Retinoblastoma-related p107 and pRb2/p130 proteins in malignant lymphomas: Distinct mechanisms of cell growth control

Clinical Cancer Research

Volumn 5, Issue 12, 1999, Pages 4065-4072

  Leoncini, Lorenzo ^a   Bellan, Cristiana ^b   Cossu, Antonio ^a   Claudio, Pier Paolo ^c,d   Lazzi, Stefano ^b   Cinti, Caterina ^e   Cevenini, Gabriele ^b   Megha, Tiziana ^b   Laurini, Lorella ^b   Luzi, Pietro ^b   Orcioni, Giulio Fraternali ^f   Piccioli, Milena ^f   Pileri, Stefano ^f   Giardino, Costantino ^d   Tosi, Piero ^b   Giordano, Antonio ^c,g  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e CNR   (Italy)

^f UNIVERSITY OF BOLOGNA   (Italy)

^g THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOBLASTOMA PROTEIN;

ARTICLE; CANCER GROWTH; CELL DIFFERENTIATION; CELL PROLIFERATION; GROWTH REGULATION; HUMAN; HUMAN TISSUE; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGED; CELL DIVISION; FEMALE; GROWTH INHIBITORS; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOMA, DIFFUSE; MALE; MIDDLE AGED; NEOPLASM STAGING; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROTEINS; RETINOBLASTOMA-LIKE PROTEIN P107; RETINOBLASTOMA-LIKE PROTEIN P130; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 17144457159     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Puri, P. L., MacLachlan, T. K., Levrero, M., and Giordano, A. The intrinsic cell cycle: from yeast to mammals. In: G. Stein, R. Baserga, A. Giordano, and D. Denhardt (eds.), Cell Cycle and Growth Control, pp. 15-79, New York: Wiley-Liss, 1999.
2. Hutchison, C., and Glover, D. M. Cell Cycle Control. Oxford: IRL Press at Oxford University Press, 1995.
3. Paggi, M. G., Baldi, A., Bonetto, F., and Giordano, A. The retinoblastoma proteins family in cell cycle and cancer. J. Cell. Biochem., 62; 418-430, 1996.
4. Claudio, P. P., Howard, C. M., Baldi, A., De Luca, A., Fu, Y., Condorelli, G. L., Sun, Y., Colburn, N., Calabretta, B., and Giordano, A. p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107. Cancer Res., 54: 5556-5560, 1994.
5. Mulligan, G., and Jacks, T. The retinoblastoma genes family: cousins with overlapping interests. Trends Genet., 14: 223-229, 1998.
6. Vairo, G., Livingston, D. M., and Ginsberg, D. Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes Dev., 9: 869-881, 1995.
7. Hurford, R. K., Cobrinik, D., Lee, M. H., and Dyson, N. pRb and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev., 11: 1447-1463, 1997.
8. Smith, E. J., Leone, G., Degregori, J., Jakoi, L., and Nevins, J. R. The accumulation of an E2F-p130 transcriptional repressor distinguishes a G(0) cell state from a G(1) cell state. Mol. Cell. Biol., 16: 6965-6976, 1996.
9. Corbeil, H. B., and Branton, P. E. Characterization of an E2F-p130 complex formed during growth arrest. Oncogene, 15: 657-668, 1997.
10. Claudio, P. P., De Luca, A., Howard, C. M., Baldi, A., Firpo, E. J., Koff, A., Paggi, M. G., and Giordano, A. Functional analysis of pRb2/p130 interaction with cyclins. Cancer Res., 56: 2003-2008, 1996.
11. Lee, B. H., Liu, M., and Mathews, M. B. Regulation of the human proliferating cell nuclear antigen promoter by the adenovirus E1A- associated protein p107. J. Virol., 72: 1138-1145, 1998.
12. Baldi, A., Esposito, V., De Luca, A., Fu, Y., Meoli, I., Giordano, G. G., Caputi, M., Baldi, F., and Giordano, A. Differential expression of Rb2/p130 and p107 in normal human tissues and in primary lung cancer. Clin. Cancer Res., 3: 1691-1697, 1997.
13. Lee, W. H., Williams, B. O., Mulligan, G., Mukai, S., Bronson, R. T., Dyson, N., Harlow, E., and Jacks, T. Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev., 10: 1621-1632, 1996.
14. Philips, A., Huet, X., Plet, A., Le Cam, L., Vié, A., and Blanchard, J. M. The retinoblastoma protein is essential for cyclin A repression in quiescent cells. Oncogene, 16: 1373-1381, 1998.
15. Herwig, S., and Strauss, M. The retinoblastoma protein: a master regulator of cell cycle, differentiation and apoptosis. Eur. J. Biochem., 246: 581-601, 1997.
16. Geradts, J., Andriko, J. W., and Abbondanzo, S. L. Loss of tumor suppressor gene expression in high-grade but not low-grade non- Hodgkin's lymphomas. Am. J. Clin. Pathol., 709; 669-674, 1998.
17. Kraft, R., Barbini, P., Leoncini, L., Del Vecchio, M. T., Megha, T., Minacci, C., Spina, D., Massai, M. R., Tosi, P., Laissue, J. A., and Cottier, H. Spatial distribution of mitosis, apoptosis and small blood vessel in malignant diffuse follicular center cell lymphomas: a nearest- neighbor analysis. Int. J. Cancer, 59: 313-318, 1994.
18. Harris, N. L., Jaffe, E. S., Stein, H., Banks, P. M., Chan, J. K. C., Cleary, M. L., Delsol, G., De Wolf-Peeters, C., Falini, B., Gatter, K. C., Grogan, T. M., Isaacson, P. G., Knowles, D. M., Mason, D. Y., Muller-Hermenelik, H. K., Pileri, S. A., Piris, M. A., Ralfkiaer, E., and Warnke, R. A. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study group. Blood. 84: 1361-1392, 1994.
19. DeVita, V. T. Principles of chemotherapy. In: V.T. DeVita, S. Hellmann, and S. A. Rosenberg (eds.), Cancer: Principles and Practice of Oncology, pp. 257-285. Philadelphia: J. B. Lippincott, 1988.
20. DeVita, V. T., Hubbard, S. M., and Longo, D. L. The chemotherapy of lymphomas: looking back, moving forward. Cancer Res., 47: 5810-5824, 1987.
21. Kwak, L. W., Halpern, J., Olshen, R. A., and Horning, S. J. Prognostic significance of actual dose intensity in diffuse large cell lymphoma: results of a tree-structured survival analysis. J. Clin. Oncol., 8: 963-977, 1990.
22. Sabattini, E., Bisgaard, K., Ascani, S., Poggi, S., Piccioli, M., Ceccarelli, C., Pieri, F., Fraternali-Orcioni, G., and Pileri, S. A. The En Vision+ system: a new immunohistochemical method for diagnostics and research. Critical comparison with the APAAP, ChemMate, CSA, LABC, and SABC techniques. J. Clin. Pathol., 51: 506-511, 1998.
23. Pileri, S., Roncador, G., Ceccarelli, C., Piccioli, M., Briskomatis, A., Sabattini, E., Ascani, S., Santini, D., Piccaluga, P. P., Leone, O., Damiani, S., Ercolessi, C., Sandri, F., Pieri, F., Leoncini, L., and Falini, B. Antigen retrieval techniques in immunohistochemistry: comparison of different methods. J. Pathol., 183: 116-123, 1997.
24. Leoncini, L., Del Vecchio, M. T., Megha, T., Barbini, P., Galieni, P., Pileri, S., Sabattini, E., Gherlinzoni, F., Tosi, P., Kraft, R., and Cottier, H. Correlations between apoplotic and proliferative indices in malignant non-Hodgkin's lymphomas. Am. J. Pathol., 142: 755-763, 1993.
25. Leoncini, L., Del Vecchio, M. T., Spina, D., Megha, T., Lazzi, S., Bellan, C., and Tosi, P. Cell growth and cell death in malignant lymphomas. A quantitative analysis. Anal. Quant. Cytol. Histol., 21: 70-74, 1999.
26. Del Vecchio, M. T., Leoncini, L., Buerki, K., Kraft, R., Megha, T., Barbini, P., Tosi, P., and Cottier, H. Diffuse centrocytic and/or centroblastic malignant non-Hodgkin's lymphomas: comparison of mitotic and pyknotic (apoptotic) indices. Int. J. Cancer, 47: 38-43, 1991.
27. Spina, D., Leoncini, L., Del Vecchio, M. T., Megha, T., Minacci, C., Poggi, S. A., Pileri, S., Tosi, P., Kraft, R., Laissue, J. A., and Cottier, H. Low versus high cell turnover in diffusely growing non-Hodgkin's lymphomas. J. Pathol., 177: 335-341, 1995.
28. Armitage, P., and Berry, G. Statistical methods in medical research. Oxford: Blackwell Scientific Publication Ltd., 1994.
29. Krzanowski, W. J., and Marriot, F. H. C. Multivariate analysis (part 2). Toronto: Halsted Press, an imprint of John Wiley and Sons, Inc., 1995.
30. Kaplan, E. L., and Meier, P. Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc., 53: 457-481, 1958.
31. Mantel, N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother. Rep., 50: 163-170, 1966.
32. Zhu, L., van den Heuvel, S., Helin, K., Helin, A., Fattaey, A., Ewen, M., Livingston, D., Dyson, N., and Harlow, E. Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev., 7: 1111-1125, 1993.
33. Smith, E. J., Leone, G., and Nevins, J. R. Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth. Cell Growth Differ., 9: 297-303, 1998.
34. Kim, Y. W., Otterson, G. A., Kratzke, R. A., Coxon, A. B., and Kaye, F. J. Differential specificity for binding of the retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein. Mol. Cell. Biol., 14: 7256-7264, 1994.
35. Stiegler, P., Kasten, M., and Giordano, A. The RB family of cell cycle regulatory factors. J. Cell. Biochern. Suppl., 30/31: 30-36, 1998.
36. Hateboer, G., Kerhoven, R. M., Shvarts, A., Bernards, R., and Beijersbergen, R. Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming protein. Genes Dev., 10: 2960-2970, 1996.
37. Howard, C., and Giordano, A. Neoplastic transformation: oncogenes, tumor suppressors, cyclins, and Cdks. In: W. Vedeckis (ed.). Hormones and Cancer, pp. 3-41. Cambridge, MA: Birkäuser Press, 1996.
38. Shirodkar, S., Ewen, M., De Caprio, J. A., Morgan, J. A., Livingston, D. M., and Chittenden, T. The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell, 68: 157-166, 1992.
39. Johnson, D. G., and Schneider-Broussard, R. Role of E2F in cell cycle control and cancer. Front. Biosci., 3: d447-d458, 1998.
40. cdc2 and cyclin B-1. Int. J. Cancer, 77: 408-414, 1998.
41. Desrivieres, S., Volarevic, S., Mercep, L., and Ferrari, S. Evidence for different mechanisms of growth inhibition of T-cell lymphoma by phorbol esters and concanavalin A. J. Biol. Chem., 272: 2470-2476, 1997.
42. Bjarnason, G. A., Jordan, R. C. K., and Sothern, R. B. Circadian variation in the expression of cell-cycle proteins in human oral epithelium. Am. J. Pathol., 154: 613-622, 1999.
43. Howard, C. M., Claudio, P. P., Gallia, G. L., Gordon, J., Giordano, G. G., Hauck, W. W., Khalili, K., and Giordano, A. Retinoblastomarelated protein pRb2/p130 suppresses tumor growth in vivo. J. Natl. Cancer Inst., 90: 1451-1460, 1998.
44. Pupa, S. M., Howard, C. M., Invernizzi, A. M., De Vecchi, R., Giani, C., Claudio, P. P., Colnaghi, M. I., Giordano, A., and Menard, S. Ectopic expression of pRb2/p130 suppresses the tumorigenicity of the c-erbB-2-overexpressing SKOV3 tumor cell line. Oncogene, 18: 651-656, 1999.
45. Takimoto, H., Tsukuda, K., Ichimura, K., Hanofusa, H., Nakamura, A., Oda, M., Harada, M., and Shimizu, K. Genetic alterations in the retinoblastoma protein-related p107 gene in human hematologic malignancies. Biochem. Biophys. Res. Commun., 251: 264-268, 1998.
46. Baldi, A., Esposito, V., De Luca, A., Howard, C. M., Mazzarella, G., Baldi, F., Caputi, M., and Giordano, A. Differential expression of the retinoblastoma gene family members, pRb/p105, p107, and pRb2/p130 in lung cancer. Clin. Cancer Res., 2: 1239-1245, 1996.
47. Susini, T., Baldi, F., Howard, C. M., Baldi, A., Taddei, G., Massi, D., Rapi, S., Savino, L., Massi, G., and Giordano, A. Expression of the retinoblastoma-related gene Rb2/p130 correlates with clinical outcome in endometrial cancer. J. Clin. Oncol., 16: 1085-1093, 1998.
48. Massaro-Giordano, M., Baldi, G., De Luca, A., Baldi, A., and Giordano, A. Differential expression of the retinoblastoma gene family members in choroidal melanoma: prognostic significance. Clin. Cancer Res., 5: 1455-1458, 1999.
49. Minimo, C., Bibbo, M., Claudio, P. P., De Luca, A., and Giordano, A. The role of pRb2/p130 protein in diagnosing lung carcinoma on fine needle aspiration biopsies. Pathol. Res. Pract., 195: 67-70, 1999.
50. Stiegler, P., and Giordano, A. Big brothers are watching: the retinoblastoma family in growth control. In: Maciera-Coelho (ed.). Progress in Molecular and Subcellular Biology: Inhibitors of Cell Growth, Vol., 20, pp. 25-42. Berlin: Springer Verlag, 1998.
51. Hoshikawa, Y., Mori, A., Amimoto, K., Iwabe, K., and Hatakeyama, M. Control of the retinoblastoma protein-independent hematopoietic cell cycle by the pRB-related p130. Proc. Natl. Acad. Sci. USA. 95: 8574-8579, 1998.
52. Ishii, H., Igarashim, T., Saito, T., Nakano, T., Mori, M., Ohyama, H., Miyamoto, T., Saito, Y., and Oh, H. Retinoblastoma protein expressed in human non-Hodgkin's lymphoma cells generates resistance against radiation-induced apoptosis. Am. J. Hematol., 55: 46-48, 1997.
53. Tiemann, F., and Hinds, P. W. Induction of DNA synthesis and apoptosis by regulated inactivation of a temperature-sensitive retinoblastoma protein. EMBO J., 17: 1040-1052, 1998.