Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent Gram-positive antibacterial activity

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 4, 2003, Pages 665-668

  Jarvest, Richard L ^a   Berge, John M ^a   Brown, Murray J ^a   Brown, Pamela ^a   Elder, John S ^a   Forrest, Andrew K ^a   Houge Frydrych, C S V ^a   O'Hanlon, Peter J ^a   McNair, David J ^a   Rittenhouse, Stephen ^b   Sheppard, Robert J ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; METHIONINE TRANSFER RNA LIGASE; METHIONINE TRANSFER RNA SYNTHETASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; CYCLIZATION; DRUG POTENCY; DRUG SELECTIVITY; ENTEROCOCCUS FAECALIS; ENZYME INHIBITION; IC 50; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS;

POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 0037293938     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)01027-2     Document Type: Article

References (10)

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