Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-positive antibacterial activity

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 7, 2003, Pages 1265-1268

  Jarvest, Richard L ^a   Berge, John M ^a   Brown, Pamela ^a   Houge Frydrych, Catherine S V ^a   O'Hanlon, Peter J ^a   McNair, David J ^a   Pope, Andrew J ^a   Rittenhouse, Stephen ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; LIGASE INHIBITOR; METHIONINE TRANSFER RNA LIGASE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG POTENCY; DRUG SYNTHESIS; ENANTIOSELECTIVITY; ENTEROCOCCUS; ENZYME INHIBITION; GRAM POSITIVE BACTERIUM; NONHUMAN; STAPHYLOCOCCUS;

BACTERIA (MICROORGANISMS); POSIBACTERIA;

EID: 0037424715     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00093-3     Document Type: Article

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