Death receptor-mediated apoptosis in human malignant glioma cells: Modulation by the CD40/CD40L system

Journal of Neuroimmunology

Volumn 162, Issue 1-2, 2005, Pages 28-42

  Wischhusen, Jörg ^a   Schneider, Dagmar ^a   Mittelbronn, Michel ^a   Meyermann, Richard ^a   Engelmann, Hartmut ^b   Jung, Gundram ^a   Wiendl, Heinz ^a   Weller, Michael ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Apoptosis; Bispecific antibodies; CD40; Glioma; TNF R1 (p55)

Indexed keywords

CASPASE 3; CASPASE 8; CD40 ANTIGEN; CD40 LIGAND; DEATH RECEPTOR; FAS ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ANTIBODY SPECIFICITY; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; GENE TRANSFER; GLIOMA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION;

EID: 17044421317     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2005.01.005     Document Type: Article

References (62)

1. S.C. Afford, S. Randhawa, A.G. Eliopoulos, S.G. Hubscher, L.S. Young, and D.H. Adams CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas-mediated hepatocyte death during allograft rejection J. Exp. Med. 189 1999 441 446
2. S.C. Afford, J. Ahmed-Choudhury, S. Randhawa, C. Russell, J. Youster, H.A. Crosby, A. Eliopoulos, S.G. Hubscher, L.S. Young, and D.H. Adams CD40 activation-induced, Fas-dependent apoptosis and NF-kappaB/AP-1 signaling in human intrahepatic biliary epithelial cells FASEB J. 15 2001 2345 2354
3. I. Airoldi, S. Lualdi, S. Bruno, L. Raffaghello, M. Occhino, C. Gambini, V. Pistoia, and M.V. Corrias Expression of costimulatory molecules in human neuroblastoma. Evidence that CD40+ neuroblastoma cells undergo apoptosis following interaction with CD40L Br. J. Cancer 88 2003 1527 1536
4. F. Aloisi, F. Ria, G. Penna, and L. Adorini Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation J. Immunol. 160 1998 4671 4680
5. F. Aloisi, G. Penna, E. Polazzi, L. Minghetti, and L. Adorini CD40-CD154 interaction and IFN-gamma are required for IL-12 but not prostaglandin E2 secretion by microglia during antigen presentation to Th1 cells J. Immunol. 162 1999 1384 1391
6. A. Ashkenazi, and V.M. Dixit Death receptors: signaling and modulation Science 281 1998 1305 1308
7. O. Bähr, J. Rieger, F. Duffner, R. Meyermann, M. Weller, and W. Wick P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells Brain Pathol. 13 2003 482 494
8. R. Batrla, M. Linnebacher, W. Rudy, S. Stumm, D. Wallwiener, and B. Gückel CD40-expressing carcinoma cells induce down-regulation of CD40 ligand (CD154) and impair T-cell functions Cancer Res. 62 2002 2052 2057
9. L. Biancone, V. Cantaluppi, M. Boccellino, L. Del Sorbo, S. Russo, A. Albini, I. Stamenkovic, and G. Camussi Activation of CD40 favors the growth and vascularization of Kaposi's sarcoma J. Immunol. 163 1999 6201 6208
10. K. Büchner, V. Henn, M. Gräfe, O.J. de Boer, A.E. Becker, and R.A. Kroczek CD40 ligand is selectively expressed on CD4+ T cells and platelets: implications for CD40-CD40L signalling in atherosclerosis J. Pathol. 201 2003 288 295
11. U. Bugajska, N.T. Georgopoulos, J. Southgate, P.W. Johnson, P. Graber, J. Gordon, P.J. Selby, and L.K. Trejdosiewicz The effects of malignant transformation on susceptibility of human urothelial cells to CD40-mediated apoptosis J. Natl. Cancer Inst. 94 2002 1381 1395
12. F.K. Chan, H.J. Chun, L. Zheng, R.M. Siegel, K.L. Bui, and M.J. Lenardo A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling Science 288 2000 2351 2354
13. A. Cremesti, F. Paris, H. Grassmé, N. Holler, J. Tschopp, Z. Fuks, E. Gulbins, and R. Kolesnick Ceramide enables fas to cap and kill J. Biol. Chem. 276 2001 23954 23961
14. C. Dallman, P.W. Johnson, and G. Packham Differential regulation of cell survival by CD40 Apoptosis 8 2003 45 53
15. J. Dhein, P.T. Daniel, B.C. Trauth, A. Oehm, P. Möller, and P.H. Krammer Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens J. Immunol. 149 1992 3166 3173
16. L. Diehl, A.T. den Boer, S.P. Schoenberger, E.I. van der Voort, T.N. Schumacher, C.J. Melief, R. Offringa, and R.E. Toes CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy Nat. Med. 5 1999 774 779
17. S.M. Elbashir, J. Harborth, W. Lendeckel, A. Yalcin, K. Weber, and T. Tuschl Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Nature 411 2001 494 498
18. A.G. Eliopoulos, and L.S. Young Activation of the cJun N-terminal kinase (JNK) pathway by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) Oncogene 16 1998 1731 1742
19. A.G. Eliopoulos, C.W. Dawson, G. Mosialos, J.E. Floettmann, M. Rowe, R.J. Armitage, J. Dawson, J.M. Zapata, D.J. Kerr, M.J. Wakelam, J.C. Reed, E. Kieff, and L.S. Young CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr Virus-encoded LMP1: involvement of TRAF3 as a common mediator Oncogene 13 1996 2243 2254
20. A.G. Eliopoulos, C. Davies, P.G. Knox, N.J. Gallagher, S.C. Afford, D.H. Adams, and L.S. Young CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily Mol. Cell. Biol. 20 2000 5503 5515
21. T. Fernandez, S. Amoroso, S. Sharpe, G.M. Jones, V. Bliskovski, A. Kovalchuk, L.M. Wakefield, S.J. Kim, M. Potter, and J.J. Letterio Disruption of transforming growth factor beta signaling by a novel ligand-dependent mechanism J. Exp. Med. 195 2002 1247 1255
22. S. Fulda, W. Wick, M. Weller, and K.M. Debatin Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo Nat. Med. 8 2002 808 815
23. N.J. Gallagher, A.G. Eliopoulos, A. Agathangelo, J. Oates, J. Crocker, and L.S. Young CD40 activation in epithelial ovarian carcinoma cells modulates growth, apoptosis, and cytokine secretion Mol. Pathol. 55 2002 110 120
24. S. Ghamande, B.L. Hylander, E. Oflazoglu, S. Lele, W. Fanslow, and E.A. Repasky Recombinant CD40 ligand therapy has significant antitumor effects on CD40-positive ovarian tumor xenografts grown in SCID mice and demonstrates an augmented effect with cisplatin Cancer Res. 61 2001 7556 7562
25. H. Grassmé, J. Bock, J. Kun, and E. Gulbins Clustering of CD40 ligand is required to form a functional contact with CD40 J. Biol. Chem. 277 2002 30289 30299
26. H. Grassmé, V. Jendrossek, J. Bock, A. Riehle, and E. Gulbins Ceramide-rich membrane rafts mediate CD40 clustering J. Immunol. 168 2002 298 307
27. M. Grell, G. Zimmermann, E. Gottfried, C.M. Chen, U. Grünwald, D.C. Huang, Y.H. Wu Lee, H. Dürkop, H. Engelmann, P. Scheurich, H. Wajant, and A. Strasser Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF EMBO J. 18 1999 3034 3043
28. N. Harper, M. Hughes, M. MacFarlane, and G.M. Cohen Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis J. Biol. Chem. 278 2003 25534 25541
29. V. Henn, J.R. Slupsky, M. Gräfe, I. Anagnostopoulos, R. Förster, G. Müller-Berghaus, and R.A. Kroczek CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells Nature 391 1998 591 594
30. S. Hess, and H. Engelmann A novel function of CD40: induction of cell death in transformed cells J. Exp. Med. 183 1996 159 167
31. S. Hess, E. Gottfried, H. Smola, U. Grünwald, M. Schuchmann, and H. Engelmann CD40 induces resistance to TNF-mediated apoptosis in a fibroblast cell line Eur. J. Immunol. 28 1998 3594 3604
32. H. Holtmann, R. Winzen, P. Holland, S. Eickemeier, E. Hoffmann, D. Wallach, N.L. Malinin, J.A. Cooper, K. Resch, and M. Kracht Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways Mol. Cell. Biol. 19 1999 6742 6753
33. H. Hsu, H.B. Shu, M.G. Pan, and D.V. Goeddel TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways Cell 84 1996 299 308
34. F.H. Igney, and P.H. Krammer Death and anti-death: tumour resistance to apoptosis Nat. Rev., Cancer 2 2002 277 288
35. N. Ishii, D. Maier, A. Merlo, M. Tada, Y. Sawamura, A.C. Diserens, and E.G. Van Meir Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines Brain Pathol. 9 1999 469 479
36. G. Jung, U. Freimann, Z. Von Marschall, R.A. Reisfeld, and W. Wilmanns Target cell-induced T cell activation with bi- and trispecific antibody fragments Eur. J. Immunol. 21 1991 2431 2435
37. G. Jung, L. Grosse-Hovest, P.H. Krammer, and H.G. Rammensee Target cell-restricted triggering of the CD95 (APO-1/Fas) death receptor with bispecific antibody fragments Cancer Res. 61 2001 1846 1848
38. P. Juo, C.J. Kuo, J. Yuan, and J. Blenis Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade Curr. Biol. 8 1998 1001 1008
39. S. Kreuz, D. Siegmund, P. Scheurich, and H. Wajant NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling Mol. Cell. Biol. 21 2001 3964 3973
40. C. Lagresle, C. Bella, P.T. Daniel, P.H. Krammer, and T. Defrance Regulation of germinal center B cell differentiation. Role of the human APO-1/Fas (CD95) molecule J. Immunol. 154 1995 5746 5756
41. D.F. Legler, O. Micheau, M.A. Doucey, J. Tschopp, and C. Bron Recruitment of TNF receptor 1 to lipid rafts is essential for TNF-alpha-mediated NF-kappaB activation Immunity 18 2003 655 664
42. O. Micheau, and J. Tschopp Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes Cell 114 2003 181 190
43. A.E. Morris, R.L. Remmele Jr., R. Klinke, B.M. Macduff, W.C. Fanslow, and R.J. Armitage Incorporation of an isoleucine zipper motif enhances the biological activity of soluble CD40L (CD154) J. Biol. Chem. 274 1999 418 423
44. R. Pluvinet, J. Petriz, J. Torras, I. Herrero-Fresneda, J.M. Cruzado, J.M. Grinyo, and J.M. Aran RNAi-mediated silencing of CD40 prevents leukocyte adhesion on CD154-activated endothelial cells Blood 2004 2004
45. W. Roth, A. Fontana, M. Trepel, J.C. Reed, J. Dichgans, and M. Weller Immunochemotherapy of malignant glioma: synergistic activity of CD95 ligand and chemotherapeutics Cancer Immunol. Immunother. 44 1997 55 63
46. W. Roth, S. Isenmann, U. Naumann, S. Kügler, M. Bähr, J. Dichgans, A. Ashkenazi, and M. Weller Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity Biochem. Biophys. Res. Commun. 265 1999 479 483
47. T.L. Rothstein, J.K. Wang, D.J. Panka, L.C. Foote, Z. Wang, B. Stanger, H. Cui, S.T. Ju, and A. Marshak-Rothstein Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells Nature 374 1995 163 165
48. Y. Ruan, S. Rabizadeh, D. Camerini, and D.E. Bredesen Expression of CD40 induces neural apoptosis J. Neurosci. Res. 50 1997 383 390
49. S. Schütze, T. Machleidt, D. Adam, R. Schwandner, K. Wiegmann, M.L. Kruse, M. Heinrich, M. Wickel, and M. Kronke Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling J. Biol. Chem. 274 1999 10203 10212
50. M. Tada, Y. Sawamura, S. Sakuma, K. Suzuki, H. Ohta, T. Aida, and H. Abe Cellular and cytokine responses of the human central nervous system to intracranial administration of tumor necrosis factor alpha for the treatment of malignant gliomas Cancer Immunol. Immunother. 36 1993 251 259
51. L. Tan, K.B. Gordon, J.P. Mueller, L.A. Matis, and S.D. Miller Presentation of proteolipid protein epitopes and B7-1-dependent activation of encephalitogenic T cells by IFN-gamma-activated SJL/J astrocytes J. Immunol. 160 1998 4271 4279
52. J. Tan, T. Town, T. Mori, D. Obregon, Y. Wu, A. DelleDonne, A. Rojiani, F. Crawford, R.A. Flavell, and M. Mullan CD40 is expressed and functional on neuronal cells EMBO J. 21 2002 643 652
53. E. Tani, H. Kitagawa, H. Ikemoto, and T. Matsumoto Proteasome inhibitors induce Fas-mediated apoptosis by c-Myc accumulation and subsequent induction of FasL message in human glioma cells FEBS Lett. 504 2001 53 58
54. M. Tone, Y. Tone, P.J. Fairchild, M. Wykes, and H. Waldmann Regulation of CD40 function by its isoforms generated through alternative splicing Proc. Natl. Acad. Sci. U. S. A. 98 2001 1751 1756
55. E.E. Varfolomeev, M.P. Boldin, T.M. Goncharov, and D. Wallach A potential mechanism of "cross-talk" between the p55 tumor necrosis factor receptor and Fas/APO1: proteins binding to the death domains of the two receptors also bind to each other J. Exp. Med. 183 1996 1271 1275
56. R.H. Vonderheide, J.P. Dutcher, J.E. Anderson, S.G. Eckhardt, K.F. Stephans, B. Razvillas, S. Garl, M.D. Butine, V.P. Perry, R.J. Armitage, R. Ghalie, D.A. Caron, and J.G. Gribben Phase I study of recombinant human CD40 ligand in cancer patients J. Clin. Oncol. 19 2001 3280 3287
57. M. Weller, K. Frei, P. Groscurth, P.H. Krammer, Y. Yonekawa, and A. Fontana Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokines J. Clin. Invest. 94 1994 954 964
58. M. Weller, M. Trepel, C. Grimmel, M. Schabet, D. Bremen, S. Krajewski, and J.C. Reed Hypericin-induced apoptosis of human malignant glioma cells is light-dependent, independent of bcl-2 expression, and does not require wild-type p53 Neurol. Res. 19 1997 459 470
59. M. Weller, J. Rieger, C. Grimmel, E.G. Van Meir, N. De Tribolet, S. Krajewski, J.C. Reed, A. von Deimling, and J. Dichgans Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses Int. J. Cancer 79 1998 640 644
60. B.G. Werneburg, S.J. Zoog, T.T. Dang, M.R. Kehry, and J.J. Crute Molecular characterization of CD40 signaling intermediates J. Biol. Chem. 276 2001 43334 43342
61. J. Wischhusen, U. Naumann, H. Ohgaki, F. Rastinejad, and M. Weller CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death Oncogene 22 2003 8233 8245
62. W.C. Yeh, J.L. Pompa, M.E. McCurrach, H.B. Shu, A.J. Elia, A. Shahinian, M. Ng, A. Wakeham, W. Khoo, K. Mitchell, W.S. El-Deiry, S.W. Lowe, D.V. Goeddel, and T.W. Mak FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis Science 279 1998 1954 1958