Differential expression of Rb2/p130 and p107 in normal human tissues and in primary lung cancer

Clinical Cancer Research

Volumn 3, Issue 10, 1997, Pages 1691-1697

  Baldi, Alfonso ^a   Esposito, Vincenzo ^a,b   De Luca, Antonio ^a   Fu, Yan ^a   Meoli, Ilernando ^b   Giordano, Giovan Giacomo ^b   Caputi, Mario ^b   Baldi, Feliciano ^b   Giordano, Antonio ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT;

ARTICLE; CANCER GRADING; CELL DIFFERENTIATION; CELL DIVISION; COMPLEX FORMATION; GROWTH REGULATION; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; LUNG CANCER; MOLECULAR CLONING; MULTIGENE FAMILY; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; TISSUE DISTRIBUTION; TUMOR SUPPRESSOR GENE;

BLOOD CELLS; BRAIN CHEMISTRY; BREAST; CELL DIFFERENTIATION; DIGESTIVE SYSTEM; ENDOCRINE GLANDS; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, RETINOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MULTIGENE FAMILY; MUSCLE PROTEINS; MUSCLE, SKELETAL; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; ORGAN SPECIFICITY; PERIPHERAL NERVES; PHOSPHOPROTEINS; PROSTATE; PROTEINS; RESPIRATORY SYSTEM; RETINOBLASTOMA-LIKE PROTEIN P107; RETINOBLASTOMA-LIKE PROTEIN P130; URINARY TRACT;

EID: 0030861489     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Paggi, M. G., Baldi, A., Bonetto, F., and Giordano, A. The retinoblastoma protein family in cell cycle and cancer. J. Cell. Biochem., 62: 418-430, 1996.
2. Ewen, M. E., Xing, Y., Lawrence, J. B., and Livingston, D. M. Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. Cell, 66: 1155-1164, 1991.
3. Mayol, X., Grana, X., Baldi, A., Sang, N., Hu, Q., and Giordano, A. Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain. Oncogene, 8: 2561-2566, 1993.
4. Moran, E. DNA tumor virus transforming proteins and the cell cycle. Curr. Opin. Genet. Dev., 3: 63-70, 1993.
5. Lam, E. W., and La Thangue, N. B. DP and E2F proteins: coordinating transcription with cell cycle progression. Curr. Opin. Cell Biol., 6: 859-866, 1994.
6. Zhu, L., Van den Heuvel, S., Helin, K., Fattaey, A., Ewen, M., Livingston, D. M., Dyson, N., and Harlow, E. Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev., 7: 1111-1125, 1993.
7. Claudio, P. P., Howard, C. M., Baldi, A., De Luca, A., Fu, Y., Condorelli, G., Sun, Y., Colburn, N., Calabretta, B., and Giordano, A. pRb2/p130 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107. Cancer Res., 54: 5556-5560, 1994.
8. Zhu, L., Enders, G., Lees, J. A., Beijersbergen, R. L., Bernards, R., and Harlow, E. The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes. EMBO J., 14: 1904-1913, 1995.
9. Goodrich, D. W., Wang, N. P., Qian, Y. W., Lee, E. Y., and Lee, W. H. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell, 67: 293-302, 1991.
10. Claudio, P. P., De Luca, A., Howard, C. M., Baldi, A., Firpo, E. J., Koff, A., Paggi, M. G., and Giordano, A. Functional analysis of pRb2/p130 interaction with cyclins. Cancer Res., 56: 2003-2008, 1996.
11. Cordon-Cardo, C. Mutation of cell cycle regulators. Biological and clinical implications for human neoplasia. Am. J. Pathol., 147: 545-560, 1995.
12. Cobrinik, D., Whyte, P., Peeper, D. S., Jacks, T., and Weinberg, R A. Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev., 7: 2392-2404, 1993.
13. Hijmans, E. M., Voorhoeve, P. M., Beijerbergen, R. L., Van'T Veer, L. J., and Bernards, R. E2F-5, a new E2F family member that interacts with p130 in vivo. Mol. Cell. Biol., 15: 3082-3089, 1995.
14. Vairo, G., Livingston, D. M., and Ginsberg, D. Functional interaction between E2F-4 and p 130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes Dev., 9: 869-881, 1995.
15. Jiang, H., Lin, J., Young, S., Goldstein, N. I., Waxman, S., Davila, V., Chellapan, S. P., and Fisher, P. B. Cell cycle gene expression and E2F transcription factor complexes in human melanoma cells induced to terminally differentiate. Oncogene, 11: 1179-1189, 1995.
16. Shirodkar, S., Ewen, M., DeCaprio, J. A., Morgan, J., Livingston, D. M., and Chitteden, T. The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell, 66: 157-166, 1992.
17. Baldi, A., Esposito, V., De Luca, A., Howard, C. M., Mazzarella, G., Baldi, F., Caputi, M., and Giordano, A. Differential expression of the retinoblastoma gene family members, pRb/p105, p107, and pRb2/p130 in lung cancer. Clinical Cancer Res., 2: 1239-1245, 1996.
18. World Health Organization. Histological typing of lung tumors, Ed. 2, pp. 25-26. Geneva: WHO, 1981.
19. Beahrs, O. H., Henson, D. E., Hutter, R. V. P., and Kennedy, B. J. Lung. In: Manual for Staging of Cancer, Ed. 4, pp. 115-122. Chicago: American Joint Committee on Cancer, 1992.
20. Smith, D. B., and Johnson, K. S. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene (Amst.), 67: 31-40, 1988.
21. Frangioni, J. V., and Neel, B. G. Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins. Anal. Biochem., 210: 179-187, 1993.
22. Giordano, A., Lee, J. H., Schepper, J. A., Herrmann, C., Harlow, E., Deuschle, U., Beach, D., and Franza, B. R. Cell cycle regulation of histone Hl kinase activity associated with adenovirus protein E1A. Science (Washington DC), 253: 1271-1275, 1991.
23. Cordon-Cardo, C., and Richon, V. M. Expression of the retinoblastoma protein is regulated in normal human tissues. Am. J. Pathol., 144: 500-510, 1994.
24. Shew, J. Y., Lin, B. T. Y., Chen, P., Tseng, B. Y., Yang-Feng, T. L., and Lee, W. H. C-terminal truncation of the retinoblastoma gene product leads to functional inactivation. Proc. Natl. Acad. Sci. USA, 87: 6-10, 1990.
25. Lee, E. Y., Chang, C. Y., Hu, N., Wang, Y. C., Lai, C. C., Herrup, K., Lee, W. H., and Bradley, A. Mice deficient for RB are nonviable and show defects in neurogenesis and hematopoiesis. Nature (Lond.), 359: 288-294, 1992.
26. Jacks, T., Fazeli, A., Schmitt, E. M., Bronson, R. T., Goodell, M. A., and Weinberg, R. A. Effects of an Rb mutation in the mouse. Nature (Lond.), 395: 295-300, 1992.
27. Clarke, A. R., Mandag, A. R., Roon, M. V., Lugt, N. M., Valk, M. V., Hooper, M. L., Berns, A., and Riele, H. T. Requirement of a functional Rb-1 gene in murine development. Nature (Lond.), 359: 328-330, 1992.
28. Gu, W., Schneider, J. W., Condorelli, G., Kaushal, S., Mahdavi, V., and Nadal-Ginard, B. Interaction of mitogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell, 72: 309-324, 1993.
29. Pertile, P., Baldi, A., De Luca, A., Bagella, L., Virgilio, L., Pisano, M. M., and Giordano, A. Molecular cloning, expression and developmental characterization of the murine retinoblastoma-related gene Rb2/p130. Cell Growth Differ., 6: 1659-1664, 1995.
30. Baldi, A., Boccia, V., Claudio, P. P., De Luca, A., and Giordano, A. Genomic structure of the human retinoblastoma-related Rb2/p130 gene. Proc. Natl. Acad. Sci. USA, 93: 4629-4632, 1996.