lungs. Am J Respir Crit Care Med 155: 506-512, 1997.
45. - cotransporter in human nasal epithelia. J Biol Chem 279: 18567-18574, 2004.
46. Takahashi M, Sano T, Yamaoka K, Kamimura T, Umemoto N, Nishitani H, and Yasuoka S. Localization of human airway trypsin-like protease in the airway: an immunohistochemical study. Histochem Cell Biol 115: 181-187, 2001.
47. Tang VW and Goodenough DA. Paracellular ion channel at the tight junction. Biophys J 84: 1660-1673, 2003.
48. Vallet V, Chraibi A, Gaeggeler HP, Horisberger JD, and Rossier BC. An epithelial serine protease activates the amiloride-sensitive sodium channel. Nature 389: 607-610, 1997.
49. Vliagoftis H, Schwingshackl A, Milne CD, Duszyk M, Hollenberg MD, Wallace JL, Befus AD, and Moqbel R. Proteinase-activated receptor-2-mediated matrix metalloproteinase-9 release from airway epithelial cells. J Allergy Clin Immunol 106: 537-545, 2000.
50. Ware LB and Matthay MA. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med 163: 1376-1383, 2001.
51. Yamaoka K, Masuda K, Ogawa H, Takagi K, Umemoto N, and Yasuoka S. Cloning and characterization of the cDNA for human airway trypsin-like protease. J Biol Chem 273: 11895-11901, 1998.
52. Yasuoka S, Ohnishi T, Kawano S, Tsuchihashi S, Ogawara M, Masuda K, Yamaoka K, Takahashi M, and Sano T. Purification, characterization, and localization of a novel trypsin-like protease found in the human airway. Am J Respir Cell Mol Biol 16: 300-308, 1997.
53. Yu JX, Chao L, and Chao J. Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA. J Biol Chem 270: 13483-13489, 1995.
54. Yue G and Matalon S. Mechanisms and sequelae of increased alveolar fluid clearance in hyperoxic rats. Am J Physiol Lung Cell Mol Physiol 272: L407-L412, 1997.